Chain sequence(s) |
A: DNQFYSVEVGDSTFTVLKRYQQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMMKKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCCPEFMKKLQPTVRNNYVENRPKKYAGLTFPKLFPDSLFPNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN B: VVRPGSLDLP |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
45 | D | A | -3.0259 | |
46 | N | A | -2.7509 | |
47 | Q | A | -2.5719 | |
48 | F | A | -1.6442 | |
49 | Y | A | -0.8442 | |
50 | S | A | -0.6135 | |
51 | V | A | -1.0639 | |
52 | E | A | -2.4322 | |
53 | V | A | 0.0000 | |
54 | G | A | -2.0256 | |
55 | D | A | -2.4098 | |
56 | S | A | -1.5071 | |
57 | T | A | -1.2427 | |
58 | F | A | 0.0000 | |
59 | T | A | -0.6725 | |
60 | V | A | 0.0000 | |
61 | L | A | -1.1797 | |
62 | K | A | -1.8580 | |
63 | R | A | -0.6699 | |
64 | Y | A | 0.0000 | |
65 | Q | A | -1.6237 | |
66 | N | A | -1.8542 | |
67 | L | A | -1.5057 | |
68 | K | A | -2.0878 | |
69 | P | A | -0.8018 | |
70 | I | A | 0.2490 | |
71 | G | A | 0.3424 | |
72 | S | A | 0.1830 | |
73 | G | A | 0.0854 | |
74 | A | A | -0.2094 | |
75 | Q | A | -0.4139 | |
76 | G | A | 0.0000 | |
77 | I | A | 0.1342 | |
78 | V | A | 0.0000 | |
79 | C | A | 0.0000 | |
80 | A | A | -0.7080 | |
81 | A | A | 0.0000 | |
82 | Y | A | -0.8944 | |
83 | D | A | 0.0000 | |
84 | A | A | -0.1327 | |
85 | V | A | 1.5010 | |
86 | L | A | 0.7722 | |
87 | D | A | -1.1545 | |
88 | R | A | -1.0895 | |
89 | N | A | -1.4606 | |
90 | V | A | 0.0000 | |
91 | A | A | 0.0000 | |
92 | I | A | 0.0000 | |
93 | K | A | 0.0000 | |
94 | K | A | -0.4479 | |
95 | L | A | 0.0000 | |
96 | S | A | -1.3314 | |
97 | R | A | -2.5599 | |
98 | P | A | 0.0000 | |
99 | F | A | -1.8768 | |
100 | Q | A | -2.1570 | |
101 | N | A | -1.9357 | |
102 | Q | A | -1.9711 | |
103 | T | A | -1.2749 | |
104 | H | A | -1.5035 | |
105 | A | A | 0.0000 | |
106 | K | A | -1.6090 | |
107 | R | A | -1.0857 | |
108 | A | A | 0.0000 | |
109 | Y | A | -0.3912 | |
110 | R | A | -0.5506 | |
111 | E | A | 0.0000 | |
112 | L | A | 0.0000 | |
113 | V | A | -0.7057 | |
114 | L | A | 0.0000 | |
115 | M | A | -0.6895 | |
116 | K | A | -1.4451 | |
117 | C | A | 0.0000 | |
118 | V | A | 0.0000 | |
119 | N | A | -2.0838 | |
120 | H | A | -1.6398 | |
121 | K | A | -2.0714 | |
122 | N | A | 0.0000 | |
123 | I | A | 0.0000 | |
124 | I | A | 0.0000 | |
125 | S | A | -0.4915 | |
126 | L | A | 0.2818 | |
127 | L | A | 0.7408 | |
128 | N | A | 0.2386 | |
129 | V | A | 0.2190 | |
130 | F | A | 0.0000 | |
131 | T | A | 0.0000 | |
132 | P | A | -1.3216 | |
133 | Q | A | -2.2385 | |
134 | K | A | -2.5678 | |
135 | T | A | -1.9925 | |
136 | L | A | -2.2432 | |
137 | E | A | -3.2725 | |
138 | E | A | -3.3027 | |
139 | F | A | 0.0000 | |
140 | Q | A | -1.9732 | |
141 | D | A | -1.2907 | |
142 | V | A | 0.0000 | |
143 | Y | A | 0.0000 | |
144 | L | A | 0.0000 | |
145 | V | A | 0.0000 | |
146 | M | A | 0.0000 | |
147 | E | A | 0.0000 | |
148 | L | A | -0.4643 | |
149 | M | A | -0.9850 | |
150 | D | A | -2.0454 | |
151 | A | A | -1.0170 | |
152 | N | A | -0.3443 | |
153 | L | A | 0.0000 | |
154 | C | A | -0.0549 | |
155 | Q | A | -0.8374 | |
156 | V | A | 0.0000 | |
157 | I | A | 0.0000 | |
158 | Q | A | -1.9886 | |
159 | M | A | -1.6961 | |
160 | E | A | -2.3826 | |
161 | L | A | -1.6651 | |
162 | D | A | -1.6550 | |
163 | H | A | 0.0000 | |
164 | E | A | -1.0771 | |
165 | R | A | -1.4428 | |
166 | M | A | 0.0000 | |
167 | S | A | 0.0000 | |
168 | Y | A | 0.0000 | |
169 | L | A | 0.0000 | |
170 | L | A | 0.0000 | |
171 | Y | A | 0.0000 | |
172 | Q | A | 0.0000 | |
173 | M | A | 0.0000 | |
174 | L | A | 0.0000 | |
175 | C | A | 0.0000 | |
176 | G | A | 0.0000 | |
177 | I | A | 0.0000 | |
178 | K | A | -1.1247 | |
179 | H | A | 0.0000 | |
180 | L | A | 0.0000 | |
181 | H | A | -0.5099 | |
182 | S | A | -0.4763 | |
183 | A | A | 0.0000 | |
184 | G | A | -0.6073 | |
185 | I | A | 0.0000 | |
186 | I | A | -0.3528 | |
187 | H | A | 0.0000 | |
188 | R | A | -0.7039 | |
189 | D | A | 0.0000 | |
190 | L | A | 0.0000 | |
191 | K | A | 0.0000 | |
192 | P | A | 0.0000 | |
193 | S | A | 0.0000 | |
194 | N | A | 0.0000 | |
195 | I | A | 0.0000 | |
196 | V | A | -0.3684 | |
197 | V | A | 0.0000 | |
198 | K | A | -1.9037 | |
199 | S | A | -1.9398 | |
200 | D | A | -2.1898 | |
201 | C | A | 0.0000 | |
202 | T | A | -1.0056 | |
203 | L | A | 0.0000 | |
204 | K | A | -0.6200 | |
205 | I | A | 0.0000 | |
206 | L | A | 0.0000 | |
207 | D | A | -0.1995 | |
208 | F | A | 0.0000 | |
209 | G | A | -0.2762 | |
210 | L | A | -0.5617 | |
211 | A | A | -0.7445 | |
212 | R | A | -1.3367 | |
213 | T | A | -0.4108 | |
214 | A | A | -0.3211 | |
215 | G | A | 0.0000 | |
216 | T | A | 0.0000 | |
217 | S | A | 0.8863 | |
218 | F | A | 1.8211 | |
219 | M | A | 0.0000 | |
220 | M | A | 1.0668 | |
221 | T | A | 0.8257 | |
222 | P | A | 0.7089 | |
223 | Y | A | 1.9590 | |
224 | V | A | 1.4412 | |
225 | V | A | 1.0480 | |
226 | T | A | 0.0000 | |
227 | R | A | -0.3220 | |
228 | Y | A | -0.1032 | |
229 | Y | A | 0.0000 | |
230 | R | A | -0.3811 | |
231 | A | A | 0.0000 | |
232 | P | A | 0.0000 | |
233 | E | A | 0.0000 | |
234 | V | A | -0.0520 | |
235 | I | A | 0.4774 | |
236 | L | A | 0.0000 | |
237 | G | A | -0.3771 | |
238 | M | A | -0.4800 | |
239 | G | A | -0.3169 | |
240 | Y | A | -0.4519 | |
241 | K | A | -1.8554 | |
242 | E | A | -2.1034 | |
243 | N | A | -1.3744 | |
244 | V | A | 0.0000 | |
245 | D | A | 0.0000 | |
246 | I | A | 0.0000 | |
247 | W | A | 0.0000 | |
248 | S | A | 0.0000 | |
249 | V | A | 0.0000 | |
250 | G | A | 0.0000 | |
251 | C | A | 0.0000 | |
252 | I | A | 0.0000 | |
253 | M | A | 0.0000 | |
254 | G | A | 0.0000 | |
255 | E | A | 0.0000 | |
256 | M | A | 0.0000 | |
257 | V | A | 0.0000 | |
258 | R | A | -1.4569 | |
259 | H | A | -1.8026 | |
260 | K | A | -1.9488 | |
261 | I | A | -0.3919 | |
262 | L | A | 0.0000 | |
263 | F | A | 0.0000 | |
264 | P | A | -0.7627 | |
265 | G | A | 0.0000 | |
266 | R | A | -1.8227 | |
267 | D | A | -0.6227 | |
268 | Y | A | 0.7907 | |
269 | I | A | 1.6488 | |
270 | D | A | -0.0408 | |
271 | Q | A | 0.0000 | |
272 | W | A | 0.0000 | |
273 | N | A | -0.3816 | |
274 | K | A | -0.9505 | |
275 | V | A | 0.0000 | |
276 | I | A | 0.0000 | |
277 | E | A | -1.6702 | |
278 | Q | A | -0.8177 | |
279 | L | A | -0.0562 | |
280 | G | A | 0.0000 | |
281 | T | A | -0.9428 | |
282 | P | A | 0.0000 | |
283 | C | A | -0.6798 | |
284 | P | A | -1.8716 | |
285 | E | A | -2.7722 | |
286 | F | A | 0.0000 | |
287 | M | A | 0.0000 | |
288 | K | A | -3.7955 | |
289 | K | A | -3.2271 | |
290 | L | A | 0.0000 | |
291 | Q | A | -2.3060 | |
292 | P | A | -1.7065 | |
293 | T | A | -1.0813 | |
294 | V | A | -1.1914 | |
295 | R | A | -2.7332 | |
296 | N | A | -2.7359 | |
297 | Y | A | -1.4568 | |
298 | V | A | 0.0000 | |
299 | E | A | -3.2068 | |
300 | N | A | -2.8621 | |
301 | R | A | -2.2814 | |
302 | P | A | -1.9512 | |
303 | K | A | -2.4027 | |
304 | Y | A | -1.0110 | |
305 | A | A | -0.3802 | |
306 | G | A | -0.4728 | |
307 | L | A | -0.0610 | |
308 | T | A | -0.3053 | |
309 | F | A | -0.4871 | |
310 | P | A | -1.2912 | |
311 | K | A | -1.8012 | |
312 | L | A | 0.0000 | |
313 | F | A | 0.0000 | |
314 | P | A | -1.3798 | |
315 | D | A | -1.9922 | |
316 | S | A | -0.7998 | |
317 | L | A | -0.5430 | |
318 | F | A | 0.0000 | |
319 | P | A | -1.4717 | |
325 | N | A | -1.9849 | |
326 | K | A | -2.0466 | |
327 | L | A | -0.1133 | |
328 | K | A | -1.3028 | |
329 | A | A | 0.0000 | |
330 | S | A | -0.9165 | |
331 | Q | A | -0.7637 | |
332 | A | A | 0.0000 | |
333 | R | A | -0.8425 | |
334 | D | A | -1.1400 | |
335 | L | A | 0.0000 | |
336 | L | A | 0.0000 | |
337 | S | A | -0.6312 | |
338 | K | A | -1.4134 | |
339 | M | A | 0.0000 | |
340 | L | A | 0.0000 | |
341 | V | A | -0.2651 | |
342 | I | A | 0.0000 | |
343 | D | A | 0.0000 | |
344 | P | A | 0.0000 | |
345 | A | A | -0.8774 | |
346 | K | A | -1.7167 | |
347 | R | A | 0.0000 | |
348 | I | A | -1.1036 | |
349 | S | A | -1.6649 | |
350 | V | A | 0.0000 | |
351 | D | A | -2.2261 | |
352 | D | A | -2.8663 | |
353 | A | A | 0.0000 | |
354 | L | A | 0.0000 | |
355 | Q | A | -2.1044 | |
356 | H | A | 0.0000 | |
357 | P | A | -0.6692 | |
358 | Y | A | 0.0000 | |
359 | I | A | 0.0000 | |
360 | N | A | -0.5181 | |
361 | V | A | 1.1049 | |
362 | W | A | 0.0000 | |
363 | Y | A | 0.2082 | |
364 | D | A | -0.6647 | |
365 | P | A | -0.9860 | |
366 | A | A | -0.7958 | |
367 | E | A | 0.0000 | |
368 | V | A | 0.0000 | |
369 | E | A | -2.1256 | |
370 | A | A | -1.4843 | |
371 | P | A | -1.0110 | |
372 | P | A | -0.9865 | |
373 | P | A | -0.9021 | |
374 | Q | A | -0.8229 | |
375 | I | A | 0.5115 | |
376 | Y | A | 0.0000 | |
377 | D | A | -2.6112 | |
378 | K | A | -3.6163 | |
379 | Q | A | -3.6518 | |
380 | L | A | -3.2651 | |
381 | D | A | -3.5327 | |
382 | E | A | -3.9558 | |
383 | R | A | -4.0238 | |
384 | E | A | -3.3503 | |
385 | H | A | -2.0854 | |
386 | T | A | -1.5497 | |
387 | I | A | -1.7653 | |
388 | E | A | -2.6679 | |
389 | E | A | -2.4117 | |
390 | W | A | 0.0000 | |
391 | K | A | -2.0315 | |
392 | E | A | -2.1861 | |
393 | L | A | -1.3044 | |
394 | I | A | 0.0000 | |
395 | Y | A | -1.2062 | |
396 | K | A | -2.0139 | |
397 | E | A | -1.4895 | |
398 | V | A | 0.0000 | |
399 | M | A | -0.5246 | |
400 | N | A | -1.4182 | |
341 | V | B | 2.6312 | |
342 | V | B | 2.1651 | |
343 | R | B | 0.3672 | |
344 | P | B | -0.4896 | |
345 | G | B | -1.0204 | |
346 | S | B | -1.5674 | |
347 | L | B | 0.0000 | |
348 | D | B | -2.1960 | |
349 | L | B | -1.3484 | |
350 | P | B | -0.7916 |