Chain sequence(s) |
A: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT B: ASKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFSYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGIT |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | VA11C |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.0842152 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | A | A | -1.1167 | |
2 | S | A | -1.5521 | |
3 | K | A | -2.0936 | |
4 | G | A | 0.0000 | |
5 | E | A | -1.5045 | |
6 | E | A | -1.9886 | |
7 | L | A | -0.8154 | |
8 | F | A | 0.0000 | |
9 | T | A | -0.5747 | |
10 | G | A | -0.3137 | |
11 | C | A | -0.0561 | mutated: VA11C |
12 | V | A | 0.0000 | |
13 | P | A | -1.3495 | |
14 | I | A | 0.0000 | |
15 | L | A | -1.1587 | |
16 | V | A | 0.0000 | |
17 | E | A | -1.9661 | |
18 | L | A | 0.0000 | |
19 | D | A | -3.2271 | |
20 | G | A | -2.6697 | |
21 | D | A | -2.2440 | |
22 | V | A | 0.0000 | |
23 | N | A | -1.7255 | |
24 | G | A | -1.2809 | |
25 | H | A | -1.7405 | |
26 | K | A | -2.6530 | |
27 | F | A | 0.0000 | |
28 | S | A | -1.7842 | |
29 | V | A | 0.0000 | |
30 | S | A | -1.1026 | |
31 | G | A | 0.0000 | |
32 | E | A | -2.4392 | |
33 | G | A | -1.8893 | |
34 | E | A | -2.1719 | |
35 | G | A | 0.0000 | |
36 | D | A | -0.7370 | |
37 | A | A | 0.0000 | |
38 | T | A | -0.2809 | |
39 | Y | A | -0.4507 | |
40 | G | A | 0.0000 | |
41 | K | A | -0.7779 | |
42 | L | A | 0.0000 | |
43 | T | A | -1.1193 | |
44 | L | A | 0.0000 | |
45 | K | A | -1.5434 | |
46 | F | A | 0.0000 | |
47 | I | A | -1.2200 | |
48 | C | A | 0.0000 | |
49 | T | A | -0.7474 | |
50 | T | A | -1.1623 | |
51 | G | A | -1.6608 | |
52 | K | A | -2.2842 | |
53 | L | A | 0.0000 | |
54 | P | A | -1.1293 | |
55 | V | A | 0.0000 | |
56 | P | A | 0.0000 | |
57 | W | A | 0.0000 | |
58 | P | A | 0.0000 | |
59 | T | A | 0.0000 | |
60 | L | A | 0.0000 | |
61 | V | A | 0.0000 | |
62 | T | A | 0.0000 | |
63 | T | A | 0.0000 | |
64 | F | A | 0.0000 | |
66 | Y | A | 0.0000 | |
67 | G | A | 0.0000 | |
68 | V | A | 0.0000 | |
69 | Q | A | 0.0000 | |
70 | C | A | 0.0000 | |
71 | F | A | 0.0000 | |
72 | S | A | 0.0000 | |
73 | R | A | -0.6706 | |
74 | Y | A | 0.0000 | |
75 | P | A | -1.6439 | |
76 | D | A | -2.7584 | |
77 | H | A | -2.3593 | |
78 | M | A | 0.0000 | |
79 | K | A | -2.3336 | |
80 | R | A | -2.7276 | |
81 | H | A | -1.6827 | |
82 | D | A | 0.0000 | |
83 | F | A | 0.0000 | |
84 | F | A | 0.0000 | |
85 | K | A | 0.0000 | |
86 | S | A | -0.9615 | |
87 | A | A | 0.0000 | |
88 | M | A | 0.0000 | |
89 | P | A | -1.0597 | |
90 | E | A | -1.6752 | |
91 | G | A | 0.0000 | |
92 | Y | A | 0.0000 | |
93 | V | A | -0.6413 | |
94 | Q | A | 0.0000 | |
95 | E | A | -2.2860 | |
96 | R | A | 0.0000 | |
97 | T | A | -0.4294 | |
98 | I | A | 0.0000 | |
99 | F | A | 0.2670 | |
100 | F | A | 0.0000 | |
101 | K | A | -2.2120 | |
102 | D | A | -2.9610 | |
103 | D | A | -2.5970 | |
104 | G | A | 0.0000 | |
105 | N | A | -0.6755 | |
106 | Y | A | 0.0000 | |
107 | K | A | -1.5595 | |
108 | T | A | 0.0000 | |
109 | R | A | -3.1441 | |
110 | A | A | 0.0000 | |
111 | E | A | -1.7836 | |
112 | V | A | 0.0000 | |
113 | K | A | -1.2136 | |
114 | F | A | -1.3449 | |
115 | E | A | -1.6866 | |
116 | G | A | -1.7584 | |
117 | D | A | -2.1589 | |
118 | T | A | -1.6502 | |
119 | L | A | 0.0000 | |
120 | V | A | 0.0000 | |
121 | N | A | 0.0000 | |
122 | R | A | -2.2421 | |
123 | I | A | 0.0000 | |
124 | E | A | -3.7845 | |
125 | L | A | 0.0000 | |
126 | K | A | -2.1386 | |
127 | G | A | 0.0000 | |
128 | I | A | -1.0648 | |
129 | D | A | -2.4591 | |
130 | F | A | 0.0000 | |
131 | K | A | -3.7352 | |
132 | E | A | -3.8467 | |
133 | D | A | -3.5174 | |
134 | G | A | -2.7671 | |
135 | N | A | -2.2207 | |
136 | I | A | 0.0000 | |
137 | L | A | -1.9451 | |
138 | G | A | -2.2737 | |
139 | H | A | -2.0997 | |
140 | K | A | -2.3559 | |
141 | L | A | 0.0000 | |
142 | E | A | -1.2774 | |
143 | Y | A | -0.3267 | |
144 | N | A | 0.0000 | |
145 | Y | A | 0.0000 | |
146 | N | A | 0.0000 | |
147 | S | A | 0.0000 | |
148 | H | A | 0.0000 | |
149 | N | A | -0.3686 | |
150 | V | A | 0.0000 | |
151 | Y | A | 0.2589 | |
152 | I | A | 0.0000 | |
153 | M | A | -0.8362 | |
154 | A | A | -1.7728 | |
155 | D | A | -2.3373 | |
156 | K | A | -3.2650 | |
157 | Q | A | -3.2018 | |
158 | K | A | -3.3979 | |
159 | N | A | -2.8573 | |
160 | G | A | 0.0000 | |
161 | I | A | 0.0000 | |
162 | K | A | -1.0975 | |
163 | V | A | 0.0000 | |
164 | N | A | -0.3124 | |
165 | F | A | 0.0000 | |
166 | K | A | -1.4604 | |
167 | I | A | 0.0000 | |
168 | R | A | -0.7844 | |
169 | H | A | 0.0000 | |
170 | N | A | -0.9325 | |
171 | I | A | 0.0000 | |
172 | E | A | -3.1605 | |
173 | D | A | -2.9772 | |
174 | G | A | -1.8731 | |
175 | S | A | -0.8288 | |
176 | V | A | -0.0463 | |
177 | Q | A | 0.0000 | |
178 | L | A | -0.7623 | |
179 | A | A | 0.0000 | |
180 | D | A | -0.7155 | |
181 | H | A | 0.0000 | |
182 | Y | A | -0.0234 | |
183 | Q | A | 0.0000 | |
184 | Q | A | -1.1664 | |
185 | N | A | 0.0000 | |
186 | T | A | -0.7651 | |
187 | P | A | -0.6812 | |
188 | I | A | -0.0461 | |
189 | G | A | -1.1124 | |
190 | D | A | -1.9856 | |
191 | G | A | -1.2643 | |
192 | P | A | -0.7656 | |
193 | V | A | -0.4589 | |
194 | L | A | -0.4511 | |
195 | L | A | -0.9443 | |
196 | P | A | 0.0000 | |
197 | D | A | -2.3826 | |
198 | N | A | -1.6386 | |
199 | H | A | 0.0000 | |
200 | Y | A | -0.0234 | |
201 | L | A | 0.0000 | |
202 | S | A | -0.0843 | |
203 | T | A | 0.0000 | |
204 | Q | A | 0.0000 | |
205 | S | A | 0.0000 | |
206 | A | A | 0.0000 | |
207 | L | A | 0.0000 | |
208 | S | A | -0.5844 | |
209 | K | A | -1.5299 | |
210 | D | A | -1.7374 | |
211 | P | A | -1.5461 | |
212 | N | A | -2.2782 | |
213 | E | A | -2.5593 | |
214 | K | A | -3.1232 | |
215 | R | A | -3.1492 | |
216 | D | A | -2.1306 | |
217 | H | A | 0.0000 | |
218 | M | A | 0.0000 | |
219 | V | A | 0.0000 | |
220 | L | A | 0.0000 | |
221 | L | A | -0.0397 | |
222 | E | A | 0.0000 | |
223 | F | A | 0.0000 | |
224 | V | A | 0.0000 | |
225 | T | A | -0.1955 | |
226 | A | A | 0.0000 | |
227 | A | A | -0.2042 | |
228 | G | A | -0.5913 | |
229 | I | A | -0.6090 | |
230 | T | A | -0.2083 | |
1 | A | B | -1.1426 | |
2 | S | B | -1.5429 | |
3 | K | B | -2.0480 | |
4 | G | B | 0.0000 | |
5 | E | B | -1.6219 | |
6 | E | B | -2.1777 | |
7 | L | B | -0.7792 | |
8 | F | B | 0.0000 | |
9 | T | B | -0.3801 | |
10 | G | B | 0.2117 | |
11 | V | B | 1.0309 | |
12 | V | B | 0.0000 | |
13 | P | B | -1.0884 | |
14 | I | B | 0.0000 | |
15 | L | B | -1.1455 | |
16 | V | B | 0.0000 | |
17 | E | B | -1.9380 | |
18 | L | B | 0.0000 | |
19 | D | B | -3.1811 | |
20 | G | B | 0.0000 | |
21 | D | B | -2.1580 | |
22 | V | B | 0.0000 | |
23 | N | B | -1.7071 | |
24 | G | B | -1.2724 | |
25 | H | B | -1.7195 | |
26 | K | B | -2.6527 | |
27 | F | B | 0.0000 | |
28 | S | B | -1.7393 | |
29 | V | B | 0.0000 | |
30 | S | B | -1.0750 | |
31 | G | B | 0.0000 | |
32 | E | B | -2.4412 | |
33 | G | B | -1.7885 | |
34 | E | B | -1.8514 | |
35 | G | B | 0.0000 | |
36 | D | B | -0.3247 | |
37 | A | B | 0.0000 | |
38 | T | B | -0.1956 | |
39 | Y | B | -0.4918 | |
40 | G | B | 0.0000 | |
41 | K | B | -0.7859 | |
42 | L | B | 0.0000 | |
43 | T | B | -1.1216 | |
44 | L | B | 0.0000 | |
45 | K | B | -1.5287 | |
46 | F | B | 0.0000 | |
47 | I | B | -1.2146 | |
48 | C | B | 0.0000 | |
49 | T | B | -0.7766 | |
50 | T | B | -1.1946 | |
51 | G | B | -1.7248 | |
52 | K | B | -2.3419 | |
53 | L | B | 0.0000 | |
54 | P | B | -1.1749 | |
55 | V | B | 0.0000 | |
56 | P | B | 0.0000 | |
57 | W | B | 0.0000 | |
58 | P | B | 0.0000 | |
59 | T | B | 0.0000 | |
60 | L | B | 0.0000 | |
61 | V | B | 0.0000 | |
62 | T | B | 0.0000 | |
63 | T | B | 0.0000 | |
64 | F | B | 0.0000 | |
66 | Y | B | 0.0000 | |
67 | G | B | 0.0000 | |
68 | V | B | 0.0000 | |
69 | Q | B | 0.0000 | |
70 | C | B | 0.0000 | |
71 | F | B | 0.0000 | |
72 | S | B | 0.0000 | |
73 | R | B | -1.0415 | |
74 | Y | B | 0.0000 | |
75 | P | B | -1.7279 | |
76 | D | B | -2.8325 | |
77 | H | B | -2.3898 | |
78 | M | B | 0.0000 | |
79 | K | B | -2.5048 | |
80 | R | B | -2.7843 | |
81 | H | B | -1.6864 | |
82 | D | B | 0.0000 | |
83 | F | B | 0.0000 | |
84 | F | B | 0.0000 | |
85 | K | B | 0.0000 | |
86 | S | B | 0.0000 | |
87 | A | B | 0.0000 | |
88 | M | B | 0.0000 | |
89 | P | B | -1.0638 | |
90 | E | B | -1.4462 | |
91 | G | B | 0.0000 | |
92 | Y | B | 0.0000 | |
93 | V | B | -0.6478 | |
94 | Q | B | 0.0000 | |
95 | E | B | -2.1221 | |
96 | R | B | 0.0000 | |
97 | T | B | -0.3549 | |
98 | I | B | 0.0000 | |
99 | F | B | 0.2981 | |
100 | F | B | 0.0000 | |
101 | K | B | -1.5652 | |
102 | D | B | -2.7236 | |
103 | D | B | -2.4946 | |
104 | G | B | 0.0000 | |
105 | N | B | -0.6147 | |
106 | Y | B | 0.0000 | |
107 | K | B | -1.4027 | |
108 | T | B | 0.0000 | |
109 | R | B | -2.9938 | |
110 | A | B | 0.0000 | |
111 | E | B | -1.7926 | |
112 | V | B | 0.0000 | |
113 | K | B | -1.1195 | |
114 | F | B | -1.2500 | |
115 | E | B | -1.5733 | |
116 | G | B | -1.7145 | |
117 | D | B | -2.1387 | |
118 | T | B | -1.4381 | |
119 | L | B | 0.0000 | |
120 | V | B | 0.0000 | |
121 | N | B | 0.0000 | |
122 | R | B | -2.2127 | |
123 | I | B | 0.0000 | |
124 | E | B | -3.6852 | |
125 | L | B | 0.0000 | |
126 | K | B | -1.9622 | |
127 | G | B | 0.0000 | |
128 | I | B | -0.9432 | |
129 | D | B | -2.4347 | |
130 | F | B | 0.0000 | |
131 | K | B | -3.9155 | |
132 | E | B | -3.9461 | |
133 | D | B | -3.5734 | |
134 | G | B | 0.0000 | |
135 | N | B | -2.1148 | |
136 | I | B | 0.0000 | |
137 | L | B | -1.9892 | |
138 | G | B | -2.2810 | |
139 | H | B | -2.0691 | |
140 | K | B | -2.2898 | |
141 | L | B | 0.0000 | |
142 | E | B | -1.2233 | |
143 | Y | B | -0.2814 | |
144 | N | B | 0.0000 | |
145 | Y | B | 0.0000 | |
146 | N | B | 0.0000 | |
147 | S | B | 0.0000 | |
148 | H | B | 0.0000 | |
149 | N | B | -0.6957 | |
150 | V | B | 0.0000 | |
151 | Y | B | 0.0711 | |
152 | I | B | 0.0000 | |
153 | M | B | -0.6486 | |
154 | A | B | -1.5843 | |
155 | D | B | 0.0000 | |
156 | K | B | -3.1480 | |
157 | Q | B | -3.1847 | |
158 | K | B | -3.4898 | |
159 | N | B | -2.8086 | |
160 | G | B | 0.0000 | |
161 | I | B | 0.0000 | |
162 | K | B | -1.0802 | |
163 | V | B | 0.0000 | |
164 | N | B | -0.5630 | |
165 | F | B | 0.0000 | |
166 | K | B | -1.2837 | |
167 | I | B | 0.0000 | |
168 | R | B | -0.6253 | |
169 | H | B | 0.0000 | |
170 | N | B | -0.8395 | |
171 | I | B | 0.0000 | |
172 | E | B | -3.1353 | |
173 | D | B | -2.9623 | |
174 | G | B | -1.8386 | |
175 | S | B | -0.8242 | |
176 | V | B | 0.0511 | |
177 | Q | B | 0.0000 | |
178 | L | B | -0.3616 | |
179 | A | B | 0.0000 | |
180 | D | B | 0.0000 | |
181 | H | B | 0.0000 | |
182 | Y | B | 0.0618 | |
183 | Q | B | 0.0000 | |
184 | Q | B | -1.4362 | |
185 | N | B | 0.0000 | |
186 | T | B | -0.8029 | |
187 | P | B | -0.6476 | |
188 | I | B | 0.0115 | |
189 | G | B | -1.0153 | |
190 | D | B | -1.9396 | |
191 | G | B | -1.2096 | |
192 | P | B | -0.7271 | |
193 | V | B | -0.3813 | |
194 | L | B | -0.4250 | |
195 | L | B | -0.7870 | |
196 | P | B | 0.0000 | |
197 | D | B | -2.2209 | |
198 | N | B | -1.3658 | |
199 | H | B | 0.0000 | |
200 | Y | B | 0.0095 | |
201 | L | B | 0.0000 | |
202 | S | B | -0.2162 | |
203 | T | B | 0.0000 | |
204 | Q | B | 0.0000 | |
205 | S | B | 0.0000 | |
206 | A | B | 0.0000 | |
207 | L | B | 0.0000 | |
208 | S | B | 0.0000 | |
209 | K | B | -1.1371 | |
210 | D | B | -1.6859 | |
211 | P | B | -1.5082 | |
212 | N | B | -2.2954 | |
213 | E | B | -2.5610 | |
214 | K | B | -3.1464 | |
215 | R | B | -3.3848 | |
216 | D | B | -2.2705 | |
217 | H | B | 0.0000 | |
218 | M | B | 0.0000 | |
219 | V | B | 0.0000 | |
220 | L | B | 0.0000 | |
221 | L | B | -0.0459 | |
222 | E | B | 0.0000 | |
223 | F | B | 0.0000 | |
224 | V | B | 0.0000 | |
225 | T | B | -0.4467 | |
226 | A | B | 0.0000 | |
227 | A | B | -0.1778 | |
228 | G | B | -0.4375 | |
229 | I | B | -0.4889 | |
230 | T | B | -0.1832 |