| Chain sequence(s) |
A: MRILMLGLDAAGKTTILYKLKLGQSVYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYK B: MRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 14 | M | A | 0.0000 | |
| 15 | R | A | -0.9372 | |
| 16 | I | A | 0.0000 | |
| 17 | L | A | 0.0000 | |
| 18 | M | A | 0.0000 | |
| 19 | L | A | 0.0000 | |
| 20 | G | A | 0.0000 | |
| 21 | L | A | 0.0000 | |
| 22 | D | A | -1.1598 | |
| 23 | A | A | -0.4346 | |
| 24 | A | A | 0.0000 | |
| 25 | G | A | -0.2560 | |
| 26 | K | A | 0.0000 | |
| 27 | T | A | -0.1744 | |
| 28 | T | A | 0.0081 | |
| 29 | I | A | 0.0000 | |
| 30 | L | A | 0.0000 | |
| 31 | Y | A | 0.7590 | |
| 32 | K | A | 0.0235 | |
| 33 | L | A | 0.0000 | |
| 34 | K | A | 0.2675 | |
| 35 | L | A | 1.3865 | |
| 36 | G | A | 0.2331 | |
| 37 | Q | A | 0.3174 | |
| 38 | S | A | 0.6247 | |
| 39 | V | A | 1.7480 | |
| 54 | Y | A | -0.6545 | |
| 55 | K | A | -2.0238 | |
| 56 | N | A | -2.1345 | |
| 57 | V | A | 0.0000 | |
| 58 | K | A | -1.0736 | |
| 59 | F | A | 0.0000 | |
| 60 | N | A | 0.0000 | |
| 61 | V | A | 0.0000 | |
| 62 | W | A | 0.0000 | |
| 63 | D | A | -1.5123 | |
| 64 | V | A | 0.0000 | |
| 65 | G | A | -1.5593 | |
| 66 | G | A | -1.6808 | |
| 67 | Q | A | -2.1389 | |
| 68 | D | A | 0.0000 | |
| 69 | K | A | -1.5435 | |
| 70 | I | A | 0.0000 | |
| 71 | R | A | -1.7251 | |
| 72 | P | A | -1.0211 | |
| 73 | L | A | -0.2968 | |
| 74 | W | A | 0.0000 | |
| 75 | R | A | -1.6939 | |
| 76 | H | A | 0.0000 | |
| 77 | Y | A | 0.0000 | |
| 78 | Y | A | 0.0000 | |
| 79 | T | A | -0.8757 | |
| 80 | G | A | -0.5190 | |
| 81 | T | A | 0.0000 | |
| 82 | Q | A | -0.9946 | |
| 83 | G | A | 0.0000 | |
| 84 | L | A | 0.0000 | |
| 85 | I | A | 0.0000 | |
| 86 | F | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | V | A | 0.0000 | |
| 89 | D | A | -0.7351 | |
| 90 | C | A | 0.0000 | |
| 91 | A | A | -1.5813 | |
| 92 | D | A | -1.7633 | |
| 93 | R | A | -2.6358 | |
| 94 | D | A | -3.0204 | |
| 95 | R | A | -2.6291 | |
| 96 | I | A | 0.0000 | |
| 97 | D | A | -3.2615 | |
| 98 | E | A | -2.5142 | |
| 99 | A | A | 0.0000 | |
| 100 | R | A | -2.5996 | |
| 101 | Q | A | -2.2568 | |
| 102 | E | A | -1.8957 | |
| 103 | L | A | 0.0000 | |
| 104 | H | A | -2.0264 | |
| 105 | R | A | -2.6698 | |
| 106 | I | A | 0.0000 | |
| 107 | I | A | 0.0000 | |
| 108 | N | A | -3.2556 | |
| 109 | D | A | 0.0000 | |
| 110 | R | A | -3.5841 | |
| 111 | E | A | -3.2562 | |
| 112 | M | A | 0.0000 | |
| 113 | R | A | -4.1961 | |
| 114 | D | A | -3.7238 | |
| 115 | A | A | 0.0000 | |
| 116 | I | A | -0.8414 | |
| 117 | I | A | 0.0000 | |
| 118 | L | A | 0.0000 | |
| 119 | I | A | 0.0000 | |
| 120 | F | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | N | A | 0.0000 | |
| 123 | K | A | -1.3488 | |
| 124 | Q | A | -1.7756 | |
| 125 | D | A | -2.1992 | |
| 126 | L | A | -0.9706 | |
| 127 | P | A | -1.3101 | |
| 128 | D | A | -2.1624 | |
| 129 | A | A | 0.0000 | |
| 130 | M | A | 0.0000 | |
| 131 | K | A | -2.0034 | |
| 132 | P | A | -1.6790 | |
| 133 | H | A | -2.3276 | |
| 134 | E | A | -2.4406 | |
| 135 | I | A | 0.0000 | |
| 136 | Q | A | -2.4505 | |
| 137 | E | A | -3.1150 | |
| 138 | K | A | -2.6128 | |
| 139 | L | A | 0.0000 | |
| 140 | G | A | -2.0624 | |
| 141 | L | A | 0.0000 | |
| 142 | T | A | -1.7591 | |
| 143 | R | A | -2.8765 | |
| 144 | I | A | 0.0000 | |
| 145 | R | A | -3.5056 | |
| 146 | D | A | -3.6733 | |
| 147 | R | A | -2.8722 | |
| 148 | N | A | -2.0437 | |
| 149 | W | A | -0.5863 | |
| 150 | Y | A | 0.3060 | |
| 151 | V | A | 0.0000 | |
| 152 | Q | A | 0.0000 | |
| 153 | P | A | -1.1328 | |
| 154 | S | A | 0.0000 | |
| 155 | C | A | -1.3098 | |
| 156 | A | A | 0.0000 | |
| 157 | T | A | -0.7417 | |
| 158 | S | A | -1.1689 | |
| 159 | G | A | -1.1127 | |
| 160 | D | A | -2.4685 | |
| 161 | G | A | -1.5678 | |
| 162 | L | A | 0.0000 | |
| 163 | Y | A | -0.9719 | |
| 164 | E | A | -1.9652 | |
| 165 | G | A | 0.0000 | |
| 166 | L | A | 0.0000 | |
| 167 | T | A | -0.6808 | |
| 168 | W | A | -0.4749 | |
| 169 | L | A | 0.0000 | |
| 170 | T | A | -0.4653 | |
| 171 | S | A | -0.8843 | |
| 172 | N | A | -1.0448 | |
| 173 | Y | A | -0.6101 | |
| 174 | K | A | -1.6378 | |
| 14 | M | B | 0.0000 | |
| 15 | R | B | -1.0843 | |
| 16 | I | B | 0.0000 | |
| 17 | L | B | 0.0000 | |
| 18 | M | B | 0.0000 | |
| 19 | L | B | 0.0000 | |
| 20 | G | B | 0.0000 | |
| 21 | L | B | 0.0000 | |
| 22 | D | B | -0.9480 | |
| 23 | A | B | -0.3395 | |
| 24 | A | B | 0.0000 | |
| 25 | G | B | -0.2429 | |
| 26 | K | B | 0.0000 | |
| 27 | T | B | -0.0330 | |
| 28 | T | B | 0.2423 | |
| 29 | I | B | 0.0000 | |
| 30 | L | B | 0.0000 | |
| 31 | Y | B | 1.0863 | |
| 32 | K | B | 0.4275 | |
| 33 | L | B | 0.0000 | |
| 34 | K | B | 0.6178 | |
| 35 | L | B | 1.2885 | |
| 36 | G | B | 0.9061 | |
| 37 | Q | B | 0.0000 | |
| 38 | S | B | 1.4280 | |
| 39 | V | B | 2.3736 | |
| 40 | T | B | 1.2308 | |
| 41 | T | B | 1.2837 | |
| 42 | I | B | 2.3731 | |
| 43 | P | B | 1.4345 | |
| 44 | T | B | 1.3406 | |
| 45 | V | B | 2.2189 | |
| 46 | G | B | 1.5317 | |
| 47 | F | B | 2.0052 | |
| 48 | N | B | 0.7989 | |
| 49 | V | B | 1.2454 | |
| 50 | E | B | -0.8886 | |
| 51 | T | B | 0.2513 | |
| 52 | V | B | 0.8153 | |
| 53 | T | B | 0.2773 | |
| 54 | Y | B | 0.3270 | |
| 55 | K | B | -1.3329 | |
| 56 | N | B | -1.8281 | |
| 57 | V | B | -1.1051 | |
| 58 | K | B | -1.3402 | |
| 59 | F | B | 0.0000 | |
| 60 | N | B | 0.0000 | |
| 61 | V | B | 0.0000 | |
| 62 | W | B | 0.0000 | |
| 63 | D | B | -1.1872 | |
| 64 | V | B | 0.0000 | |
| 65 | G | B | -1.3628 | |
| 66 | G | B | -1.5378 | |
| 67 | Q | B | -1.8906 | |
| 68 | D | B | 0.0000 | |
| 69 | K | B | -0.9628 | |
| 70 | I | B | 0.0000 | |
| 71 | R | B | -0.8445 | |
| 72 | P | B | -0.4629 | |
| 73 | L | B | 0.0602 | |
| 74 | W | B | 0.0000 | |
| 75 | R | B | -1.0624 | |
| 76 | H | B | 0.0000 | |
| 77 | Y | B | 0.0000 | |
| 78 | Y | B | 0.0000 | |
| 79 | T | B | -0.7252 | |
| 80 | G | B | -0.5120 | |
| 81 | T | B | 0.0000 | |
| 82 | Q | B | -1.0692 | |
| 83 | G | B | 0.0000 | |
| 84 | L | B | 0.0000 | |
| 85 | I | B | 0.0000 | |
| 86 | F | B | 0.0000 | |
| 87 | V | B | 0.0000 | |
| 88 | V | B | 0.0000 | |
| 89 | D | B | -0.6893 | |
| 90 | C | B | 0.0000 | |
| 91 | A | B | -1.7988 | |
| 92 | D | B | -2.0671 | |
| 93 | R | B | -2.9521 | |
| 94 | D | B | -3.0233 | |
| 95 | R | B | -2.5591 | |
| 96 | I | B | 0.0000 | |
| 97 | D | B | -3.1073 | |
| 98 | E | B | -2.4345 | |
| 99 | A | B | 0.0000 | |
| 100 | R | B | -2.4093 | |
| 101 | Q | B | -2.2040 | |
| 102 | E | B | -1.6671 | |
| 103 | L | B | 0.0000 | |
| 104 | H | B | -1.8060 | |
| 105 | R | B | -2.2546 | |
| 106 | I | B | 0.0000 | |
| 107 | I | B | 0.0000 | |
| 108 | N | B | -2.8282 | |
| 109 | D | B | -2.7011 | |
| 110 | R | B | -3.3549 | |
| 111 | E | B | -2.7638 | |
| 112 | M | B | 0.0000 | |
| 113 | R | B | -4.1164 | |
| 114 | D | B | -3.4209 | |
| 115 | A | B | 0.0000 | |
| 116 | I | B | 0.0000 | |
| 117 | I | B | 0.0000 | |
| 118 | L | B | 0.0000 | |
| 119 | I | B | 0.0000 | |
| 120 | F | B | 0.0000 | |
| 121 | A | B | 0.0000 | |
| 122 | N | B | 0.0000 | |
| 123 | K | B | -1.3463 | |
| 124 | Q | B | -1.7528 | |
| 125 | D | B | -2.1896 | |
| 126 | L | B | -1.0482 | |
| 127 | P | B | -1.3221 | |
| 128 | D | B | -2.3706 | |
| 129 | A | B | -1.8679 | |
| 130 | M | B | 0.0000 | |
| 131 | K | B | -2.0438 | |
| 132 | P | B | -1.7152 | |
| 133 | H | B | -2.3923 | |
| 134 | E | B | -2.5617 | |
| 135 | I | B | 0.0000 | |
| 136 | Q | B | -2.3852 | |
| 137 | E | B | -3.1748 | |
| 138 | K | B | -2.6921 | |
| 139 | L | B | 0.0000 | |
| 140 | G | B | -2.1119 | |
| 141 | L | B | 0.0000 | |
| 142 | T | B | -1.8884 | |
| 143 | R | B | -2.9147 | |
| 144 | I | B | 0.0000 | |
| 145 | R | B | -3.5181 | |
| 146 | D | B | -3.7759 | |
| 147 | R | B | -3.1567 | |
| 148 | N | B | -2.0849 | |
| 149 | W | B | -0.7292 | |
| 150 | Y | B | 0.2639 | |
| 151 | V | B | 0.0000 | |
| 152 | Q | B | 0.0000 | |
| 153 | P | B | -1.1404 | |
| 154 | S | B | 0.0000 | |
| 155 | C | B | -1.2393 | |
| 156 | A | B | 0.0000 | |
| 157 | T | B | -0.6438 | |
| 158 | S | B | -1.0889 | |
| 159 | G | B | 0.0000 | |
| 160 | D | B | -2.1097 | |
| 161 | G | B | 0.0000 | |
| 162 | L | B | 0.0000 | |
| 163 | Y | B | 0.1338 | |
| 164 | E | B | -1.3594 | |
| 165 | G | B | 0.0000 | |
| 166 | L | B | 0.0360 | |
| 167 | T | B | -0.2884 | |
| 168 | W | B | -0.0166 | |
| 169 | L | B | 0.0000 | |
| 170 | T | B | 0.1751 | |
| 171 | S | B | -0.0674 | |
| 172 | N | B | -0.1517 | |
| 173 | Y | B | 0.4894 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine