Project name: 4lx2_A

Chain sequence(s)	A: DFQGMLEEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMMCVRHADYLNDDQKVRSLLTTSSTINSIKKVLKKRGDDFFETVSFWLSSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSSDLAIQQIYQQQLVRVLENNILQPMIVSSGMLEHEGTTYTLDSILRQLNSSFHSSSVMCQHGMDPELIKQVVKQMMFYIIGAITLNNNLLLRKDMCSWSKGMQQIRYNVSQLEEWLRDKNLMMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKDSPQLLMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFIISRV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1456
• Maximal score value: 1.4767
• Average score: -0.8473
• Total score value: -305.8917

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1470	D	A	-1.4814
1471	F	A	-0.4405
1472	Q	A	-1.4084
1473	G	A	0.0000
1474	M	A	0.0000
1475	L	A	0.0000
1476	E	A	-1.6010
1477	Y	A	0.0000
1478	K	A	-2.9770
1479	K	A	-3.2713
1480	E	A	-3.2958
1481	D	A	0.0000
1482	E	A	0.0000
1483	Q	A	-2.3936
1484	K	A	-2.1828
1485	L	A	0.0000
1486	V	A	0.0000
1487	K	A	-2.1271
1488	N	A	-2.0201
1489	L	A	0.0000
1490	I	A	0.0000
1491	L	A	-2.2213
1492	E	A	-2.5603
1493	L	A	0.0000
1494	K	A	-2.7151
1495	P	A	-2.2025
1496	R	A	-2.4576
1497	G	A	-0.7170
1498	V	A	1.1072
1499	A	A	0.6171
1500	V	A	0.0000
1501	N	A	-0.0950
1502	L	A	1.4767
1503	I	A	0.7118
1504	P	A	-0.0756
1505	G	A	0.0000
1506	L	A	0.0000
1507	P	A	0.0000
1508	A	A	0.0000
1509	Y	A	0.0000
1510	I	A	0.0000
1511	L	A	0.0000
1512	F	A	0.0000
1513	M	A	0.0000
1514	C	A	0.0000
1515	V	A	0.0000
1516	R	A	0.0000
1517	H	A	0.0000
1518	A	A	0.0000
1519	D	A	0.0000
1520	Y	A	1.0734
1521	L	A	0.4753
1522	N	A	-1.1961
1523	D	A	-1.7358
1524	D	A	-2.2076
1525	Q	A	-2.5477
1526	K	A	0.0000
1527	V	A	0.0000
1528	R	A	-2.5351
1529	S	A	-1.5587
1530	L	A	0.0000
1531	L	A	0.0000
1532	T	A	-0.8299
1533	S	A	-1.0895
1534	T	A	0.0000
1535	I	A	0.0000
1536	N	A	-1.8364
1537	S	A	0.0000
1538	I	A	0.0000
1539	K	A	-2.6061
1540	K	A	-2.9937
1541	V	A	0.0000
1542	L	A	0.0000
1543	K	A	-3.6883
1544	K	A	-3.8129
1545	R	A	-3.5569
1546	G	A	-3.2141
1547	D	A	-3.5057
1548	D	A	-2.6631
1549	F	A	0.0000
1550	E	A	-2.2462
1551	T	A	0.0000
1552	V	A	0.0000
1553	S	A	0.0000
1554	F	A	0.0000
1555	W	A	0.0000
1556	L	A	0.0000
1557	S	A	0.0000
1558	N	A	0.0000
1559	T	A	0.0000
1560	C	A	0.0000
1561	R	A	-0.2571
1562	F	A	0.0000
1563	L	A	0.0000
1564	H	A	0.0000
1565	C	A	0.0000
1566	L	A	0.0000
1567	K	A	-0.7570
1568	Q	A	0.0000
1569	Y	A	0.0000
1570	S	A	-1.3461
1571	G	A	-2.1684
1572	E	A	-3.0578
1573	E	A	-3.1202
1574	G	A	-2.0067
1575	F	A	-1.5901
1576	M	A	-2.2091
1577	K	A	-2.7442
1578	H	A	-2.0002
1579	N	A	-1.8270
1580	T	A	-1.7183
1581	S	A	-1.9028
1582	R	A	-2.9301
1583	Q	A	0.0000
1584	N	A	-2.6574
1585	E	A	-2.9406
1586	H	A	0.0000
1587	C	A	-1.1926
1588	L	A	-0.6056
1589	T	A	-0.5961
1590	N	A	-1.1265
1591	F	A	-1.1269
1592	D	A	-2.2342
1593	L	A	-1.6549
1594	A	A	-1.4987
1595	E	A	-2.2097
1596	Y	A	-1.4029
1597	R	A	-1.3609
1598	Q	A	-1.6056
1599	V	A	-0.3085
1600	L	A	0.0000
1601	S	A	-0.4957
1602	D	A	-0.8516
1603	L	A	0.0000
1604	A	A	0.0000
1605	I	A	-0.0006
1606	Q	A	-1.3051
1607	I	A	0.0000
1608	Y	A	0.0000
1609	Q	A	-1.0275
1610	Q	A	-1.2532
1611	L	A	0.0000
1612	V	A	0.0000
1613	R	A	-1.3872
1614	V	A	0.0000
1615	L	A	0.0000
1616	E	A	0.0000
1617	N	A	-1.5520
1618	I	A	-0.3413
1619	L	A	0.0000
1620	Q	A	-0.9463
1621	P	A	-0.6221
1622	M	A	0.0000
1623	I	A	0.0000
1624	V	A	-0.2837
1625	S	A	-0.8941
1626	G	A	0.0000
1627	M	A	0.0000
1628	L	A	0.0000
1629	E	A	-2.2565
1630	H	A	-2.1801
1631	E	A	-2.4647
1655	G	A	-0.4431
1656	T	A	-0.2379
1657	Y	A	-0.3931
1658	T	A	-1.2572
1659	L	A	0.0000
1660	D	A	-2.2183
1661	S	A	-1.4518
1662	I	A	0.0000
1663	L	A	-1.5303
1664	R	A	-2.4948
1665	Q	A	-1.3778
1666	L	A	0.0000
1667	N	A	-1.2306
1668	S	A	-0.9008
1669	F	A	0.0000
1670	H	A	0.0000
1671	S	A	-0.3767
1672	V	A	0.0000
1673	M	A	0.0000
1674	C	A	-0.0681
1675	Q	A	-1.0429
1676	H	A	0.0000
1677	G	A	-0.5386
1678	M	A	0.0000
1679	D	A	0.0000
1680	P	A	-0.8091
1681	E	A	-1.2758
1682	L	A	0.0000
1683	I	A	0.0000
1684	K	A	-1.2706
1685	Q	A	-0.6733
1686	V	A	0.0000
1687	V	A	0.0000
1688	K	A	-0.9740
1689	Q	A	0.0000
1690	M	A	0.0000
1691	F	A	0.0000
1692	Y	A	-0.7583
1693	I	A	0.0000
1694	I	A	0.0000
1695	G	A	0.0000
1696	A	A	0.0000
1697	I	A	-0.2642
1698	T	A	0.0000
1699	L	A	0.0000
1700	N	A	0.2113
1701	N	A	0.0961
1702	L	A	0.0000
1703	L	A	0.0000
1704	L	A	0.6072
1705	R	A	-1.2552
1706	K	A	-2.6370
1707	D	A	-2.7778
1708	M	A	0.0000
1709	C	A	0.0000
1710	S	A	0.0934
1711	W	A	1.0760
1712	S	A	0.2081
1713	K	A	-0.6380
1714	G	A	0.0000
1715	M	A	0.1989
1716	Q	A	0.0000
1717	I	A	0.0000
1718	R	A	-1.1692
1719	Y	A	0.0069
1720	N	A	0.0000
1721	V	A	0.0000
1722	S	A	-0.9222
1723	Q	A	-1.3943
1724	L	A	0.0000
1725	E	A	-2.0527
1726	E	A	-3.3985
1727	W	A	0.0000
1728	L	A	0.0000
1729	R	A	-4.1456
1730	D	A	-3.8062
1731	K	A	-2.8700
1732	N	A	-3.0665
1733	L	A	0.0000
1734	M	A	-2.1875
1735	N	A	-1.9463
1736	S	A	0.0000
1737	G	A	-1.3861
1738	A	A	0.0000
1739	K	A	-1.9427
1740	E	A	-2.5327
1741	T	A	-1.3760
1742	L	A	0.0000
1743	E	A	-1.5238
1744	P	A	-0.7707
1745	L	A	0.0000
1746	I	A	-0.8253
1747	Q	A	0.0000
1748	A	A	0.0000
1749	A	A	0.0000
1750	Q	A	-0.7084
1751	L	A	0.0000
1752	L	A	0.0000
1753	Q	A	-0.3690
1754	V	A	-0.8304
1755	K	A	-2.3317
1756	K	A	-2.6492
1757	K	A	-3.2873
1758	T	A	-2.8965
1759	D	A	-3.4600
1760	D	A	-3.6985
1761	D	A	-2.9842
1762	A	A	0.0000
1763	E	A	-2.7139
1764	A	A	-1.5778
1765	I	A	0.0000
1766	C	A	-1.1701
1767	S	A	-0.7044
1768	M	A	-0.4937
1769	C	A	0.0000
1770	N	A	-1.3323
1771	A	A	-0.7410
1772	L	A	0.0000
1773	T	A	-0.8119
1774	T	A	-0.9920
1775	A	A	-0.3348
1776	Q	A	0.0000
1777	I	A	0.0000
1778	V	A	-0.3933
1779	K	A	-0.4000
1780	V	A	0.0000
1781	L	A	0.0000
1782	N	A	-1.2229
1783	L	A	0.0000
1784	Y	A	0.0000
1785	T	A	-1.2377
1786	P	A	-0.9263
1787	V	A	0.1924
1788	N	A	-1.2964
1789	E	A	-1.7322
1790	F	A	0.2347
1791	E	A	-1.4000
1792	E	A	-3.0136
1793	R	A	-2.6553
1794	V	A	-1.5557
1795	S	A	-0.5758
1796	V	A	0.9234
1797	S	A	-0.1670
1798	F	A	0.0000
1799	I	A	-0.5059
1800	R	A	-1.5841
1801	T	A	-1.7203
1802	I	A	0.0000
1803	Q	A	-1.9698
1804	M	A	-1.9389
1805	R	A	-2.8063
1806	L	A	0.0000
1807	R	A	-3.6289
1808	D	A	-3.6870
1809	R	A	-3.1580
1810	K	A	-2.9838
1811	D	A	-2.4565
1812	S	A	-1.3580
1813	P	A	-1.1263
1814	Q	A	-1.3009
1815	L	A	-0.1153
1816	L	A	0.1747
1817	M	A	-0.8745
1818	D	A	-2.3128
1819	A	A	-1.6207
1820	K	A	-2.3997
1821	H	A	-1.6106
1822	I	A	-0.5241
1823	F	A	0.0984
1824	P	A	0.1589
1825	V	A	0.4391
1826	T	A	0.1758
1827	F	A	0.1582
1828	P	A	-0.0823
1829	F	A	0.1306
1830	N	A	-0.4368
1831	P	A	-0.5607
1832	S	A	-0.2659
1833	S	A	-0.2715
1834	L	A	0.2543
1835	A	A	-0.2749
1836	L	A	0.0000
1837	E	A	-0.9487
1838	T	A	-0.5130
1839	I	A	0.0000
1840	Q	A	-1.2291
1841	I	A	-0.4993
1842	P	A	0.0720
1843	A	A	-0.2725
1844	S	A	-0.0337
1845	L	A	-0.3803
1846	G	A	-0.5432
1847	L	A	0.0000
1848	G	A	-0.4170
1849	F	A	-0.4323
1850	I	A	0.0000
1851	S	A	-1.1001
1852	R	A	-1.3820
1853	V	A	-0.5779