Project name: 27be4a3841d434e

Chain sequence(s)	A: MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2718
• Maximal score value: 3.0848
• Average score: -0.255
• Total score value: -122.6385

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.6986
2	S	A	0.3342
3	T	A	0.0434
4	L	A	0.1589
5	C	A	0.0000
6	P	A	-0.0619
7	P	A	-0.0970
8	P	A	0.0000
9	S	A	0.0486
10	P	A	0.0052
11	A	A	0.0000
12	V	A	1.0436
13	A	A	0.4647
14	K	A	0.0000
15	T	A	0.0000
16	E	A	-0.2849
17	I	A	1.2487
18	A	A	0.0000
19	L	A	0.2800
20	S	A	-0.1797
21	G	A	-0.4649
22	K	A	-1.1048
23	S	A	-0.5152
24	P	A	-0.3528
25	L	A	-0.7417
26	L	A	0.0000
27	A	A	0.0000
28	A	A	0.0000
29	T	A	-0.1781
30	F	A	0.4481
31	A	A	-0.1518
32	Y	A	0.2314
33	W	A	0.6312
34	D	A	-1.1544
35	N	A	-0.7919
36	I	A	1.4130
37	L	A	1.2413
38	G	A	0.1954
39	P	A	-0.2480
40	R	A	-1.3958
41	V	A	-0.5585
42	R	A	-1.6419
43	H	A	-0.7432
44	I	A	0.2732
45	W	A	0.4563
46	A	A	-0.4741
47	P	A	-0.5591
48	K	A	0.0000
49	T	A	-0.9938
50	E	A	-1.9062
51	Q	A	-1.1620
52	V	A	0.6882
53	L	A	0.1432
54	L	A	0.0000
55	S	A	-1.0177
56	D	A	-2.1881
57	G	A	-1.4943
58	E	A	-0.8704
59	I	A	0.0000
60	T	A	-0.8459
61	F	A	-0.4684
62	L	A	0.0000
63	A	A	-0.1201
64	N	A	-0.1651
65	H	A	0.0000
66	T	A	-0.0209
67	L	A	1.0870
68	N	A	-0.1911
69	G	A	-1.5708
70	E	A	-1.2507
71	I	A	1.1938
72	L	A	-0.0721
73	R	A	-2.5507
74	N	A	-2.1243
75	A	A	0.0000
76	E	A	-1.5612
77	S	A	-0.7922
78	G	A	-0.4477
79	A	A	0.3501
80	I	A	1.1811
81	D	A	-0.0694
82	V	A	0.0000
83	K	A	0.0000
84	F	A	1.9657
85	F	A	0.0000
86	V	A	0.0000
87	L	A	0.6826
88	S	A	0.2592
89	E	A	0.0000
90	K	A	-1.3177
91	G	A	0.0000
92	V	A	0.0000
93	I	A	0.0128
94	I	A	0.0000
95	V	A	0.0000
96	S	A	0.0000
97	L	A	0.0000
98	I	A	0.0000
99	F	A	0.0000
100	D	A	0.0000
101	G	A	-0.4265
102	N	A	0.0000
103	W	A	-0.7300
104	N	A	-2.0132
105	G	A	-2.3475
106	D	A	-2.9992
107	R	A	0.0000
108	S	A	-0.8223
109	T	A	-0.6367
110	Y	A	0.0000
111	G	A	0.0000
112	L	A	1.4486
113	S	A	0.7606
114	I	A	0.0000
115	I	A	0.0000
116	L	A	1.2903
117	P	A	0.0725
118	Q	A	-0.9526
119	T	A	-0.4319
120	E	A	0.2022
121	L	A	0.0000
122	S	A	-0.2035
123	F	A	0.6119
124	Y	A	0.0000
125	L	A	0.0000
126	P	A	0.0336
127	L	A	0.2852
128	H	A	0.0000
129	R	A	-0.4272
130	V	A	0.4348
131	C	A	0.5970
132	V	A	0.2128
133	D	A	-0.6402
134	R	A	-0.5940
135	L	A	0.0000
136	T	A	0.0000
137	H	A	0.0000
138	I	A	0.0000
139	I	A	0.0000
140	R	A	0.0000
141	K	A	0.0000
142	G	A	0.0000
143	R	A	0.0000
144	I	A	0.0000
145	W	A	0.0000
146	M	A	0.0000
147	H	A	0.0000
148	K	A	-0.8628
149	E	A	-1.4084
150	R	A	-2.2711
151	Q	A	-1.1090
152	E	A	-1.1058
153	N	A	-1.6225
154	V	A	-0.7534
155	Q	A	-1.4856
156	K	A	-1.9233
157	I	A	-1.2125
158	I	A	0.0000
159	L	A	-1.8729
160	E	A	-2.5505
161	G	A	0.0000
162	T	A	0.0000
163	E	A	-2.6483
164	R	A	-1.8634
165	M	A	-0.4163
166	E	A	-0.9227
167	D	A	0.0000
168	Q	A	0.0000
169	G	A	0.2096
170	Q	A	0.0000
171	S	A	0.0000
172	I	A	1.1952
173	I	A	1.4197
174	P	A	0.9422
175	M	A	1.5192
176	L	A	1.2153
177	T	A	0.4967
178	G	A	0.2709
179	E	A	0.0000
180	V	A	0.0000
181	I	A	0.0000
182	P	A	0.0000
183	V	A	0.0000
184	M	A	0.0000
185	E	A	0.0000
186	L	A	0.0000
187	L	A	0.0000
188	S	A	0.0000
189	S	A	-0.0348
190	M	A	0.0000
191	K	A	0.0000
192	S	A	-0.4979
193	H	A	-1.0972
194	S	A	-0.7681
195	V	A	-0.7030
196	P	A	-1.3545
197	E	A	-2.8461
198	E	A	-3.2718
199	I	A	0.0000
200	D	A	-2.1663
201	I	A	0.0000
202	A	A	0.0000
203	D	A	-2.6162
204	T	A	0.0000
205	V	A	0.0000
206	L	A	0.0000
207	N	A	-2.1357
208	D	A	-1.6462
209	D	A	0.0000
210	D	A	-1.8126
211	I	A	-0.1471
212	G	A	0.0000
213	D	A	-0.7322
214	S	A	-0.5656
215	C	A	0.0000
216	H	A	0.0000
217	E	A	-0.7328
218	G	A	-0.5617
219	F	A	0.0000
220	L	A	0.0000
221	L	A	-0.2238
222	N	A	-1.2076
223	A	A	0.0000
224	I	A	-0.3928
225	S	A	-0.6156
226	S	A	-0.9699
227	H	A	-1.3425
228	L	A	0.0000
229	Q	A	-1.0983
230	T	A	-0.4775
231	C	A	0.3617
232	G	A	0.1385
233	C	A	0.6281
234	S	A	0.0867
235	V	A	-0.0590
236	V	A	0.0000
237	V	A	0.3751
238	G	A	-0.0170
239	S	A	-0.4189
240	S	A	-0.4077
241	A	A	0.0000
242	E	A	-0.7157
243	K	A	-0.7549
244	V	A	0.0000
245	N	A	0.0000
246	K	A	-0.7404
247	I	A	-0.1713
248	V	A	0.0000
249	R	A	0.0000
250	T	A	0.0000
251	L	A	0.0000
252	C	A	0.0000
253	L	A	0.6202
254	F	A	0.7756
255	L	A	0.0000
256	T	A	0.0000
257	P	A	-0.6627
258	A	A	-1.2217
259	E	A	-0.9823
260	R	A	-1.4786
261	K	A	0.0000
262	C	A	0.0000
263	S	A	0.0000
264	R	A	-1.3371
265	L	A	0.0000
266	C	A	0.0000
267	E	A	-1.4296
268	A	A	-1.2115
269	E	A	-1.2613
270	S	A	-0.9632
271	S	A	-0.7238
272	F	A	0.0000
273	K	A	0.0000
274	Y	A	0.4683
275	E	A	0.3131
276	S	A	0.0000
277	G	A	0.0000
278	L	A	0.1414
279	F	A	0.0000
280	V	A	0.0000
281	Q	A	-0.9062
282	G	A	-0.5089
283	L	A	0.0000
284	L	A	0.6712
285	K	A	-0.4205
286	D	A	-1.3218
287	S	A	-0.6343
288	T	A	0.0000
289	G	A	0.0000
290	S	A	-0.5732
291	F	A	0.3387
292	V	A	0.0000
293	L	A	0.0000
294	P	A	0.1697
295	F	A	0.0000
296	R	A	0.0000
297	Q	A	0.3531
298	V	A	0.4354
299	M	A	0.0000
300	Y	A	0.0000
301	A	A	0.5020
302	P	A	0.4165
303	Y	A	1.1774
304	P	A	-0.1141
305	T	A	-0.3624
306	T	A	-0.7289
307	H	A	-1.3778
308	I	A	-0.2050
309	D	A	-1.5909
310	V	A	-1.0301
311	D	A	-1.2304
312	V	A	0.4498
313	N	A	-1.0229
314	T	A	-0.7072
315	V	A	-0.8783
316	K	A	-1.5168
317	Q	A	-0.6686
318	M	A	0.3227
319	P	A	0.0000
320	P	A	0.1070
321	C	A	0.3748
322	H	A	0.0000
323	E	A	0.0000
324	H	A	-0.4042
325	I	A	-0.4571
326	Y	A	0.0000
327	N	A	0.0000
328	Q	A	-0.8591
329	R	A	-1.8253
330	R	A	-1.1952
331	Y	A	-0.0837
332	M	A	0.0000
333	R	A	-0.5888
334	S	A	-0.3849
335	E	A	-0.5651
336	L	A	0.0000
337	T	A	-0.6886
338	A	A	-0.8124
339	F	A	0.0000
340	W	A	-0.6303
341	R	A	-1.6707
342	A	A	-1.0293
343	T	A	-1.4304
344	S	A	-1.7113
345	E	A	-2.8160
346	E	A	-2.8070
347	D	A	-2.7225
348	M	A	-0.7637
349	A	A	0.0000
350	Q	A	-1.4064
351	D	A	-0.7046
352	T	A	0.0161
353	I	A	0.0000
354	I	A	0.3249
355	Y	A	0.7219
356	T	A	0.0000
357	D	A	0.0000
358	E	A	-1.1714
359	S	A	-0.6748
360	F	A	0.0000
361	T	A	-0.7356
362	P	A	-0.2578
363	D	A	-0.1864
364	L	A	0.0000
365	N	A	0.3802
366	I	A	1.9838
367	F	A	1.8440
368	Q	A	0.8388
369	D	A	0.4413
370	V	A	0.4981
371	L	A	1.4492
372	H	A	0.4767
373	R	A	0.0000
374	D	A	-0.3336
375	T	A	-0.1261
376	L	A	0.0451
377	V	A	0.0000
378	K	A	-1.5441
379	A	A	-0.3090
380	F	A	0.3594
381	L	A	0.7224
382	D	A	0.3400
383	Q	A	0.1509
384	V	A	0.9594
385	F	A	0.0000
386	Q	A	-0.0970
387	L	A	0.0000
388	K	A	0.0000
389	P	A	0.1184
390	G	A	0.1420
391	L	A	0.6711
392	S	A	0.1470
393	L	A	0.0000
394	R	A	0.0000
395	S	A	-0.1069
396	T	A	-0.3074
397	F	A	0.0000
398	L	A	-0.0192
399	A	A	-0.0665
400	Q	A	-0.6392
401	F	A	0.0000
402	L	A	1.7249
403	L	A	2.4729
404	V	A	3.0848
405	L	A	2.5519
406	H	A	1.5146
407	R	A	0.6089
408	K	A	-0.2338
409	A	A	0.0000
410	L	A	0.0056
411	T	A	-0.8129
412	L	A	0.0000
413	I	A	0.0000
414	K	A	-1.1711
415	Y	A	0.0000
416	I	A	0.0000
417	E	A	0.0000
418	D	A	-1.3856
419	D	A	0.0000
420	T	A	0.0000
421	Q	A	-2.1880
422	K	A	-2.5016
423	G	A	-1.8879
424	K	A	-2.5856
425	K	A	-1.7068
426	P	A	-1.4321
427	F	A	-0.6334
428	K	A	-1.4680
429	S	A	-0.5698
430	L	A	0.9631
431	R	A	-0.5346
432	N	A	0.0000
433	L	A	0.4318
434	K	A	-0.2441
435	I	A	0.0000
436	D	A	-0.6425
437	L	A	0.6518
438	D	A	-1.0171
439	L	A	-0.0945
440	T	A	-0.0680
441	A	A	0.0000
442	E	A	-1.9901
443	G	A	-1.0026
444	D	A	0.0000
445	L	A	-0.1315
446	N	A	-0.8411
447	I	A	0.0000
448	I	A	0.0000
449	M	A	0.7795
450	A	A	0.0000
451	L	A	0.0000
452	A	A	0.0000
453	E	A	-0.5014
454	K	A	0.0000
455	I	A	0.0000
456	K	A	-1.4027
457	P	A	-0.7761
458	G	A	0.0007
459	L	A	-0.0108
460	H	A	-0.5487
461	S	A	0.3200
462	F	A	1.2575
463	I	A	2.3623
464	F	A	2.2599
465	G	A	0.0000
466	R	A	-0.9347
467	P	A	-0.3261
468	F	A	0.0000
469	Y	A	0.0000
470	T	A	-1.4066
471	S	A	-0.9010
472	V	A	0.0000
473	Q	A	-1.6854
474	E	A	0.0000
475	R	A	-1.3752
476	D	A	-1.1058
477	V	A	-0.2483
478	L	A	0.7966
479	M	A	1.2276
480	T	A	1.1492
481	F	A	2.3661