Project name: 19822f6bbc1ee9
Status: done
submitted: 2018-03-18 12:18:42, status changed: 2018-03-18 13:28:26
Settings
Chain sequence(s)
|
A: RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHLLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.6388
-
Maximal score value
-
1.9401
-
Average score
-
-0.8318
-
Total score value
-
-298.6242
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
65 |
R |
A |
-2.7606 |
|
66 |
K |
A |
-3.0113 |
|
67 |
P |
A |
-2.2775 |
|
68 |
K |
A |
-2.3014 |
|
69 |
T |
A |
0.0000 |
|
70 |
G |
A |
0.0000 |
|
71 |
I |
A |
0.0000 |
|
72 |
L |
A |
0.0000 |
|
73 |
M |
A |
0.0000 |
|
74 |
L |
A |
0.0000 |
|
75 |
N |
A |
0.0000 |
|
76 |
M |
A |
0.2413 |
|
77 |
G |
A |
0.0000 |
|
78 |
G |
A |
0.0000 |
|
79 |
P |
A |
0.0000 |
|
80 |
E |
A |
-1.3452 |
|
81 |
T |
A |
-1.2825 |
|
82 |
L |
A |
-1.4193 |
|
83 |
G |
A |
-1.2647 |
|
84 |
D |
A |
-1.8314 |
|
85 |
V |
A |
0.0000 |
|
86 |
H |
A |
-1.9284 |
|
87 |
D |
A |
-1.7952 |
|
88 |
F |
A |
0.0000 |
|
89 |
L |
A |
0.0000 |
|
90 |
L |
A |
-0.3462 |
|
91 |
R |
A |
-0.2824 |
|
92 |
L |
A |
0.0387 |
|
93 |
F |
A |
0.3733 |
|
94 |
L |
A |
-0.1963 |
|
95 |
D |
A |
0.0000 |
|
96 |
R |
A |
-1.6213 |
|
97 |
D |
A |
-0.6721 |
|
98 |
L |
A |
0.0802 |
|
99 |
M |
A |
0.0354 |
|
100 |
T |
A |
-0.0487 |
|
101 |
L |
A |
0.3175 |
|
102 |
P |
A |
0.5370 |
|
103 |
I |
A |
1.1802 |
|
104 |
Q |
A |
0.0000 |
|
105 |
N |
A |
-1.1977 |
|
106 |
K |
A |
-1.0950 |
|
107 |
L |
A |
0.4835 |
|
108 |
A |
A |
0.0000 |
|
109 |
P |
A |
-0.5651 |
|
110 |
F |
A |
0.2710 |
|
111 |
I |
A |
-0.3126 |
|
112 |
A |
A |
0.0000 |
|
113 |
K |
A |
-2.4334 |
|
114 |
R |
A |
-2.8078 |
|
115 |
R |
A |
-2.4252 |
|
116 |
T |
A |
0.0000 |
|
117 |
P |
A |
-2.4796 |
|
118 |
K |
A |
-3.1037 |
|
119 |
I |
A |
-2.1617 |
|
120 |
Q |
A |
-2.7555 |
|
121 |
E |
A |
-3.6388 |
|
122 |
Q |
A |
-2.7099 |
|
123 |
Y |
A |
-2.4119 |
|
124 |
R |
A |
-3.5430 |
|
125 |
R |
A |
-3.0642 |
|
126 |
I |
A |
-1.6689 |
|
127 |
G |
A |
-1.4017 |
|
128 |
G |
A |
-1.9740 |
|
129 |
G |
A |
-1.6389 |
|
130 |
S |
A |
-0.7399 |
|
131 |
P |
A |
-0.2330 |
|
132 |
I |
A |
0.0000 |
|
133 |
K |
A |
-0.0046 |
|
134 |
I |
A |
0.8904 |
|
135 |
W |
A |
-0.1273 |
|
136 |
T |
A |
0.0000 |
|
137 |
S |
A |
-0.7355 |
|
138 |
K |
A |
-1.9641 |
|
139 |
Q |
A |
0.0000 |
|
140 |
G |
A |
0.0000 |
|
141 |
E |
A |
-2.8629 |
|
142 |
G |
A |
-2.0809 |
|
143 |
M |
A |
0.0000 |
|
144 |
V |
A |
0.0000 |
|
145 |
K |
A |
-2.7782 |
|
146 |
L |
A |
-1.6820 |
|
147 |
L |
A |
0.0000 |
|
148 |
D |
A |
-2.2654 |
|
149 |
E |
A |
-2.3523 |
|
150 |
L |
A |
-0.9873 |
|
151 |
S |
A |
0.0000 |
|
152 |
P |
A |
-1.4609 |
|
153 |
N |
A |
-1.6795 |
|
154 |
T |
A |
0.0000 |
|
155 |
A |
A |
-1.8254 |
|
156 |
P |
A |
-1.9978 |
|
157 |
H |
A |
0.0000 |
|
158 |
K |
A |
-1.5452 |
|
159 |
Y |
A |
-0.4408 |
|
160 |
Y |
A |
-0.3759 |
|
161 |
I |
A |
0.0502 |
|
162 |
G |
A |
0.0000 |
|
163 |
F |
A |
0.0000 |
|
164 |
R |
A |
-0.2624 |
|
165 |
Y |
A |
0.0000 |
|
166 |
V |
A |
-0.7819 |
|
167 |
H |
A |
-1.3122 |
|
168 |
P |
A |
-0.7448 |
|
169 |
L |
A |
-0.6778 |
|
170 |
T |
A |
0.0000 |
|
171 |
E |
A |
-1.5506 |
|
172 |
E |
A |
-1.8108 |
|
173 |
A |
A |
0.0000 |
|
174 |
I |
A |
0.0000 |
|
175 |
E |
A |
-2.9228 |
|
176 |
E |
A |
-3.5419 |
|
177 |
M |
A |
0.0000 |
|
178 |
E |
A |
-2.6533 |
|
179 |
R |
A |
-3.3788 |
|
180 |
D |
A |
-3.1165 |
|
181 |
G |
A |
-2.3775 |
|
182 |
L |
A |
0.0000 |
|
183 |
E |
A |
-2.3517 |
|
184 |
R |
A |
-1.5765 |
|
185 |
A |
A |
0.0000 |
|
186 |
I |
A |
0.0000 |
|
187 |
A |
A |
0.0000 |
|
188 |
F |
A |
0.0000 |
|
189 |
T |
A |
0.0000 |
|
190 |
Q |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
P |
A |
0.0000 |
|
193 |
Q |
A |
0.0000 |
|
194 |
Y |
A |
0.0000 |
|
195 |
S |
A |
0.0000 |
|
196 |
C |
A |
0.2372 |
|
197 |
S |
A |
0.0504 |
|
198 |
T |
A |
0.1036 |
|
199 |
T |
A |
0.0000 |
|
200 |
G |
A |
0.0000 |
|
201 |
S |
A |
0.0000 |
|
202 |
S |
A |
0.0000 |
|
203 |
L |
A |
0.0000 |
|
204 |
N |
A |
0.0000 |
|
205 |
A |
A |
0.0000 |
|
206 |
I |
A |
0.0000 |
|
207 |
Y |
A |
-1.1042 |
|
208 |
R |
A |
-1.5758 |
|
209 |
Y |
A |
0.0000 |
|
210 |
Y |
A |
0.0000 |
|
211 |
N |
A |
-2.7951 |
|
212 |
Q |
A |
-2.2753 |
|
213 |
V |
A |
-1.7531 |
|
214 |
G |
A |
-2.4643 |
|
215 |
R |
A |
-3.2918 |
|
216 |
K |
A |
-2.8748 |
|
217 |
P |
A |
-1.5261 |
|
218 |
T |
A |
-1.5099 |
|
219 |
M |
A |
0.0000 |
|
220 |
K |
A |
-1.1767 |
|
221 |
W |
A |
0.0000 |
|
222 |
S |
A |
0.0000 |
|
223 |
T |
A |
0.0000 |
|
224 |
I |
A |
0.0000 |
|
225 |
D |
A |
0.0000 |
|
226 |
R |
A |
-0.3830 |
|
227 |
W |
A |
0.0000 |
|
228 |
P |
A |
-0.5673 |
|
229 |
T |
A |
-0.7521 |
|
230 |
H |
A |
-0.7620 |
|
231 |
H |
A |
-1.4200 |
|
232 |
L |
A |
-0.4894 |
|
233 |
L |
A |
0.0000 |
|
234 |
I |
A |
0.0000 |
|
235 |
Q |
A |
-1.0018 |
|
236 |
C |
A |
0.0000 |
|
237 |
F |
A |
0.0000 |
|
238 |
A |
A |
0.0000 |
|
239 |
D |
A |
-1.1248 |
|
240 |
H |
A |
0.0000 |
|
241 |
I |
A |
0.0000 |
|
242 |
L |
A |
-0.5180 |
|
243 |
K |
A |
-2.4543 |
|
244 |
E |
A |
-2.4501 |
|
245 |
L |
A |
0.0000 |
|
246 |
D |
A |
-2.4358 |
|
247 |
H |
A |
-2.2829 |
|
248 |
F |
A |
0.0000 |
|
249 |
P |
A |
-0.9535 |
|
250 |
L |
A |
-0.5161 |
|
251 |
E |
A |
-1.9283 |
|
252 |
K |
A |
-2.2486 |
|
253 |
R |
A |
-1.9620 |
|
254 |
S |
A |
-1.6039 |
|
255 |
E |
A |
-2.6313 |
|
256 |
V |
A |
0.0000 |
|
257 |
V |
A |
0.0000 |
|
258 |
I |
A |
0.0000 |
|
259 |
L |
A |
0.0000 |
|
260 |
F |
A |
0.0000 |
|
261 |
S |
A |
0.0000 |
|
262 |
A |
A |
0.0000 |
|
263 |
H |
A |
-1.0160 |
|
264 |
L |
A |
0.0000 |
|
265 |
L |
A |
0.0000 |
|
266 |
P |
A |
0.3018 |
|
267 |
M |
A |
0.0072 |
|
268 |
S |
A |
-0.3237 |
|
269 |
V |
A |
0.1555 |
|
270 |
V |
A |
-0.3475 |
|
271 |
N |
A |
-1.2609 |
|
272 |
R |
A |
-0.6397 |
|
273 |
G |
A |
-0.5192 |
|
274 |
D |
A |
0.0000 |
|
275 |
P |
A |
-0.6262 |
|
276 |
Y |
A |
0.0000 |
|
277 |
P |
A |
-0.7197 |
|
278 |
Q |
A |
-1.3590 |
|
279 |
E |
A |
-0.9319 |
|
280 |
V |
A |
0.0000 |
|
281 |
S |
A |
-1.0468 |
|
282 |
A |
A |
-0.9202 |
|
283 |
T |
A |
0.0000 |
|
284 |
V |
A |
0.0000 |
|
285 |
Q |
A |
-1.7820 |
|
286 |
K |
A |
-2.8344 |
|
287 |
V |
A |
0.0000 |
|
288 |
M |
A |
0.0000 |
|
289 |
E |
A |
-3.5159 |
|
290 |
R |
A |
-3.6355 |
|
291 |
L |
A |
0.0000 |
|
292 |
E |
A |
-2.5354 |
|
293 |
Y |
A |
-0.5327 |
|
294 |
C |
A |
-0.2369 |
|
295 |
N |
A |
0.0000 |
|
296 |
P |
A |
-0.3609 |
|
297 |
Y |
A |
-0.4863 |
|
298 |
R |
A |
-1.6458 |
|
299 |
L |
A |
-0.7953 |
|
300 |
V |
A |
0.0000 |
|
301 |
W |
A |
0.0000 |
|
302 |
Q |
A |
-1.0645 |
|
303 |
S |
A |
-0.8978 |
|
304 |
K |
A |
-1.3086 |
|
305 |
V |
A |
0.2242 |
|
306 |
G |
A |
-0.2150 |
|
307 |
P |
A |
-0.2292 |
|
308 |
M |
A |
0.2075 |
|
309 |
P |
A |
-0.1483 |
|
310 |
W |
A |
0.1361 |
|
311 |
L |
A |
-0.0738 |
|
312 |
G |
A |
-0.5995 |
|
313 |
P |
A |
-0.9861 |
|
314 |
Q |
A |
-1.3464 |
|
315 |
T |
A |
0.0000 |
|
316 |
D |
A |
0.0000 |
|
317 |
E |
A |
-2.2972 |
|
318 |
S |
A |
-1.7689 |
|
319 |
I |
A |
0.0000 |
|
320 |
K |
A |
-2.5804 |
|
321 |
G |
A |
-2.3105 |
|
322 |
L |
A |
-2.0564 |
|
323 |
C |
A |
0.0000 |
|
324 |
E |
A |
-3.6068 |
|
325 |
R |
A |
-3.3182 |
|
326 |
G |
A |
-2.3459 |
|
327 |
R |
A |
-2.6909 |
|
328 |
K |
A |
-2.7262 |
|
329 |
N |
A |
0.0000 |
|
330 |
I |
A |
0.0000 |
|
331 |
L |
A |
0.0000 |
|
332 |
L |
A |
0.0000 |
|
333 |
V |
A |
0.0000 |
|
334 |
P |
A |
0.0000 |
|
335 |
I |
A |
0.0000 |
|
336 |
A |
A |
0.0000 |
|
337 |
F |
A |
-0.0713 |
|
338 |
T |
A |
-0.3537 |
|
339 |
S |
A |
0.0000 |
|
340 |
D |
A |
-1.3658 |
|
341 |
H |
A |
-0.5559 |
|
342 |
I |
A |
-0.4751 |
|
343 |
E |
A |
-0.8876 |
|
344 |
T |
A |
0.0000 |
|
345 |
L |
A |
-0.2203 |
|
346 |
Y |
A |
0.0000 |
|
347 |
E |
A |
-0.3864 |
|
348 |
L |
A |
-0.2322 |
|
349 |
D |
A |
-0.1477 |
|
350 |
I |
A |
0.8596 |
|
351 |
E |
A |
-0.8181 |
|
352 |
Y |
A |
-0.0947 |
|
353 |
S |
A |
-0.5521 |
|
354 |
Q |
A |
-1.4947 |
|
355 |
V |
A |
-0.9356 |
|
356 |
L |
A |
0.0000 |
|
357 |
A |
A |
-2.3859 |
|
358 |
K |
A |
-2.5935 |
|
359 |
E |
A |
-3.0273 |
|
360 |
C |
A |
-2.8930 |
|
361 |
G |
A |
-2.2245 |
|
362 |
V |
A |
-2.2276 |
|
363 |
E |
A |
-2.1583 |
|
364 |
N |
A |
-1.9057 |
|
365 |
I |
A |
-1.3926 |
|
366 |
R |
A |
-2.3589 |
|
367 |
R |
A |
-1.7825 |
|
368 |
A |
A |
0.0000 |
|
369 |
E |
A |
-2.6480 |
|
370 |
S |
A |
0.0000 |
|
371 |
L |
A |
0.0000 |
|
372 |
N |
A |
-0.9047 |
|
373 |
G |
A |
-0.7624 |
|
374 |
N |
A |
-0.8654 |
|
375 |
P |
A |
-0.6722 |
|
376 |
L |
A |
-0.0982 |
|
377 |
F |
A |
0.0000 |
|
378 |
S |
A |
-1.1687 |
|
379 |
K |
A |
-0.8487 |
|
380 |
A |
A |
0.0000 |
|
381 |
L |
A |
0.0000 |
|
382 |
A |
A |
0.0000 |
|
383 |
D |
A |
-0.6401 |
|
384 |
L |
A |
-0.3051 |
|
385 |
V |
A |
0.0000 |
|
386 |
H |
A |
-0.6792 |
|
387 |
S |
A |
-1.1431 |
|
388 |
H |
A |
-1.3498 |
|
389 |
I |
A |
-1.4555 |
|
390 |
Q |
A |
-2.0190 |
|
391 |
S |
A |
-1.9677 |
|
392 |
N |
A |
-2.2509 |
|
393 |
E |
A |
-2.5372 |
|
394 |
L |
A |
-1.1171 |
|
395 |
C |
A |
-1.1980 |
|
396 |
S |
A |
-1.3759 |
|
397 |
K |
A |
-2.1278 |
|
398 |
Q |
A |
-1.5027 |
|
399 |
L |
A |
-0.7701 |
|
400 |
T |
A |
-0.5186 |
|
401 |
L |
A |
0.5541 |
|
402 |
S |
A |
0.4982 |
|
403 |
C |
A |
0.7308 |
|
404 |
P |
A |
0.5275 |
|
405 |
L |
A |
1.2695 |
|
406 |
C |
A |
1.1968 |
|
407 |
V |
A |
1.9401 |
|
408 |
N |
A |
0.1180 |
|
409 |
P |
A |
-0.4875 |
|
410 |
V |
A |
-0.8766 |
|
411 |
C |
A |
-0.8720 |
|
412 |
R |
A |
-2.3692 |
|
413 |
E |
A |
-2.3006 |
|
414 |
T |
A |
0.0000 |
|
415 |
K |
A |
-1.2725 |
|
416 |
S |
A |
-1.2547 |
|
417 |
F |
A |
0.0000 |
|
418 |
F |
A |
0.0000 |
|
419 |
T |
A |
-0.6441 |
|
420 |
S |
A |
-0.4323 |
|
421 |
Q |
A |
-0.5328 |
|
422 |
Q |
A |
-0.6765 |
|
423 |
L |
A |
0.3912 |
|