Project name: 2AG4

Chain sequence(s)	A: HMSSFSWDNCDEGKDPAVIRSLTLEPDPIVVPGNVTLSVVGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI; B: HMSSFSWDNCDEGKDPAVIRSLTLEPDPIVVPGNVTLSVVGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1753
• Maximal score value: 1.8868
• Average score: -0.5119
• Total score value: -167.9069

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	H	A	-0.5144
2	M	A	0.3820
3	S	A	-0.1645
4	S	A	-0.2427
5	F	A	-0.3129
6	S	A	-0.2918
7	W	A	-0.5025
8	D	A	-1.9811
9	N	A	0.0000
10	C	A	-1.1772
11	D	A	-2.2159
12	E	A	-2.9045
13	G	A	-2.3822
14	K	A	-1.8522
15	D	A	0.0000
16	P	A	0.0000
17	A	A	-0.7593
18	V	A	0.0000
19	I	A	-0.7537
20	R	A	-1.8936
21	S	A	-0.7729
22	L	A	-0.1366
23	T	A	-0.2967
24	L	A	-0.7784
25	E	A	-1.9094
26	P	A	-1.2995
27	D	A	-1.5671
28	P	A	-1.0911
29	I	A	-0.6253
30	V	A	0.0903
31	V	A	0.5328
32	P	A	0.2385
33	G	A	0.2954
34	N	A	-0.1796
35	V	A	-0.5643
36	T	A	-1.1704
37	L	A	-0.7784
38	S	A	-0.7484
39	V	A	0.0760
40	V	A	0.0432
41	G	A	-0.2309
42	S	A	-0.8464
43	T	A	0.0000
44	S	A	-1.1539
45	V	A	0.0000
46	P	A	-1.5090
47	L	A	-0.7285
48	S	A	-0.5258
49	S	A	-1.0188
50	P	A	-1.3197
51	L	A	0.0000
52	K	A	-1.2449
53	V	A	-0.1618
54	D	A	-0.3322
55	L	A	0.3774
56	V	A	-0.0918
57	L	A	-0.2343
58	E	A	-0.5504
59	K	A	-0.1748
60	E	A	0.2688
61	V	A	1.4689
62	A	A	0.7554
63	G	A	0.7821
64	L	A	1.8868
65	W	A	0.9671
66	I	A	0.3939
67	K	A	-1.1773
68	I	A	0.0000
69	P	A	-0.2325
70	C	A	0.3418
71	T	A	-0.1835
72	D	A	-0.9316
73	Y	A	0.8717
74	I	A	0.9020
75	G	A	0.0000
76	S	A	0.2622
77	C	A	0.0000
78	T	A	-0.0991
79	F	A	-0.4612
80	E	A	-2.2301
81	H	A	-1.7900
82	F	A	-0.5318
83	C	A	0.0000
84	D	A	-1.8463
85	V	A	0.0533
86	L	A	0.0809
87	D	A	-1.0117
88	M	A	0.8289
89	L	A	1.4257
90	I	A	0.1136
91	P	A	-0.6660
92	T	A	-1.0076
93	G	A	-1.4514
94	E	A	-2.0258
95	P	A	-1.8339
96	C	A	-1.3032
97	P	A	-1.5676
98	E	A	-2.1863
99	P	A	-1.7578
100	L	A	-1.0417
101	R	A	-1.9196
102	T	A	-0.9060
103	Y	A	-0.1677
104	G	A	-0.6821
105	L	A	-0.3458
106	P	A	-0.4365
107	C	A	0.0000
108	H	A	-0.5921
109	C	A	-0.7816
110	P	A	-0.8445
111	F	A	-1.1514
112	K	A	-2.5955
113	E	A	-2.7768
114	G	A	-1.5379
115	T	A	-0.7692
116	Y	A	-0.1358
117	S	A	-0.0946
118	L	A	0.0000
119	P	A	-0.8536
120	K	A	-2.0422
121	S	A	0.0000
122	E	A	-1.6571
123	F	A	0.1491
124	V	A	1.2893
125	V	A	0.7975
126	P	A	-0.1938
127	D	A	-0.9763
128	L	A	-0.1179
129	E	A	-1.3202
130	L	A	-0.2425
131	P	A	-0.2060
132	S	A	-0.2083
133	W	A	0.1913
134	L	A	0.0129
135	T	A	0.0209
136	T	A	-0.1858
137	G	A	-0.4033
138	N	A	-0.5202
139	Y	A	-0.3532
140	R	A	-0.9548
141	I	A	-0.3325
142	E	A	-0.6790
143	S	A	0.1231
144	V	A	0.2235
145	L	A	-0.0430
146	S	A	0.0000
147	S	A	-1.0263
148	S	A	-0.9152
149	G	A	-1.1120
150	K	A	-1.2803
151	R	A	-1.1358
152	L	A	0.0000
153	G	A	0.0000
154	C	A	-0.5374
155	I	A	-0.5887
156	K	A	-1.0284
157	I	A	-0.3645
158	A	A	-0.5042
159	A	A	-0.2965
160	S	A	-0.5728
161	L	A	-0.2358
162	K	A	-0.5207
163	G	A	0.3601
164	I	A	1.5088
1	H	B	-0.5239
2	M	B	0.4049
3	S	B	-0.1324
4	S	B	-0.2077
5	F	B	-0.2963
6	S	B	-0.3450
7	W	B	-0.6446
8	D	B	-2.0208
9	N	B	0.0000
10	C	B	-1.2813
11	D	B	-1.9552
12	E	B	-2.5918
13	G	B	-2.2473
14	K	B	-3.1753
15	D	B	0.0000
16	P	B	0.0000
17	A	B	-0.7600
18	V	B	0.0000
19	I	B	-0.6532
20	R	B	-1.8167
21	S	B	-0.7700
22	L	B	-0.1369
23	T	B	-0.1950
24	L	B	-0.8458
25	E	B	-2.0657
26	P	B	-1.3534
27	D	B	-1.5100
28	P	B	-1.0183
29	I	B	-0.5459
30	V	B	0.3130
31	V	B	0.5780
32	P	B	0.1751
33	G	B	-0.0607
34	N	B	-0.6945
35	V	B	0.0000
36	T	B	-1.4014
37	L	B	-0.8804
38	S	B	-0.7518
39	V	B	0.0995
40	V	B	0.0719
41	G	B	-0.2129
42	S	B	-0.4916
43	T	B	-0.3509
44	S	B	-0.6760
45	V	B	-0.4574
46	P	B	-0.8064
47	L	B	-0.3745
48	S	B	-0.5231
49	S	B	-0.9494
50	P	B	-1.2560
51	L	B	0.0000
52	K	B	-1.3163
53	V	B	-0.1207
54	D	B	-0.3015
55	L	B	0.4086
56	V	B	-0.0218
57	L	B	-0.1448
58	E	B	0.0000
59	K	B	0.0352
60	E	B	0.0000
61	V	B	1.3933
62	A	B	0.6093
63	G	B	0.5425
64	L	B	1.7926
65	W	B	0.9673
66	I	B	0.5512
67	K	B	-0.9976
68	I	B	0.0000
69	P	B	-0.1703
70	C	B	0.3704
71	T	B	-0.1785
72	D	B	-0.9170
73	Y	B	0.8724
74	I	B	0.9541
75	G	B	0.0000
76	S	B	0.3202
77	C	B	0.0000
78	T	B	-0.0914
79	F	B	-0.4226
80	E	B	-2.1713
81	H	B	-1.7139
82	F	B	-0.3982
83	C	B	0.0000
84	D	B	-1.7991
85	V	B	0.1270
86	L	B	0.1170
87	D	B	-0.9954
88	M	B	0.8312
89	L	B	1.4417
90	I	B	0.1412
91	P	B	-0.6639
92	T	B	-1.0166
93	G	B	-1.4524
94	E	B	-2.0248
95	P	B	-1.8905
96	C	B	-1.4011
97	P	B	-1.6415
98	E	B	-2.2599
99	P	B	-1.8147
100	L	B	-1.1249
101	R	B	-2.1343
102	T	B	-0.9655
103	Y	B	-0.1549
104	G	B	-0.7029
105	L	B	-0.3746
106	P	B	-0.4828
107	C	B	0.0000
108	H	B	-0.5916
109	C	B	-0.7929
110	P	B	-0.7197
111	F	B	-0.7944
112	K	B	-1.8052
113	E	B	-1.1684
114	G	B	-0.7978
115	T	B	-0.4434
116	Y	B	-0.0165
117	S	B	-0.0674
118	L	B	0.0000
119	P	B	-0.8306
120	K	B	-2.0713
121	S	B	0.0000
122	E	B	-1.8413
123	F	B	-0.0924
124	V	B	1.0234
125	V	B	0.6781
126	P	B	-0.2942
127	D	B	-1.1959
128	L	B	0.0005
129	E	B	-1.1712
130	L	B	0.1385
131	P	B	0.0073
132	S	B	-0.0782
133	W	B	0.3300
134	L	B	0.1602
135	T	B	0.2202
136	T	B	-0.0800
137	G	B	-0.3536
138	N	B	-0.5015
139	Y	B	0.0000
140	R	B	-0.9379
141	I	B	-0.4419
142	E	B	-0.8474
143	S	B	0.0156
144	V	B	0.1080
145	L	B	-0.2695
146	S	B	0.0000
147	S	B	-1.4528
148	S	B	-1.2948
149	G	B	-1.7321
150	K	B	-2.5665
151	R	B	-2.1763
152	L	B	0.0000
153	G	B	0.0000
154	C	B	-0.5690
155	I	B	-0.7311
156	K	B	-1.4788
157	I	B	-0.5973
158	A	B	-0.5961
159	A	B	-0.1748
160	S	B	-0.4979
161	L	B	-0.4025
162	K	B	-0.5362
163	G	B	0.6504
164	I	B	1.8553