| Chain sequence(s) |
A: MQIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIELNASSIYIIFDYE B: MKPEKIDCNFKLIYCELEFSLEEVLAISRNVYKRV |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.2456 | |
| 2 | Q | A | -0.3144 | |
| 3 | I | A | 0.3071 | |
| 4 | V | A | -0.2801 | |
| 5 | Q | A | -1.1426 | |
| 6 | I | A | 0.0000 | |
| 7 | E | A | -2.6734 | |
| 8 | Q | A | -2.3820 | |
| 9 | A | A | -1.5697 | |
| 10 | P | A | -1.5393 | |
| 11 | K | A | -2.2739 | |
| 12 | D | A | -1.4672 | |
| 13 | Y | A | 0.0000 | |
| 14 | I | A | 0.0000 | |
| 15 | S | A | 0.0000 | |
| 16 | D | A | 0.0000 | |
| 17 | I | A | 0.0000 | |
| 18 | K | A | -0.2919 | |
| 19 | I | A | 0.0000 | |
| 20 | I | A | 0.0000 | |
| 21 | P | A | -1.0542 | |
| 22 | S | A | -1.0375 | |
| 23 | K | A | -1.7038 | |
| 24 | S | A | -1.0762 | |
| 25 | L | A | 0.0000 | |
| 26 | L | A | 0.0000 | |
| 27 | L | A | 0.0000 | |
| 28 | I | A | 0.0000 | |
| 29 | T | A | 0.0000 | |
| 30 | S | A | 0.0000 | |
| 31 | W | A | 0.0000 | |
| 32 | D | A | -1.4641 | |
| 33 | G | A | 0.0000 | |
| 34 | S | A | 0.0000 | |
| 35 | L | A | 0.0000 | |
| 36 | T | A | 0.0000 | |
| 37 | V | A | 0.0000 | |
| 38 | Y | A | 0.0000 | |
| 39 | K | A | -1.3565 | |
| 40 | F | A | 0.0000 | |
| 41 | D | A | -1.9889 | |
| 42 | I | A | -1.1098 | |
| 43 | Q | A | -1.5167 | |
| 44 | A | A | -1.2137 | |
| 45 | K | A | -1.3584 | |
| 46 | N | A | -2.1451 | |
| 47 | V | A | -1.8754 | |
| 48 | D | A | -2.1639 | |
| 49 | L | A | -0.4474 | |
| 50 | L | A | 0.5315 | |
| 51 | Q | A | 0.4160 | |
| 52 | S | A | -0.2406 | |
| 53 | L | A | -0.7698 | |
| 54 | R | A | -2.1324 | |
| 55 | Y | A | -1.5229 | |
| 56 | K | A | -2.1294 | |
| 57 | H | A | -1.2983 | |
| 58 | P | A | -0.8421 | |
| 59 | L | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | C | A | 0.0000 | |
| 62 | C | A | 0.0000 | |
| 63 | N | A | 0.0000 | |
| 64 | F | A | 0.0000 | |
| 65 | I | A | 0.0000 | |
| 66 | D | A | -2.0553 | |
| 67 | N | A | -1.9222 | |
| 68 | T | A | -1.4186 | |
| 69 | D | A | -2.0535 | |
| 70 | L | A | -1.2320 | |
| 71 | Q | A | -0.8650 | |
| 72 | I | A | 0.0000 | |
| 73 | Y | A | 0.0000 | |
| 74 | V | A | 0.0000 | |
| 75 | G | A | 0.0000 | |
| 76 | T | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | Q | A | -0.9126 | |
| 79 | G | A | 0.0000 | |
| 80 | E | A | -0.8736 | |
| 81 | I | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | K | A | -0.9279 | |
| 84 | V | A | 0.0000 | |
| 85 | D | A | -0.0325 | |
| 86 | L | A | 0.8996 | |
| 87 | I | A | 1.7802 | |
| 88 | G | A | 0.4832 | |
| 89 | S | A | -0.1999 | |
| 90 | P | A | -0.4308 | |
| 91 | S | A | -0.3597 | |
| 92 | F | A | -0.6520 | |
| 93 | Q | A | -1.0399 | |
| 94 | A | A | -0.7575 | |
| 95 | L | A | 0.0000 | |
| 96 | T | A | -1.1147 | |
| 97 | N | A | -1.7510 | |
| 98 | N | A | -1.7951 | |
| 99 | E | A | -2.4711 | |
| 100 | A | A | -1.5982 | |
| 101 | N | A | -1.8528 | |
| 102 | L | A | -1.1085 | |
| 103 | G | A | 0.0000 | |
| 104 | I | A | 0.0000 | |
| 105 | C | A | 0.0000 | |
| 106 | R | A | -0.2773 | |
| 107 | I | A | 0.0000 | |
| 108 | C | A | -0.5663 | |
| 109 | K | A | -1.4762 | |
| 110 | Y | A | -1.4302 | |
| 111 | G | A | -1.9381 | |
| 112 | D | A | -2.8574 | |
| 113 | D | A | -2.7251 | |
| 114 | K | A | -2.1668 | |
| 115 | L | A | 0.0000 | |
| 116 | I | A | 0.0000 | |
| 117 | A | A | 0.0000 | |
| 118 | A | A | 0.0000 | |
| 119 | S | A | 0.0000 | |
| 120 | W | A | 0.0000 | |
| 121 | D | A | -0.8387 | |
| 122 | G | A | 0.0000 | |
| 123 | L | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | E | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | I | A | 0.0000 | |
| 128 | D | A | -1.0985 | |
| 129 | P | A | -1.5709 | |
| 130 | R | A | -2.5237 | |
| 131 | N | A | -1.8734 | |
| 132 | Y | A | -0.1335 | |
| 133 | G | A | -0.9799 | |
| 134 | D | A | -1.3245 | |
| 135 | G | A | 0.0000 | |
| 136 | V | A | 0.0000 | |
| 137 | I | A | 0.3725 | |
| 138 | A | A | -0.0842 | |
| 139 | V | A | 0.2909 | |
| 140 | K | A | 0.0000 | |
| 141 | N | A | -1.1210 | |
| 142 | L | A | -0.9203 | |
| 143 | N | A | -1.6773 | |
| 144 | S | A | -1.3642 | |
| 145 | N | A | -2.3475 | |
| 146 | N | A | -2.3377 | |
| 147 | T | A | -1.7558 | |
| 148 | K | A | -2.3185 | |
| 149 | V | A | -0.9054 | |
| 150 | K | A | -1.7957 | |
| 151 | N | A | -1.2319 | |
| 152 | K | A | 0.0000 | |
| 153 | I | A | 0.0000 | |
| 154 | F | A | 0.0000 | |
| 155 | T | A | 0.0000 | |
| 156 | M | A | 0.0000 | |
| 157 | D | A | -0.7051 | |
| 158 | T | A | -0.9564 | |
| 159 | N | A | -1.1653 | |
| 160 | S | A | -1.2285 | |
| 161 | S | A | -1.2595 | |
| 162 | R | A | -1.5241 | |
| 163 | L | A | 0.0000 | |
| 164 | I | A | 0.0000 | |
| 165 | V | A | 0.0000 | |
| 166 | G | A | 0.0000 | |
| 167 | M | A | 0.0000 | |
| 168 | N | A | 0.0000 | |
| 169 | N | A | -1.6382 | |
| 170 | S | A | -1.6051 | |
| 171 | Q | A | -1.6888 | |
| 172 | V | A | 0.0000 | |
| 173 | Q | A | -0.3591 | |
| 174 | W | A | -0.5425 | |
| 175 | F | A | 0.0000 | |
| 176 | R | A | -2.4003 | |
| 177 | L | A | 0.0000 | |
| 178 | P | A | -0.7055 | |
| 179 | L | A | -1.3880 | |
| 180 | C | A | -2.2589 | |
| 181 | E | A | -3.0898 | |
| 182 | D | A | -3.8038 | |
| 183 | D | A | -3.9214 | |
| 184 | N | A | -3.2332 | |
| 185 | G | A | -1.5392 | |
| 186 | T | A | -0.6084 | |
| 187 | I | A | -0.1273 | |
| 188 | E | A | -1.6767 | |
| 189 | E | A | -2.6888 | |
| 190 | S | A | 0.0000 | |
| 191 | G | A | -1.3699 | |
| 192 | L | A | -1.1887 | |
| 193 | K | A | -1.9405 | |
| 194 | Y | A | -0.7808 | |
| 195 | Q | A | 0.0000 | |
| 196 | I | A | 0.0000 | |
| 197 | R | A | -0.2802 | |
| 198 | D | A | -0.4110 | |
| 199 | V | A | 0.0000 | |
| 200 | A | A | 0.0000 | |
| 201 | L | A | 0.0000 | |
| 202 | L | A | 0.0000 | |
| 203 | P | A | -1.7407 | |
| 204 | K | A | -2.4420 | |
| 205 | E | A | -2.9054 | |
| 206 | Q | A | -2.7765 | |
| 207 | E | A | -2.8726 | |
| 208 | G | A | 0.0000 | |
| 209 | Y | A | 0.0000 | |
| 210 | A | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | S | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | I | A | 0.0000 | |
| 215 | D | A | 0.0000 | |
| 216 | G | A | 0.0000 | |
| 217 | R | A | -1.3909 | |
| 218 | V | A | 0.0000 | |
| 219 | A | A | 0.0000 | |
| 220 | V | A | 0.0000 | |
| 221 | E | A | 0.0000 | |
| 222 | F | A | -1.4933 | |
| 223 | F | A | -1.9989 | |
| 224 | D | A | -3.1295 | |
| 225 | D | A | -2.7718 | |
| 232 | S | A | -1.6766 | |
| 233 | S | A | -1.9424 | |
| 234 | K | A | -2.1027 | |
| 235 | R | A | -1.2646 | |
| 236 | F | A | -0.4993 | |
| 237 | A | A | -0.4396 | |
| 238 | F | A | -0.7854 | |
| 239 | R | A | -2.1446 | |
| 240 | C | A | 0.0000 | |
| 241 | H | A | 0.0000 | |
| 242 | R | A | -2.1462 | |
| 243 | L | A | -0.7809 | |
| 244 | N | A | -1.6383 | |
| 245 | L | A | -0.7482 | |
| 246 | K | A | -2.2712 | |
| 247 | D | A | -2.9923 | |
| 248 | T | A | -2.3741 | |
| 249 | N | A | -2.2127 | |
| 250 | L | A | -1.7891 | |
| 251 | A | A | 0.0000 | |
| 252 | Y | A | -0.3858 | |
| 253 | P | A | 0.0000 | |
| 254 | V | A | 0.0000 | |
| 255 | N | A | 0.0000 | |
| 256 | S | A | 0.0000 | |
| 257 | I | A | 0.0000 | |
| 258 | E | A | -0.5765 | |
| 259 | F | A | -0.4464 | |
| 260 | S | A | 0.0000 | |
| 261 | P | A | -1.3986 | |
| 262 | R | A | -2.0605 | |
| 263 | H | A | -1.6724 | |
| 264 | K | A | -1.4285 | |
| 265 | F | A | -0.7695 | |
| 266 | L | A | 0.0000 | |
| 267 | Y | A | 0.0000 | |
| 268 | T | A | 0.0000 | |
| 269 | A | A | 0.0000 | |
| 270 | G | A | 0.0000 | |
| 271 | S | A | 0.0000 | |
| 272 | D | A | 0.0000 | |
| 273 | G | A | 0.0000 | |
| 274 | I | A | -0.6553 | |
| 275 | I | A | 0.0000 | |
| 276 | S | A | 0.0000 | |
| 277 | C | A | 0.0000 | |
| 278 | W | A | -1.3255 | |
| 279 | N | A | -1.8963 | |
| 280 | L | A | 0.0000 | |
| 281 | Q | A | -2.2543 | |
| 282 | T | A | -2.1482 | |
| 283 | R | A | -3.1230 | |
| 284 | K | A | -3.0882 | |
| 285 | K | A | -2.1250 | |
| 286 | I | A | -0.8831 | |
| 287 | K | A | -1.1777 | |
| 288 | N | A | -1.3431 | |
| 289 | F | A | 0.0000 | |
| 290 | A | A | -0.9426 | |
| 291 | K | A | -1.9593 | |
| 292 | F | A | -0.9902 | |
| 293 | N | A | -1.5371 | |
| 294 | E | A | -2.4048 | |
| 295 | D | A | -1.4803 | |
| 296 | S | A | 0.0000 | |
| 297 | V | A | 0.0000 | |
| 298 | V | A | 0.0000 | |
| 299 | K | A | -0.3383 | |
| 300 | I | A | 0.0000 | |
| 301 | A | A | 0.0000 | |
| 302 | C | A | -0.5487 | |
| 303 | S | A | 0.0000 | |
| 304 | D | A | -2.0973 | |
| 305 | N | A | -1.6215 | |
| 306 | I | A | 0.0000 | |
| 307 | L | A | 0.0000 | |
| 308 | C | A | 0.0000 | |
| 309 | L | A | 0.0000 | |
| 310 | A | A | 0.0000 | |
| 311 | T | A | 0.0000 | |
| 312 | S | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | D | A | 0.0000 | |
| 315 | T | A | -0.3745 | |
| 316 | F | A | 0.0000 | |
| 317 | K | A | 0.0000 | |
| 318 | T | A | -0.2623 | |
| 319 | N | A | -0.4719 | |
| 320 | A | A | -0.5631 | |
| 321 | A | A | -0.8090 | |
| 322 | I | A | -0.6574 | |
| 323 | D | A | -1.9722 | |
| 324 | Q | A | -1.2964 | |
| 325 | T | A | -0.7514 | |
| 326 | I | A | -0.4930 | |
| 327 | E | A | -1.5015 | |
| 328 | L | A | -1.0971 | |
| 329 | N | A | -1.9877 | |
| 330 | A | A | -1.5240 | |
| 331 | S | A | 0.0000 | |
| 332 | S | A | -1.1337 | |
| 333 | I | A | 0.0000 | |
| 334 | Y | A | -0.0933 | |
| 335 | I | A | 0.0000 | |
| 336 | I | A | 0.0000 | |
| 337 | F | A | 0.0000 | |
| 338 | D | A | -0.9918 | |
| 339 | Y | A | 0.0000 | |
| 340 | E | A | -1.1384 | |
| 353 | M | B | 0.2553 | |
| 354 | K | B | -1.5702 | |
| 355 | P | B | -1.9249 | |
| 356 | E | B | -3.2505 | |
| 357 | K | B | -2.8355 | |
| 358 | I | B | -1.0392 | |
| 359 | D | B | -0.6983 | |
| 360 | C | B | -0.3417 | |
| 361 | N | B | -0.3821 | |
| 362 | F | B | -0.0326 | |
| 363 | K | B | -1.2665 | |
| 364 | L | B | 0.0000 | |
| 365 | I | B | 0.0000 | |
| 366 | Y | B | 0.4675 | |
| 367 | C | B | 0.2152 | |
| 368 | E | B | -1.1215 | |
| 377 | L | B | 1.1190 | |
| 378 | E | B | 0.0000 | |
| 379 | F | B | 0.5684 | |
| 380 | S | B | 0.0000 | |
| 381 | L | B | 0.0000 | |
| 382 | E | B | -0.1615 | |
| 383 | E | B | 0.0000 | |
| 384 | V | B | 0.0000 | |
| 385 | L | B | 0.0000 | |
| 386 | A | B | 0.0000 | |
| 387 | I | B | -0.5469 | |
| 388 | S | B | -0.7914 | |
| 389 | R | B | -1.2538 | |
| 390 | N | B | -2.0895 | |
| 391 | V | B | -1.1514 | |
| 392 | Y | B | 0.0000 | |
| 393 | K | B | -2.4193 | |
| 394 | R | B | -2.0581 | |
| 395 | V | B | 0.5038 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine