Chain sequence(s) |
A: EFDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDVECKFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDERELLFETSEVVDVAKLMKAYISMIVKKRYST B: HKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGS |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | PA1686R |
Energy difference between WT (input) and mutated protein (by FoldX) | 13.4914 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1501 | E | A | -1.7109 | |
1502 | F | A | 0.0111 | |
1503 | D | A | -1.8243 | |
1504 | T | A | -1.2108 | |
1505 | P | A | -1.0942 | |
1506 | T | A | 0.0000 | |
1507 | Q | A | -1.7029 | |
1508 | Q | A | -2.3221 | |
1509 | L | A | 0.0000 | |
1510 | I | A | 0.0000 | |
1511 | Q | A | -2.8797 | |
1512 | D | A | -2.3373 | |
1513 | I | A | 0.0000 | |
1514 | K | A | -3.1681 | |
1515 | E | A | -3.0107 | |
1516 | N | A | -1.7800 | |
1517 | C | A | -1.0331 | |
1518 | L | A | 0.3467 | |
1519 | N | A | -1.1276 | |
1520 | S | A | -1.4146 | |
1521 | D | A | -2.2934 | |
1522 | V | A | -1.3263 | |
1523 | V | A | 0.0000 | |
1524 | E | A | -2.7304 | |
1525 | Q | A | -2.4095 | |
1526 | I | A | -1.8393 | |
1527 | Y | A | 0.0000 | |
1528 | K | A | -3.1733 | |
1529 | R | A | -2.9680 | |
1530 | N | A | -1.6974 | |
1531 | P | A | -1.1446 | |
1532 | I | A | -0.1464 | |
1533 | L | A | 0.0000 | |
1534 | R | A | -0.8112 | |
1535 | Y | A | -0.6141 | |
1536 | T | A | -0.9857 | |
1537 | H | A | -1.6103 | |
1538 | H | A | -1.7973 | |
1539 | P | A | -1.5662 | |
1540 | L | A | 0.0000 | |
1541 | H | A | -1.6129 | |
1542 | S | A | -1.2426 | |
1543 | P | A | -0.8959 | |
1544 | L | A | 0.0000 | |
1545 | L | A | 0.0000 | |
1546 | P | A | -0.7202 | |
1547 | L | A | 0.0000 | |
1548 | P | A | -0.6062 | |
1549 | Y | A | -0.3352 | |
1550 | G | A | -1.3912 | |
1551 | D | A | -2.0837 | |
1552 | I | A | -1.0831 | |
1553 | N | A | -0.9436 | |
1554 | L | A | -0.5220 | |
1555 | N | A | -1.6613 | |
1556 | L | A | -0.8317 | |
1557 | L | A | 0.0000 | |
1558 | K | A | -3.0336 | |
1559 | D | A | -3.2030 | |
1560 | K | A | -3.1060 | |
1561 | G | A | -2.1460 | |
1562 | Y | A | -1.6044 | |
1563 | T | A | -1.3052 | |
1564 | T | A | -0.8165 | |
1565 | L | A | 0.0000 | |
1566 | Q | A | -1.8287 | |
1567 | D | A | -2.3967 | |
1568 | E | A | -1.6974 | |
1569 | A | A | 0.0000 | |
1570 | I | A | -1.6761 | |
1571 | K | A | -2.5268 | |
1572 | I | A | 0.0000 | |
1573 | F | A | 0.0000 | |
1574 | N | A | -1.9646 | |
1575 | S | A | 0.0000 | |
1576 | L | A | 0.0000 | |
1577 | Q | A | -1.8674 | |
1578 | Q | A | -1.7468 | |
1579 | L | A | 0.0000 | |
1580 | E | A | -0.9674 | |
1581 | S | A | -0.7687 | |
1582 | M | A | -0.5798 | |
1583 | S | A | -0.8622 | |
1584 | D | A | -1.7420 | |
1585 | P | A | -0.9941 | |
1586 | I | A | -1.1167 | |
1587 | P | A | -0.5819 | |
1588 | I | A | -0.2571 | |
1589 | I | A | 0.0000 | |
1590 | Q | A | -0.4132 | |
1591 | G | A | -0.3676 | |
1592 | I | A | 0.0000 | |
1593 | L | A | 0.0000 | |
1594 | Q | A | -0.4399 | |
1595 | T | A | -0.8799 | |
1596 | G | A | 0.0000 | |
1597 | H | A | -1.1506 | |
1598 | D | A | -1.1764 | |
1599 | L | A | 0.0000 | |
1600 | R | A | -2.3340 | |
1601 | P | A | -1.4265 | |
1602 | L | A | 0.0000 | |
1603 | R | A | -1.0774 | |
1604 | D | A | -0.9690 | |
1605 | E | A | 0.0000 | |
1606 | L | A | 0.0000 | |
1607 | Y | A | 0.0000 | |
1608 | C | A | 0.0000 | |
1609 | Q | A | 0.0000 | |
1610 | L | A | 0.0000 | |
1611 | I | A | 0.0000 | |
1612 | K | A | 0.0000 | |
1613 | Q | A | 0.0000 | |
1614 | T | A | 0.0000 | |
1615 | N | A | 0.0000 | |
1616 | K | A | -1.6285 | |
1617 | V | A | -0.8998 | |
1618 | P | A | -0.9400 | |
1619 | H | A | -1.1637 | |
1620 | P | A | -0.7974 | |
1621 | G | A | -0.3835 | |
1622 | S | A | 0.1521 | |
1623 | V | A | 1.4188 | |
1624 | G | A | 0.1802 | |
1625 | N | A | 0.0000 | |
1626 | L | A | 0.4915 | |
1627 | Y | A | 0.5042 | |
1628 | S | A | 0.1791 | |
1629 | W | A | 0.0000 | |
1630 | Q | A | 0.0000 | |
1631 | I | A | 0.0000 | |
1632 | L | A | 0.0000 | |
1633 | T | A | 0.0000 | |
1634 | C | A | 0.0000 | |
1635 | L | A | 0.0000 | |
1636 | S | A | 0.0000 | |
1637 | C | A | 0.0000 | |
1638 | T | A | 0.0000 | |
1639 | F | A | 0.0000 | |
1640 | L | A | -0.3212 | |
1641 | P | A | 0.0000 | |
1642 | S | A | -1.2655 | |
1643 | R | A | -2.4139 | |
1644 | G | A | -2.0139 | |
1645 | I | A | -1.2941 | |
1646 | L | A | -1.4707 | |
1647 | K | A | -2.5262 | |
1648 | Y | A | 0.0000 | |
1649 | L | A | 0.0000 | |
1650 | K | A | -1.1730 | |
1651 | F | A | -1.0439 | |
1652 | H | A | 0.0000 | |
1653 | L | A | 0.0000 | |
1654 | K | A | -1.9739 | |
1655 | R | A | -2.1145 | |
1656 | I | A | 0.0000 | |
1657 | R | A | -2.4089 | |
1658 | E | A | -3.0404 | |
1659 | Q | A | -2.3579 | |
1660 | F | A | -1.4132 | |
1661 | P | A | -1.4447 | |
1662 | G | A | -1.2499 | |
1663 | S | A | -1.1691 | |
1664 | E | A | -1.4368 | |
1665 | M | A | 0.0000 | |
1666 | E | A | 0.0000 | |
1667 | K | A | -1.3492 | |
1668 | Y | A | 0.0000 | |
1669 | A | A | 0.0000 | |
1670 | L | A | -0.3805 | |
1671 | F | A | -0.2907 | |
1672 | T | A | 0.0000 | |
1673 | Y | A | -0.9037 | |
1674 | E | A | -1.6468 | |
1675 | S | A | 0.0000 | |
1676 | L | A | 0.0000 | |
1677 | K | A | -2.7820 | |
1678 | K | A | -2.5800 | |
1679 | T | A | 0.0000 | |
1680 | K | A | -1.9288 | |
1681 | C | A | -0.5448 | |
1682 | R | A | 0.0000 | |
1683 | E | A | -1.7971 | |
1684 | F | A | -0.9028 | |
1685 | V | A | 0.0000 | |
1686 | R | A | 0.0000 | mutated: PA1686R |
1687 | S | A | 0.0000 | |
1688 | R | A | -2.4553 | |
1689 | D | A | -3.0797 | |
1690 | E | A | 0.0000 | |
1691 | I | A | 0.0000 | |
1692 | E | A | -3.2112 | |
1693 | A | A | -2.8340 | |
1694 | L | A | 0.0000 | |
1695 | I | A | -1.3482 | |
1696 | H | A | -2.1517 | |
1697 | R | A | -2.2031 | |
1698 | Q | A | -2.8349 | |
1699 | E | A | -3.0384 | |
1700 | M | A | 0.0000 | |
1701 | T | A | -1.3139 | |
1702 | S | A | -0.7828 | |
1703 | T | A | -0.6901 | |
1704 | V | A | 0.0000 | |
1705 | Y | A | -0.2602 | |
1706 | C | A | -0.2747 | |
1707 | H | A | -0.6266 | |
1708 | G | A | -0.9369 | |
1709 | G | A | -0.9068 | |
1710 | G | A | -0.7358 | |
1711 | S | A | -0.7070 | |
1712 | C | A | -0.7833 | |
1713 | K | A | -1.6827 | |
1714 | I | A | 0.0000 | |
1715 | T | A | -1.1045 | |
1716 | I | A | 0.0000 | |
1717 | N | A | -1.3501 | |
1718 | S | A | 0.0000 | |
1719 | H | A | -0.9275 | |
1720 | T | A | -1.1575 | |
1721 | T | A | -1.4599 | |
1722 | A | A | 0.0000 | |
1723 | G | A | -2.3817 | |
1724 | E | A | -3.0716 | |
1725 | V | A | 0.0000 | |
1726 | V | A | -1.9583 | |
1727 | E | A | -3.6240 | |
1728 | K | A | -3.5998 | |
1729 | L | A | 0.0000 | |
1730 | I | A | -2.2068 | |
1731 | R | A | -3.1930 | |
1732 | G | A | -1.8249 | |
1733 | L | A | -0.5534 | |
1734 | A | A | -1.3161 | |
1735 | M | A | 0.0000 | |
1736 | E | A | -3.7361 | |
1737 | D | A | -3.2776 | |
1738 | S | A | -2.3962 | |
1739 | R | A | -2.6340 | |
1740 | N | A | 0.0000 | |
1741 | M | A | -0.0091 | |
1742 | F | A | 0.0000 | |
1743 | A | A | 0.0000 | |
1744 | L | A | 0.0000 | |
1745 | F | A | 0.0000 | |
1746 | E | A | 0.0000 | |
1747 | Y | A | -0.3756 | |
1748 | N | A | 0.0000 | |
1749 | G | A | -0.5545 | |
1750 | H | A | -1.0086 | |
1751 | V | A | -0.1434 | |
1752 | D | A | -1.2794 | |
1753 | K | A | -1.4504 | |
1754 | A | A | -0.9640 | |
1755 | I | A | 0.0000 | |
1756 | E | A | -2.2038 | |
1757 | S | A | -2.0592 | |
1758 | R | A | -2.6038 | |
1759 | T | A | -1.5115 | |
1760 | V | A | -1.0410 | |
1761 | V | A | 0.0000 | |
1762 | A | A | 0.0000 | |
1763 | D | A | -0.4273 | |
1764 | V | A | 0.0000 | |
1765 | L | A | -0.4273 | |
1766 | A | A | 0.0000 | |
1767 | K | A | -0.7470 | |
1768 | F | A | 0.0000 | |
1769 | E | A | -1.2092 | |
1770 | K | A | -0.9008 | |
1771 | L | A | -0.1771 | |
1772 | A | A | -0.4835 | |
1773 | A | A | -0.4129 | |
1774 | T | A | -0.5077 | |
1775 | S | A | -0.7313 | |
1776 | E | A | -1.2682 | |
1777 | V | A | 0.5939 | |
1778 | G | A | -0.4817 | |
1779 | D | A | -0.6136 | |
1780 | L | A | 0.4614 | |
1781 | P | A | -0.1089 | |
1782 | W | A | 0.0419 | |
1783 | K | A | -0.2102 | |
1784 | F | A | 0.0000 | |
1785 | Y | A | -0.0457 | |
1786 | F | A | 0.0000 | |
1787 | K | A | 0.0000 | |
1788 | L | A | 0.0000 | |
1789 | Y | A | 0.3089 | |
1790 | C | A | 0.0000 | |
1791 | F | A | -0.1205 | |
1792 | L | A | -0.7043 | |
1793 | D | A | -1.3859 | |
1794 | T | A | -1.5627 | |
1795 | D | A | -2.6541 | |
1796 | N | A | -2.6303 | |
1797 | V | A | -1.9760 | |
1798 | P | A | -1.9708 | |
1799 | K | A | -3.2334 | |
1800 | D | A | -2.8186 | |
1801 | S | A | -1.0349 | |
1802 | V | A | 0.2031 | |
1803 | E | A | 0.0000 | |
1804 | F | A | 0.0000 | |
1805 | A | A | -0.5665 | |
1806 | F | A | 0.1624 | |
1807 | M | A | 0.0000 | |
1808 | F | A | 0.0000 | |
1809 | E | A | -0.5398 | |
1810 | Q | A | -0.4196 | |
1811 | A | A | 0.0000 | |
1812 | H | A | 0.0000 | |
1813 | E | A | -0.9898 | |
1814 | A | A | -0.6440 | |
1815 | V | A | 0.0000 | |
1816 | I | A | -1.2906 | |
1817 | H | A | -1.9394 | |
1818 | G | A | -1.6256 | |
1819 | H | A | -1.1248 | |
1820 | H | A | 0.0000 | |
1821 | P | A | -1.3347 | |
1822 | A | A | -1.7337 | |
1823 | P | A | -2.0379 | |
1824 | E | A | -3.1000 | |
1825 | E | A | -3.0160 | |
1826 | N | A | -1.9537 | |
1827 | L | A | -1.2464 | |
1828 | Q | A | 0.0000 | |
1829 | V | A | -0.7482 | |
1830 | L | A | 0.0000 | |
1831 | A | A | 0.0000 | |
1832 | A | A | 0.0000 | |
1833 | L | A | 0.0000 | |
1834 | R | A | 0.0000 | |
1835 | L | A | 0.0000 | |
1836 | Q | A | 0.0000 | |
1837 | Y | A | -0.8679 | |
1838 | L | A | 0.2764 | |
1839 | Q | A | -0.7295 | |
1840 | G | A | -1.6567 | |
1841 | D | A | -2.7222 | |
1842 | Y | A | -1.7082 | |
1843 | T | A | -0.3561 | |
1844 | L | A | 0.7390 | |
1845 | H | A | -0.1569 | |
1846 | A | A | -0.1609 | |
1847 | A | A | 0.0867 | |
1848 | I | A | 0.0585 | |
1849 | P | A | -0.6807 | |
1850 | P | A | -1.2465 | |
1851 | L | A | 0.0000 | |
1852 | E | A | -2.8869 | |
1853 | E | A | -2.7750 | |
1854 | V | A | 0.0000 | |
1855 | Y | A | 0.0000 | |
1856 | S | A | -2.0946 | |
1857 | L | A | -2.0666 | |
1858 | Q | A | -3.0715 | |
1859 | R | A | -3.4981 | |
1860 | L | A | -2.6457 | |
1861 | K | A | -3.4497 | |
1862 | A | A | -2.4738 | |
1863 | R | A | -2.7471 | |
1910 | D | A | -1.9201 | |
1911 | M | A | -0.5606 | |
1912 | W | A | -1.2369 | |
1913 | I | A | -2.1713 | |
1914 | K | A | -2.9622 | |
1915 | E | A | -3.2219 | |
1916 | E | A | -2.7132 | |
1917 | V | A | -1.9722 | |
1918 | S | A | -2.1270 | |
1919 | S | A | -1.8148 | |
1920 | A | A | 0.0000 | |
1921 | R | A | -2.0261 | |
1922 | A | A | -1.0696 | |
1923 | S | A | -1.1827 | |
1924 | I | A | 0.0000 | |
1925 | I | A | -0.9624 | |
1926 | D | A | -1.7532 | |
1927 | K | A | -1.9804 | |
1928 | W | A | 0.0000 | |
1929 | R | A | -3.0154 | |
1930 | K | A | -3.1619 | |
1931 | F | A | -2.3107 | |
1932 | Q | A | -2.9494 | |
1933 | G | A | -2.1950 | |
1934 | M | A | -2.2946 | |
1935 | N | A | -2.8029 | |
1936 | Q | A | -2.7351 | |
1937 | E | A | -3.8949 | |
1938 | Q | A | -3.1314 | |
1939 | A | A | 0.0000 | |
1940 | M | A | 0.0000 | |
1941 | A | A | -1.9835 | |
1942 | K | A | -1.5250 | |
1943 | Y | A | 0.0000 | |
1944 | M | A | 0.0000 | |
1945 | A | A | -0.8986 | |
1946 | L | A | -0.6282 | |
1947 | I | A | 0.0000 | |
1948 | K | A | -1.6493 | |
1949 | E | A | -1.9648 | |
1950 | W | A | -1.2291 | |
1951 | P | A | -1.0711 | |
1952 | G | A | -0.7564 | |
1953 | Y | A | -0.4005 | |
1954 | G | A | 0.0000 | |
1955 | S | A | -0.1538 | |
1956 | T | A | 0.0634 | |
1957 | L | A | -0.3441 | |
1958 | F | A | -0.9885 | |
1959 | D | A | -2.4644 | |
1960 | V | A | 0.0000 | |
1961 | E | A | -2.4564 | |
1962 | C | A | -1.4691 | |
1963 | K | A | -2.0817 | |
1967 | F | A | 0.7140 | |
1968 | P | A | -0.7024 | |
1969 | Q | A | -2.1098 | |
1970 | E | A | -2.5351 | |
1971 | L | A | 0.0000 | |
1972 | W | A | 0.0000 | |
1973 | L | A | 0.0000 | |
1974 | G | A | 0.0000 | |
1975 | V | A | 0.0000 | |
1976 | S | A | -0.5419 | |
1977 | A | A | -0.7822 | |
1978 | D | A | -1.7543 | |
1979 | A | A | -0.9888 | |
1980 | V | A | 0.0000 | |
1981 | S | A | 0.0000 | |
1982 | V | A | 0.0000 | |
1983 | Y | A | 0.0000 | |
1984 | K | A | -2.1327 | |
1985 | R | A | -2.2882 | |
1986 | G | A | -2.1596 | |
1987 | E | A | -2.4142 | |
1988 | G | A | -1.9549 | |
1989 | R | A | -2.3848 | |
1990 | P | A | -0.8620 | |
1991 | L | A | 0.2087 | |
1992 | E | A | 0.4130 | |
1993 | V | A | 1.2486 | |
1994 | F | A | 0.0000 | |
1995 | Q | A | -1.4356 | |
1996 | Y | A | 0.0000 | |
1997 | E | A | -2.2034 | |
1998 | H | A | -1.6160 | |
1999 | I | A | 0.0000 | |
2000 | L | A | 0.0430 | |
2001 | S | A | -0.1580 | |
2002 | F | A | 0.0000 | |
2003 | G | A | -0.1745 | |
2004 | A | A | -0.0454 | |
2005 | P | A | 0.3045 | |
2006 | L | A | 0.8918 | |
2007 | A | A | -0.0589 | |
2008 | N | A | -1.2307 | |
2009 | T | A | 0.0000 | |
2010 | Y | A | 0.0000 | |
2011 | K | A | -0.6352 | |
2012 | I | A | 0.0000 | |
2013 | V | A | -1.2470 | |
2014 | V | A | -1.9649 | |
2015 | D | A | -3.2601 | |
2016 | E | A | -3.7226 | |
2017 | R | A | -3.8422 | |
2018 | E | A | -3.0815 | |
2019 | L | A | -0.8581 | |
2020 | L | A | -0.5084 | |
2021 | F | A | 0.0000 | |
2022 | E | A | -2.3026 | |
2023 | T | A | 0.0000 | |
2024 | S | A | -1.3539 | |
2025 | E | A | -1.4455 | |
2026 | V | A | 0.0000 | |
2027 | V | A | 0.2878 | |
2028 | D | A | -0.7843 | |
2029 | V | A | 0.0000 | |
2030 | A | A | 0.0000 | |
2031 | K | A | -0.6550 | |
2032 | L | A | 0.0000 | |
2033 | M | A | 0.0000 | |
2034 | K | A | -0.8878 | |
2035 | A | A | -0.0911 | |
2036 | Y | A | 0.0000 | |
2037 | I | A | 0.0000 | |
2038 | S | A | -0.7366 | |
2039 | M | A | -0.8876 | |
2040 | I | A | 0.0000 | |
2041 | V | A | 0.0000 | |
2042 | K | A | -1.9421 | |
2043 | K | A | -1.9962 | |
2044 | R | A | -1.1155 | |
2045 | Y | A | 0.1736 | |
2046 | S | A | -0.8273 | |
2047 | T | A | -0.8189 | |
1408 | H | B | -1.9380 | |
1409 | K | B | -2.5775 | |
1410 | P | B | -1.7483 | |
1411 | T | B | -1.8423 | |
1412 | E | B | -2.6800 | |
1413 | D | B | -2.0141 | |
1414 | P | B | -0.9754 | |
1415 | A | B | -0.5686 | |
1416 | S | B | -0.9434 | |
1417 | V | B | -0.4619 | |
1418 | Y | B | -0.0479 | |
1419 | E | B | -1.9080 | |
1420 | Q | B | -2.4402 | |
1421 | D | B | -3.5232 | |
1422 | D | B | -2.9292 | |
1423 | L | B | -0.9187 | |
1424 | S | B | -1.4380 | |
1425 | E | B | -3.0710 | |
1426 | Q | B | -2.3145 | |
1427 | M | B | 0.0000 | |
1428 | A | B | -1.2259 | |
1429 | S | B | -1.3400 | |
1430 | L | B | 0.0000 | |
1431 | E | B | -2.0599 | |
1432 | G | B | -1.4326 | |
1433 | L | B | 0.0000 | |
1434 | M | B | -1.6694 | |
1435 | K | B | -2.5703 | |
1436 | Q | B | -1.9184 | |
1437 | L | B | 0.0000 | |
1438 | N | B | -1.1435 | |
1439 | A | B | -0.8323 | |
1440 | I | B | -0.3563 | |
1441 | T | B | -0.3317 | |
1442 | G | B | -0.6990 | |
1443 | S | B | -0.7138 |