Project name: 2WCV [mutate: EA112Y, EB112Y, EC112Y, ED112Y, EE112Y, EF112Y, EG112Y, EH112Y, EI112Y, EJ112Y]

Status: done

submitted: 2017-09-13 11:12:49, status changed: 2017-09-13 11:47:42
Settings
Chain sequence(s) A: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
C: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
B: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
E: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
D: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
G: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
F: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
I: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
H: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
J: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues EA112Y, EB112Y, EC112Y, ED112Y, EE112Y, EF112Y, EG112Y, EH112Y, EI112Y, EJ112Y
Energy difference between WT (input) and mutated protein (by FoldX) 4.30376 kcal/mol

CAUTION: Your mutation/s can destabilize the protein structure

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-3.7173
Maximal score value
1.9046
Average score
-0.524
Total score value
-730.9416

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 1.4699
2 L A 1.2603
3 K A -0.6434
4 T A -0.2068
5 I A 0.6701
6 S A 0.3480
7 P A 0.5483
8 L A 0.5338
9 I A 0.0000
10 S A -0.7339
11 P A -1.1126
12 E A -2.4394
13 L A 0.0000
14 L A -1.1468
15 K A -2.4379
16 V A 0.0000
17 L A 0.0000
18 A A -0.8463
19 E A -1.1283
20 M A 0.0000
21 G A 0.0000
22 H A 0.0000
23 G A -0.1056
24 D A 0.0000
25 E A -0.5856
26 I A 0.0000
27 I A 0.0000
28 F A 0.0000
29 S A 0.0000
30 D A 0.0000
31 A A -1.1624
32 H A -0.6224
33 F A 0.0000
34 P A 0.0000
35 A A 0.0000
36 H A -0.5815
37 S A -0.6710
38 M A -0.7909
39 G A -1.2964
40 P A -1.2350
41 Q A -0.9214
42 V A -0.3522
43 I A -0.8162
44 R A -1.2640
45 A A -1.0882
46 D A -2.1028
47 G A -1.4398
48 L A -0.6711
49 L A -0.4332
50 V A 0.0000
51 S A 0.0000
52 D A -0.7999
53 L A 0.0000
54 L A 0.0000
55 Q A -1.5786
56 A A 0.0000
57 I A 0.0000
58 I A -0.0975
59 P A -0.0737
60 L A 0.5173
61 F A 0.0000
62 E A -0.6115
63 L A -0.1497
64 D A 0.0000
65 S A -0.2247
66 Y A 0.2241
67 A A 0.2118
68 P A -0.0438
69 P A 0.0000
70 L A 0.0000
71 V A 0.0000
72 M A 0.0000
73 M A 0.0000
74 A A -0.2072
75 A A -0.7664
76 V A 0.0000
77 E A -1.4058
78 G A -0.8669
79 D A -0.6444
80 T A -0.7426
81 L A -0.9874
82 D A -2.1763
83 P A -2.1065
84 E A -3.1181
85 V A 0.0000
86 E A -2.4449
87 R A -3.3671
88 R A -2.6508
89 Y A 0.0000
90 R A -2.9016
91 N A -2.5252
92 A A -1.8617
93 L A 0.0000
94 S A -0.9828
95 L A -0.6608
98 P A -0.0547
99 C A 0.0963
100 P A -0.4095
101 D A -1.5574
102 I A 0.0000
103 I A 0.1592
104 R A -0.2371
105 I A 0.1020
106 N A -0.3070
107 R A 0.2747
108 F A 1.4616
109 A A 0.8269
110 F A 0.0000
111 Y A 0.6292
112 Y A 0.8348 mutated: EA112Y
113 R A -0.3596
114 A A 0.0000
115 Q A -1.5370
116 K A -2.0898
117 A A 0.0000
118 F A -0.7667
119 A A 0.0000
120 I A 0.0000
121 V A 0.0000
122 I A 0.0000
123 T A 0.0000
124 G A -1.3937
125 E A 0.0000
126 R A -2.1524
127 A A -1.9028
128 K A -1.9193
129 Y A 0.0000
130 G A 0.0000
131 N A 0.0000
132 I A 0.0000
133 L A 0.0000
134 L A 0.0000
135 K A -0.3842
136 K A 0.0000
137 G A 0.0000
138 V A -0.3301
139 T A -0.3926
140 P A -0.6014
1 M B 1.3235
2 L B 0.9624
3 K B -0.7822
4 T B -0.2571
5 I B 0.5871
6 S B 0.2609
7 P B 0.5131
8 L B 0.5052
9 I B 0.0000
10 S B -0.6962
11 P B -1.0710
12 E B -2.3020
13 L B 0.0000
14 L B -1.1095
15 K B -2.3501
16 V B 0.0000
17 L B 0.0000
18 A B -0.6536
19 E B -1.1229
20 M B 0.0000
21 G B 0.0000
22 H B -0.2454
23 G B -0.4618
24 D B 0.0000
25 E B -0.6300
26 I B 0.0000
27 I B 0.0000
28 F B 0.0000
29 S B 0.0000
30 D B 0.0000
31 A B -1.1364
32 H B 0.0000
33 F B 0.0000
34 P B 0.0000
35 A B 0.0000
36 H B -0.6343
37 S B -0.7713
38 M B -0.8509
39 G B -1.2449
40 P B -1.2284
41 Q B -1.0129
42 V B -0.4002
43 I B -0.8385
44 R B -1.2932
45 A B -1.0676
46 D B -2.0638
47 G B -1.3619
48 L B -0.3342
49 L B -0.2549
50 V B 0.0000
51 S B -1.1698
52 D B -0.7336
53 L B 0.0000
54 L B 0.0000
55 Q B -1.6730
56 A B -0.5371
57 I B 0.0000
58 I B 0.0000
59 P B -0.4015
60 L B 0.1415
61 F B 0.0000
62 E B -0.8045
63 L B -0.2513
64 D B 0.0000
65 S B -0.0833
66 Y B 0.2831
67 A B 0.1604
68 P B -0.3461
69 P B 0.0000
70 L B 0.0000
71 V B 0.0000
72 M B 0.0000
73 M B 0.0000
74 A B 0.0000
75 A B -0.6444
76 V B -0.4067
77 E B -1.4420
78 G B -1.3450
79 D B -1.4835
80 T B -1.3784
81 L B -1.1312
82 D B -2.4449
83 P B -2.0307
84 E B -2.7283
85 V B 0.0000
86 E B -2.5307
87 R B -3.6572
88 R B -2.7912
89 Y B 0.0000
90 R B -3.1742
91 N B -2.7115
92 A B 0.0000
93 L B 0.0000
94 S B -1.1181
95 L B -0.5062
96 Q B -1.1063
97 A B -0.5519
98 P B -0.9230
99 C B -0.9919
100 P B -1.1337
101 D B -1.9929
102 I B 0.0000
103 I B -0.6711
104 R B -0.5018
105 I B 0.0000
106 N B -0.1419
107 R B 0.2863
108 F B 1.2515
109 A B 0.0000
110 F B 0.0000
111 Y B 0.0000
112 Y B 0.1262 mutated: EB112Y
113 R B -0.5842
114 A B 0.0000
115 Q B -1.6248
116 K B -2.3565
117 A B 0.0000
118 F B 0.0000
119 A B 0.0000
120 I B 0.0000
121 V B 0.0000
122 I B 0.0000
123 T B 0.0000
124 G B -1.2809
125 E B 0.0000
126 R B -2.0708
127 A B -1.5257
128 K B -1.5868
129 Y B 0.0000
130 G B 0.0000
131 N B 0.0000
132 I B 0.0000
133 L B 0.0000
134 L B 0.0000
135 K B -0.4333
136 K B 0.0000
137 G B 0.0000
138 V B -0.3026
139 T B -0.4603
140 P B -0.5589
1 M C 1.4269
2 L C 1.1337
3 K C -0.7080
4 T C -0.2444
5 I C 0.6112
6 S C 0.4046
7 P C 0.6156
8 L C 0.6845
9 I C 0.0000
10 S C -0.6535
11 P C -1.0577
12 E C -2.2844
13 L C 0.0000
14 L C -1.1190
15 K C -2.3773
16 V C 0.0000
17 L C 0.0000
18 A C -0.7952
19 E C -1.0596
20 M C 0.0000
21 G C 0.0000
22 H C 0.0000
23 G C -0.1637
24 D C 0.0000
25 E C -0.7196
26 I C 0.0000
27 I C 0.0000
28 F C 0.0000
29 S C 0.0000
30 D C 0.0000
31 A C -1.0686
32 H C -0.6071
33 F C 0.0000
34 P C 0.0000
35 A C 0.0000
36 H C -0.5852
37 S C -0.9206
38 M C 0.0000
39 G C -1.4441
40 P C -1.2632
41 Q C -0.7932
42 V C -0.2603
43 I C -0.7209
44 R C -1.2118
45 A C -1.0194
46 D C -2.0396
47 G C -1.1728
48 L C -0.5703
49 L C -0.3042
50 V C 0.0000
51 S C -0.8074
52 D C -0.6981
53 L C 0.0000
54 L C 0.0000
55 Q C -1.4120
56 A C -0.3472
57 I C 0.0000
58 I C -0.1289
59 P C -0.0897
60 L C 0.5012
61 F C 0.0000
62 E C -0.7858
63 L C -0.3090
64 D C 0.0000
65 S C -0.1586
66 Y C 0.0619
67 A C 0.0060
68 P C -0.3896
69 P C 0.0000
70 L C 0.0000
71 V C 0.0000
72 M C 0.0000
73 M C 0.0000
74 A C -0.6357
75 A C -0.9945
76 V C -1.2833
77 E C -2.4779
78 G C -1.6892
79 D C -1.1041
80 T C -0.7997
81 L C -0.6882
82 D C -2.0489
83 P C -2.1236
84 E C -3.0111
85 V C 0.0000
86 E C -2.3387
87 R C -3.4106
88 R C -2.4953
89 Y C 0.0000
90 R C -2.3460
91 N C -2.3782
92 A C 0.0000
93 L C 0.0000
94 S C -0.9140
97 A C -0.0999
98 P C -0.6828
99 C C -0.8388
100 P C -1.0092
101 D C -1.7402
102 I C 0.0000
103 I C 0.2032
104 R C -0.2835
105 I C -0.4450
106 N C -1.5048
107 R C -1.1189
108 F C -0.6724
109 A C -0.5099
110 F C 0.0000
111 Y C -0.8685
112 Y C -0.8595 mutated: EC112Y
113 R C -1.4818
114 A C 0.0000
115 Q C -2.2047
116 K C -2.5228
117 A C 0.0000
118 F C -0.8723
119 A C 0.0000
120 I C 0.0000
121 V C 0.0000
122 I C 0.0000
123 T C 0.0000
124 G C 0.0000
125 E C 0.0000
126 R C -1.8839
127 A C -1.5229
128 K C -1.2167
129 Y C -0.6314
130 G C 0.0000
131 N C 0.0000
132 I C 0.0000
133 L C 0.0000
134 L C 0.0000
135 K C -0.4978
136 K C 0.0000
137 G C 0.0000
138 V C -0.4046
139 T C -0.5630
140 P C -0.7530
1 M D 1.3770
2 L D 1.1057
3 K D -0.7081
4 T D -0.2075
5 I D 0.6569
6 S D 0.2056
7 P D 0.4179
8 L D 0.2789
9 I D 0.0000
10 S D -0.7287
11 P D -1.1275
12 E D -2.4165
13 L D 0.0000
14 L D -1.1995
15 K D -2.4185
16 V D 0.0000
17 L D 0.0000
18 A D -0.8297
19 E D -1.1411
20 M D 0.0000
21 G D 0.0000
22 H D 0.0000
23 G D -0.3715
24 D D 0.0000
25 E D -0.6284
26 I D 0.0000
27 I D 0.0000
28 F D 0.0000
29 S D 0.0000
30 D D 0.0000
31 A D -1.0573
32 H D 0.0000
33 F D 0.0000
34 P D 0.0000
35 A D 0.0000
36 H D -0.5940
37 S D -0.7916
38 M D -0.9491
39 G D -1.3206
40 P D -1.2568
41 Q D -0.9000
42 V D -0.4703
43 I D -0.7421
44 R D -1.2965
45 A D -0.9499
46 D D -1.9606
47 G D -1.2856
48 L D -0.5131
49 L D -0.1654
50 V D 0.0000
51 S D 0.0000
52 D D -1.2445
53 L D 0.0000
54 L D 0.0000
55 Q D -1.5558
56 A D -0.4546
57 I D 0.0000
58 I D -0.1233
59 P D -0.1382
60 L D 0.4740
61 F D 0.0000
62 E D -0.5045
63 L D -0.0798
64 D D 0.0000
65 S D -0.0809
66 Y D 0.2077
67 A D -0.0325
68 P D -0.3183
69 P D 0.0000
70 L D 0.0000
71 V D 0.0000
72 M D 0.0000
73 M D 0.0000
74 A D -0.5854
75 A D -1.0695
76 V D -1.0697
77 E D -2.0441
78 G D -1.5003
79 D D -1.4539
80 T D -0.9960
81 L D -1.1392
82 D D -2.5495
83 P D -2.4080
84 E D -3.2309
85 V D 0.0000
86 E D -2.4571
87 R D -3.5902
88 R D -2.8090
89 Y D 0.0000
90 R D -2.3393
91 N D -2.2284
92 A D 0.0000
93 L D 0.0000
94 S D -0.8964
95 L D -0.3367
96 Q D -0.9178
97 A D -0.5384
98 P D -0.8339
99 C D -0.8426
100 P D -1.0365
101 D D -1.8037
102 I D 0.0000
103 I D -0.0096
104 R D -0.4066
105 I D -0.4176
106 N D -1.0688
107 R D -0.4727
108 F D 0.1416
109 A D -0.1977
110 F D 0.0000
111 Y D -0.3118
112 Y D -0.5111 mutated: ED112Y
113 R D -0.9934
114 A D 0.0000
115 Q D -1.9236
116 K D -2.3419
117 A D 0.0000
118 F D 0.0000
119 A D 0.0000
120 I D 0.0000
121 V D 0.0000
122 I D 0.0000
123 T D 0.0000
124 G D 0.0000
125 E D 0.0000
126 R D -1.9738
127 A D -1.6518
128 K D -1.5788
129 Y D 0.0000
130 G D 0.0000
131 N D 0.0000
132 I D 0.0000
133 L D 0.0000
134 L D 0.0000
135 K D -0.3362
136 K D 0.0000
137 G D 0.0000
138 V D -0.2707
139 T D -0.4030
140 P D -0.5762
1 M E 1.3982
2 L E 1.0886
3 K E -0.7344
4 T E -0.2660
5 I E 0.5892
6 S E 0.1831
7 P E 0.5448
8 L E 0.5516
9 I E 0.0000
10 S E -0.6892
11 P E -1.1127
12 E E -2.4380
13 L E 0.0000
14 L E -1.2220
15 K E -2.4294
16 V E 0.0000
17 L E 0.0000
18 A E -0.8208
19 E E -1.1298
20 M E 0.0000
21 G E 0.0000
22 H E 0.0000
23 G E -0.0870
24 D E 0.0000
25 E E -0.5737
26 I E 0.0000
27 I E 0.0000
28 F E 0.0000
29 S E 0.0000
30 D E 0.0000
31 A E -1.0775
32 H E -0.6329
33 F E 0.0000
34 P E 0.0000
35 A E 0.0000
36 H E -0.5927
37 S E -0.7969
38 M E 0.0000
39 G E -1.1299
40 P E -1.0924
41 Q E -0.9960
42 V E -0.3552
43 I E -0.8131
44 R E -1.2629
45 A E -1.1207
46 D E -2.0855
47 G E -1.2081
48 L E -0.6055
49 L E -0.2124
50 V E 0.0000
51 S E -0.9646
52 D E -0.6736
53 L E 0.0000
54 L E 0.0000
55 Q E -1.1464
56 A E 0.0000
57 I E 0.0000
58 I E 0.0000
59 P E 0.1359
60 L E 0.4482
61 F E 0.0000
62 E E -0.6268
63 L E -0.1448
64 D E 0.0000
65 S E -0.1402
66 Y E 0.1614
67 A E -0.0680
68 P E 0.0000
69 P E 0.0000
70 L E 0.0000
71 V E 0.0000
72 M E 0.0000
73 M E 0.0000
74 A E -0.2709
75 A E -0.6122
76 V E -0.6704
77 E E -1.9895
78 G E -1.4071
79 D E -1.0129
80 T E -0.6744
81 L E -0.5514
82 D E -1.7480
83 P E -2.0515
84 E E -3.1296
85 V E 0.0000
86 E E -2.5276
87 R E -3.5997
88 R E -2.8079
89 Y E 0.0000
90 R E -2.4292
91 N E -2.1971
92 A E 0.0000
93 L E 0.0000
94 S E -0.2315
95 L E 1.0272
97 A E 0.4316
98 P E -0.3698
99 C E 0.0000
100 P E -0.9952
101 D E -1.9825
102 I E 0.0000
103 I E 0.0000
104 R E -0.6912
105 I E 0.0000
106 N E -0.1099
107 R E 0.0000
108 F E -0.2390
109 A E 0.0000
110 F E 0.0000
111 Y E 0.0000
112 Y E -0.5959 mutated: EE112Y
113 R E -0.9822
114 A E 0.0000
115 Q E -1.3862
116 K E -1.9636
117 A E 0.0000
118 F E -0.6853
119 A E 0.0000
120 I E 0.0000
121 V E 0.0000
122 I E 0.0000
123 T E 0.0000
124 G E -1.2438
125 E E 0.0000
126 R E -1.9104
127 A E -1.4481
128 K E -1.1632
129 Y E 0.0000
130 G E 0.0000
131 N E 0.0000
132 I E 0.0000
133 L E 0.0000
134 L E 0.0000
135 K E -0.3679
136 K E 0.0000
137 G E 0.0000
138 V E -0.0572
139 T E -0.2729
140 P E -0.5758
1 M F 1.3982
2 L F 1.1243
3 K F -0.7422
4 T F -0.3193
5 I F 0.4495
6 S F 0.2487
7 P F 0.4594
8 L F 0.4239
9 I F 0.0000
10 S F -0.7277
11 P F -1.0849
12 E F -2.4957
13 L F 0.0000
14 L F -1.1931
15 K F -2.4031
16 V F 0.0000
17 L F 0.0000
18 A F -0.8344
19 E F -1.1729
20 M F 0.0000
21 G F 0.0000
22 H F 0.0000
23 G F -0.0790
24 D F 0.0000
25 E F 0.0000
26 I F 0.0000
27 I F 0.0000
28 F F 0.0000
29 S F 0.0000
30 D F 0.0000
31 A F -1.0864
32 H F 0.0000
33 F F 0.0000
34 P F 0.0000
35 A F 0.0000
36 H F -0.6834
37 S F -0.9567
38 M F 0.0000
39 G F -1.4648
40 P F -1.3540
41 Q F -0.9439
42 V F -0.3285
43 I F -0.8000
44 R F -1.4409
45 A F -1.0333
46 D F -2.0326
47 G F -1.3339
48 L F -0.5350
49 L F -0.2733
50 V F 0.0000
51 S F -1.1223
52 D F -0.9189
53 L F 0.0000
54 L F 0.0000
55 Q F -1.5718
56 A F 0.0000
57 I F 0.0000
58 I F -0.1006
59 P F -0.0846
60 L F 0.5133
61 F F 0.0000
62 E F -0.6186
63 L F -0.1308
64 D F 0.0000
65 S F -0.0075
66 Y F 0.3757
67 A F 0.0486
68 P F -0.2043
69 P F 0.0000
70 L F 0.0000
71 V F 0.0000
72 M F 0.0000
73 M F 0.0000
74 A F -0.5814
75 A F -1.2545
76 V F 0.0000
77 E F -2.7111
78 G F -1.8760
79 D F -1.6932
80 T F -1.1541
81 L F -1.1827
82 D F -2.6482
83 P F -2.4300
84 E F -3.2718
85 V F 0.0000
86 E F -2.4412
87 R F -3.5141
88 R F -2.5911
89 Y F 0.0000
90 R F -2.6560
91 N F -2.5508
92 A F 0.0000
93 L F 0.0000
94 S F -1.2843
95 L F -1.5030
96 Q F -1.6052
97 A F -0.6730
98 P F -0.4466
99 C F -0.2603
100 P F -0.5968
101 D F -1.4507
102 I F -0.3685
103 I F 0.3008
104 R F -0.1610
105 I F -0.1954
106 N F -1.1505
107 R F 0.0000
108 F F 0.0455
109 A F 0.1518
110 F F 0.0000
111 Y F -0.0988
112 Y F 0.3182 mutated: EF112Y
113 R F -0.6496
114 A F 0.0000
115 Q F -1.8655
116 K F -2.2238
117 A F 0.0000
118 F F 0.0000
119 A F 0.0000
120 I F 0.0000
121 V F 0.0000
122 I F 0.0000
123 T F 0.0000
124 G F 0.0000
125 E F 0.0000
126 R F -2.0252
127 A F -1.7780
128 K F -1.7341
129 Y F 0.0000
130 G F 0.0000
131 N F 0.0000
132 I F 0.0000
133 L F 0.0000
134 L F 0.0000
135 K F -0.3212
136 K F 0.0000
137 G F 0.0000
138 V F -0.2882
139 T F -0.4139
140 P F -0.6257
1 M G 1.4540
2 L G 1.2018
3 K G -0.7014
4 T G -0.2625
5 I G 0.5672
6 S G 0.2336
7 P G 0.5716
8 L G 0.5284
9 I G 0.0000
10 S G -0.5726
11 P G -0.8622
12 E G -1.9541
13 L G 0.0000
14 L G -0.9841
15 K G -2.2269
16 V G 0.0000
17 L G 0.0000
18 A G -0.6238
19 E G -1.0958
20 M G 0.0000
21 G G 0.0000
22 H G -0.2095
23 G G -0.2309
24 D G 0.0000
25 E G -0.6599
26 I G 0.0000
27 I G 0.0000
28 F G 0.0000
29 S G 0.0000
30 D G 0.0000
31 A G -1.1252
32 H G -0.6298
33 F G 0.0000
34 P G 0.0000
35 A G 0.0000
36 H G -0.7001
37 S G -0.9014
38 M G 0.0000
39 G G -1.3710
40 P G -1.3063
41 Q G -0.9056
42 V G -0.5336
43 I G 0.0000
44 R G -1.3273
45 A G -1.0594
46 D G -2.0511
47 G G -1.3526
48 L G -0.5322
49 L G -0.3541
50 V G 0.0000
51 S G -1.1290
52 D G -0.7184
53 L G 0.0000
54 L G 0.0000
55 Q G -1.5212
56 A G 0.0000
57 I G 0.0000
58 I G 0.0000
59 P G -0.3416
60 L G 0.3346
61 F G 0.0000
62 E G -0.6173
63 L G -0.1159
64 D G 0.0000
65 S G -0.0815
66 Y G 0.3137
67 A G 0.0502
68 P G -0.3674
69 P G 0.0000
70 L G 0.0000
71 V G 0.0000
72 M G 0.0000
73 M G 0.0000
74 A G -0.2300
75 A G -0.8358
76 V G -0.9480
77 E G -2.0425
78 G G -1.4820
79 D G -1.2208
80 T G -0.7902
81 L G -0.6693
82 D G -1.8601
83 P G -2.0677
84 E G -3.1198
85 V G 0.0000
86 E G -2.4919
87 R G -3.6396
88 R G -2.7910
89 Y G 0.0000
90 R G -2.9237
91 N G -2.5613
92 A G 0.0000
93 L G 0.0000
94 S G -1.0760
95 L G -0.4558
96 Q G -1.1088
97 A G -0.5739
98 P G -0.8395
99 C G -0.9056
100 P G -1.0706
101 D G -1.9188
102 I G 0.0000
103 I G -0.0995
104 R G -0.5287
105 I G 0.1272
106 N G -0.0342
107 R G 0.5414
108 F G 1.8298
109 A G 0.6837
110 F G 0.0000
111 Y G 0.3390
112 Y G 0.1479 mutated: EG112Y
113 R G -0.8468
114 A G 0.0000
115 Q G -2.0023
116 K G -2.4609
117 A G 0.0000
118 F G 0.0000
119 A G 0.0000
120 I G 0.0000
121 V G 0.0000
122 I G 0.0000
123 T G 0.0000
124 G G 0.0000
125 E G 0.0000
126 R G -2.0042
127 A G -1.6143
128 K G -1.3563
129 Y G 0.0000
130 G G 0.0000
131 N G 0.0000
132 I G 0.0000
133 L G 0.0000
134 L G 0.0000
135 K G -0.3936
136 K G 0.0000
137 G G 0.0000
138 V G -0.2819
139 T G -0.4266
140 P G -0.6057
1 M H 1.2798
2 L H 0.7417
3 K H -0.9062
4 T H -0.3658
5 I H 0.5129
6 S H 0.2568
7 P H 0.6721
8 L H 1.0180
9 I H 0.0000
10 S H -0.6148
11 P H -1.1218
12 E H -2.4290
13 L H 0.0000
14 L H -1.1858
15 K H -2.4087
16 V H 0.0000
17 L H 0.0000
18 A H -0.8052
19 E H -1.0886
20 M H 0.0000
21 G H 0.0000
22 H H 0.0000
23 G H -0.1513
24 D H 0.0000
25 E H 0.0000
26 I H 0.0000
27 I H 0.0000
28 F H 0.0000
29 S H 0.0000
30 D H 0.0000
31 A H -0.9885
32 H H -0.6119
33 F H 0.0000
34 P H 0.0000
35 A H 0.0000
36 H H -0.6575
37 S H -0.7593
38 M H 0.0000
39 G H -1.2342
40 P H -1.2250
41 Q H -1.0886
42 V H -0.3902
43 I H -0.7921
44 R H -1.2099
45 A H -0.8950
46 D H -1.7974
47 G H -1.0409
48 L H -0.3192
49 L H -0.2662
50 V H 0.0000
51 S H -1.0916
52 D H -0.7560
53 L H 0.0000
54 L H 0.0000
55 Q H -1.5100
56 A H 0.0000
57 I H 0.0000
58 I H 0.0000
59 P H -0.2552
60 L H 0.5284
61 F H 0.0000
62 E H -0.5953
63 L H -0.1990
64 D H 0.0000
65 S H -0.2719
66 Y H 0.0134
67 A H -0.1462
68 P H 0.0000
69 P H 0.0000
70 L H 0.0000
71 V H 0.0000
72 M H 0.0000
73 M H 0.0000
74 A H -0.3452
75 A H -0.7441
76 V H -0.7928
77 E H -2.1076
78 G H -1.5795
79 D H -1.2602
80 T H -0.7723
81 L H -0.5558
82 D H -1.9044
83 P H -2.0308
84 E H -2.9659
85 V H 0.0000
86 E H -2.5244
87 R H -3.5128
88 R H -2.6173
89 Y H 0.0000
90 R H -2.5095
91 N H -2.3295
92 A H 0.0000
93 L H 0.0000
94 S H -0.9153
95 L H -0.4316
96 Q H -0.8990
97 A H -0.4820
98 P H -0.8370
99 C H 0.0000
100 P H -1.1672
101 D H -2.2655
102 I H 0.0000
103 I H 0.0000
104 R H -0.6333
105 I H 0.0000
106 N H -0.3369
107 R H -0.3172
108 F H -0.1536
109 A H 0.0000
110 F H 0.0000
111 Y H 0.0000
112 Y H 0.0000 mutated: EH112Y
113 R H -0.9510
114 A H 0.0000
115 Q H -1.8092
116 K H -2.0847
117 A H 0.0000
118 F H -0.6530
119 A H 0.0000
120 I H 0.0000
121 V H 0.0000
122 I H 0.0000
123 T H 0.0000
124 G H 0.0000
125 E H 0.0000
126 R H -1.9287
127 A H -1.5215
128 K H -1.1640
129 Y H 0.0000
130 G H 0.0000
131 N H 0.0000
132 I H 0.0000
133 L H 0.0000
134 L H 0.0000
135 K H -0.3026
136 K H 0.0000
137 G H 0.0000
138 V H -0.4091
139 T H -0.4154
140 P H -0.6254
1 M I 1.3104
2 L I 0.9429
3 K I -0.8230
4 T I -0.3222
5 I I 0.4732
6 S I 0.2062
7 P I 0.4174
8 L I 0.5158
9 I I 0.0000
10 S I -0.6690
11 P I -1.0612
12 E I -2.3411
13 L I 0.0000
14 L I -1.0526
15 K I -2.3456
16 V I 0.0000
17 L I 0.0000
18 A I -0.8230
19 E I -1.1243
20 M I 0.0000
21 G I 0.0000
22 H I -0.2412
23 G I -0.1979
24 D I 0.0000
25 E I -0.6386
26 I I 0.0000
27 I I 0.0000
28 F I 0.0000
29 S I 0.0000
30 D I 0.0000
31 A I -1.1227
32 H I -0.6826
33 F I 0.0000
34 P I 0.0000
35 A I 0.0000
36 H I -0.5984
37 S I -0.8129
38 M I -0.8814
39 G I -1.4002
40 P I -1.2736
41 Q I -0.7948
42 V I -0.4541
43 I I -0.7661
44 R I -1.3830
45 A I -1.0098
46 D I -2.0154
47 G I -1.3288
48 L I -0.3163
49 L I -0.1180
50 V I 0.0000
51 S I 0.0000
52 D I -0.6094
53 L I 0.0000
54 L I 0.0000
55 Q I -1.0482
56 A I 0.0000
57 I I 0.0000
58 I I -0.0772
59 P I -0.1528
60 L I 0.4346
61 F I 0.0000
62 E I -0.6635
63 L I -0.2127
64 D I 0.0000
65 S I -0.2576
66 Y I 0.1159
67 A I -0.0382
68 P I -0.2709
69 P I -0.3593
70 L I 0.0000
71 V I 0.0000
72 M I 0.0000
73 M I 0.0000
74 A I -0.3048
75 A I -0.8919
76 V I 0.0000
77 E I -1.5846
78 G I -0.8530
79 D I -0.7695
80 T I -0.8019
81 L I -1.2935
82 D I -2.7923
83 P I -2.5580
84 E I -3.1833
85 V I 0.0000
86 E I -2.7130
87 R I -3.7173
88 R I -2.6597
89 Y I 0.0000
90 R I -2.4414
91 N I -2.4608
92 A I 0.0000
93 L I 0.0000
94 S I -0.9246
95 L I -0.3453
96 Q I -1.0657
97 A I -0.6093
98 P I -0.8321
99 C I 0.0000
100 P I -0.6873
101 D I -0.8898
102 I I 0.0000
103 I I 0.1848
104 R I -0.0235
105 I I 0.1193
106 N I -0.2532
107 R I 0.1049
108 F I 1.1709
109 A I 0.5879
110 F I 0.0000
111 Y I 0.3614
112 Y I 0.5788 mutated: EI112Y
113 R I -0.6380
114 A I 0.0000
115 Q I -1.8424
116 K I -2.2692
117 A I 0.0000
118 F I 0.0000
119 A I 0.0000
120 I I 0.0000
121 V I 0.0000
122 I I 0.0000
123 T I 0.0000
124 G I 0.0000
125 E I 0.0000
126 R I -2.0707
127 A I -1.7379
128 K I -1.6232
129 Y I 0.0000
130 G I 0.0000
131 N I 0.0000
132 I I 0.0000
133 L I 0.0000
134 L I 0.0000
135 K I -0.4361
136 K I 0.0000
137 G I 0.0000
138 V I -0.4238
139 T I -0.4583
140 P I -0.5838
1 M J 1.3116
2 L J 0.8562
3 K J -0.8513
4 T J -0.3226
5 I J 0.5681
6 S J 0.1742
7 P J 0.5419
8 L J 0.7487
9 I J 0.0000
10 S J -0.6595
11 P J -1.1148
12 E J -2.4240
13 L J 0.0000
14 L J -1.1766
15 K J -2.4256
16 V J 0.0000
17 L J 0.0000
18 A J -0.8245
19 E J -1.1591
20 M J 0.0000
21 G J 0.0000
22 H J 0.0000
23 G J -0.4646
24 D J 0.0000
25 E J -0.5994
26 I J 0.0000
27 I J 0.0000
28 F J 0.0000
29 S J 0.0000
30 D J 0.0000
31 A J -1.0837
32 H J -0.6617
33 F J 0.0000
34 P J 0.0000
35 A J 0.0000
36 H J -0.5540
37 S J -0.7871
38 M J 0.0000
39 G J -1.3589
40 P J -1.1968
41 Q J -0.8696
42 V J -0.2937
43 I J -0.8181
44 R J -1.3958
45 A J -1.1293
46 D J -2.1183
47 G J -1.2297
48 L J -0.4604
49 L J -0.2862
50 V J 0.0000
51 S J 0.0000
52 D J -0.7100
53 L J 0.0000
54 L J 0.0000
55 Q J -1.2820
56 A J 0.0000
57 I J 0.0000
58 I J 0.0000
59 P J -0.0441
60 L J 0.7519
61 F J 0.0000
62 E J -0.5667
63 L J 0.0000
64 D J 0.0000
65 S J -0.1710
66 Y J -0.0579
67 A J -0.3056
68 P J -0.4864
69 P J -0.5532
70 L J 0.0000
71 V J 0.0000
72 M J 0.0000
73 M J 0.0000
74 A J -0.1656
75 A J -0.6642
76 V J -0.4408
77 E J -1.9239
78 G J 0.0000
79 D J -0.9213
80 T J -1.1440
81 L J -0.9303
82 D J -2.4448
83 P J -2.3676
84 E J -3.0553
85 V J 0.0000
86 E J 0.0000
87 R J -3.4260
88 R J -2.5647
89 Y J 0.0000
90 R J -2.4163
91 N J -2.0128
92 A J 0.0000
93 L J 0.0000
94 S J -0.5662
95 L J 0.2830
96 Q J -0.6824
97 A J -0.3864
98 P J -0.2847
99 C J -0.6531
100 P J -1.0515
101 D J -1.8453
102 I J 0.0000
103 I J 0.0000
104 R J -0.3636
105 I J 0.0000
106 N J 0.0066
107 R J 0.4548
108 F J 1.9046
109 A J 0.0000
110 F J 0.0000
111 Y J 0.3817
112 Y J 0.3580 mutated: EJ112Y
113 R J -0.4009
114 A J 0.0000
115 Q J -1.9589
116 K J -2.2387
117 A J 0.0000
118 F J -0.7461
119 A J 0.0000
120 I J 0.0000
121 V J 0.0000
122 I J 0.0000
123 T J 0.0000
124 G J 0.0000
125 E J 0.0000
126 R J -1.9679
127 A J -1.6379
128 K J -1.4323
129 Y J -0.7282
130 G J 0.0000
131 N J 0.0000
132 I J 0.0000
133 L J 0.0000
134 L J 0.0000
135 K J -0.4828
136 K J -0.5020
137 G J 0.0000
138 V J -0.3682
139 T J -0.3950
140 P J -0.6995

 

Laboratory of Theory of Biopolymers 2015