Project name: Hola [mutate: VA11C]

Status: done

submitted: 2019-01-11 17:18:15, status changed: 2019-01-11 17:35:16
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Chain sequence(s) A: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT
B: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues VA11C
Energy difference between WT (input) and mutated protein (by FoldX) -0.0842152 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-3.9461
Maximal score value
1.0309
Average score
-0.8521
Total score value
-390.2441

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 A A -1.1167
2 S A -1.5521
3 K A -2.0936
4 G A 0.0000
5 E A -1.5045
6 E A -1.9886
7 L A -0.8154
8 F A 0.0000
9 T A -0.5747
10 G A -0.3137
11 C A -0.0561 mutated: VA11C
12 V A 0.0000
13 P A -1.3495
14 I A 0.0000
15 L A -1.1587
16 V A 0.0000
17 E A -1.9661
18 L A 0.0000
19 D A -3.2271
20 G A -2.6697
21 D A -2.2440
22 V A 0.0000
23 N A -1.7255
24 G A -1.2809
25 H A -1.7405
26 K A -2.6530
27 F A 0.0000
28 S A -1.7842
29 V A 0.0000
30 S A -1.1026
31 G A 0.0000
32 E A -2.4392
33 G A -1.8893
34 E A -2.1719
35 G A 0.0000
36 D A -0.7370
37 A A 0.0000
38 T A -0.2809
39 Y A -0.4507
40 G A 0.0000
41 K A -0.7779
42 L A 0.0000
43 T A -1.1193
44 L A 0.0000
45 K A -1.5434
46 F A 0.0000
47 I A -1.2200
48 C A 0.0000
49 T A -0.7474
50 T A -1.1623
51 G A -1.6608
52 K A -2.2842
53 L A 0.0000
54 P A -1.1293
55 V A 0.0000
56 P A 0.0000
57 W A 0.0000
58 P A 0.0000
59 T A 0.0000
60 L A 0.0000
61 V A 0.0000
62 T A 0.0000
63 T A 0.0000
64 F A 0.0000
66 Y A 0.0000
67 G A 0.0000
68 V A 0.0000
69 Q A 0.0000
70 C A 0.0000
71 F A 0.0000
72 S A 0.0000
73 R A -0.6706
74 Y A 0.0000
75 P A -1.6439
76 D A -2.7584
77 H A -2.3593
78 M A 0.0000
79 K A -2.3336
80 R A -2.7276
81 H A -1.6827
82 D A 0.0000
83 F A 0.0000
84 F A 0.0000
85 K A 0.0000
86 S A -0.9615
87 A A 0.0000
88 M A 0.0000
89 P A -1.0597
90 E A -1.6752
91 G A 0.0000
92 Y A 0.0000
93 V A -0.6413
94 Q A 0.0000
95 E A -2.2860
96 R A 0.0000
97 T A -0.4294
98 I A 0.0000
99 F A 0.2670
100 F A 0.0000
101 K A -2.2120
102 D A -2.9610
103 D A -2.5970
104 G A 0.0000
105 N A -0.6755
106 Y A 0.0000
107 K A -1.5595
108 T A 0.0000
109 R A -3.1441
110 A A 0.0000
111 E A -1.7836
112 V A 0.0000
113 K A -1.2136
114 F A -1.3449
115 E A -1.6866
116 G A -1.7584
117 D A -2.1589
118 T A -1.6502
119 L A 0.0000
120 V A 0.0000
121 N A 0.0000
122 R A -2.2421
123 I A 0.0000
124 E A -3.7845
125 L A 0.0000
126 K A -2.1386
127 G A 0.0000
128 I A -1.0648
129 D A -2.4591
130 F A 0.0000
131 K A -3.7352
132 E A -3.8467
133 D A -3.5174
134 G A -2.7671
135 N A -2.2207
136 I A 0.0000
137 L A -1.9451
138 G A -2.2737
139 H A -2.0997
140 K A -2.3559
141 L A 0.0000
142 E A -1.2774
143 Y A -0.3267
144 N A 0.0000
145 Y A 0.0000
146 N A 0.0000
147 S A 0.0000
148 H A 0.0000
149 N A -0.3686
150 V A 0.0000
151 Y A 0.2589
152 I A 0.0000
153 M A -0.8362
154 A A -1.7728
155 D A -2.3373
156 K A -3.2650
157 Q A -3.2018
158 K A -3.3979
159 N A -2.8573
160 G A 0.0000
161 I A 0.0000
162 K A -1.0975
163 V A 0.0000
164 N A -0.3124
165 F A 0.0000
166 K A -1.4604
167 I A 0.0000
168 R A -0.7844
169 H A 0.0000
170 N A -0.9325
171 I A 0.0000
172 E A -3.1605
173 D A -2.9772
174 G A -1.8731
175 S A -0.8288
176 V A -0.0463
177 Q A 0.0000
178 L A -0.7623
179 A A 0.0000
180 D A -0.7155
181 H A 0.0000
182 Y A -0.0234
183 Q A 0.0000
184 Q A -1.1664
185 N A 0.0000
186 T A -0.7651
187 P A -0.6812
188 I A -0.0461
189 G A -1.1124
190 D A -1.9856
191 G A -1.2643
192 P A -0.7656
193 V A -0.4589
194 L A -0.4511
195 L A -0.9443
196 P A 0.0000
197 D A -2.3826
198 N A -1.6386
199 H A 0.0000
200 Y A -0.0234
201 L A 0.0000
202 S A -0.0843
203 T A 0.0000
204 Q A 0.0000
205 S A 0.0000
206 A A 0.0000
207 L A 0.0000
208 S A -0.5844
209 K A -1.5299
210 D A -1.7374
211 P A -1.5461
212 N A -2.2782
213 E A -2.5593
214 K A -3.1232
215 R A -3.1492
216 D A -2.1306
217 H A 0.0000
218 M A 0.0000
219 V A 0.0000
220 L A 0.0000
221 L A -0.0397
222 E A 0.0000
223 F A 0.0000
224 V A 0.0000
225 T A -0.1955
226 A A 0.0000
227 A A -0.2042
228 G A -0.5913
229 I A -0.6090
230 T A -0.2083
1 A B -1.1426
2 S B -1.5429
3 K B -2.0480
4 G B 0.0000
5 E B -1.6219
6 E B -2.1777
7 L B -0.7792
8 F B 0.0000
9 T B -0.3801
10 G B 0.2117
11 V B 1.0309
12 V B 0.0000
13 P B -1.0884
14 I B 0.0000
15 L B -1.1455
16 V B 0.0000
17 E B -1.9380
18 L B 0.0000
19 D B -3.1811
20 G B 0.0000
21 D B -2.1580
22 V B 0.0000
23 N B -1.7071
24 G B -1.2724
25 H B -1.7195
26 K B -2.6527
27 F B 0.0000
28 S B -1.7393
29 V B 0.0000
30 S B -1.0750
31 G B 0.0000
32 E B -2.4412
33 G B -1.7885
34 E B -1.8514
35 G B 0.0000
36 D B -0.3247
37 A B 0.0000
38 T B -0.1956
39 Y B -0.4918
40 G B 0.0000
41 K B -0.7859
42 L B 0.0000
43 T B -1.1216
44 L B 0.0000
45 K B -1.5287
46 F B 0.0000
47 I B -1.2146
48 C B 0.0000
49 T B -0.7766
50 T B -1.1946
51 G B -1.7248
52 K B -2.3419
53 L B 0.0000
54 P B -1.1749
55 V B 0.0000
56 P B 0.0000
57 W B 0.0000
58 P B 0.0000
59 T B 0.0000
60 L B 0.0000
61 V B 0.0000
62 T B 0.0000
63 T B 0.0000
64 F B 0.0000
66 Y B 0.0000
67 G B 0.0000
68 V B 0.0000
69 Q B 0.0000
70 C B 0.0000
71 F B 0.0000
72 S B 0.0000
73 R B -1.0415
74 Y B 0.0000
75 P B -1.7279
76 D B -2.8325
77 H B -2.3898
78 M B 0.0000
79 K B -2.5048
80 R B -2.7843
81 H B -1.6864
82 D B 0.0000
83 F B 0.0000
84 F B 0.0000
85 K B 0.0000
86 S B 0.0000
87 A B 0.0000
88 M B 0.0000
89 P B -1.0638
90 E B -1.4462
91 G B 0.0000
92 Y B 0.0000
93 V B -0.6478
94 Q B 0.0000
95 E B -2.1221
96 R B 0.0000
97 T B -0.3549
98 I B 0.0000
99 F B 0.2981
100 F B 0.0000
101 K B -1.5652
102 D B -2.7236
103 D B -2.4946
104 G B 0.0000
105 N B -0.6147
106 Y B 0.0000
107 K B -1.4027
108 T B 0.0000
109 R B -2.9938
110 A B 0.0000
111 E B -1.7926
112 V B 0.0000
113 K B -1.1195
114 F B -1.2500
115 E B -1.5733
116 G B -1.7145
117 D B -2.1387
118 T B -1.4381
119 L B 0.0000
120 V B 0.0000
121 N B 0.0000
122 R B -2.2127
123 I B 0.0000
124 E B -3.6852
125 L B 0.0000
126 K B -1.9622
127 G B 0.0000
128 I B -0.9432
129 D B -2.4347
130 F B 0.0000
131 K B -3.9155
132 E B -3.9461
133 D B -3.5734
134 G B 0.0000
135 N B -2.1148
136 I B 0.0000
137 L B -1.9892
138 G B -2.2810
139 H B -2.0691
140 K B -2.2898
141 L B 0.0000
142 E B -1.2233
143 Y B -0.2814
144 N B 0.0000
145 Y B 0.0000
146 N B 0.0000
147 S B 0.0000
148 H B 0.0000
149 N B -0.6957
150 V B 0.0000
151 Y B 0.0711
152 I B 0.0000
153 M B -0.6486
154 A B -1.5843
155 D B 0.0000
156 K B -3.1480
157 Q B -3.1847
158 K B -3.4898
159 N B -2.8086
160 G B 0.0000
161 I B 0.0000
162 K B -1.0802
163 V B 0.0000
164 N B -0.5630
165 F B 0.0000
166 K B -1.2837
167 I B 0.0000
168 R B -0.6253
169 H B 0.0000
170 N B -0.8395
171 I B 0.0000
172 E B -3.1353
173 D B -2.9623
174 G B -1.8386
175 S B -0.8242
176 V B 0.0511
177 Q B 0.0000
178 L B -0.3616
179 A B 0.0000
180 D B 0.0000
181 H B 0.0000
182 Y B 0.0618
183 Q B 0.0000
184 Q B -1.4362
185 N B 0.0000
186 T B -0.8029
187 P B -0.6476
188 I B 0.0115
189 G B -1.0153
190 D B -1.9396
191 G B -1.2096
192 P B -0.7271
193 V B -0.3813
194 L B -0.4250
195 L B -0.7870
196 P B 0.0000
197 D B -2.2209
198 N B -1.3658
199 H B 0.0000
200 Y B 0.0095
201 L B 0.0000
202 S B -0.2162
203 T B 0.0000
204 Q B 0.0000
205 S B 0.0000
206 A B 0.0000
207 L B 0.0000
208 S B 0.0000
209 K B -1.1371
210 D B -1.6859
211 P B -1.5082
212 N B -2.2954
213 E B -2.5610
214 K B -3.1464
215 R B -3.3848
216 D B -2.2705
217 H B 0.0000
218 M B 0.0000
219 V B 0.0000
220 L B 0.0000
221 L B -0.0459
222 E B 0.0000
223 F B 0.0000
224 V B 0.0000
225 T B -0.4467
226 A B 0.0000
227 A B -0.1778
228 G B -0.4375
229 I B -0.4889
230 T B -0.1832

 

Laboratory of Theory of Biopolymers 2015