Project name: 26944a1d0612622
Status: done
submitted: 2018-12-10 10:13:18, status changed: 2018-12-10 10:23:31
Settings
Chain sequence(s)
|
A: MEKYVAAMVLSAAGDALGYYNGKWEFLQDGEKIHRQLAQLGGLDALDVGRWRVSDDTVMHLATAEALVEAGKAPKLTQLYYLLAKHYQDCMEDMDGRAPGGASVHNAMQLKPGKPNGWRIPFNSHEGGCGAAMRAMCIGLRFPHHSQLDTLIQVSIESGRMTHHHPTGYLGALASALFTAYAVNSRPPLQWGKGLMELLPEAKKYIVQSGYFVEENLQHWSYFQTKWENYLKLRGILDGESAPTFPESFGVKERDQFYTSLSYSGWGGSSGHDAPMIAYDAVLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVSPSNYEKLEYRNRLEETTARALYSLGSKEDTVISL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.2424
-
Maximal score value
-
1.3397
-
Average score
-
-0.6822
-
Total score value
-
-243.5613
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
-0.8369 |
|
2 |
E |
A |
-2.0835 |
|
3 |
K |
A |
-1.7768 |
|
4 |
Y |
A |
0.0000 |
|
5 |
V |
A |
0.0000 |
|
6 |
A |
A |
0.0000 |
|
7 |
A |
A |
0.0000 |
|
8 |
M |
A |
0.0000 |
|
9 |
V |
A |
0.0000 |
|
10 |
L |
A |
0.0000 |
|
11 |
S |
A |
0.0000 |
|
12 |
A |
A |
0.0000 |
|
13 |
A |
A |
0.0000 |
|
14 |
G |
A |
0.0000 |
|
15 |
D |
A |
0.0000 |
|
16 |
A |
A |
0.0000 |
|
17 |
L |
A |
0.0000 |
|
18 |
G |
A |
0.0000 |
|
19 |
Y |
A |
0.0000 |
|
20 |
Y |
A |
-1.0354 |
|
21 |
N |
A |
-1.7860 |
|
22 |
G |
A |
-0.9905 |
|
23 |
K |
A |
-1.4342 |
|
24 |
W |
A |
0.0000 |
|
25 |
E |
A |
0.0000 |
|
26 |
F |
A |
0.5443 |
|
27 |
L |
A |
-0.7002 |
|
28 |
Q |
A |
-1.5149 |
|
29 |
D |
A |
-2.4124 |
|
30 |
G |
A |
0.0000 |
|
31 |
E |
A |
-2.6250 |
|
32 |
K |
A |
-2.8863 |
|
33 |
I |
A |
0.0000 |
|
34 |
H |
A |
-1.8942 |
|
35 |
R |
A |
-2.7979 |
|
36 |
Q |
A |
-1.9351 |
|
37 |
L |
A |
0.0000 |
|
38 |
A |
A |
-1.3887 |
|
39 |
Q |
A |
-1.6087 |
|
40 |
L |
A |
-0.6549 |
|
41 |
G |
A |
-0.8488 |
|
42 |
G |
A |
-1.1176 |
|
43 |
L |
A |
0.0000 |
|
44 |
D |
A |
-1.7763 |
|
45 |
A |
A |
-0.8763 |
|
46 |
L |
A |
0.0000 |
|
47 |
D |
A |
-1.6379 |
|
48 |
V |
A |
0.0000 |
|
49 |
G |
A |
-2.2171 |
|
50 |
R |
A |
-2.5985 |
|
51 |
W |
A |
0.0000 |
|
52 |
R |
A |
-1.4838 |
|
53 |
V |
A |
0.0000 |
|
54 |
S |
A |
0.0000 |
|
55 |
D |
A |
0.0000 |
|
56 |
D |
A |
0.0000 |
|
57 |
T |
A |
0.0000 |
|
58 |
V |
A |
0.0000 |
|
59 |
M |
A |
0.0000 |
|
60 |
H |
A |
0.0000 |
|
61 |
L |
A |
0.0000 |
|
62 |
A |
A |
0.0000 |
|
63 |
T |
A |
0.0000 |
|
64 |
A |
A |
0.0000 |
|
65 |
E |
A |
-0.8472 |
|
66 |
A |
A |
0.0000 |
|
67 |
L |
A |
0.0000 |
|
68 |
V |
A |
-0.8666 |
|
69 |
E |
A |
-1.8854 |
|
70 |
A |
A |
-1.4182 |
|
71 |
G |
A |
-1.4201 |
|
72 |
K |
A |
-2.1341 |
|
73 |
A |
A |
-0.9518 |
|
74 |
P |
A |
0.0000 |
|
75 |
K |
A |
-1.1707 |
|
76 |
L |
A |
0.0000 |
|
77 |
T |
A |
-0.4688 |
|
78 |
Q |
A |
-0.9863 |
|
79 |
L |
A |
0.0000 |
|
80 |
Y |
A |
0.0000 |
|
81 |
Y |
A |
-0.7025 |
|
82 |
L |
A |
-0.5792 |
|
83 |
L |
A |
0.0000 |
|
84 |
A |
A |
0.0000 |
|
85 |
K |
A |
-1.5931 |
|
86 |
H |
A |
-1.2334 |
|
87 |
Y |
A |
0.0000 |
|
88 |
Q |
A |
-2.0402 |
|
89 |
D |
A |
-2.7326 |
|
90 |
C |
A |
-1.7844 |
|
91 |
M |
A |
0.0000 |
|
92 |
E |
A |
-2.8648 |
|
93 |
D |
A |
-2.3406 |
|
94 |
M |
A |
0.0000 |
|
95 |
D |
A |
-2.5139 |
|
96 |
G |
A |
-1.7117 |
|
97 |
R |
A |
0.0000 |
|
98 |
A |
A |
-0.5509 |
|
99 |
P |
A |
-0.6973 |
|
100 |
G |
A |
-0.5476 |
|
101 |
G |
A |
-0.7839 |
|
102 |
A |
A |
-0.7546 |
|
103 |
S |
A |
0.0000 |
|
104 |
V |
A |
-0.6114 |
|
105 |
H |
A |
-1.1980 |
|
106 |
N |
A |
-0.9249 |
|
107 |
A |
A |
0.0000 |
|
108 |
M |
A |
-1.1579 |
|
109 |
Q |
A |
-1.5782 |
|
110 |
L |
A |
0.0000 |
|
111 |
K |
A |
-2.5537 |
|
112 |
P |
A |
-2.0331 |
|
113 |
G |
A |
-2.0401 |
|
114 |
K |
A |
-2.7616 |
|
115 |
P |
A |
-1.9666 |
|
116 |
N |
A |
-2.1171 |
|
117 |
G |
A |
-2.2374 |
|
118 |
W |
A |
0.0000 |
|
119 |
R |
A |
-1.1758 |
|
120 |
I |
A |
0.0000 |
|
121 |
P |
A |
-0.1742 |
|
122 |
F |
A |
-0.5323 |
|
123 |
N |
A |
-1.1859 |
|
124 |
S |
A |
-1.1885 |
|
125 |
H |
A |
-1.3418 |
|
126 |
E |
A |
0.0000 |
|
127 |
G |
A |
-0.4025 |
|
128 |
G |
A |
-0.2762 |
|
129 |
C |
A |
-0.0775 |
|
130 |
G |
A |
0.0000 |
|
131 |
A |
A |
0.0000 |
|
132 |
A |
A |
0.0000 |
|
133 |
M |
A |
0.0000 |
|
134 |
R |
A |
0.0000 |
|
135 |
A |
A |
0.0000 |
|
136 |
M |
A |
0.0000 |
|
137 |
C |
A |
0.0000 |
|
138 |
I |
A |
0.0000 |
|
139 |
G |
A |
0.0000 |
|
140 |
L |
A |
0.0000 |
|
141 |
R |
A |
0.0000 |
|
142 |
F |
A |
0.0000 |
|
143 |
P |
A |
0.0000 |
|
144 |
H |
A |
-1.5913 |
|
145 |
H |
A |
-1.7154 |
|
146 |
S |
A |
-1.3720 |
|
147 |
Q |
A |
0.0000 |
|
148 |
L |
A |
-1.1886 |
|
149 |
D |
A |
-2.0446 |
|
150 |
T |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
I |
A |
0.0000 |
|
153 |
Q |
A |
-0.5387 |
|
154 |
V |
A |
0.0000 |
|
155 |
S |
A |
0.0000 |
|
156 |
I |
A |
0.0000 |
|
157 |
E |
A |
0.0000 |
|
158 |
S |
A |
0.0000 |
|
159 |
G |
A |
0.0000 |
|
160 |
R |
A |
0.0000 |
|
161 |
M |
A |
0.0000 |
|
162 |
T |
A |
0.0000 |
|
163 |
H |
A |
0.0000 |
|
164 |
H |
A |
0.0000 |
|
165 |
H |
A |
0.0000 |
|
166 |
P |
A |
0.0000 |
|
167 |
T |
A |
0.0000 |
|
168 |
G |
A |
0.0000 |
|
169 |
Y |
A |
0.0000 |
|
170 |
L |
A |
0.0000 |
|
171 |
G |
A |
0.0000 |
|
172 |
A |
A |
0.0000 |
|
173 |
L |
A |
0.0000 |
|
174 |
A |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
A |
A |
0.0000 |
|
177 |
L |
A |
0.0000 |
|
178 |
F |
A |
0.0000 |
|
179 |
T |
A |
0.0000 |
|
180 |
A |
A |
0.0000 |
|
181 |
Y |
A |
-0.7409 |
|
182 |
A |
A |
0.0000 |
|
183 |
V |
A |
-0.5179 |
|
184 |
N |
A |
-1.5615 |
|
185 |
S |
A |
-1.1686 |
|
186 |
R |
A |
-1.5070 |
|
187 |
P |
A |
-0.7959 |
|
188 |
P |
A |
-0.3420 |
|
189 |
L |
A |
-0.6211 |
|
190 |
Q |
A |
-1.2367 |
|
191 |
W |
A |
0.0000 |
|
192 |
G |
A |
0.0000 |
|
193 |
K |
A |
-1.8722 |
|
194 |
G |
A |
-1.1391 |
|
195 |
L |
A |
0.0000 |
|
196 |
M |
A |
-1.4841 |
|
197 |
E |
A |
-2.3944 |
|
198 |
L |
A |
0.0000 |
|
199 |
L |
A |
0.0000 |
|
200 |
P |
A |
-1.8902 |
|
201 |
E |
A |
-2.6014 |
|
202 |
A |
A |
0.0000 |
|
203 |
K |
A |
-1.8039 |
|
204 |
K |
A |
-2.5555 |
|
205 |
Y |
A |
-1.7874 |
|
206 |
I |
A |
0.0000 |
|
207 |
V |
A |
-0.7592 |
|
208 |
Q |
A |
-1.4414 |
|
209 |
S |
A |
-0.4956 |
|
210 |
G |
A |
-0.3569 |
|
211 |
Y |
A |
0.2729 |
|
212 |
F |
A |
0.3134 |
|
213 |
V |
A |
-0.4881 |
|
214 |
E |
A |
-1.8676 |
|
215 |
E |
A |
-1.7100 |
|
216 |
N |
A |
0.0000 |
|
217 |
L |
A |
-0.6740 |
|
218 |
Q |
A |
-1.7449 |
|
219 |
H |
A |
-1.1581 |
|
220 |
W |
A |
0.0000 |
|
221 |
S |
A |
-0.4700 |
|
222 |
Y |
A |
-0.1968 |
|
223 |
F |
A |
0.0000 |
|
224 |
Q |
A |
-0.8653 |
|
225 |
T |
A |
-0.8854 |
|
226 |
K |
A |
-0.8733 |
|
227 |
W |
A |
0.0000 |
|
228 |
E |
A |
-1.7001 |
|
229 |
N |
A |
-1.8694 |
|
230 |
Y |
A |
0.0000 |
|
231 |
L |
A |
0.0000 |
|
232 |
K |
A |
-1.8103 |
|
233 |
L |
A |
0.1318 |
|
234 |
R |
A |
0.0000 |
|
235 |
G |
A |
-0.9867 |
|
236 |
I |
A |
0.0000 |
|
237 |
L |
A |
-1.5586 |
|
238 |
D |
A |
-2.8488 |
|
239 |
G |
A |
0.0000 |
|
240 |
E |
A |
-2.4432 |
|
241 |
S |
A |
-1.2622 |
|
242 |
A |
A |
-0.3651 |
|
243 |
P |
A |
-0.1275 |
|
244 |
T |
A |
-0.1523 |
|
245 |
F |
A |
0.0761 |
|
246 |
P |
A |
-0.7968 |
|
247 |
E |
A |
-1.8479 |
|
248 |
S |
A |
-1.4141 |
|
249 |
F |
A |
-1.1477 |
|
250 |
G |
A |
-1.2615 |
|
251 |
V |
A |
-1.6557 |
|
252 |
K |
A |
-2.8735 |
|
253 |
E |
A |
-2.2404 |
|
254 |
R |
A |
0.0000 |
|
255 |
D |
A |
-2.0309 |
|
256 |
Q |
A |
-1.9882 |
|
257 |
F |
A |
-0.9363 |
|
258 |
Y |
A |
0.0000 |
|
259 |
T |
A |
-0.5236 |
|
260 |
S |
A |
-0.3702 |
|
261 |
L |
A |
0.0000 |
|
262 |
S |
A |
0.2221 |
|
263 |
Y |
A |
0.9049 |
|
264 |
S |
A |
0.1777 |
|
265 |
G |
A |
-0.2553 |
|
266 |
W |
A |
0.1893 |
|
267 |
G |
A |
0.0000 |
|
268 |
G |
A |
0.0000 |
|
269 |
S |
A |
0.0385 |
|
270 |
S |
A |
0.0000 |
|
271 |
G |
A |
0.0000 |
|
272 |
H |
A |
0.0000 |
|
273 |
D |
A |
0.0000 |
|
274 |
A |
A |
0.0000 |
|
275 |
P |
A |
0.0000 |
|
276 |
M |
A |
0.0000 |
|
277 |
I |
A |
0.0000 |
|
278 |
A |
A |
0.0000 |
|
279 |
Y |
A |
0.0000 |
|
280 |
D |
A |
0.0000 |
|
281 |
A |
A |
0.0000 |
|
282 |
V |
A |
0.0000 |
|
283 |
L |
A |
0.0392 |
|
284 |
A |
A |
-0.3635 |
|
285 |
A |
A |
0.0000 |
|
286 |
G |
A |
-1.1768 |
|
287 |
D |
A |
-2.3933 |
|
288 |
S |
A |
-1.8492 |
|
289 |
W |
A |
0.0000 |
|
290 |
K |
A |
-1.7436 |
|
291 |
E |
A |
-1.8510 |
|
292 |
L |
A |
0.0000 |
|
293 |
A |
A |
0.0000 |
|
294 |
H |
A |
-0.9521 |
|
295 |
R |
A |
-0.7865 |
|
296 |
A |
A |
0.0000 |
|
297 |
F |
A |
0.0000 |
|
298 |
F |
A |
0.0000 |
|
299 |
H |
A |
0.0000 |
|
300 |
G |
A |
0.0000 |
|
301 |
G |
A |
0.0000 |
|
302 |
D |
A |
0.0450 |
|
303 |
S |
A |
0.0000 |
|
304 |
D |
A |
0.0000 |
|
305 |
S |
A |
0.0000 |
|
306 |
T |
A |
0.0000 |
|
307 |
A |
A |
0.0000 |
|
308 |
A |
A |
0.0000 |
|
309 |
I |
A |
0.0000 |
|
310 |
A |
A |
0.0000 |
|
311 |
G |
A |
0.0000 |
|
312 |
C |
A |
0.0000 |
|
313 |
W |
A |
0.0000 |
|
314 |
W |
A |
0.0000 |
|
315 |
G |
A |
0.0000 |
|
316 |
V |
A |
0.0000 |
|
317 |
M |
A |
-0.7078 |
|
318 |
Y |
A |
-1.1052 |
|
319 |
G |
A |
0.0000 |
|
320 |
F |
A |
-1.0760 |
|
321 |
K |
A |
-2.0019 |
|
322 |
G |
A |
-1.7447 |
|
323 |
V |
A |
0.0000 |
|
324 |
S |
A |
-1.2031 |
|
325 |
P |
A |
-1.1248 |
|
326 |
S |
A |
-1.3657 |
|
327 |
N |
A |
0.0000 |
|
328 |
Y |
A |
-1.2868 |
|
329 |
E |
A |
-2.3378 |
|
330 |
K |
A |
-3.0599 |
|
331 |
L |
A |
0.0000 |
|
332 |
E |
A |
-1.7774 |
|
333 |
Y |
A |
-1.4367 |
|
334 |
R |
A |
-2.4508 |
|
335 |
N |
A |
-2.7172 |
|
336 |
R |
A |
-2.2155 |
|
337 |
L |
A |
0.0000 |
|
338 |
E |
A |
-2.6458 |
|
339 |
E |
A |
-3.2424 |
|
340 |
T |
A |
0.0000 |
|
341 |
A |
A |
0.0000 |
|
342 |
R |
A |
-2.5802 |
|
343 |
A |
A |
-1.4088 |
|
344 |
L |
A |
0.0000 |
|
345 |
Y |
A |
-0.9287 |
|
346 |
S |
A |
-1.0593 |
|
347 |
L |
A |
0.0000 |
|
348 |
G |
A |
0.0000 |
|
349 |
S |
A |
-1.2358 |
|
350 |
K |
A |
-2.8787 |
|
351 |
E |
A |
-3.2073 |
|
352 |
D |
A |
-1.9032 |
|
353 |
T |
A |
-0.6735 |
|
354 |
V |
A |
0.1184 |
|
355 |
I |
A |
0.7441 |
|
356 |
S |
A |
0.7281 |
|
357 |
L |
A |
1.3397 |
|