Project name: 115cb2faf8c585d

Chain sequence(s)	A: TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCFIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2607
• Maximal score value: 0.9737
• Average score: -0.6022
• Total score value: -178.2553

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
28	T	A	-0.3275
29	L	A	-0.3707
30	P	A	-1.5522
31	K	A	-2.7573
32	R	A	-3.2607
33	V	A	0.0000
34	K	A	-1.2086
35	I	A	0.0000
36	V	A	0.0000
37	E	A	0.0000
38	V	A	0.0000
39	G	A	0.0000
40	P	A	0.0000
41	R	A	0.0000
42	D	A	-0.3497
43	G	A	0.0000
44	L	A	0.0000
45	Q	A	-0.6350
46	N	A	-0.9447
47	E	A	-1.2324
48	K	A	-2.0138
49	N	A	-1.2982
50	I	A	0.7709
51	V	A	0.0000
52	S	A	0.2657
53	T	A	-0.4808
54	P	A	-0.7159
55	V	A	-0.0612
56	K	A	0.0000
57	I	A	-1.0951
58	K	A	-1.3093
59	L	A	0.0000
60	I	A	0.0000
61	D	A	-1.4209
62	M	A	-1.3643
63	L	A	0.0000
64	S	A	0.0000
65	E	A	-2.1790
66	A	A	0.0000
67	G	A	-1.1725
68	L	A	0.0000
69	S	A	-0.6387
70	V	A	0.0000
71	I	A	0.0000
72	E	A	0.0000
73	T	A	0.0000
74	T	A	0.0000
75	S	A	0.0000
76	F	A	0.0000
77	V	A	0.0000
78	S	A	-0.6547
79	P	A	-0.8908
80	K	A	-1.3187
81	W	A	0.2388
82	V	A	-0.1174
83	P	A	-0.4484
84	Q	A	-0.4760
85	M	A	0.0000
86	G	A	-0.8705
87	D	A	-1.0259
88	H	A	-1.1370
89	T	A	-1.5391
90	E	A	-2.6232
91	V	A	0.0000
92	L	A	0.0000
93	K	A	-2.8903
94	G	A	-2.3172
95	I	A	0.0000
96	Q	A	-2.3658
97	K	A	-2.3681
98	F	A	-1.3122
99	P	A	-0.8556
100	G	A	-0.8373
101	I	A	-0.7720
102	N	A	-1.4009
103	Y	A	0.0000
104	P	A	0.0000
105	V	A	0.0000
106	L	A	0.0000
107	T	A	0.0000
108	P	A	0.0000
109	N	A	-1.0152
110	L	A	-1.2047
111	K	A	-2.1818
112	G	A	0.0000
113	F	A	0.0000
114	E	A	-2.0779
115	A	A	-1.0692
116	A	A	0.0000
117	V	A	-0.4189
118	A	A	-0.2247
119	A	A	0.0000
120	G	A	-0.7907
121	A	A	0.0000
122	K	A	-1.9526
123	E	A	0.0000
124	V	A	0.0000
125	V	A	0.0000
126	I	A	0.0000
127	F	A	0.6740
128	G	A	0.2715
129	A	A	0.0000
130	A	A	0.0000
131	S	A	0.0000
132	E	A	-0.6817
133	L	A	-0.5444
134	F	A	0.0000
135	T	A	0.0000
136	K	A	-1.6837
137	K	A	-2.1112
138	N	A	-1.2354
139	I	A	-0.4673
140	N	A	-1.5050
141	C	A	-0.9642
142	F	A	-0.0175
143	I	A	-0.7494
144	E	A	-2.4140
145	E	A	-2.4492
146	S	A	0.0000
147	F	A	0.0000
148	Q	A	-2.5540
149	R	A	-2.0086
150	F	A	0.0000
151	D	A	-1.5367
152	A	A	-1.2107
153	I	A	0.0000
154	L	A	0.0000
155	K	A	-2.2928
156	A	A	-1.6471
157	A	A	0.0000
158	Q	A	-2.3515
159	S	A	-1.5394
160	A	A	-1.3931
161	N	A	-1.9579
162	I	A	-1.3184
163	S	A	-0.8684
164	V	A	0.0000
165	R	A	0.0000
166	G	A	0.0000
167	Y	A	0.0000
168	V	A	0.0000
169	S	A	0.0839
170	C	A	0.0000
171	A	A	0.0000
172	L	A	0.0000
173	G	A	0.0000
174	C	A	0.0000
175	P	A	-0.0333
176	Y	A	-0.1866
177	E	A	-0.9610
178	G	A	-1.1631
179	K	A	-1.8409
180	I	A	0.0000
181	S	A	-1.0527
182	P	A	-1.1900
183	A	A	-1.2170
184	K	A	-1.1403
185	V	A	0.0000
186	A	A	0.0000
187	E	A	-2.6864
188	V	A	0.0000
189	T	A	0.0000
190	K	A	-2.1800
191	K	A	-2.0582
192	F	A	0.0000
193	Y	A	-0.2981
194	S	A	-0.4549
195	M	A	-0.6053
196	G	A	-0.7587
197	C	A	0.0000
198	Y	A	0.6717
199	E	A	0.0000
200	I	A	0.0000
201	S	A	0.0000
202	L	A	0.0000
203	G	A	0.0000
204	D	A	0.0000
205	T	A	0.0645
206	I	A	0.0000
207	G	A	0.0000
208	V	A	0.6876
209	G	A	0.0000
210	T	A	-0.0023
211	P	A	-0.6486
212	G	A	-1.1335
213	I	A	-0.8874
214	M	A	0.0000
215	K	A	-2.1218
216	D	A	-2.3548
217	M	A	0.0000
218	L	A	0.0000
219	S	A	-1.3254
220	A	A	-1.5787
221	V	A	0.0000
222	M	A	-0.9442
223	Q	A	-1.9959
224	E	A	-2.7193
225	V	A	0.0000
226	P	A	-0.4325
227	L	A	0.2299
228	A	A	0.3894
229	A	A	0.0000
230	L	A	0.0000
231	A	A	0.0000
232	V	A	0.0000
233	H	A	0.0000
234	C	A	0.0000
235	H	A	0.0000
236	D	A	-0.3096
237	T	A	0.0494
238	Y	A	0.9737
239	G	A	-0.0728
240	Q	A	-0.1134
241	A	A	0.0000
242	L	A	0.1514
243	A	A	0.0957
244	N	A	0.0000
245	T	A	0.0000
246	L	A	0.3989
247	M	A	-0.2277
248	A	A	0.0000
249	L	A	0.0000
250	Q	A	-0.9015
251	M	A	-0.3065
252	G	A	-0.1815
253	V	A	0.0000
254	S	A	-0.7581
255	V	A	-0.2951
256	V	A	0.0000
257	D	A	0.0000
258	S	A	0.0000
259	S	A	0.0000
260	V	A	0.0000
261	A	A	0.0000
262	G	A	0.0000
263	L	A	0.0000
264	G	A	0.0000
265	G	A	-0.7572
266	C	A	-0.3684
267	P	A	-0.3826
268	Y	A	0.0408
269	A	A	-0.4969
270	Q	A	-1.3694
271	G	A	-1.0271
272	A	A	-0.4960
273	S	A	-0.3646
274	G	A	0.0000
275	N	A	0.0000
276	L	A	0.0000
277	A	A	0.0000
278	T	A	0.0000
279	E	A	0.0000
280	D	A	0.0000
281	L	A	0.0000
282	V	A	0.0000
283	Y	A	0.7494
284	M	A	0.2688
285	L	A	0.0000
286	E	A	-1.7382
287	G	A	-0.7669
288	L	A	-0.3872
289	G	A	-1.5607
290	I	A	0.0000
291	H	A	-2.8086
292	T	A	-2.1112
293	G	A	-1.5370
294	V	A	0.0000
295	N	A	-1.7692
296	L	A	-1.3468
297	Q	A	-2.2258
298	K	A	-2.7855
299	L	A	0.0000
300	L	A	0.0000
301	E	A	-2.6363
302	A	A	0.0000
303	G	A	0.0000
304	N	A	-2.2641
305	F	A	-1.0702
306	I	A	0.0000
307	C	A	0.0000
308	Q	A	-2.2088
309	A	A	-0.8886
310	L	A	0.0000
311	N	A	-2.2453
312	R	A	-2.6576
313	K	A	-2.7360
314	T	A	-2.0016
315	S	A	-1.3005
316	S	A	0.0000
317	K	A	-2.1612
318	V	A	0.0000
319	A	A	0.0000
320	Q	A	-1.8241
321	A	A	-0.7906
322	T	A	-0.4256
323	C	A	0.3625