Project name: 6FXN

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2595
• Maximal score value: 2.1635
• Average score: -0.7171
• Total score value: -309.0692

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6432
3	E	A	-2.5678
4	L	A	0.0000
5	T	A	-1.3509
6	Q	A	-0.8798
7	D	A	-1.2707
8	P	A	-1.1064
9	A	A	-0.9962
10	V	A	-0.6628
11	S	A	-0.2520
12	V	A	0.0000
13	A	A	-0.0739
14	L	A	-0.1740
15	G	A	-0.9342
16	Q	A	-1.3268
17	T	A	-1.1910
18	V	A	0.0000
19	R	A	-1.9040
20	V	A	0.0000
21	T	A	-0.9388
22	C	A	0.0000
23	Q	A	-2.1383
24	G	A	0.0000
25	D	A	-3.1041
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.6097
29	S	A	-1.2658
30	Y	A	0.0647
31	Y	A	0.6905
32	A	A	0.3614
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	K	A	-1.8124
39	P	A	-1.5811
40	G	A	-1.3619
41	Q	A	-1.8649
42	A	A	-1.1033
43	P	A	0.0000
44	V	A	0.5391
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-0.7477
49	G	A	0.0000
50	K	A	-2.0626
51	N	A	-2.4040
52	N	A	-2.0291
53	R	A	-1.8084
54	P	A	-0.7206
55	S	A	-0.8072
56	G	A	-0.7572
57	I	A	-0.5273
58	P	A	-1.2024
59	D	A	-2.1352
60	R	A	-1.2163
61	F	A	0.0000
62	S	A	-1.5480
63	G	A	-1.3155
64	S	A	-0.9451
65	S	A	-1.0027
66	S	A	-0.9054
67	G	A	-1.7514
68	N	A	-2.1987
69	T	A	-1.5083
70	A	A	0.0000
71	S	A	-0.7615
72	L	A	0.0000
73	T	A	-0.8770
74	I	A	0.0000
75	T	A	-1.1887
76	G	A	-0.8845
77	A	A	0.0000
78	Q	A	-1.4222
79	A	A	0.0000
80	E	A	-2.6524
81	D	A	0.0000
82	E	A	-2.4089
83	A	A	0.0000
84	D	A	-2.3632
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.3894
89	S	A	0.0000
90	R	A	-0.6465
91	D	A	-1.4426
92	S	A	-1.5244
93	S	A	-0.8404
94	G	A	-0.5975
95	N	A	-1.0232
96	H	A	-0.8995
97	W	A	0.0000
98	V	A	-0.9878
99	F	A	0.0000
100	G	A	0.0000
101	G	A	-1.2269
102	G	A	-1.3828
103	T	A	0.0000
104	E	A	-2.4082
105	L	A	0.0000
106	T	A	-0.6261
107	V	A	0.0000
108	L	A	0.5504
109	G	A	-0.1986
110	Q	A	-0.5338
111	P	A	-1.0750
112	K	A	-2.3079
113	A	A	-1.3706
114	A	A	-0.7774
115	P	A	-0.6457
116	S	A	-0.3885
117	V	A	0.0000
118	T	A	-0.4267
119	L	A	0.0000
120	F	A	0.0000
121	P	A	-0.0609
122	P	A	-0.4190
123	S	A	-1.0452
124	S	A	-1.4494
125	E	A	-2.1025
126	E	A	0.0000
127	L	A	-2.2583
128	Q	A	-2.3251
129	A	A	-1.9626
130	N	A	-2.8155
131	K	A	-2.8715
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.7640
140	D	A	-1.5588
141	F	A	0.0000
142	Y	A	-1.2190
143	P	A	-1.0496
144	G	A	-0.9694
145	A	A	-0.4692
146	V	A	-0.1918
147	T	A	-0.1550
148	V	A	0.2830
149	A	A	-0.2485
150	W	A	0.0000
151	K	A	-1.2214
152	A	A	-1.1546
153	D	A	-1.8445
154	S	A	-1.0819
155	S	A	-0.6830
156	P	A	-0.8072
157	V	A	-0.5245
158	K	A	-1.5027
159	A	A	-0.6737
160	G	A	-0.3557
161	V	A	-0.0586
162	E	A	-0.4334
163	T	A	0.0033
164	T	A	-0.0454
165	T	A	-0.1880
166	P	A	-0.2968
167	S	A	-0.5765
168	K	A	-1.1388
169	Q	A	-1.1739
170	S	A	-1.3694
171	N	A	-1.8445
172	N	A	0.0000
173	K	A	-1.4361
174	Y	A	-0.8116
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	0.9835
181	S	A	0.0288
182	L	A	-0.7455
183	T	A	-1.9160
184	P	A	-2.5863
185	E	A	-3.2595
186	Q	A	-2.3504
187	W	A	0.0000
188	K	A	-3.0020
189	S	A	0.0000
190	H	A	-2.3262
191	R	A	-2.5393
192	S	A	-1.6577
193	Y	A	0.0000
194	S	A	0.0000
195	C	A	0.0000
196	Q	A	-0.7987
197	V	A	0.0000
198	T	A	-0.5313
199	H	A	0.0000
200	E	A	-2.3518
201	G	A	-1.4616
202	S	A	-0.8593
203	T	A	-0.4925
204	V	A	-0.2912
205	E	A	-1.6521
206	K	A	-1.5578
207	T	A	-1.0537
208	V	A	0.0000
209	A	A	-0.9596
210	P	A	-1.2218
2	V	A	1.0467
3	Q	A	-1.0549
4	L	A	0.0000
5	Q	A	-1.8116
6	Q	A	-1.4926
7	S	A	-1.0560
8	G	A	-0.8461
9	A	A	-0.5879
10	E	A	-0.8892
11	V	A	-0.6550
12	K	A	-1.5663
13	K	A	-2.4410
14	P	A	-1.9846
15	G	A	-1.6175
16	S	A	-1.3158
17	S	A	-1.5567
18	V	A	0.0000
19	R	A	-2.4933
20	V	A	0.0000
21	S	A	-1.0372
22	C	A	0.0000
23	K	A	-1.2853
24	A	A	-0.9536
25	S	A	-0.7976
26	G	A	-0.8605
27	G	A	-0.9678
28	T	A	-0.9942
29	F	A	0.0000
30	N	A	-0.4791
31	N	A	-0.8828
32	N	A	-0.8927
33	A	A	-0.2539
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.7872
39	Q	A	-0.8973
40	A	A	-1.2004
41	P	A	-1.1254
42	G	A	-1.2462
43	Q	A	-1.8844
44	G	A	-1.5414
45	L	A	0.0000
46	E	A	-1.3776
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	-0.1974
51	I	A	0.4368
52	I	A	0.9135
53	P	A	0.6088
54	M	A	1.3996
55	F	A	2.1635
56	G	A	0.7626
57	T	A	0.1567
58	A	A	-0.1763
59	K	A	-1.4849
60	Y	A	-1.4187
61	S	A	-1.5789
62	Q	A	-2.4412
63	N	A	-2.2869
64	F	A	0.0000
65	Q	A	-2.4635
66	G	A	-1.5501
67	R	A	-1.6136
68	V	A	0.0000
69	A	A	-1.1471
70	I	A	0.0000
71	T	A	-0.2614
72	A	A	-0.3163
73	D	A	-0.9517
74	E	A	-1.0097
75	S	A	-0.7916
76	T	A	-0.7216
77	G	A	0.0000
78	T	A	-0.7764
79	A	A	0.0000
80	S	A	0.0000
81	M	A	0.0000
82	E	A	-2.1797
83	L	A	0.0000
84	S	A	-1.2982
85	S	A	-1.1737
86	L	A	0.0000
87	R	A	-2.9770
88	S	A	-2.2882
89	E	A	-2.5203
90	D	A	0.0000
91	T	A	-1.0364
92	A	A	0.0000
93	V	A	-0.0002
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.5357
99	S	A	0.0000
100	R	A	-1.3308
101	D	A	-1.1683
102	L	A	0.4241
103	L	A	1.8993
104	L	A	1.8365
105	F	A	0.7838
106	P	A	0.7307
107	H	A	-0.2579
108	H	A	-0.6367
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.4240
112	P	A	-0.0791
113	W	A	0.0000
114	G	A	0.0000
115	R	A	-2.5174
116	G	A	-1.2404
117	T	A	0.0000
118	M	A	-0.0971
119	V	A	0.0000
120	T	A	-0.7929
121	V	A	0.0000
122	S	A	-1.1614
123	S	A	-1.2149
124	A	A	-0.6552
125	S	A	-0.6790
126	T	A	-0.6912
127	K	A	-1.1176
128	G	A	-1.2730
129	P	A	-0.5934
130	S	A	-0.2186
131	V	A	0.0000
132	F	A	-0.7045
133	P	A	-1.1227
134	L	A	0.0000
135	A	A	-0.9670
136	P	A	-1.0047
137	S	A	-0.7906
138	S	A	-1.2267
139	K	A	-2.1762
140	S	A	-1.4830
141	T	A	-1.0245
142	S	A	-0.9835
143	G	A	-1.1967
144	G	A	-0.9547
145	T	A	-0.8450
146	A	A	0.0000
147	A	A	-0.3654
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	0.0000
154	D	A	-0.4701
155	Y	A	0.0000
156	F	A	-0.1853
157	P	A	0.0000
158	E	A	-0.4857
159	P	A	-0.6343
160	V	A	-0.4409
161	T	A	-0.6162
162	V	A	-0.1011
163	S	A	-0.4604
164	W	A	0.0000
165	N	A	-0.8149
166	S	A	-0.7386
167	G	A	-0.4218
168	A	A	-0.1794
169	L	A	0.0071
170	T	A	-0.2311
171	S	A	-0.3640
172	G	A	-0.5556
173	V	A	-0.2348
174	H	A	-0.5943
175	T	A	-0.2542
176	F	A	0.0000
177	P	A	-0.1269
178	A	A	0.2357
179	V	A	0.0000
180	L	A	0.9863
181	Q	A	0.0090
182	S	A	-0.2783
183	S	A	-0.3189
184	G	A	-0.1619
185	L	A	0.0286
186	Y	A	0.4415
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.3393
194	V	A	0.0000
195	P	A	-0.6021
196	S	A	-1.0287
197	S	A	-0.7681
198	S	A	-0.7947
199	L	A	0.0000
200	G	A	-1.3940
201	T	A	-1.1092
202	Q	A	-1.6092
203	T	A	-1.3496
204	Y	A	0.0000
205	I	A	-1.4817
206	C	A	0.0000
207	N	A	0.0000
208	V	A	0.0000
209	N	A	-2.0663
210	H	A	0.0000
211	K	A	-2.4190
212	P	A	-1.4428
213	S	A	-1.6821
214	N	A	-2.4184
215	T	A	-2.0544
216	K	A	-2.7301
217	V	A	-1.6160
218	D	A	-2.6845
219	K	A	-2.3125
220	K	A	-2.7103
221	V	A	0.0000
222	E	A	-2.6400
223	P	A	-1.7423