| Chain sequence(s) |
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC B: QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -0.8141 | |
| 2 | I | A | 0.1601 | |
| 3 | V | A | 1.3201 | |
| 4 | L | A | 0.2400 | |
| 5 | S | A | -0.4818 | |
| 6 | Q | A | -0.7840 | |
| 7 | S | A | -0.2530 | |
| 8 | P | A | 0.3100 | |
| 9 | A | A | 0.6575 | |
| 10 | I | A | 1.7043 | |
| 11 | L | A | 0.6210 | |
| 12 | S | A | -0.1890 | |
| 13 | A | A | 0.0000 | |
| 14 | S | A | -1.9905 | |
| 15 | P | A | -2.4657 | |
| 16 | G | A | -2.1860 | |
| 17 | E | A | -2.9114 | |
| 18 | K | A | -3.0465 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.6490 | |
| 21 | M | A | 0.0000 | |
| 22 | T | A | -0.5598 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -1.6497 | |
| 25 | A | A | -0.5161 | |
| 26 | S | A | -0.2515 | |
| 27 | S | A | -0.3664 | |
| 28 | S | A | -0.5803 | |
| 29 | V | A | 0.0000 | |
| 30 | S | A | -0.1165 | |
| 31 | Y | A | 0.4338 | |
| 32 | I | A | 0.0000 | |
| 33 | H | A | 0.0000 | |
| 34 | W | A | 0.0000 | |
| 35 | F | A | 0.0000 | |
| 36 | Q | A | 0.0000 | |
| 37 | Q | A | -0.6609 | |
| 38 | K | A | -0.9967 | |
| 39 | P | A | -0.9066 | |
| 40 | G | A | -0.8494 | |
| 41 | S | A | -0.6882 | |
| 42 | S | A | -0.4547 | |
| 43 | P | A | 0.0000 | |
| 44 | K | A | -0.6762 | |
| 45 | P | A | 0.0000 | |
| 46 | W | A | -0.0098 | |
| 47 | I | A | 0.0000 | |
| 48 | Y | A | 0.2039 | |
| 49 | A | A | 0.1410 | |
| 50 | T | A | -0.0656 | |
| 51 | S | A | -0.3696 | |
| 52 | N | A | -0.4613 | |
| 53 | L | A | 0.3137 | |
| 54 | A | A | 0.0000 | |
| 55 | S | A | -0.6925 | |
| 56 | G | A | -0.5046 | |
| 57 | V | A | 0.0000 | |
| 58 | P | A | 0.5452 | |
| 59 | V | A | 1.5242 | |
| 60 | R | A | -0.3169 | |
| 61 | F | A | 0.0000 | |
| 62 | S | A | -0.0446 | |
| 63 | G | A | -0.3365 | |
| 64 | S | A | -0.4194 | |
| 65 | G | A | -0.6937 | |
| 66 | S | A | -0.6328 | |
| 67 | G | A | -0.6779 | |
| 68 | T | A | -0.9183 | |
| 69 | S | A | -1.0991 | |
| 70 | Y | A | 0.0000 | |
| 71 | S | A | -0.5487 | |
| 72 | L | A | 0.0000 | |
| 73 | T | A | -0.8062 | |
| 74 | I | A | 0.0000 | |
| 75 | S | A | -1.8144 | |
| 76 | R | A | -3.4734 | |
| 77 | V | A | 0.0000 | |
| 78 | E | A | -3.0216 | |
| 79 | A | A | 0.0000 | |
| 80 | E | A | -3.0533 | |
| 81 | D | A | 0.0000 | |
| 82 | A | A | 0.0000 | |
| 83 | A | A | 0.0000 | |
| 84 | T | A | -0.2109 | |
| 85 | Y | A | 0.0000 | |
| 86 | Y | A | -0.0607 | |
| 87 | C | A | 0.0000 | |
| 88 | Q | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | W | A | 0.0000 | |
| 91 | T | A | -0.5084 | |
| 92 | S | A | -1.1121 | |
| 93 | N | A | -1.7331 | |
| 94 | P | A | 0.0000 | |
| 95 | P | A | 0.0000 | |
| 96 | T | A | 0.0166 | |
| 97 | F | A | 0.2483 | |
| 98 | G | A | -0.1176 | |
| 99 | G | A | -0.8646 | |
| 100 | G | A | -0.1911 | |
| 101 | T | A | 0.0000 | |
| 102 | K | A | 0.0132 | |
| 103 | L | A | 0.0000 | |
| 104 | E | A | 0.0000 | |
| 105 | I | A | 0.0000 | |
| 106 | K | A | -2.0105 | |
| 107 | R | A | -1.3596 | |
| 108 | T | A | -0.3622 | |
| 109 | V | A | -0.0327 | |
| 110 | A | A | -0.2085 | |
| 111 | A | A | -0.2444 | |
| 112 | P | A | -0.3122 | |
| 113 | S | A | -0.3892 | |
| 114 | V | A | 0.0000 | |
| 115 | F | A | 0.1839 | |
| 116 | I | A | 0.2058 | |
| 117 | F | A | 0.0000 | |
| 118 | P | A | -0.6797 | |
| 119 | P | A | -0.6487 | |
| 120 | S | A | 0.0000 | |
| 121 | D | A | -2.7005 | |
| 122 | E | A | -2.5683 | |
| 123 | Q | A | 0.0000 | |
| 124 | L | A | -1.9970 | |
| 125 | K | A | -2.7695 | |
| 126 | S | A | -1.8631 | |
| 127 | G | A | -1.3624 | |
| 128 | T | A | -1.4224 | |
| 129 | A | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | V | A | 0.0000 | |
| 132 | V | A | 0.0000 | |
| 133 | C | A | 0.0000 | |
| 134 | L | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | N | A | -0.5682 | |
| 137 | N | A | -1.2185 | |
| 138 | F | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | P | A | -1.6997 | |
| 141 | R | A | -2.4754 | |
| 142 | E | A | -3.0191 | |
| 143 | A | A | 0.0000 | |
| 144 | K | A | -2.7994 | |
| 145 | V | A | -1.6927 | |
| 146 | Q | A | -1.6108 | |
| 147 | W | A | 0.0000 | |
| 148 | K | A | -0.8515 | |
| 149 | V | A | 0.0000 | |
| 150 | D | A | -1.6703 | |
| 151 | N | A | -1.5401 | |
| 152 | A | A | -0.4146 | |
| 153 | L | A | 0.0736 | |
| 154 | Q | A | -0.7925 | |
| 155 | S | A | -0.9754 | |
| 156 | G | A | -1.2398 | |
| 157 | N | A | -1.5646 | |
| 158 | S | A | -1.5560 | |
| 159 | Q | A | -1.5339 | |
| 160 | E | A | -1.7516 | |
| 161 | S | A | -0.3806 | |
| 162 | V | A | 0.2267 | |
| 163 | T | A | -0.3335 | |
| 164 | E | A | -1.1094 | |
| 165 | Q | A | 0.0000 | |
| 166 | D | A | -2.3563 | |
| 167 | S | A | -2.7017 | |
| 168 | K | A | -3.1243 | |
| 169 | D | A | -2.1775 | |
| 170 | S | A | 0.0000 | |
| 171 | T | A | 0.0000 | |
| 172 | Y | A | 0.0000 | |
| 173 | S | A | 0.0000 | |
| 174 | L | A | 0.0000 | |
| 175 | S | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | T | A | -0.6496 | |
| 178 | L | A | 0.0000 | |
| 179 | T | A | -0.4513 | |
| 180 | L | A | -0.6446 | |
| 181 | S | A | -1.0662 | |
| 182 | K | A | -2.0800 | |
| 183 | A | A | -1.6905 | |
| 184 | D | A | -2.3330 | |
| 185 | Y | A | 0.0000 | |
| 186 | E | A | -2.8307 | |
| 187 | K | A | -3.1371 | |
| 188 | H | A | -2.7580 | |
| 189 | K | A | -3.2073 | |
| 190 | V | A | -1.7180 | |
| 191 | Y | A | 0.0000 | |
| 192 | A | A | 0.0000 | |
| 193 | C | A | 0.0000 | |
| 194 | E | A | -1.1068 | |
| 195 | V | A | 0.0000 | |
| 196 | T | A | -1.3732 | |
| 197 | H | A | 0.0000 | |
| 198 | Q | A | -1.7461 | |
| 199 | G | A | -0.5046 | |
| 200 | L | A | -0.2974 | |
| 201 | S | A | -0.4586 | |
| 202 | S | A | -0.4453 | |
| 203 | P | A | -0.6077 | |
| 204 | V | A | -0.1282 | |
| 205 | T | A | -0.5871 | |
| 206 | K | A | -0.6652 | |
| 207 | S | A | -0.5782 | |
| 208 | F | A | -1.1835 | |
| 209 | N | A | -2.5219 | |
| 210 | R | A | -2.5971 | |
| 211 | G | A | -2.4038 | |
| 212 | E | A | -2.9195 | |
| 1 | Q | B | -0.9381 | |
| 2 | V | B | 0.1502 | |
| 3 | Q | B | -1.1451 | |
| 4 | L | B | 0.0000 | |
| 5 | Q | B | -1.5350 | |
| 6 | Q | B | -1.0658 | |
| 7 | P | B | -0.9713 | |
| 8 | G | B | -1.1627 | |
| 9 | A | B | -0.8527 | |
| 10 | E | B | -0.8512 | |
| 11 | L | B | -0.4245 | |
| 12 | V | B | 0.0000 | |
| 13 | K | B | -1.9378 | |
| 14 | P | B | -1.3855 | |
| 15 | G | B | -1.1866 | |
| 16 | A | B | -0.9712 | |
| 17 | S | B | -1.2831 | |
| 18 | V | B | 0.0000 | |
| 19 | K | B | -2.0648 | |
| 20 | M | B | 0.0000 | |
| 21 | S | B | -0.7654 | |
| 22 | C | B | 0.0000 | |
| 23 | K | B | -1.4255 | |
| 24 | A | B | 0.0000 | |
| 25 | S | B | -0.6032 | |
| 26 | G | B | -0.3076 | |
| 27 | Y | B | 0.0632 | |
| 28 | T | B | -0.2153 | |
| 29 | F | B | 0.0000 | |
| 30 | T | B | -0.6528 | |
| 31 | S | B | 0.2952 | |
| 32 | Y | B | 0.8871 | |
| 33 | N | B | 0.0000 | |
| 34 | M | B | 0.0000 | |
| 35 | H | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | V | B | 0.0000 | |
| 38 | K | B | 0.0000 | |
| 39 | Q | B | -0.7761 | |
| 40 | T | B | 0.0000 | |
| 41 | P | B | -1.3763 | |
| 42 | G | B | -1.5449 | |
| 43 | R | B | -2.4585 | |
| 44 | G | B | -1.5320 | |
| 45 | L | B | 0.0000 | |
| 46 | E | B | -1.3578 | |
| 47 | W | B | 0.0000 | |
| 48 | I | B | 0.0000 | |
| 49 | G | B | 0.0000 | |
| 50 | A | B | 0.0000 | |
| 51 | I | B | 0.0000 | |
| 52 | Y | B | -0.3137 | |
| 53 | P | B | 0.0000 | |
| 54 | G | B | -1.3319 | |
| 55 | N | B | -1.9853 | |
| 56 | G | B | -2.1495 | |
| 57 | D | B | -2.3236 | |
| 58 | T | B | -1.0652 | |
| 59 | S | B | -0.7504 | |
| 60 | Y | B | -1.1741 | |
| 61 | N | B | -1.9657 | |
| 62 | Q | B | -2.7473 | |
| 63 | K | B | -2.9756 | |
| 64 | F | B | -2.3060 | |
| 65 | K | B | -3.0015 | |
| 66 | G | B | -2.2309 | |
| 67 | K | B | -2.0793 | |
| 68 | A | B | 0.0000 | |
| 69 | T | B | -0.9473 | |
| 70 | L | B | 0.0000 | |
| 71 | T | B | -0.5239 | |
| 72 | A | B | -1.2444 | |
| 73 | D | B | -1.9414 | |
| 74 | K | B | -2.3607 | |
| 75 | S | B | -1.3859 | |
| 76 | S | B | -1.1172 | |
| 77 | S | B | -1.2925 | |
| 78 | T | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | Y | B | -0.4867 | |
| 81 | M | B | 0.0000 | |
| 82 | Q | B | -1.4750 | |
| 83 | L | B | 0.0000 | |
| 84 | S | B | -1.0731 | |
| 85 | S | B | -0.8992 | |
| 86 | L | B | 0.0000 | |
| 87 | T | B | -1.2934 | |
| 88 | S | B | -1.4562 | |
| 89 | E | B | -1.9663 | |
| 90 | D | B | -1.1753 | |
| 91 | S | B | -0.8357 | |
| 92 | A | B | 0.0000 | |
| 93 | V | B | 0.1108 | |
| 94 | Y | B | 0.0000 | |
| 95 | Y | B | 0.0000 | |
| 96 | C | B | 0.0000 | |
| 97 | A | B | 0.0000 | |
| 98 | R | B | 0.0000 | |
| 99 | S | B | 0.0000 | |
| 100 | T | B | 0.9050 | |
| 101 | Y | B | 1.8529 | |
| 102 | Y | B | 1.8599 | |
| 103 | G | B | 0.3112 | |
| 104 | G | B | -0.3610 | |
| 105 | D | B | 0.0230 | |
| 106 | W | B | 0.0000 | |
| 107 | Y | B | 0.4531 | |
| 108 | F | B | 0.0000 | |
| 109 | N | B | -0.1652 | |
| 110 | V | B | 0.0000 | |
| 111 | W | B | 0.0000 | |
| 112 | G | B | 0.0000 | |
| 113 | A | B | -0.6337 | |
| 114 | G | B | -0.3556 | |
| 115 | T | B | 0.0000 | |
| 116 | T | B | -0.2814 | |
| 117 | V | B | 0.0000 | |
| 118 | T | B | -0.6806 | |
| 119 | V | B | 0.0000 | |
| 120 | S | B | -0.7681 | |
| 121 | A | B | -0.7137 | |
| 122 | A | B | -0.4690 | |
| 123 | S | B | -0.6372 | |
| 124 | T | B | -0.8153 | |
| 125 | K | B | -1.4782 | |
| 126 | G | B | -1.6929 | |
| 127 | P | B | 0.0000 | |
| 128 | S | B | -0.5866 | |
| 129 | V | B | 0.0000 | |
| 130 | F | B | -0.5168 | |
| 131 | P | B | -1.0472 | |
| 132 | L | B | 0.0000 | |
| 133 | A | B | -0.8799 | |
| 134 | P | B | -1.1832 | |
| 135 | S | B | -2.1116 | |
| 136 | S | B | -1.7615 | |
| 137 | K | B | -2.4182 | |
| 138 | S | B | -1.5583 | |
| 139 | T | B | -1.2363 | |
| 140 | S | B | -1.0119 | |
| 141 | G | B | -0.8954 | |
| 142 | G | B | -0.8969 | |
| 143 | T | B | -0.6591 | |
| 144 | A | B | 0.0000 | |
| 145 | A | B | 0.0000 | |
| 146 | L | B | 0.0000 | |
| 147 | G | B | 0.0000 | |
| 148 | C | B | 0.0000 | |
| 149 | L | B | 0.0000 | |
| 150 | V | B | 0.0000 | |
| 151 | K | B | -0.1627 | |
| 152 | D | B | -0.6531 | |
| 153 | Y | B | 0.0000 | |
| 154 | F | B | -0.3623 | |
| 155 | P | B | 0.0000 | |
| 156 | E | B | -0.3819 | |
| 157 | P | B | -0.6796 | |
| 158 | V | B | -0.5935 | |
| 159 | T | B | -0.5692 | |
| 160 | V | B | -0.2851 | |
| 161 | S | B | -0.3302 | |
| 162 | W | B | 0.0000 | |
| 163 | N | B | -0.7293 | |
| 164 | S | B | -0.6137 | |
| 165 | G | B | -0.4329 | |
| 166 | A | B | -0.1086 | |
| 167 | L | B | 0.1782 | |
| 168 | T | B | -0.1358 | |
| 169 | S | B | -0.2146 | |
| 170 | G | B | -0.3186 | |
| 171 | V | B | -0.0186 | |
| 172 | H | B | -0.3097 | |
| 173 | T | B | -0.0799 | |
| 174 | F | B | 0.0000 | |
| 175 | P | B | -0.1998 | |
| 176 | A | B | 0.0412 | |
| 177 | V | B | 0.2569 | |
| 178 | L | B | 0.7677 | |
| 179 | Q | B | -0.1082 | |
| 180 | S | B | -0.3869 | |
| 181 | S | B | -0.3461 | |
| 182 | G | B | -0.1394 | |
| 183 | L | B | -0.0155 | |
| 184 | Y | B | 0.2792 | |
| 185 | S | B | 0.0000 | |
| 186 | L | B | 0.0000 | |
| 187 | S | B | -0.0734 | |
| 188 | S | B | 0.0000 | |
| 189 | V | B | 0.0000 | |
| 190 | V | B | 0.0000 | |
| 191 | T | B | -0.1762 | |
| 192 | V | B | 0.0000 | |
| 193 | P | B | -0.7131 | |
| 194 | S | B | -0.6835 | |
| 195 | S | B | -0.7614 | |
| 196 | S | B | -0.8154 | |
| 197 | L | B | 0.0000 | |
| 198 | G | B | -1.4673 | |
| 199 | T | B | -0.9333 | |
| 200 | Q | B | -1.6645 | |
| 201 | T | B | -1.2324 | |
| 202 | Y | B | 0.0000 | |
| 203 | I | B | -1.2993 | |
| 204 | C | B | 0.0000 | |
| 205 | N | B | -1.4389 | |
| 206 | V | B | 0.0000 | |
| 207 | N | B | -1.9575 | |
| 208 | H | B | 0.0000 | |
| 209 | K | B | -2.8164 | |
| 210 | P | B | -1.8649 | |
| 211 | S | B | -1.9560 | |
| 212 | N | B | -2.6288 | |
| 213 | T | B | -2.2094 | |
| 214 | K | B | -2.6398 | |
| 215 | V | B | -1.4893 | |
| 216 | D | B | -2.2736 | |
| 217 | K | B | -2.0347 | |
| 218 | K | B | -2.5185 | |
| 219 | V | B | 0.0000 | |
| 220 | E | B | -2.8254 | |
| 221 | P | B | -2.1821 | |
| 222 | K | B | -2.6246 | |
| 223 | S | B | -1.3988 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine