Project name: ARG_10p_6fxn
Status: done
submitted: 2018-08-12 11:58:00, status changed: 2018-08-12 12:08:00
Settings
Chain sequence(s)
|
A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-2.9948
-
Maximal score value
-
2.4933
-
Average score
-
-0.6974
-
Total score value
-
-300.5982
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
2 |
S |
A |
-1.4208 |
|
3 |
E |
A |
-2.2974 |
|
4 |
L |
A |
-1.5778 |
|
5 |
T |
A |
-1.5004 |
|
6 |
Q |
A |
-1.4973 |
|
7 |
D |
A |
-2.3486 |
|
8 |
P |
A |
-1.6443 |
|
9 |
A |
A |
-1.2674 |
|
10 |
V |
A |
-0.8988 |
|
11 |
S |
A |
-0.2555 |
|
12 |
V |
A |
0.0000 |
|
13 |
A |
A |
-0.0222 |
|
14 |
L |
A |
-0.1170 |
|
15 |
G |
A |
-0.8753 |
|
16 |
Q |
A |
-1.2535 |
|
17 |
T |
A |
-1.1985 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-1.9037 |
|
20 |
V |
A |
0.0000 |
|
21 |
T |
A |
-1.2328 |
|
22 |
C |
A |
0.0000 |
|
23 |
Q |
A |
-2.5571 |
|
24 |
G |
A |
-2.3966 |
|
25 |
D |
A |
-2.6067 |
|
26 |
S |
A |
0.0000 |
|
27 |
L |
A |
0.0000 |
|
28 |
R |
A |
-2.8088 |
|
29 |
S |
A |
-1.2572 |
|
30 |
Y |
A |
-0.4713 |
|
31 |
Y |
A |
-0.3354 |
|
32 |
A |
A |
0.0000 |
|
33 |
S |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
Y |
A |
0.0000 |
|
36 |
Q |
A |
-0.4495 |
|
37 |
Q |
A |
0.0000 |
|
38 |
K |
A |
-1.7073 |
|
39 |
P |
A |
-1.2788 |
|
40 |
G |
A |
-1.5113 |
|
41 |
Q |
A |
-1.8518 |
|
42 |
A |
A |
-0.9989 |
|
43 |
P |
A |
0.0000 |
|
44 |
V |
A |
0.9793 |
|
45 |
L |
A |
0.0000 |
|
46 |
V |
A |
0.0000 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-1.1062 |
|
49 |
G |
A |
0.0000 |
|
50 |
K |
A |
-2.4647 |
|
51 |
N |
A |
-2.2564 |
|
52 |
N |
A |
-2.0571 |
|
53 |
R |
A |
-1.6757 |
|
54 |
P |
A |
-0.5957 |
|
55 |
S |
A |
-0.6188 |
|
56 |
G |
A |
-0.8064 |
|
57 |
I |
A |
-0.5764 |
|
58 |
P |
A |
-1.2619 |
|
59 |
D |
A |
-2.1128 |
|
60 |
R |
A |
-1.3065 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-1.4547 |
|
63 |
G |
A |
-1.2320 |
|
64 |
S |
A |
-1.0545 |
|
65 |
S |
A |
-1.3120 |
|
66 |
S |
A |
-1.2796 |
|
67 |
G |
A |
-2.1455 |
|
68 |
N |
A |
-2.8314 |
|
69 |
T |
A |
-1.8276 |
|
70 |
A |
A |
0.0000 |
|
71 |
S |
A |
0.0000 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-1.0008 |
|
74 |
I |
A |
0.0000 |
|
75 |
T |
A |
-1.1963 |
|
76 |
G |
A |
-0.8887 |
|
77 |
A |
A |
0.0000 |
|
78 |
Q |
A |
-1.3873 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.4713 |
|
81 |
D |
A |
0.0000 |
|
82 |
E |
A |
-1.9812 |
|
83 |
A |
A |
0.0000 |
|
84 |
D |
A |
-1.7679 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
S |
A |
-0.2511 |
|
89 |
S |
A |
0.0000 |
|
90 |
R |
A |
-0.9514 |
|
91 |
D |
A |
-1.3636 |
|
92 |
S |
A |
-1.3845 |
|
93 |
S |
A |
-0.7809 |
|
94 |
G |
A |
-0.7963 |
|
95 |
N |
A |
-1.4026 |
|
96 |
H |
A |
-1.0373 |
|
97 |
W |
A |
0.0000 |
|
98 |
V |
A |
-0.6473 |
|
99 |
F |
A |
-0.4490 |
|
100 |
G |
A |
0.0000 |
|
101 |
G |
A |
-1.3024 |
|
102 |
G |
A |
-1.4260 |
|
103 |
T |
A |
0.0000 |
|
104 |
E |
A |
-2.2106 |
|
105 |
L |
A |
0.0000 |
|
106 |
T |
A |
-0.4344 |
|
107 |
V |
A |
0.0000 |
|
108 |
L |
A |
0.8018 |
|
109 |
G |
A |
-0.0567 |
|
110 |
Q |
A |
0.0000 |
|
111 |
P |
A |
-1.0337 |
|
112 |
K |
A |
-2.1733 |
|
113 |
A |
A |
-1.0989 |
|
114 |
A |
A |
-0.7973 |
|
115 |
P |
A |
-0.4160 |
|
116 |
S |
A |
-0.4277 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.3245 |
|
119 |
L |
A |
-0.3018 |
|
120 |
F |
A |
0.0000 |
|
121 |
P |
A |
-0.0409 |
|
122 |
P |
A |
-0.3550 |
|
123 |
S |
A |
-0.8868 |
|
124 |
S |
A |
-1.2591 |
|
125 |
E |
A |
-1.6923 |
|
126 |
E |
A |
0.0000 |
|
127 |
L |
A |
-1.7838 |
|
128 |
Q |
A |
-2.0757 |
|
129 |
A |
A |
-1.6822 |
|
130 |
N |
A |
-2.4382 |
|
131 |
K |
A |
-2.1966 |
|
132 |
A |
A |
0.0000 |
|
133 |
T |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
V |
A |
0.0000 |
|
136 |
C |
A |
0.0000 |
|
137 |
L |
A |
0.0000 |
|
138 |
I |
A |
0.0000 |
|
139 |
S |
A |
-0.5728 |
|
140 |
D |
A |
-1.1612 |
|
141 |
F |
A |
0.0000 |
|
142 |
Y |
A |
-1.1655 |
|
143 |
P |
A |
-1.0384 |
|
144 |
G |
A |
-0.9193 |
|
145 |
A |
A |
-0.3399 |
|
146 |
V |
A |
-0.1680 |
|
147 |
T |
A |
-0.1529 |
|
148 |
V |
A |
0.0089 |
|
149 |
A |
A |
-0.4821 |
|
150 |
W |
A |
0.0000 |
|
151 |
K |
A |
-1.0859 |
|
152 |
A |
A |
0.0000 |
|
153 |
D |
A |
-1.3072 |
|
154 |
S |
A |
-0.9182 |
|
155 |
S |
A |
-0.8247 |
|
156 |
P |
A |
-0.9161 |
|
157 |
V |
A |
-0.6605 |
|
158 |
K |
A |
-1.4477 |
|
159 |
A |
A |
-0.5065 |
|
160 |
G |
A |
0.0279 |
|
161 |
V |
A |
0.4724 |
|
162 |
E |
A |
0.3007 |
|
163 |
T |
A |
0.2856 |
|
164 |
T |
A |
0.0531 |
|
165 |
T |
A |
-0.1350 |
|
166 |
P |
A |
-0.2949 |
|
167 |
S |
A |
-0.5708 |
|
168 |
K |
A |
-1.1469 |
|
169 |
Q |
A |
-1.1381 |
|
170 |
S |
A |
-1.3100 |
|
171 |
N |
A |
-1.8460 |
|
172 |
N |
A |
-1.8642 |
|
173 |
K |
A |
-1.7509 |
|
174 |
Y |
A |
-0.8081 |
|
175 |
A |
A |
0.0000 |
|
176 |
A |
A |
0.0000 |
|
177 |
S |
A |
0.0000 |
|
178 |
S |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
L |
A |
1.2532 |
|
181 |
S |
A |
0.2753 |
|
182 |
L |
A |
-0.4267 |
|
183 |
T |
A |
-1.6711 |
|
184 |
P |
A |
-2.2734 |
|
185 |
E |
A |
-2.9822 |
|
186 |
Q |
A |
-2.1576 |
|
187 |
W |
A |
0.0000 |
|
188 |
K |
A |
-2.9948 |
|
189 |
S |
A |
0.0000 |
|
190 |
H |
A |
-2.2833 |
|
191 |
R |
A |
-2.5011 |
|
192 |
S |
A |
0.0000 |
|
193 |
Y |
A |
0.0000 |
|
194 |
S |
A |
0.0000 |
|
195 |
C |
A |
0.0000 |
|
196 |
Q |
A |
-1.3764 |
|
197 |
V |
A |
0.0000 |
|
198 |
T |
A |
-0.7456 |
|
199 |
H |
A |
0.0000 |
|
200 |
E |
A |
-2.3055 |
|
201 |
G |
A |
-1.4273 |
|
202 |
S |
A |
-0.8849 |
|
203 |
T |
A |
-0.7878 |
|
204 |
V |
A |
-0.8084 |
|
205 |
E |
A |
-2.2889 |
|
206 |
K |
A |
-1.9425 |
|
207 |
T |
A |
-1.0986 |
|
208 |
V |
A |
0.0000 |
|
209 |
A |
A |
-0.8954 |
|
210 |
P |
A |
-1.0166 |
|
2 |
V |
A |
1.0847 |
|
3 |
Q |
A |
-0.8147 |
|
4 |
L |
A |
-1.0230 |
|
5 |
Q |
A |
-1.5797 |
|
6 |
Q |
A |
-1.0984 |
|
7 |
S |
A |
-1.2271 |
|
8 |
G |
A |
-1.1189 |
|
9 |
A |
A |
-1.0581 |
|
10 |
E |
A |
-1.4072 |
|
11 |
V |
A |
-0.9798 |
|
12 |
K |
A |
-1.8220 |
|
13 |
K |
A |
-2.4518 |
|
14 |
P |
A |
-2.0078 |
|
15 |
G |
A |
-1.4068 |
|
16 |
S |
A |
-1.1754 |
|
17 |
S |
A |
-1.4037 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-2.4202 |
|
20 |
V |
A |
0.0000 |
|
21 |
S |
A |
-0.9873 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.3323 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.6228 |
|
26 |
G |
A |
-0.5560 |
|
27 |
G |
A |
-1.0367 |
|
28 |
T |
A |
-1.2502 |
|
29 |
F |
A |
0.0000 |
|
30 |
N |
A |
-1.6997 |
|
31 |
N |
A |
-0.8347 |
|
32 |
N |
A |
-0.5207 |
|
33 |
A |
A |
-0.0026 |
|
34 |
I |
A |
0.0000 |
|
35 |
N |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
R |
A |
-0.5493 |
|
39 |
Q |
A |
-0.7823 |
|
40 |
A |
A |
-1.0774 |
|
41 |
P |
A |
-0.8770 |
|
42 |
G |
A |
-1.2256 |
|
43 |
Q |
A |
-1.8055 |
|
44 |
G |
A |
-1.3193 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-0.9255 |
|
47 |
W |
A |
0.0000 |
|
48 |
M |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
G |
A |
0.0000 |
|
51 |
I |
A |
0.3771 |
|
52 |
I |
A |
0.2037 |
|
53 |
P |
A |
-0.3106 |
|
54 |
M |
A |
0.6295 |
|
55 |
F |
A |
1.3894 |
|
56 |
G |
A |
0.2342 |
|
57 |
T |
A |
-0.0167 |
|
58 |
A |
A |
-0.2288 |
|
59 |
K |
A |
-1.0285 |
|
60 |
Y |
A |
-0.4062 |
|
61 |
S |
A |
-1.1387 |
|
62 |
Q |
A |
-2.0763 |
|
63 |
N |
A |
-2.1587 |
|
64 |
F |
A |
0.0000 |
|
65 |
Q |
A |
-2.0770 |
|
66 |
G |
A |
-1.4437 |
|
67 |
R |
A |
-1.2028 |
|
68 |
V |
A |
-0.8632 |
|
69 |
A |
A |
-0.5962 |
|
70 |
I |
A |
0.0000 |
|
71 |
T |
A |
-0.5647 |
|
72 |
A |
A |
-0.9799 |
|
73 |
D |
A |
-2.1500 |
|
74 |
E |
A |
-2.5072 |
|
75 |
S |
A |
-1.4521 |
|
76 |
T |
A |
-1.2176 |
|
77 |
G |
A |
0.0000 |
|
78 |
T |
A |
-1.2942 |
|
79 |
A |
A |
0.0000 |
|
80 |
S |
A |
0.0000 |
|
81 |
M |
A |
0.0000 |
|
82 |
E |
A |
-1.8516 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-1.2004 |
|
85 |
S |
A |
-1.1340 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
-2.4707 |
|
88 |
S |
A |
-2.1103 |
|
89 |
E |
A |
-2.3729 |
|
90 |
D |
A |
0.0000 |
|
91 |
T |
A |
-0.9003 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
-0.0593 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
-0.2834 |
|
99 |
S |
A |
0.0000 |
|
100 |
R |
A |
-0.0850 |
|
101 |
D |
A |
0.7273 |
|
102 |
L |
A |
1.5725 |
|
103 |
L |
A |
2.4933 |
|
104 |
L |
A |
2.3545 |
|
105 |
F |
A |
1.4507 |
|
106 |
P |
A |
0.6984 |
|
107 |
H |
A |
-0.6217 |
|
108 |
H |
A |
-0.5437 |
|
109 |
A |
A |
0.0000 |
|
110 |
L |
A |
0.0000 |
|
111 |
S |
A |
0.0815 |
|
112 |
P |
A |
0.0193 |
|
113 |
W |
A |
-0.2734 |
|
114 |
G |
A |
0.0000 |
|
115 |
R |
A |
-2.3117 |
|
116 |
G |
A |
0.0000 |
|
117 |
T |
A |
0.0000 |
|
118 |
M |
A |
-0.2949 |
|
119 |
V |
A |
0.0000 |
|
120 |
T |
A |
-0.9134 |
|
121 |
V |
A |
0.0000 |
|
122 |
S |
A |
-1.2166 |
|
123 |
S |
A |
-1.1599 |
|
124 |
A |
A |
-0.6797 |
|
125 |
S |
A |
-0.7028 |
|
126 |
T |
A |
-0.7232 |
|
127 |
K |
A |
-0.9949 |
|
128 |
G |
A |
-1.1716 |
|
129 |
P |
A |
-0.4792 |
|
130 |
S |
A |
-0.2217 |
|
131 |
V |
A |
0.0000 |
|
132 |
F |
A |
0.0000 |
|
133 |
P |
A |
-0.9644 |
|
134 |
L |
A |
0.0000 |
|
135 |
A |
A |
-0.8842 |
|
136 |
P |
A |
-0.8230 |
|
137 |
S |
A |
-0.7219 |
|
138 |
S |
A |
-1.2745 |
|
139 |
K |
A |
-2.0100 |
|
140 |
S |
A |
-1.4195 |
|
141 |
T |
A |
-0.8843 |
|
142 |
S |
A |
-0.8838 |
|
143 |
G |
A |
-0.8677 |
|
144 |
G |
A |
-1.1318 |
|
145 |
T |
A |
-0.9199 |
|
146 |
A |
A |
0.0000 |
|
147 |
A |
A |
-0.1168 |
|
148 |
L |
A |
0.0000 |
|
149 |
G |
A |
0.0000 |
|
150 |
C |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
V |
A |
0.0000 |
|
153 |
K |
A |
0.0000 |
|
154 |
D |
A |
-0.2360 |
|
155 |
Y |
A |
0.0000 |
|
156 |
F |
A |
-0.0913 |
|
157 |
P |
A |
0.0000 |
|
158 |
E |
A |
-0.6546 |
|
159 |
P |
A |
-0.7342 |
|
160 |
V |
A |
-0.5684 |
|
161 |
T |
A |
-0.4762 |
|
162 |
V |
A |
-0.2932 |
|
163 |
S |
A |
-0.3269 |
|
164 |
W |
A |
0.0000 |
|
165 |
N |
A |
-0.6390 |
|
166 |
S |
A |
-0.5934 |
|
167 |
G |
A |
-0.3050 |
|
168 |
A |
A |
-0.1417 |
|
169 |
L |
A |
0.1162 |
|
170 |
T |
A |
-0.1431 |
|
171 |
S |
A |
-0.2690 |
|
172 |
G |
A |
-0.3445 |
|
173 |
V |
A |
0.1149 |
|
174 |
H |
A |
-0.1747 |
|
175 |
T |
A |
0.0015 |
|
176 |
F |
A |
0.0000 |
|
177 |
P |
A |
-0.2335 |
|
178 |
A |
A |
0.2467 |
|
179 |
V |
A |
0.0000 |
|
180 |
L |
A |
1.1596 |
|
181 |
Q |
A |
0.2493 |
|
182 |
S |
A |
-0.1605 |
|
183 |
S |
A |
-0.2165 |
|
184 |
G |
A |
0.0097 |
|
185 |
L |
A |
0.2916 |
|
186 |
Y |
A |
0.4322 |
|
187 |
S |
A |
0.0000 |
|
188 |
L |
A |
0.0000 |
|
189 |
S |
A |
0.0000 |
|
190 |
S |
A |
0.0000 |
|
191 |
V |
A |
0.1538 |
|
192 |
V |
A |
0.0000 |
|
193 |
T |
A |
-0.2413 |
|
194 |
V |
A |
0.0000 |
|
195 |
P |
A |
-0.5334 |
|
196 |
S |
A |
-0.9208 |
|
197 |
S |
A |
-0.7258 |
|
198 |
S |
A |
-0.4612 |
|
199 |
L |
A |
-0.8617 |
|
200 |
G |
A |
-0.9767 |
|
201 |
T |
A |
-0.6304 |
|
202 |
Q |
A |
-1.1289 |
|
203 |
T |
A |
-1.1398 |
|
204 |
Y |
A |
0.0000 |
|
205 |
I |
A |
-1.1219 |
|
206 |
C |
A |
0.0000 |
|
207 |
N |
A |
-1.3902 |
|
208 |
V |
A |
0.0000 |
|
209 |
N |
A |
-1.8219 |
|
210 |
H |
A |
0.0000 |
|
211 |
K |
A |
-2.8018 |
|
212 |
P |
A |
-1.7155 |
|
213 |
S |
A |
-1.8042 |
|
214 |
N |
A |
-2.5458 |
|
215 |
T |
A |
-1.9991 |
|
216 |
K |
A |
-2.5393 |
|
217 |
V |
A |
-1.3350 |
|
218 |
D |
A |
-2.4313 |
|
219 |
K |
A |
-2.0363 |
|
220 |
K |
A |
-2.5975 |
|
221 |
V |
A |
0.0000 |
|
222 |
E |
A |
-2.4923 |
|
223 |
P |
A |
-1.4143 |
|