Project name: 21473280bac1b3a
Status: done
submitted: 2018-04-12 18:09:04, status changed: 2018-04-16 01:01:47
Settings
Chain sequence(s)
|
B: EDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRKDSYVGDEAQSILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLCASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.6075
-
Maximal score value
-
1.6196
-
Average score
-
-0.7275
-
Total score value
-
-261.9094
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
3 |
E |
B |
-2.8674 |
|
4 |
D |
B |
-3.0733 |
|
5 |
S |
B |
-2.2698 |
|
6 |
T |
B |
-1.5257 |
|
7 |
A |
B |
-0.7979 |
|
8 |
L |
B |
0.0000 |
|
9 |
V |
B |
0.0000 |
|
10 |
C |
B |
0.0000 |
|
11 |
D |
B |
0.0000 |
|
12 |
N |
B |
0.0000 |
|
13 |
G |
B |
-0.1407 |
|
14 |
S |
B |
0.0000 |
|
15 |
G |
B |
-0.1573 |
|
16 |
L |
B |
0.7310 |
|
17 |
C |
B |
0.0000 |
|
18 |
K |
B |
-0.1747 |
|
19 |
A |
B |
0.0000 |
|
20 |
G |
B |
0.0000 |
|
21 |
F |
B |
-1.2541 |
|
22 |
A |
B |
-0.7882 |
|
23 |
G |
B |
-1.2407 |
|
24 |
D |
B |
-2.5602 |
|
25 |
D |
B |
-2.7078 |
|
26 |
A |
B |
-1.7901 |
|
27 |
P |
B |
-1.3597 |
|
28 |
R |
B |
-2.1655 |
|
29 |
A |
B |
0.0000 |
|
30 |
V |
B |
0.1533 |
|
31 |
F |
B |
0.0000 |
|
32 |
P |
B |
-0.3318 |
|
33 |
S |
B |
0.0000 |
|
34 |
I |
B |
0.0000 |
|
35 |
V |
B |
0.0000 |
|
36 |
G |
B |
0.0000 |
|
37 |
R |
B |
-1.5419 |
|
38 |
P |
B |
-1.2944 |
|
39 |
R |
B |
-1.4180 |
|
50 |
K |
B |
-2.7085 |
|
51 |
D |
B |
-2.8175 |
|
52 |
S |
B |
-1.7119 |
|
53 |
Y |
B |
-1.4403 |
|
54 |
V |
B |
0.0000 |
|
55 |
G |
B |
0.0000 |
|
56 |
D |
B |
-2.5665 |
|
57 |
E |
B |
-2.0424 |
|
58 |
A |
B |
0.0000 |
|
59 |
Q |
B |
-2.0937 |
|
60 |
S |
B |
-1.2530 |
|
64 |
I |
B |
1.4657 |
|
65 |
L |
B |
0.0634 |
|
66 |
T |
B |
-0.3675 |
|
67 |
L |
B |
-0.2009 |
|
68 |
K |
B |
-0.9224 |
|
69 |
Y |
B |
-0.3469 |
|
70 |
P |
B |
0.0000 |
|
71 |
I |
B |
0.0000 |
|
72 |
E |
B |
-1.7023 |
|
73 |
H |
B |
-1.4373 |
|
74 |
G |
B |
-0.6065 |
|
75 |
I |
B |
-0.2123 |
|
76 |
I |
B |
0.0000 |
|
77 |
T |
B |
-0.6422 |
|
78 |
N |
B |
-1.1083 |
|
79 |
W |
B |
-1.3117 |
|
80 |
D |
B |
-2.2404 |
|
81 |
D |
B |
0.0000 |
|
82 |
M |
B |
0.0000 |
|
83 |
E |
B |
-1.9483 |
|
84 |
K |
B |
-1.7152 |
|
85 |
I |
B |
0.0000 |
|
86 |
W |
B |
0.0000 |
|
87 |
H |
B |
-1.4378 |
|
88 |
H |
B |
0.0000 |
|
89 |
S |
B |
0.0000 |
|
90 |
F |
B |
0.0000 |
|
91 |
Y |
B |
-0.9203 |
|
92 |
N |
B |
-1.4734 |
|
93 |
E |
B |
-1.5735 |
|
94 |
L |
B |
0.0000 |
|
95 |
R |
B |
-1.9893 |
|
96 |
V |
B |
-1.7485 |
|
97 |
A |
B |
-1.4001 |
|
98 |
P |
B |
0.0000 |
|
99 |
E |
B |
-2.2970 |
|
100 |
E |
B |
-2.7917 |
|
101 |
H |
B |
0.0000 |
|
102 |
P |
B |
-0.7476 |
|
103 |
T |
B |
0.0000 |
|
104 |
L |
B |
0.0000 |
|
105 |
L |
B |
0.0000 |
|
106 |
T |
B |
0.0000 |
|
107 |
E |
B |
0.0000 |
|
108 |
A |
B |
0.0000 |
|
109 |
P |
B |
0.0000 |
|
110 |
L |
B |
0.6557 |
|
111 |
N |
B |
-0.0188 |
|
112 |
P |
B |
-0.8341 |
|
113 |
K |
B |
-2.0359 |
|
114 |
A |
B |
-1.4124 |
|
115 |
N |
B |
-1.3250 |
|
116 |
R |
B |
-1.5357 |
|
117 |
E |
B |
-1.7077 |
|
118 |
K |
B |
-1.6535 |
|
119 |
M |
B |
0.0000 |
|
120 |
T |
B |
0.0000 |
|
121 |
Q |
B |
-1.6946 |
|
122 |
I |
B |
0.0000 |
|
123 |
M |
B |
0.0000 |
|
124 |
F |
B |
0.0000 |
|
125 |
E |
B |
-2.5538 |
|
126 |
T |
B |
-1.5338 |
|
127 |
F |
B |
0.0000 |
|
128 |
N |
B |
-2.3369 |
|
129 |
V |
B |
0.0000 |
|
130 |
P |
B |
-1.3362 |
|
131 |
A |
B |
-0.8537 |
|
132 |
M |
B |
0.0000 |
|
133 |
Y |
B |
0.0000 |
|
134 |
V |
B |
0.0000 |
|
135 |
A |
B |
0.0000 |
|
136 |
I |
B |
0.8601 |
|
137 |
Q |
B |
0.0764 |
|
138 |
A |
B |
0.0000 |
|
139 |
V |
B |
0.2710 |
|
140 |
L |
B |
0.0000 |
|
141 |
S |
B |
0.0000 |
|
142 |
L |
B |
0.0000 |
|
143 |
C |
B |
0.0180 |
|
144 |
A |
B |
0.0689 |
|
145 |
S |
B |
-0.3529 |
|
146 |
G |
B |
-0.5871 |
|
147 |
R |
B |
-0.8828 |
|
148 |
T |
B |
-0.7993 |
|
149 |
T |
B |
-0.7418 |
|
150 |
G |
B |
0.0000 |
|
151 |
I |
B |
0.0000 |
|
152 |
V |
B |
0.0000 |
|
153 |
L |
B |
0.0000 |
|
154 |
D |
B |
-0.6155 |
|
155 |
S |
B |
0.0000 |
|
156 |
G |
B |
-0.7936 |
|
157 |
D |
B |
-1.1012 |
|
158 |
G |
B |
-1.0530 |
|
159 |
V |
B |
-1.1129 |
|
160 |
T |
B |
0.0000 |
|
161 |
H |
B |
0.0000 |
|
162 |
N |
B |
0.0000 |
|
163 |
V |
B |
0.0000 |
|
164 |
P |
B |
0.0000 |
|
165 |
I |
B |
0.0000 |
|
166 |
Y |
B |
-0.1555 |
|
167 |
E |
B |
-1.4140 |
|
168 |
G |
B |
-0.0866 |
|
169 |
Y |
B |
0.7848 |
|
170 |
A |
B |
0.0000 |
|
171 |
L |
B |
0.0551 |
|
172 |
P |
B |
-0.2808 |
|
173 |
H |
B |
-1.1475 |
|
174 |
A |
B |
0.0000 |
|
175 |
I |
B |
-0.5518 |
|
176 |
M |
B |
-0.8467 |
|
177 |
R |
B |
-1.5715 |
|
178 |
L |
B |
0.0000 |
|
179 |
D |
B |
-1.3336 |
|
180 |
L |
B |
0.0000 |
|
181 |
A |
B |
0.0000 |
|
182 |
G |
B |
0.0000 |
|
183 |
R |
B |
-1.4947 |
|
184 |
D |
B |
-1.2179 |
|
185 |
L |
B |
0.0000 |
|
186 |
T |
B |
0.0000 |
|
187 |
D |
B |
-1.6201 |
|
188 |
Y |
B |
-0.9938 |
|
189 |
L |
B |
0.0000 |
|
190 |
M |
B |
0.0000 |
|
191 |
K |
B |
-1.9442 |
|
192 |
I |
B |
0.0000 |
|
193 |
L |
B |
0.0000 |
|
194 |
T |
B |
-1.8652 |
|
195 |
E |
B |
-2.9300 |
|
196 |
R |
B |
-2.3924 |
|
197 |
G |
B |
-1.7740 |
|
198 |
Y |
B |
-0.9095 |
|
199 |
S |
B |
-0.5514 |
|
200 |
F |
B |
0.0000 |
|
201 |
V |
B |
0.9875 |
|
202 |
T |
B |
0.3096 |
|
203 |
T |
B |
-0.1774 |
|
204 |
A |
B |
-0.6009 |
|
205 |
E |
B |
-0.7232 |
|
206 |
R |
B |
-1.2765 |
|
207 |
E |
B |
-1.6030 |
|
208 |
I |
B |
-1.1949 |
|
209 |
V |
B |
0.0000 |
|
210 |
R |
B |
-2.4061 |
|
211 |
D |
B |
-2.4999 |
|
212 |
I |
B |
0.0000 |
|
213 |
K |
B |
0.0000 |
|
214 |
E |
B |
-3.0837 |
|
215 |
K |
B |
-2.9010 |
|
216 |
L |
B |
0.0000 |
|
217 |
C |
B |
0.0000 |
|
218 |
Y |
B |
-0.4106 |
|
219 |
V |
B |
0.0000 |
|
220 |
A |
B |
0.0000 |
|
221 |
L |
B |
-0.7268 |
|
222 |
D |
B |
-1.3896 |
|
223 |
F |
B |
-1.3876 |
|
224 |
E |
B |
-2.4778 |
|
225 |
N |
B |
-2.3049 |
|
226 |
E |
B |
-1.5650 |
|
227 |
M |
B |
-1.0847 |
|
228 |
A |
B |
-0.9251 |
|
229 |
T |
B |
-0.8099 |
|
230 |
A |
B |
-0.8635 |
|
231 |
A |
B |
-0.2706 |
|
232 |
S |
B |
-0.3426 |
|
233 |
S |
B |
-0.6706 |
|
234 |
S |
B |
-0.9509 |
|
235 |
S |
B |
-0.9004 |
|
236 |
L |
B |
0.0000 |
|
237 |
E |
B |
-2.0409 |
|
238 |
K |
B |
-1.4864 |
|
239 |
S |
B |
-1.0184 |
|
240 |
Y |
B |
0.0000 |
|
241 |
E |
B |
-2.2930 |
|
242 |
L |
B |
-1.7728 |
|
243 |
P |
B |
-1.6843 |
|
244 |
D |
B |
-2.6229 |
|
245 |
G |
B |
-2.2673 |
|
246 |
Q |
B |
-2.0657 |
|
247 |
V |
B |
-0.9410 |
|
248 |
I |
B |
0.0000 |
|
249 |
T |
B |
-0.8515 |
|
250 |
I |
B |
0.0000 |
|
251 |
G |
B |
-1.2457 |
|
252 |
N |
B |
-0.7592 |
|
253 |
E |
B |
0.0000 |
|
254 |
R |
B |
-1.0354 |
|
255 |
F |
B |
0.0000 |
|
256 |
R |
B |
-0.2965 |
|
257 |
C |
B |
0.0000 |
|
258 |
P |
B |
0.0000 |
|
259 |
E |
B |
0.0000 |
|
260 |
T |
B |
0.0000 |
|
261 |
L |
B |
0.0000 |
|
262 |
F |
B |
0.0000 |
|
263 |
Q |
B |
-0.5905 |
|
264 |
P |
B |
0.0000 |
|
265 |
S |
B |
-0.5385 |
|
266 |
F |
B |
0.2316 |
|
267 |
I |
B |
-0.0760 |
|
268 |
G |
B |
-0.5114 |
|
269 |
M |
B |
-0.8070 |
|
270 |
E |
B |
-1.8022 |
|
271 |
S |
B |
-1.1495 |
|
272 |
A |
B |
-0.8073 |
|
273 |
G |
B |
0.0000 |
|
274 |
I |
B |
0.0000 |
|
275 |
H |
B |
-0.7142 |
|
276 |
E |
B |
-0.8680 |
|
277 |
T |
B |
-0.7235 |
|
278 |
T |
B |
0.0000 |
|
279 |
Y |
B |
-0.4889 |
|
280 |
N |
B |
-1.0802 |
|
281 |
S |
B |
0.0000 |
|
282 |
I |
B |
0.0000 |
|
283 |
M |
B |
-0.7228 |
|
284 |
K |
B |
-2.0076 |
|
285 |
C |
B |
0.0000 |
|
286 |
D |
B |
-1.6822 |
|
287 |
I |
B |
-0.2303 |
|
288 |
D |
B |
-1.8772 |
|
289 |
I |
B |
-1.4466 |
|
290 |
R |
B |
-1.7790 |
|
291 |
K |
B |
-2.7486 |
|
292 |
D |
B |
-2.6031 |
|
293 |
L |
B |
0.0000 |
|
294 |
Y |
B |
0.0000 |
|
295 |
A |
B |
-1.8116 |
|
296 |
N |
B |
-1.3142 |
|
297 |
N |
B |
0.0000 |
|
298 |
V |
B |
0.0000 |
|
299 |
L |
B |
0.0000 |
|
300 |
S |
B |
0.0000 |
|
301 |
G |
B |
-1.0261 |
|
302 |
G |
B |
-1.2927 |
|
303 |
T |
B |
0.0000 |
|
304 |
T |
B |
0.0000 |
|
305 |
M |
B |
-0.5746 |
|
306 |
Y |
B |
0.0000 |
|
307 |
P |
B |
-0.5841 |
|
308 |
G |
B |
-0.6208 |
|
309 |
I |
B |
0.0000 |
|
310 |
A |
B |
-1.1748 |
|
311 |
D |
B |
-2.1817 |
|
312 |
R |
B |
0.0000 |
|
313 |
M |
B |
0.0000 |
|
314 |
Q |
B |
-1.8474 |
|
315 |
K |
B |
-1.7602 |
|
316 |
E |
B |
-1.0464 |
|
317 |
I |
B |
0.0000 |
|
318 |
T |
B |
-0.7838 |
|
319 |
A |
B |
-0.1405 |
|
320 |
L |
B |
0.2799 |
|
321 |
A |
B |
0.0000 |
|
322 |
P |
B |
-0.5099 |
|
323 |
S |
B |
-0.4370 |
|
324 |
T |
B |
-0.5903 |
|
325 |
M |
B |
-1.5029 |
|
326 |
K |
B |
-2.4515 |
|
327 |
I |
B |
0.0000 |
|
328 |
K |
B |
-1.5636 |
|
329 |
I |
B |
0.0000 |
|
330 |
I |
B |
-0.0972 |
|
331 |
A |
B |
-0.4751 |
|
332 |
P |
B |
-0.5090 |
|
333 |
P |
B |
-0.8220 |
|
334 |
E |
B |
-1.5840 |
|
335 |
R |
B |
0.0000 |
|
336 |
K |
B |
-1.8324 |
|
337 |
Y |
B |
-1.0311 |
|
338 |
S |
B |
0.0000 |
|
339 |
V |
B |
0.0000 |
|
340 |
W |
B |
0.0000 |
|
341 |
I |
B |
0.0000 |
|
342 |
G |
B |
0.0000 |
|
343 |
G |
B |
0.0000 |
|
344 |
S |
B |
0.0000 |
|
345 |
I |
B |
0.2748 |
|
346 |
L |
B |
0.5062 |
|
347 |
A |
B |
0.0000 |
|
348 |
S |
B |
-0.0787 |
|
349 |
L |
B |
0.2107 |
|
350 |
S |
B |
-0.4153 |
|
351 |
T |
B |
-0.4475 |
|
352 |
F |
B |
0.0000 |
|
353 |
Q |
B |
-1.3142 |
|
354 |
Q |
B |
-1.4628 |
|
355 |
M |
B |
-0.6479 |
|
356 |
W |
B |
0.0000 |
|
357 |
I |
B |
0.0000 |
|
358 |
S |
B |
-1.1893 |
|
359 |
K |
B |
-2.2806 |
|
360 |
Q |
B |
-2.7693 |
|
361 |
E |
B |
-2.5416 |
|
362 |
Y |
B |
0.0000 |
|
363 |
D |
B |
-3.6075 |
|
364 |
E |
B |
-3.2572 |
|
365 |
A |
B |
-1.8169 |
|
366 |
G |
B |
-1.5666 |
|
367 |
P |
B |
-1.2391 |
|
368 |
S |
B |
-1.2248 |
|
369 |
I |
B |
0.0000 |
|
370 |
V |
B |
0.0000 |
|
371 |
H |
B |
-1.2351 |
|
372 |
R |
B |
-1.7139 |
|
373 |
K |
B |
-0.7889 |
|
374 |
C |
B |
0.0000 |
|
375 |
F |
B |
1.6196 |
|