Project name: 26407b8b49dd20e

Chain sequence(s)	A: QTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERRIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; C: QTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELLAFLEEAQSRATAILQRANMVANPAWRSL; B: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERRIHGMSPAEYMECYGLLDERRLQVAHCVYFDRRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; E: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRRLSFLPPERELLAFLEEAQSRATAILQRANMVANPAWRSL; D: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; G: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; F: MQTLSIQHGTLVTMDQQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; I: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELLAFLEEAQSRATAILQQRANMVANPAWRSL; H: TLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; K: MQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCCVYFDRRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRRLSFLPPERELLAFLEEAQSRATAILQRANMVANPAWRSL; J: QTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL; L: MQTLSIQHGTLVTMDQQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQQVELCSIMEETAVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAESDHDERIHGMSPAEYMECYGLLDERRLQVAHCVYFDRKDVRLLHRHNVKVASQVVSNAYLGSGVAPVPEMVEERGMAVGIGTDNGNSNDSVNMIGDMKFMAHIHRAVHRDADVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQTTPHHHLAATIVFQAYGNEVDTVLIDGNVVMENRRLSFLPPERELAFLEEAQSRATAILQRANMVANPAWRSL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3573
• Maximal score value: 1.3539
• Average score: -0.5243
• Total score value: -2979.4368

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	Q	A	-2.4406
3	T	A	-2.1112
4	L	A	-1.4479
5	S	A	0.0000
6	I	A	0.0000
7	Q	A	-0.9804
8	H	A	-2.2002
9	G	A	0.0000
10	T	A	-0.9306
11	L	A	0.0000
12	V	A	0.0000
13	T	A	0.0000
14	M	A	0.0000
15	D	A	0.0000
16	Q	A	-0.9418
17	Y	A	0.2673
18	R	A	-0.5347
19	R	A	-0.7739
20	V	A	0.3362
21	L	A	-0.2365
22	G	A	-1.1763
23	D	A	-2.3500
24	S	A	0.0000
25	W	A	0.0000
26	V	A	0.0000
27	H	A	0.0000
28	V	A	0.0000
29	Q	A	-2.6136
30	D	A	-3.2431
31	G	A	-2.7422
32	R	A	-2.9561
33	I	A	0.0000
34	V	A	-0.4907
35	A	A	-0.0036
36	L	A	0.5960
37	G	A	-0.0377
38	V	A	-0.4741
39	H	A	-0.6515
40	A	A	-0.8831
41	E	A	-1.4124
42	S	A	-0.0268
43	V	A	1.3473
44	P	A	0.7544
45	P	A	0.2503
46	P	A	-0.3814
47	A	A	-1.3019
48	D	A	-2.3541
49	R	A	-1.9419
50	V	A	0.2514
51	I	A	0.0000
52	D	A	-1.6380
53	A	A	0.0000
54	R	A	-2.9888
55	G	A	-2.1919
56	K	A	-1.8129
57	V	A	0.0000
58	V	A	0.0000
59	L	A	0.0000
60	P	A	0.0000
61	G	A	0.0000
62	F	A	0.0000
63	I	A	0.0000
64	N	A	0.0000
65	A	A	0.0000
66	H	A	0.0000
67	T	A	0.0000
68	H	A	0.0000
69	V	A	0.0000
70	N	A	0.0000
71	Q	A	0.0000
72	I	A	0.0000
73	L	A	0.0000
74	L	A	0.0000
75	R	A	0.0000
76	G	A	0.0000
77	G	A	0.0000
78	P	A	0.0000
79	S	A	0.0000
80	H	A	-0.2894
81	G	A	-0.3623
82	R	A	-0.4210
83	Q	A	-0.5926
84	F	A	-0.0943
85	Y	A	0.2226
86	D	A	0.0000
87	W	A	0.0000
88	L	A	0.3130
89	F	A	0.1491
90	N	A	0.0000
91	V	A	0.0000
92	V	A	0.0000
93	Y	A	0.0000
94	P	A	0.0000
95	G	A	0.0000
96	Q	A	0.0000
97	K	A	-2.2206
98	A	A	-1.7458
99	M	A	0.0000
100	R	A	-2.7994
101	P	A	-2.1348
102	E	A	-2.4902
103	D	A	0.0000
104	V	A	0.0000
105	A	A	-1.1262
106	V	A	0.0000
107	A	A	0.0000
108	V	A	0.0000
109	R	A	-0.4524
110	L	A	0.0000
111	Y	A	0.0000
112	C	A	0.0000
113	A	A	0.0000
114	E	A	0.0000
115	A	A	0.0000
116	V	A	0.0000
117	R	A	-0.7556
118	S	A	0.0000
119	G	A	0.0000
120	I	A	0.0000
121	T	A	0.0000
122	T	A	0.0000
123	I	A	0.0000
124	N	A	0.0000
125	E	A	0.0000
126	N	A	0.0000
127	A	A	0.0000
128	D	A	-0.0407
129	S	A	0.0000
130	A	A	0.0000
131	I	A	0.1613
132	Y	A	-0.2933
133	P	A	-0.5841
134	G	A	-1.1970
135	N	A	0.0000
136	I	A	-0.5735
137	E	A	-1.7350
138	A	A	-1.4478
139	A	A	0.0000
140	M	A	0.0000
141	A	A	-0.8891
142	V	A	0.0000
143	Y	A	0.0000
144	G	A	-1.0802
145	E	A	-1.9181
146	V	A	0.0000
147	G	A	-1.0127
148	V	A	0.0000
149	R	A	0.0000
150	V	A	0.0000
151	V	A	0.0000
152	Y	A	0.0000
153	A	A	0.0000
154	R	A	0.0000
155	M	A	0.0000
156	F	A	0.0000
157	F	A	0.0722
158	D	A	0.0000
159	R	A	-0.2522
160	M	A	0.2015
161	D	A	-0.9877
162	G	A	-1.5917
163	R	A	-2.3803
164	I	A	0.0000
165	Q	A	-1.8795
166	G	A	-1.4346
167	Y	A	-1.0370
168	V	A	0.0000
169	D	A	-1.3486
170	A	A	0.0000
171	L	A	0.0000
172	K	A	0.0000
173	A	A	-0.9094
174	R	A	-1.2549
175	S	A	-0.9433
176	P	A	-1.5660
177	Q	A	-1.9101
178	V	A	0.0000
179	E	A	-2.1806
180	L	A	-0.5094
181	C	A	-0.3624
182	S	A	-0.0919
183	I	A	0.0000
184	M	A	0.2064
185	E	A	0.0000
186	E	A	-1.6217
187	T	A	-1.3517
188	A	A	-1.2455
189	V	A	-1.0294
190	A	A	0.0000
191	K	A	-1.8993
192	D	A	-2.4263
193	R	A	-1.9562
194	I	A	0.0000
195	T	A	-1.7916
196	A	A	-1.9046
197	L	A	0.0000
198	S	A	0.0000
199	D	A	-2.4893
200	Q	A	-2.1451
201	Y	A	-1.4060
202	H	A	-1.4652
203	G	A	-1.2348
204	T	A	-0.9636
205	A	A	-0.8080
206	G	A	-0.7992
207	G	A	-0.8129
208	R	A	-0.7302
209	I	A	0.0000
210	S	A	-0.3924
211	V	A	0.0000
212	W	A	0.0000
213	P	A	0.0000
214	A	A	0.0000
215	P	A	0.0000
216	A	A	0.0000
217	T	A	-0.0604
218	T	A	0.0000
219	T	A	0.0000
220	A	A	0.0944
221	V	A	0.0000
222	T	A	-0.6577
223	V	A	-1.0009
224	E	A	-2.0936
225	G	A	0.0000
226	M	A	0.0000
227	R	A	-1.7414
228	W	A	-1.2178
229	A	A	0.0000
230	Q	A	-1.5452
231	A	A	-1.6179
232	F	A	0.0000
233	A	A	0.0000
234	R	A	-3.2811
235	D	A	-3.0814
236	R	A	-2.2456
237	A	A	-1.6304
238	V	A	0.0000
239	M	A	0.0000
240	W	A	0.0000
241	T	A	0.0000
242	L	A	0.0000
243	H	A	-0.1058
244	M	A	0.0000
245	A	A	0.0000
246	E	A	0.0000
247	S	A	-1.1840
248	D	A	-2.3251
249	H	A	-1.7935
250	D	A	0.0000
251	E	A	-2.2200
252	R	A	-2.6886
253	I	A	0.0000
254	H	A	-1.5179
255	G	A	-1.5293
256	M	A	0.0000
257	S	A	-1.3552
258	P	A	0.0000
259	A	A	0.0000
260	E	A	-0.7819
261	Y	A	0.0000
262	M	A	0.0000
263	E	A	-0.6336
264	C	A	0.0000
265	Y	A	-0.5229
266	G	A	-0.8372
267	L	A	0.0000
268	L	A	0.0000
269	D	A	0.0000
270	E	A	-3.0415
271	R	A	-2.2680
272	L	A	0.0000
273	Q	A	0.0000
274	V	A	0.0000
275	A	A	0.0000
276	H	A	0.0000
277	C	A	0.0000
278	V	A	-0.0699
279	Y	A	-0.6642
280	F	A	-1.0037
281	D	A	-2.5219
282	R	A	-2.8743
283	K	A	-2.0752
284	D	A	0.0000
285	V	A	0.0000
286	R	A	0.0000
287	L	A	0.0000
288	L	A	0.0000
289	H	A	-1.1915
290	R	A	-1.1344
291	H	A	-1.7389
292	N	A	-2.4402
293	V	A	0.0000
294	K	A	-1.2525
295	V	A	0.0000
296	A	A	0.0000
297	S	A	0.0000
298	Q	A	0.0000
299	V	A	0.0000
300	V	A	0.0000
301	S	A	0.0000
302	N	A	0.0000
303	A	A	0.0000
304	Y	A	0.0000
305	L	A	0.0000
306	G	A	0.0000
307	S	A	0.0000
308	G	A	0.0000
309	V	A	0.2609
310	A	A	0.0000
311	P	A	-0.3978
312	V	A	0.0000
313	P	A	0.0000
314	E	A	-0.9362
315	M	A	0.0000
316	V	A	-0.2204
317	E	A	-0.5466
318	R	A	-0.7335
319	G	A	-0.8502
320	M	A	0.0000
321	A	A	0.0000
322	V	A	0.0000
323	G	A	0.0000
324	I	A	0.0000
325	G	A	0.0000
326	T	A	0.0000
327	D	A	0.0000
328	N	A	0.0000
329	G	A	0.0000
330	N	A	0.0000
331	S	A	0.0000
332	N	A	0.0000
333	D	A	0.0000
334	S	A	0.0000
335	V	A	0.0000
336	N	A	0.0000
337	M	A	0.0000
338	I	A	0.0000
339	G	A	-0.3210
340	D	A	0.0000
341	M	A	0.0000
342	K	A	-0.2963
343	F	A	0.0000
344	M	A	0.0000
345	A	A	0.0000
346	H	A	0.0000
347	I	A	0.0000
348	H	A	0.0000
349	R	A	0.0000
350	A	A	0.0000
351	V	A	-0.1714
352	H	A	-1.1919
353	R	A	-1.8618
354	D	A	0.0000
355	A	A	0.0000
356	D	A	-0.5801
357	V	A	0.0000
358	L	A	0.0000
359	T	A	0.0000
360	P	A	0.0000
361	E	A	0.0000
362	K	A	-0.1920
363	I	A	0.0000
364	L	A	0.0000
365	E	A	0.0000
366	M	A	0.0000
367	A	A	0.0000
368	T	A	0.0000
369	I	A	-0.2815
370	D	A	0.0000
371	G	A	0.0000
372	A	A	0.0000
373	R	A	-1.1626
374	S	A	0.0000
375	L	A	0.0000
376	G	A	-1.4529
377	M	A	-1.1133
378	D	A	-1.5147
379	H	A	-1.9173
380	E	A	-2.1175
381	I	A	0.0000
382	G	A	0.0000
383	S	A	0.0000
384	I	A	0.0000
385	E	A	-0.8480
386	T	A	-0.4522
387	G	A	-1.1469
388	K	A	0.0000
389	R	A	-2.0003
390	A	A	0.0000
391	D	A	0.0000
392	L	A	0.0000
393	I	A	0.0000
394	L	A	0.0000
395	L	A	0.0000
396	D	A	-1.2624
397	L	A	0.0000
398	R	A	-1.2125
399	H	A	-0.6907
400	P	A	0.0000
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