Chain sequence(s) |
A: LRVAPTVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYSTLIDGLCKAGKLDEALKLFEEMVEKGIKPNVVTYSTLIDGLCKAGKLDEALKLFEMKGIKPNVVTYNTLIDGLCKAGKLDEALKLFEEMKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGLDEALKLFEEMVEKGIKPDELTYRRVVEY |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | LA42A |
Energy difference between WT (input) and mutated protein (by FoldX) | 0.23166 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
42 | A | A | -0.4754 | mutated: LA42A |
43 | R | A | -1.1986 | |
47 | V | A | 1.1553 | |
48 | A | A | 0.5082 | |
49 | P | A | 0.2925 | |
50 | T | A | 0.7713 | |
51 | V | A | 1.0628 | |
52 | V | A | 2.1642 | |
53 | T | A | 0.9980 | |
54 | Y | A | 0.0000 | |
55 | N | A | 0.0000 | |
56 | T | A | 0.4549 | |
57 | L | A | 0.5232 | |
58 | I | A | 0.0000 | |
59 | D | A | -1.9295 | |
60 | G | A | -1.6450 | |
61 | L | A | -2.0890 | |
62 | C | A | -2.5993 | |
63 | K | A | -2.8770 | |
64 | A | A | -2.2238 | |
65 | G | A | -2.6322 | |
66 | K | A | -3.2119 | |
67 | L | A | -2.9976 | |
68 | D | A | -3.4027 | |
69 | E | A | -3.4344 | |
70 | A | A | 0.0000 | |
71 | L | A | -2.0503 | |
72 | K | A | -3.0804 | |
73 | L | A | -1.6501 | |
74 | F | A | -1.3027 | |
75 | E | A | -2.5498 | |
76 | E | A | -2.2092 | |
77 | M | A | 0.0000 | |
78 | V | A | -1.1449 | |
79 | E | A | -2.7731 | |
80 | K | A | -2.8410 | |
81 | G | A | -1.7275 | |
82 | I | A | -1.3829 | |
83 | K | A | -1.7615 | |
84 | P | A | 0.0000 | |
85 | D | A | -0.4521 | |
86 | V | A | 0.5160 | |
87 | V | A | 1.6585 | |
88 | T | A | 0.0000 | |
89 | Y | A | 0.0000 | |
90 | N | A | 0.0000 | |
91 | T | A | 0.0000 | |
92 | L | A | 0.0000 | |
93 | I | A | 0.0000 | |
94 | D | A | -1.5364 | |
95 | G | A | 0.0000 | |
96 | L | A | 0.0000 | |
97 | C | A | -2.2090 | |
98 | K | A | -2.6533 | |
99 | A | A | -1.7850 | |
100 | G | A | -2.2836 | |
101 | K | A | -2.7504 | |
102 | L | A | 0.0000 | |
103 | D | A | -3.2701 | |
104 | E | A | -3.4121 | |
105 | A | A | 0.0000 | |
106 | L | A | -2.1921 | |
107 | K | A | -3.2191 | |
108 | L | A | 0.0000 | |
109 | F | A | -1.6713 | |
110 | E | A | -2.6494 | |
111 | E | A | -2.3130 | |
112 | M | A | 0.0000 | |
113 | V | A | -1.2331 | |
114 | E | A | -2.8447 | |
115 | K | A | -2.9575 | |
116 | G | A | -1.8907 | |
117 | I | A | 0.0000 | |
118 | K | A | -1.9557 | |
119 | P | A | 0.0000 | |
120 | D | A | -0.4103 | |
121 | V | A | 0.6292 | |
122 | V | A | 1.8719 | |
123 | T | A | 0.0000 | |
124 | Y | A | 0.0000 | |
125 | N | A | 0.0000 | |
126 | T | A | 0.0000 | |
127 | L | A | 0.0000 | |
128 | I | A | 0.0000 | |
129 | D | A | -0.9813 | |
130 | G | A | -1.5016 | |
131 | L | A | 0.0000 | |
132 | C | A | -1.8303 | |
133 | K | A | -2.4122 | |
134 | A | A | -1.6242 | |
135 | G | A | -1.9066 | |
136 | K | A | -2.3147 | |
137 | L | A | -2.2408 | |
138 | D | A | -3.1262 | |
139 | E | A | -3.3707 | |
140 | A | A | 0.0000 | |
141 | L | A | -2.1096 | |
142 | K | A | -3.1995 | |
143 | L | A | 0.0000 | |
144 | F | A | -1.5378 | |
145 | E | A | -2.3631 | |
146 | E | A | -1.8711 | |
147 | M | A | 0.0000 | |
148 | V | A | -0.5975 | |
149 | E | A | -2.3286 | |
150 | K | A | -2.2503 | |
151 | G | A | -1.3670 | |
152 | I | A | -0.8749 | |
153 | K | A | -1.6734 | |
154 | P | A | 0.0000 | |
155 | D | A | -0.1086 | |
156 | V | A | 0.4115 | |
157 | V | A | 1.4807 | |
158 | T | A | 0.0000 | |
159 | Y | A | 0.0000 | |
160 | N | A | 0.4307 | |
161 | T | A | 0.0000 | |
162 | L | A | 0.0000 | |
163 | I | A | 0.0000 | |
164 | D | A | 0.0000 | |
165 | G | A | 0.0000 | |
166 | L | A | 0.0000 | |
167 | C | A | -1.5486 | |
168 | K | A | -1.8583 | |
169 | A | A | -1.3059 | |
170 | G | A | -1.8491 | |
171 | K | A | -2.2776 | |
172 | L | A | -2.1680 | |
173 | D | A | -2.8645 | |
174 | E | A | -2.9323 | |
175 | A | A | 0.0000 | |
176 | L | A | -1.8528 | |
177 | K | A | -2.7928 | |
178 | L | A | 0.0000 | |
179 | F | A | -1.3691 | |
180 | E | A | -2.5849 | |
181 | E | A | -1.9453 | |
182 | M | A | 0.0000 | |
183 | V | A | -0.8270 | |
184 | E | A | -2.3937 | |
185 | K | A | -2.0462 | |
186 | G | A | -1.4469 | |
187 | I | A | -0.9184 | |
188 | K | A | -1.7176 | |
189 | P | A | -0.7407 | |
190 | D | A | -0.6866 | |
191 | V | A | -0.3042 | |
192 | V | A | 0.5208 | |
193 | T | A | 0.0000 | |
194 | Y | A | 0.0000 | |
195 | S | A | 0.0000 | |
196 | T | A | 0.0000 | |
197 | L | A | 0.0000 | |
198 | I | A | 0.0000 | |
199 | D | A | 0.0000 | |
200 | G | A | 0.0000 | |
201 | L | A | 0.0000 | |
202 | C | A | -1.8512 | |
203 | K | A | -2.3888 | |
204 | A | A | -1.5365 | |
205 | G | A | -1.9960 | |
206 | K | A | -2.2674 | |
207 | L | A | -2.1054 | |
208 | D | A | -2.9448 | |
209 | E | A | -3.1577 | |
210 | A | A | 0.0000 | |
211 | L | A | -1.9192 | |
212 | K | A | -3.1396 | |
213 | L | A | -1.8204 | |
214 | F | A | -1.9992 | |
215 | E | A | -3.1870 | |
216 | E | A | -2.9150 | |
217 | M | A | 0.0000 | |
218 | V | A | -2.1193 | |
219 | E | A | -3.3399 | |
220 | K | A | -3.2300 | |
221 | G | A | -2.3461 | |
222 | I | A | -1.7069 | |
223 | K | A | -2.0125 | |
224 | P | A | 0.0000 | |
225 | N | A | -0.7976 | |
226 | V | A | -0.1811 | |
227 | V | A | 0.0000 | |
228 | T | A | 0.0000 | |
229 | Y | A | 0.2432 | |
230 | S | A | 0.0000 | |
231 | T | A | 0.0000 | |
232 | L | A | 0.0000 | |
233 | I | A | 0.0000 | |
234 | D | A | -1.1650 | |
235 | G | A | 0.0000 | |
236 | L | A | 0.0000 | |
237 | C | A | 0.0000 | |
238 | K | A | -2.7712 | |
239 | A | A | -1.5736 | |
240 | G | A | -1.9991 | |
241 | K | A | -2.3297 | |
242 | L | A | -2.0895 | |
243 | D | A | -2.9028 | |
244 | E | A | -2.7510 | |
245 | A | A | 0.0000 | |
246 | L | A | -1.8220 | |
247 | K | A | -2.8092 | |
248 | L | A | -1.4861 | |
249 | F | A | 0.0000 | |
250 | E | A | -2.3531 | |
252 | M | A | -1.5219 | |
255 | K | A | -2.2556 | |
256 | G | A | -1.8275 | |
257 | I | A | -1.4461 | |
258 | K | A | -1.9495 | |
259 | P | A | -1.1268 | |
260 | N | A | -0.7856 | |
261 | V | A | -0.0308 | |
262 | V | A | 0.5763 | |
263 | T | A | 0.0000 | |
264 | Y | A | 0.0000 | |
265 | N | A | 0.0000 | |
266 | T | A | -0.4469 | |
267 | L | A | 0.0000 | |
268 | I | A | 0.0000 | |
269 | D | A | -2.3722 | |
270 | G | A | 0.0000 | |
271 | L | A | 0.0000 | |
272 | C | A | 0.0000 | |
273 | K | A | -3.0463 | |
274 | A | A | -1.8334 | |
275 | G | A | -2.1981 | |
276 | K | A | -2.6773 | |
277 | L | A | 0.0000 | |
278 | D | A | -3.1794 | |
279 | E | A | -3.5225 | |
280 | A | A | 0.0000 | |
281 | L | A | -2.0309 | |
282 | K | A | -2.8245 | |
283 | L | A | 0.0000 | |
284 | F | A | -1.5728 | |
285 | E | A | -2.3989 | |
286 | E | A | -1.4574 | |
287 | M | A | -0.1597 | |
290 | K | A | -2.1835 | |
291 | G | A | -1.5592 | |
292 | I | A | -1.5156 | |
293 | K | A | -2.3703 | |
294 | P | A | -1.5447 | |
295 | D | A | -1.8079 | |
296 | V | A | -0.0895 | |
297 | V | A | 1.3564 | |
298 | T | A | 0.0000 | |
299 | Y | A | 0.0000 | |
300 | N | A | 0.0000 | |
301 | T | A | -0.3450 | |
302 | L | A | 0.0000 | |
303 | I | A | 0.0000 | |
304 | D | A | -2.1898 | |
305 | G | A | 0.0000 | |
306 | L | A | 0.0000 | |
307 | C | A | 0.0000 | |
308 | K | A | -2.8393 | |
309 | A | A | -1.7142 | |
310 | G | A | -2.0702 | |
311 | K | A | -2.3786 | |
312 | L | A | -2.1833 | |
313 | D | A | -2.8829 | |
314 | E | A | -2.8587 | |
315 | A | A | 0.0000 | |
316 | L | A | -1.8990 | |
317 | K | A | -3.1299 | |
318 | L | A | 0.0000 | |
319 | F | A | -1.7659 | |
320 | E | A | -2.8945 | |
321 | E | A | -2.5953 | |
322 | M | A | 0.0000 | |
323 | V | A | -1.1426 | |
324 | E | A | -2.7294 | |
325 | K | A | -2.7571 | |
326 | G | A | -1.8387 | |
327 | I | A | 0.0000 | |
328 | K | A | -2.3331 | |
329 | P | A | 0.0000 | |
330 | D | A | -1.5395 | |
331 | V | A | -0.2372 | |
332 | V | A | 1.4887 | |
333 | T | A | 0.0000 | |
334 | Y | A | 0.0000 | |
335 | N | A | 0.0000 | |
336 | T | A | 0.0000 | |
337 | L | A | 0.0000 | |
338 | I | A | 0.0000 | |
339 | D | A | -1.2302 | |
340 | G | A | -1.7235 | |
341 | L | A | 0.0000 | |
342 | C | A | 0.0000 | |
343 | K | A | -2.4424 | |
344 | A | A | -1.6132 | |
345 | G | A | -2.0477 | |
346 | K | A | -2.4293 | |
347 | L | A | -2.0656 | |
348 | D | A | -2.8521 | |
349 | E | A | -2.7643 | |
350 | A | A | 0.0000 | |
351 | L | A | -2.0501 | |
352 | K | A | -2.9458 | |
353 | L | A | 0.0000 | |
354 | F | A | 0.0000 | |
355 | E | A | -2.6885 | |
356 | E | A | -2.2593 | |
357 | M | A | 0.0000 | |
358 | V | A | -0.8423 | |
359 | E | A | -2.5551 | |
360 | K | A | -2.4599 | |
361 | G | A | -1.6044 | |
362 | I | A | -1.4171 | |
363 | K | A | -1.9673 | |
364 | P | A | 0.0000 | |
365 | D | A | -0.0437 | |
366 | V | A | 0.5212 | |
367 | V | A | 1.6072 | |
368 | T | A | 0.0000 | |
369 | Y | A | 0.0000 | |
370 | N | A | 0.2825 | |
371 | T | A | 0.0000 | |
372 | L | A | 0.0000 | |
373 | I | A | 0.0000 | |
374 | D | A | -0.9248 | |
375 | G | A | 0.0000 | |
376 | L | A | 0.0000 | |
377 | C | A | -1.1687 | |
378 | K | A | -1.9875 | |
379 | A | A | -1.2321 | |
380 | G | A | -1.0133 | |
382 | L | A | -0.8005 | |
383 | D | A | -2.1234 | |
384 | E | A | -2.2587 | |
385 | A | A | 0.0000 | |
386 | L | A | -1.3429 | |
387 | K | A | -2.9282 | |
388 | L | A | 0.0000 | |
389 | F | A | -1.2591 | |
390 | E | A | -2.5226 | |
391 | E | A | -2.0440 | |
392 | M | A | 0.0000 | |
393 | V | A | -0.8352 | |
394 | E | A | -2.3966 | |
395 | K | A | -2.2492 | |
396 | G | A | -1.4220 | |
397 | I | A | -1.1809 | |
398 | K | A | -1.7425 | |
399 | P | A | -0.6643 | |
400 | D | A | -1.3772 | |
401 | E | A | -2.0207 | |
402 | L | A | -0.5519 | |
403 | T | A | 0.0000 | |
404 | Y | A | -0.4070 | |
405 | R | A | -1.9150 | |
406 | R | A | -1.0979 | |
407 | V | A | 0.0000 | |
408 | V | A | 0.9617 | |
409 | E | A | -1.0779 | |
411 | Y | A | 1.2402 |