Chain sequence(s) |
A: ATRAIPELTKLLNDEDQVVVNNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHRREEGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTTSRVLKVLSVCSSNKKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMMVCQVGGIEALVRTVLRRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRM B: LKAADSDPTAPPYDSLLVFDYEGGEAASLSLDYLNEWGNRFKKLADMY |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
149 | A | A | -0.6827 | |
150 | T | A | -1.3565 | |
151 | R | A | -2.0003 | |
152 | A | A | 0.0000 | |
153 | I | A | 0.0000 | |
154 | P | A | -1.5827 | |
155 | E | A | -1.9767 | |
156 | L | A | 0.0000 | |
157 | T | A | 0.0000 | |
158 | K | A | -2.7008 | |
159 | L | A | 0.0000 | |
160 | L | A | 0.0000 | |
161 | N | A | -2.6287 | |
162 | D | A | -2.5093 | |
163 | E | A | -3.0171 | |
164 | D | A | -2.2861 | |
165 | Q | A | -1.4608 | |
166 | V | A | 0.5037 | |
167 | V | A | 0.0000 | |
168 | V | A | 0.0000 | |
169 | N | A | -0.5463 | |
170 | K | A | -0.3777 | |
171 | A | A | 0.0000 | |
172 | A | A | 0.0000 | |
173 | V | A | -0.2684 | |
174 | M | A | 0.0000 | |
175 | V | A | 0.0000 | |
176 | H | A | -0.8620 | |
177 | Q | A | -1.2332 | |
178 | L | A | 0.0000 | |
179 | S | A | 0.0000 | |
180 | K | A | -2.9774 | |
181 | K | A | -3.4917 | |
182 | E | A | -3.1762 | |
183 | A | A | -1.6939 | |
184 | S | A | 0.0000 | |
185 | R | A | -2.2716 | |
186 | H | A | -1.9192 | |
187 | A | A | -1.5006 | |
188 | I | A | 0.0000 | |
189 | M | A | 0.0000 | |
190 | R | A | -2.3924 | |
191 | S | A | -1.5160 | |
192 | P | A | -1.6152 | |
193 | Q | A | -1.8194 | |
194 | M | A | 0.0000 | |
195 | V | A | 0.0000 | |
196 | S | A | -1.2075 | |
197 | A | A | 0.0000 | |
198 | I | A | 0.0000 | |
199 | V | A | 0.0000 | |
200 | R | A | -2.0933 | |
201 | T | A | 0.0000 | |
202 | M | A | 0.0000 | |
203 | Q | A | -1.9924 | |
204 | N | A | -2.2644 | |
205 | T | A | -1.9288 | |
206 | N | A | -1.9729 | |
207 | D | A | -1.4443 | |
208 | V | A | -0.7745 | |
209 | E | A | -2.0344 | |
210 | T | A | 0.0000 | |
211 | A | A | -1.3592 | |
212 | R | A | -1.5014 | |
213 | C | A | -0.8254 | |
214 | T | A | 0.0000 | |
215 | A | A | 0.0000 | |
216 | G | A | 0.0000 | |
217 | T | A | 0.0000 | |
218 | L | A | 0.0000 | |
219 | H | A | -0.3125 | |
220 | N | A | -1.2518 | |
221 | L | A | 0.0000 | |
222 | S | A | 0.0000 | |
223 | H | A | -1.7563 | |
224 | H | A | -2.2938 | |
225 | R | A | -2.8666 | |
226 | E | A | -2.6936 | |
227 | G | A | 0.0000 | |
228 | L | A | 0.0000 | |
229 | L | A | -0.9301 | |
230 | A | A | -1.2271 | |
231 | I | A | 0.0000 | |
232 | F | A | -0.5384 | |
233 | K | A | -1.3203 | |
234 | S | A | -1.1407 | |
235 | G | A | -0.8999 | |
236 | G | A | 0.0000 | |
237 | I | A | 0.0000 | |
238 | P | A | -0.4371 | |
239 | A | A | 0.0000 | |
240 | L | A | 0.0000 | |
241 | V | A | 0.0000 | |
242 | K | A | -1.5503 | |
243 | M | A | 0.0000 | |
244 | L | A | 0.0000 | |
245 | G | A | -1.0827 | |
246 | S | A | -0.6860 | |
247 | P | A | -0.5667 | |
248 | V | A | -0.7045 | |
249 | D | A | -1.8349 | |
250 | S | A | -0.7355 | |
251 | V | A | 0.0000 | |
252 | L | A | 0.0000 | |
253 | F | A | -0.1930 | |
254 | Y | A | 0.0499 | |
255 | A | A | 0.0000 | |
256 | I | A | 0.0000 | |
257 | T | A | 0.1754 | |
258 | T | A | 0.0000 | |
259 | L | A | 0.0000 | |
260 | H | A | 0.0000 | |
261 | N | A | -0.7861 | |
262 | L | A | 0.0000 | |
263 | L | A | 0.0000 | |
264 | L | A | -0.9402 | |
265 | H | A | -1.7764 | |
266 | Q | A | -1.8028 | |
267 | E | A | -2.0077 | |
268 | G | A | -1.0046 | |
269 | A | A | 0.0000 | |
270 | K | A | -0.3988 | |
271 | M | A | 0.6101 | |
272 | A | A | 0.5798 | |
273 | V | A | 0.0000 | |
274 | R | A | 0.2090 | |
275 | L | A | 1.4494 | |
276 | A | A | 0.2744 | |
277 | G | A | -0.3267 | |
278 | G | A | 0.0000 | |
279 | L | A | 0.0000 | |
280 | Q | A | -1.3879 | |
281 | K | A | -1.3524 | |
282 | M | A | 0.0000 | |
283 | V | A | 0.0000 | |
284 | A | A | -0.9564 | |
285 | L | A | 0.0000 | |
286 | L | A | 0.0000 | |
287 | N | A | -1.9012 | |
288 | K | A | -1.6075 | |
289 | T | A | -1.0695 | |
290 | N | A | -1.1432 | |
291 | V | A | -0.2375 | |
292 | K | A | -0.3484 | |
293 | F | A | 0.0000 | |
294 | L | A | 0.0000 | |
295 | A | A | 0.0000 | |
296 | I | A | 0.0000 | |
297 | T | A | 0.0000 | |
298 | T | A | 0.0000 | |
299 | D | A | 0.0000 | |
300 | C | A | 0.0000 | |
301 | L | A | 0.0000 | |
302 | Q | A | 0.0000 | |
303 | I | A | -0.1198 | |
304 | L | A | 0.0000 | |
305 | A | A | 0.0000 | |
306 | Y | A | -0.0078 | |
307 | G | A | -0.7840 | |
308 | N | A | -1.0279 | |
309 | Q | A | -1.3759 | |
310 | E | A | -1.8522 | |
311 | S | A | 0.0000 | |
312 | K | A | 0.0000 | |
313 | L | A | 0.3152 | |
314 | I | A | 0.2060 | |
315 | I | A | 0.0000 | |
316 | L | A | 0.2955 | |
317 | A | A | 0.3450 | |
318 | S | A | -0.2771 | |
319 | G | A | -0.3793 | |
320 | G | A | 0.0000 | |
321 | P | A | 0.0000 | |
322 | Q | A | -1.3373 | |
323 | A | A | -1.0348 | |
324 | L | A | 0.0000 | |
325 | V | A | 0.0000 | |
326 | N | A | -1.7849 | |
327 | I | A | 0.0000 | |
328 | M | A | 0.0000 | |
329 | R | A | -1.3759 | |
330 | T | A | -0.8525 | |
331 | Y | A | -0.2309 | |
332 | T | A | -0.2227 | |
333 | Y | A | -0.0086 | |
334 | E | A | -0.6378 | |
335 | K | A | -0.5914 | |
336 | L | A | 0.0000 | |
337 | L | A | 0.0000 | |
338 | W | A | -0.4455 | |
339 | T | A | 0.0000 | |
340 | T | A | 0.0000 | |
341 | S | A | 0.0000 | |
342 | R | A | 0.0000 | |
343 | V | A | 0.0000 | |
344 | L | A | 0.0000 | |
345 | K | A | 0.0000 | |
346 | V | A | 0.0000 | |
347 | L | A | 0.0000 | |
348 | S | A | 0.0000 | |
349 | V | A | -0.2186 | |
350 | C | A | 0.0000 | |
351 | S | A | -0.3240 | |
352 | S | A | -0.0142 | |
353 | N | A | 0.0000 | |
354 | K | A | 0.0000 | |
355 | P | A | -0.7722 | |
356 | A | A | -0.8718 | |
357 | I | A | 0.0000 | |
358 | V | A | 0.0000 | |
359 | E | A | -2.2402 | |
360 | A | A | 0.0000 | |
361 | G | A | -1.4035 | |
362 | G | A | 0.0000 | |
363 | M | A | 0.0000 | |
364 | Q | A | -0.7310 | |
365 | A | A | 0.0000 | |
366 | L | A | 0.0000 | |
367 | G | A | 0.3033 | |
368 | L | A | 1.0120 | |
369 | H | A | 0.0821 | |
370 | L | A | 0.0000 | |
371 | T | A | -0.2950 | |
372 | D | A | -0.8653 | |
373 | P | A | -1.0332 | |
374 | S | A | -1.3253 | |
375 | Q | A | -1.8226 | |
376 | R | A | -1.5646 | |
377 | L | A | 0.0000 | |
378 | V | A | 0.0000 | |
379 | Q | A | -0.8977 | |
380 | N | A | 0.0000 | |
381 | C | A | 0.0000 | |
382 | L | A | 0.0000 | |
383 | W | A | -0.2448 | |
384 | T | A | 0.0000 | |
385 | L | A | 0.0000 | |
386 | R | A | -0.1119 | |
387 | N | A | 0.0000 | |
388 | L | A | 0.0000 | |
389 | S | A | 0.0000 | |
390 | D | A | 0.0493 | |
391 | A | A | -0.5790 | |
392 | A | A | 0.0000 | |
393 | T | A | -1.6006 | |
394 | K | A | -2.4838 | |
395 | Q | A | -2.3697 | |
396 | E | A | -3.1011 | |
397 | G | A | -2.0921 | |
398 | M | A | 0.0000 | |
399 | E | A | -2.5923 | |
400 | G | A | -1.2964 | |
401 | L | A | 0.0000 | |
402 | L | A | 0.0000 | |
403 | G | A | -1.0079 | |
404 | T | A | -0.6074 | |
405 | L | A | 0.0000 | |
406 | V | A | 0.0000 | |
407 | Q | A | -1.2053 | |
408 | L | A | -0.8935 | |
409 | L | A | 0.0000 | |
410 | G | A | -1.5146 | |
411 | S | A | -1.2810 | |
412 | D | A | -1.8495 | |
413 | D | A | -0.9754 | |
414 | I | A | -0.1004 | |
415 | N | A | -0.9072 | |
416 | V | A | 0.0000 | |
417 | V | A | 0.0000 | |
418 | T | A | -0.6394 | |
419 | C | A | 0.0000 | |
420 | A | A | 0.0000 | |
421 | A | A | 0.0000 | |
422 | G | A | 0.0000 | |
423 | I | A | 0.0000 | |
424 | L | A | 0.0000 | |
425 | S | A | 0.0000 | |
426 | N | A | 0.0000 | |
427 | L | A | 0.0000 | |
428 | T | A | 0.0000 | |
429 | C | A | 0.0000 | |
430 | N | A | -1.1578 | |
431 | N | A | -1.0723 | |
432 | Y | A | -0.3439 | |
433 | K | A | -1.7756 | |
434 | N | A | 0.0000 | |
435 | K | A | 0.0000 | |
436 | M | A | -0.6057 | |
437 | M | A | -0.7594 | |
438 | V | A | 0.0000 | |
439 | C | A | 0.0000 | |
440 | Q | A | -0.7917 | |
441 | V | A | -0.2570 | |
442 | G | A | -0.3827 | |
443 | G | A | 0.0000 | |
444 | I | A | 0.0000 | |
445 | E | A | -0.5467 | |
446 | A | A | -0.9143 | |
447 | L | A | 0.0000 | |
448 | V | A | 0.0000 | |
449 | R | A | -1.7360 | |
450 | T | A | 0.0000 | |
451 | V | A | 0.0000 | |
452 | L | A | -0.8707 | |
453 | R | A | -2.4102 | |
454 | A | A | 0.0000 | |
455 | G | A | -1.9149 | |
456 | D | A | -3.1453 | |
457 | R | A | -2.9520 | |
458 | E | A | -2.6094 | |
459 | D | A | -2.5930 | |
460 | I | A | 0.0000 | |
461 | T | A | 0.0000 | |
462 | E | A | -1.6081 | |
463 | P | A | 0.0000 | |
464 | A | A | 0.0000 | |
465 | I | A | 0.0000 | |
466 | C | A | 0.0000 | |
467 | A | A | 0.0000 | |
468 | L | A | 0.0000 | |
469 | R | A | 0.0000 | |
470 | H | A | 0.0000 | |
471 | L | A | 0.0000 | |
472 | T | A | 0.0000 | |
473 | S | A | 0.0000 | |
474 | R | A | -1.1924 | |
475 | H | A | -1.4427 | |
476 | Q | A | -1.9530 | |
477 | E | A | -1.7611 | |
478 | A | A | 0.0000 | |
479 | E | A | -2.1902 | |
480 | M | A | -1.1874 | |
481 | A | A | 0.0000 | |
482 | Q | A | 0.0000 | |
483 | N | A | -0.4436 | |
484 | A | A | 0.0000 | |
485 | V | A | 0.0000 | |
486 | R | A | 0.5442 | |
487 | L | A | 1.5013 | |
488 | H | A | 0.6326 | |
489 | Y | A | 1.4190 | |
490 | G | A | 0.0000 | |
491 | L | A | 0.0000 | |
492 | P | A | -0.4434 | |
493 | V | A | -0.1171 | |
494 | V | A | 0.0000 | |
495 | V | A | 0.0000 | |
496 | K | A | -1.6885 | |
497 | L | A | 0.0000 | |
498 | L | A | 0.0000 | |
499 | H | A | -1.1873 | |
500 | P | A | -1.1891 | |
501 | P | A | -1.2292 | |
502 | S | A | -1.6467 | |
503 | H | A | -1.2814 | |
504 | W | A | -0.3323 | |
505 | P | A | -0.4517 | |
506 | L | A | 0.0000 | |
507 | I | A | 0.0000 | |
508 | K | A | -0.8373 | |
509 | A | A | 0.0000 | |
510 | T | A | 0.0000 | |
511 | V | A | 0.0000 | |
512 | G | A | -0.2174 | |
513 | L | A | 0.0000 | |
514 | I | A | 0.0000 | |
515 | R | A | -0.2193 | |
516 | N | A | 0.0000 | |
517 | L | A | 0.0000 | |
518 | A | A | 0.0000 | |
519 | L | A | -0.1775 | |
520 | C | A | 0.0000 | |
521 | P | A | -0.4170 | |
522 | A | A | -0.1619 | |
523 | N | A | 0.0000 | |
524 | H | A | 0.0000 | |
525 | A | A | -0.9339 | |
526 | P | A | -1.0890 | |
527 | L | A | 0.0000 | |
528 | R | A | -1.5778 | |
529 | E | A | -2.3345 | |
530 | Q | A | -1.9382 | |
531 | G | A | -1.4218 | |
532 | A | A | 0.0000 | |
533 | I | A | 0.0000 | |
534 | P | A | -0.5731 | |
535 | R | A | -0.9879 | |
536 | L | A | 0.0000 | |
537 | V | A | 0.0000 | |
538 | Q | A | -1.4917 | |
539 | L | A | 0.0000 | |
540 | L | A | 0.0000 | |
541 | V | A | -0.8416 | |
542 | R | A | -2.2073 | |
543 | A | A | 0.0000 | |
544 | H | A | 0.0000 | |
545 | Q | A | -2.2876 | |
546 | D | A | -2.8168 | |
547 | T | A | -2.3923 | |
548 | Q | A | -2.5888 | |
549 | R | A | -2.8658 | |
564 | V | A | 0.2696 | |
565 | R | A | -1.6318 | |
566 | M | A | -1.6291 | |
567 | E | A | -1.6281 | |
568 | E | A | -1.4288 | |
569 | I | A | 0.0000 | |
570 | V | A | 0.0000 | |
571 | E | A | -0.9631 | |
572 | G | A | -0.7305 | |
573 | C | A | 0.0000 | |
574 | T | A | 0.0000 | |
575 | G | A | 0.0000 | |
576 | A | A | 0.0000 | |
577 | L | A | 0.0000 | |
578 | H | A | 0.0000 | |
579 | I | A | 0.0000 | |
580 | L | A | 0.0000 | |
581 | A | A | 0.0000 | |
582 | R | A | -1.2111 | |
583 | D | A | -0.3229 | |
584 | V | A | 1.0454 | |
585 | H | A | 0.1576 | |
586 | N | A | 0.0000 | |
587 | R | A | 0.0000 | |
588 | I | A | 1.3629 | |
589 | V | A | 0.8345 | |
590 | I | A | 0.0000 | |
591 | R | A | -0.2238 | |
592 | G | A | -0.1042 | |
593 | L | A | -0.0867 | |
594 | N | A | -1.0989 | |
595 | T | A | 0.0000 | |
596 | I | A | 0.0000 | |
597 | P | A | -0.8218 | |
598 | L | A | -0.3800 | |
599 | F | A | 0.0000 | |
600 | V | A | 0.0000 | |
601 | Q | A | -0.6496 | |
602 | L | A | 0.0000 | |
603 | L | A | 0.0000 | |
604 | Y | A | 0.7132 | |
605 | S | A | 0.1214 | |
606 | P | A | 0.0278 | |
607 | I | A | -0.1561 | |
608 | E | A | -1.4430 | |
609 | N | A | -1.1166 | |
610 | I | A | 0.0000 | |
611 | Q | A | -0.4394 | |
612 | R | A | 0.0000 | |
613 | V | A | -0.2189 | |
614 | A | A | 0.0000 | |
615 | A | A | 0.0000 | |
616 | G | A | 0.0000 | |
617 | V | A | 0.0000 | |
618 | L | A | 0.0000 | |
619 | C | A | 0.0000 | |
620 | E | A | -0.7435 | |
621 | L | A | 0.0000 | |
622 | A | A | 0.0000 | |
623 | Q | A | -1.5159 | |
624 | D | A | -1.9080 | |
625 | K | A | -3.4199 | |
626 | E | A | -3.2871 | |
627 | A | A | 0.0000 | |
628 | A | A | 0.0000 | |
629 | E | A | -3.6418 | |
630 | A | A | -2.4258 | |
631 | I | A | 0.0000 | |
632 | E | A | -2.7098 | |
633 | A | A | -1.8871 | |
634 | E | A | -2.0601 | |
635 | G | A | -1.4111 | |
636 | A | A | 0.0000 | |
637 | T | A | -0.8410 | |
638 | A | A | -0.7467 | |
639 | P | A | 0.0000 | |
640 | L | A | 0.0000 | |
641 | T | A | -0.7791 | |
642 | E | A | -1.6892 | |
643 | L | A | -1.1206 | |
644 | L | A | -0.8670 | |
645 | H | A | -1.8731 | |
646 | S | A | -2.1884 | |
647 | R | A | -2.7463 | |
648 | N | A | -2.4034 | |
649 | E | A | -2.4018 | |
650 | G | A | 0.0000 | |
651 | V | A | 0.0000 | |
652 | A | A | -1.1333 | |
653 | T | A | -0.6385 | |
654 | Y | A | 0.0000 | |
655 | A | A | 0.0000 | |
656 | A | A | 0.5190 | |
657 | A | A | 0.0000 | |
658 | V | A | 0.0000 | |
659 | L | A | 0.8699 | |
660 | F | A | 1.6537 | |
661 | R | A | -0.4141 | |
662 | M | A | -0.5148 | |
661 | L | B | -0.7267 | |
662 | K | B | -1.9931 | |
663 | A | B | -1.5162 | |
664 | A | B | 0.0000 | |
665 | D | B | -2.4288 | |
666 | S | B | -1.7539 | |
667 | D | B | -1.7000 | |
668 | P | B | -0.8981 | |
669 | T | B | -0.3023 | |
670 | A | B | -0.3989 | |
671 | P | B | 0.1233 | |
672 | P | B | 0.3026 | |
673 | Y | B | 0.8083 | |
674 | D | B | 0.0182 | |
675 | S | B | 0.4079 | |
676 | L | B | 0.9205 | |
677 | L | B | 1.0977 | |
678 | V | B | 1.7232 | |
679 | F | B | 0.4877 | |
680 | D | B | -0.9051 | |
681 | Y | B | -0.0773 | |
682 | E | B | -0.5165 | |
683 | G | B | -0.5538 | |
685 | G | B | -0.9398 | |
687 | E | B | -1.8468 | |
688 | A | B | 0.0000 | |
689 | A | B | -0.4902 | |
690 | S | B | -0.4199 | |
691 | L | B | -0.1971 | |
693 | S | B | 0.0340 | |
694 | L | B | 0.4457 | |
706 | D | B | -2.0542 | |
707 | Y | B | -1.2693 | |
708 | L | B | 0.0000 | |
709 | N | B | -3.4300 | |
710 | E | B | -2.9385 | |
711 | W | B | -2.3006 | |
712 | G | B | -2.3871 | |
713 | N | B | -3.1902 | |
714 | R | B | -2.6032 | |
715 | F | B | 0.0000 | |
716 | K | B | -4.1286 | |
717 | K | B | -3.5330 | |
718 | L | B | 0.0000 | |
719 | A | B | -2.5535 | |
720 | D | B | -2.6505 | |
721 | M | B | -0.8998 | |
722 | Y | B | 0.0990 |