Project name: AP_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1482
• Maximal score value: 2.6853
• Average score: -0.7184
• Total score value: -309.6235

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6343
3	E	A	-2.4478
4	L	A	0.0000
5	T	A	-1.3921
6	Q	A	-1.6594
7	D	A	-2.3814
8	P	A	-1.7705
9	A	A	0.0000
10	V	A	-1.0597
11	S	A	-0.3216
12	V	A	0.0000
13	A	A	-0.0146
14	L	A	-0.1847
15	G	A	-0.9038
16	Q	A	-1.3505
17	T	A	-1.1211
18	V	A	0.0000
19	R	A	-1.8968
20	V	A	0.0000
21	T	A	-1.1414
22	C	A	0.0000
23	Q	A	-2.1168
24	G	A	-2.4126
25	D	A	-3.1412
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.7421
29	S	A	-1.3595
30	Y	A	-0.6892
31	Y	A	-0.2859
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	-0.6293
37	Q	A	0.0000
38	K	A	-1.7323
39	P	A	-1.4641
40	G	A	-1.3418
41	Q	A	-1.9402
42	A	A	-1.1409
43	P	A	0.0000
44	V	A	0.4151
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.0686
49	G	A	0.0000
50	K	A	-2.4864
51	N	A	-2.2725
52	N	A	-2.0771
53	R	A	-1.8293
54	P	A	-0.6724
55	S	A	-0.6444
56	G	A	-0.8052
57	I	A	-0.7173
58	P	A	-1.3001
59	D	A	-2.1606
60	R	A	-1.3770
61	F	A	0.0000
62	S	A	-1.4948
63	G	A	-1.3213
64	S	A	-1.0938
65	S	A	-1.1730
66	S	A	-1.0896
67	G	A	-1.8176
68	N	A	-2.1394
69	T	A	-1.3997
70	A	A	0.0000
71	S	A	0.0000
72	L	A	0.0000
73	T	A	-0.9688
74	I	A	0.0000
75	T	A	-1.2501
76	G	A	-1.1394
77	A	A	0.0000
78	Q	A	-1.5999
79	A	A	0.0000
80	E	A	-2.4463
81	D	A	0.0000
82	E	A	-2.0818
83	A	A	-1.7730
84	D	A	-1.6816
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.2706
89	S	A	0.0000
90	R	A	-0.7186
91	D	A	-1.4370
92	S	A	-1.6609
93	S	A	-0.7897
94	G	A	0.0000
95	N	A	-1.2797
96	H	A	-1.0015
97	W	A	-0.2850
98	V	A	-0.4580
99	F	A	-0.3670
100	G	A	0.0000
101	G	A	-1.5473
102	G	A	0.0000
103	T	A	0.0000
104	E	A	-2.5393
105	L	A	0.0000
106	T	A	-0.5414
107	V	A	0.0000
108	L	A	0.8912
109	G	A	-0.0574
110	Q	A	0.0000
111	P	A	-1.0330
112	K	A	-2.2150
113	A	A	-1.3028
114	A	A	-0.7393
115	P	A	0.0000
116	S	A	-0.4752
117	V	A	0.0000
118	T	A	-0.4209
119	L	A	-0.3402
120	F	A	0.0000
121	P	A	-0.0449
122	P	A	0.0000
123	S	A	-1.1009
124	S	A	-1.5644
125	E	A	-2.3122
126	E	A	0.0000
127	L	A	-2.2444
128	Q	A	-2.4045
129	A	A	-1.9471
130	N	A	-2.8126
131	K	A	-2.8704
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.5356
140	D	A	-1.0778
141	F	A	0.0000
142	Y	A	-1.2055
143	P	A	-1.1154
144	G	A	-0.9457
145	A	A	-0.3559
146	V	A	-0.1496
147	T	A	-0.0945
148	V	A	0.1038
149	A	A	-0.2407
150	W	A	0.0000
151	K	A	-0.7937
152	A	A	0.0000
153	D	A	-1.2204
154	S	A	-0.8452
155	S	A	-0.7434
156	P	A	-0.8901
157	V	A	-0.5700
158	K	A	-1.4020
159	A	A	-0.4225
160	G	A	0.1196
161	V	A	0.6200
162	E	A	0.4689
163	T	A	0.3768
164	T	A	0.0000
165	T	A	-0.1620
166	P	A	-0.2652
167	S	A	-0.5893
168	K	A	-1.1656
169	Q	A	-1.2410
170	S	A	-1.3938
171	N	A	-2.0364
172	N	A	-1.9636
173	K	A	-1.7800
174	Y	A	-0.8313
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.3870
181	S	A	0.3052
182	L	A	-0.5662
183	T	A	-1.8804
184	P	A	-2.5156
185	E	A	-3.1482
186	Q	A	-2.2620
187	W	A	0.0000
188	K	A	-3.0350
189	S	A	0.0000
190	H	A	-2.2343
191	R	A	-2.4721
192	S	A	-1.5392
193	Y	A	0.0000
194	S	A	-1.0502
195	C	A	0.0000
196	Q	A	-1.0877
197	V	A	0.0000
198	T	A	-0.6613
199	H	A	0.0000
200	E	A	-2.3327
201	G	A	-1.4229
202	S	A	-0.8330
203	T	A	-0.7236
204	V	A	-0.7395
205	E	A	-2.1576
206	K	A	-1.8615
207	T	A	-1.0628
208	V	A	0.0000
209	A	A	-0.9025
210	P	A	-1.0276
2	V	A	1.0662
3	Q	A	-0.9959
4	L	A	0.0000
5	Q	A	-2.0939
6	Q	A	-1.4197
7	S	A	-1.3942
8	G	A	-1.4936
9	A	A	0.0000
10	E	A	-1.4133
11	V	A	-0.7888
12	K	A	-1.5625
13	K	A	-2.2813
14	P	A	-1.8749
15	G	A	-1.3803
16	S	A	-1.1820
17	S	A	-1.4184
18	V	A	0.0000
19	R	A	-2.4438
20	V	A	0.0000
21	S	A	-1.0862
22	C	A	0.0000
23	K	A	-1.5016
24	A	A	0.0000
25	S	A	-0.8480
26	G	A	-0.6713
27	G	A	-1.1110
28	T	A	-1.4530
29	F	A	0.0000
30	N	A	-1.8061
31	N	A	-1.0459
32	N	A	0.0000
33	A	A	-0.0667
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.5809
39	Q	A	-0.8254
40	A	A	-1.1069
41	P	A	-0.9030
42	G	A	-1.2771
43	Q	A	-1.8352
44	G	A	-1.3303
45	L	A	0.0000
46	E	A	-0.7626
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.3639
52	I	A	0.2612
53	P	A	0.0000
54	M	A	0.3316
55	F	A	1.4955
56	G	A	0.3670
57	T	A	-0.0553
58	A	A	-0.2290
59	K	A	-1.1569
60	Y	A	-0.5557
61	S	A	-1.1949
62	Q	A	-2.1397
63	N	A	-2.2382
64	F	A	0.0000
65	Q	A	-2.1450
66	G	A	-1.4939
67	R	A	-1.2054
68	V	A	-0.8574
69	A	A	-0.6907
70	I	A	0.0000
71	T	A	-0.6295
72	A	A	-1.0732
73	D	A	-2.3827
74	E	A	-2.2380
75	S	A	-1.4126
76	T	A	-1.2756
77	G	A	0.0000
78	T	A	-1.3915
79	A	A	0.0000
80	S	A	0.0000
81	M	A	0.0000
82	E	A	-1.8247
83	L	A	0.0000
84	S	A	-1.1655
85	S	A	-1.0661
86	L	A	0.0000
87	R	A	-2.4322
88	S	A	-2.0580
89	E	A	-2.3762
90	D	A	0.0000
91	T	A	-0.8955
92	A	A	0.0000
93	V	A	-0.0386
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.3693
99	S	A	-0.5399
100	R	A	-0.7069
101	D	A	0.6194
102	L	A	1.8174
103	L	A	2.6853
104	L	A	2.3014
105	F	A	1.2020
106	P	A	0.6775
107	H	A	-0.8815
108	H	A	-0.7641
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.1355
112	P	A	0.1017
113	W	A	-0.4643
114	G	A	0.0000
115	R	A	-2.4258
116	G	A	-1.3453
117	T	A	0.0000
118	M	A	-0.3712
119	V	A	0.0000
120	T	A	-0.6828
121	V	A	0.0000
122	S	A	-1.1035
123	S	A	-0.9079
124	A	A	-0.5729
125	S	A	-0.6903
126	T	A	-0.6475
127	K	A	-0.9328
128	G	A	-1.3125
129	P	A	-0.5806
130	S	A	-0.2605
131	V	A	0.0000
132	F	A	-0.5483
133	P	A	-0.9956
134	L	A	0.0000
135	A	A	-0.7089
136	P	A	-0.8241
137	S	A	-0.7369
138	S	A	-1.2167
139	K	A	-1.9996
140	S	A	-1.3872
141	T	A	-0.8718
142	S	A	-0.8876
143	G	A	-0.8526
144	G	A	-1.1750
145	T	A	-0.8934
146	A	A	0.0000
147	A	A	-0.1200
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.2911
154	D	A	-0.3698
155	Y	A	0.0000
156	F	A	-0.2187
157	P	A	0.0000
158	E	A	-0.8371
159	P	A	-0.9665
160	V	A	0.0000
161	T	A	-0.6366
162	V	A	-0.3395
163	S	A	-0.3105
164	W	A	0.0000
165	N	A	-0.6670
166	S	A	-0.5481
167	G	A	-0.3277
168	A	A	-0.1078
169	L	A	0.0831
170	T	A	-0.1286
171	S	A	-0.2921
172	G	A	-0.4015
173	V	A	0.0636
174	H	A	-0.2523
175	T	A	-0.0511
176	F	A	0.0000
177	P	A	-0.0811
178	A	A	0.2145
179	V	A	0.0000
180	L	A	1.2519
181	Q	A	0.2768
182	S	A	-0.1244
183	S	A	-0.2243
184	G	A	-0.0085
185	L	A	0.1936
186	Y	A	0.3710
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.2300
194	V	A	0.0000
195	P	A	-0.5113
196	S	A	-0.9580
197	S	A	-0.8005
198	S	A	-0.5590
199	L	A	-1.0299
200	G	A	-1.0702
201	T	A	-0.7362
202	Q	A	-1.3143
203	T	A	-1.2220
204	Y	A	0.0000
205	I	A	-1.2173
206	C	A	0.0000
207	N	A	-1.4113
208	V	A	0.0000
209	N	A	-1.8456
210	H	A	0.0000
211	K	A	-2.9479
212	P	A	-1.8244
213	S	A	-1.8448
214	N	A	-2.5380
215	T	A	-2.0331
216	K	A	-2.6628
217	V	A	-1.4505
218	D	A	-2.5265
219	K	A	-2.2466
220	K	A	-2.5799
221	V	A	0.0000
222	E	A	-2.5020
223	P	A	-1.2308