Project name: Valen_Spliceo_All_Stat

Chain sequence(s)	A: GTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPI; B: GRANIRLPPEVNRILYIRNLPYKITAEEMYDIFGKYGPIRQIRVGNTPETRGTAYVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2001
• Maximal score value: 2.2783
• Average score: -1.0021
• Total score value: -134.2814

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
378	G	A	-0.8009
379	T	A	-1.1345
380	P	A	-1.5818
381	E	A	-2.2995
382	Q	A	-1.6476
383	L	A	0.0402
384	Q	A	-0.4126
385	A	A	-0.0036
386	W	A	0.3191
387	R	A	-1.0762
388	W	A	-1.0077
389	E	A	-2.7035
390	R	A	-3.0927
391	E	A	-2.6427
392	I	A	-0.8085
393	D	A	-2.8564
394	E	A	-3.8836
395	R	A	-4.2001
396	N	A	-3.6130
397	R	A	-3.2564
398	P	A	-1.5306
399	L	A	-0.1545
400	S	A	-1.5190
401	D	A	-3.1667
402	E	A	-3.6875
403	E	A	-2.8913
404	L	A	-2.1377
405	D	A	-2.9482
406	A	A	-1.8553
407	M	A	-0.9854
408	F	A	0.0000
409	P	A	-1.3449
410	E	A	-2.3553
411	G	A	-1.9059
412	Y	A	-1.5381
413	K	A	-1.4223
414	V	A	0.1339
415	L	A	0.1975
416	P	A	-0.3898
417	P	A	-0.6553
418	P	A	-0.4832
419	A	A	-0.0851
420	G	A	0.2172
421	Y	A	0.7882
422	V	A	2.2315
423	P	A	1.4602
424	I	A	2.2783
7	G	B	-1.3441
8	R	B	-2.0919
9	A	B	-1.0779
10	N	B	-1.0405
11	I	B	0.3655
12	R	B	-0.9991
13	L	B	-0.1712
14	P	B	-0.8691
15	P	B	-1.1508
16	E	B	-2.1056
17	V	B	0.0000
18	N	B	-1.0567
19	R	B	-1.3348
20	I	B	0.0000
21	L	B	0.0000
22	Y	B	0.5751
23	I	B	0.0000
24	R	B	-0.9549
25	N	B	-0.8600
26	L	B	0.0000
27	P	B	-0.3802
28	Y	B	0.1422
29	K	B	-0.9674
30	I	B	-0.3854
31	T	B	-0.8262
32	A	B	-1.1990
33	E	B	-2.4904
34	E	B	-2.2638
35	M	B	0.0000
36	Y	B	-1.7042
37	D	B	-2.7123
38	I	B	-1.2958
39	F	B	0.0000
40	G	B	-1.4921
41	K	B	-1.8524
42	Y	B	-0.9531
43	G	B	-1.0645
44	P	B	-1.3165
45	I	B	-1.2762
46	R	B	-2.4295
47	Q	B	-1.1888
48	I	B	0.0000
49	R	B	-0.2624
50	V	B	-0.4489
51	G	B	0.0000
52	N	B	-2.0416
53	T	B	-1.9608
54	P	B	-1.8560
55	E	B	-2.5855
56	T	B	-2.2284
57	R	B	-2.6392
58	G	B	-1.4066
59	T	B	-1.0576
60	A	B	0.0000
61	Y	B	0.2673
62	V	B	0.0000
63	V	B	0.0000
64	Y	B	0.0000
65	E	B	-2.7507
66	D	B	-1.7021
67	I	B	-0.2430
68	F	B	0.7775
69	D	B	-0.9873
70	A	B	0.0000
71	K	B	-1.0813
72	N	B	-1.2519
73	A	B	0.0000
74	C	B	0.0000
75	D	B	-2.5057
76	H	B	-1.9500
77	L	B	0.0000
78	S	B	-0.7075
79	G	B	-0.4510
80	F	B	-0.0734
81	N	B	-0.9289
82	V	B	-0.3346
83	C	B	-0.3266
84	N	B	-1.6192
85	R	B	-1.8433
86	Y	B	-0.1685
87	L	B	0.0000
88	V	B	0.3986
89	V	B	0.3877
90	L	B	0.9434
91	Y	B	0.1913
92	Y	B	-0.3311
93	N	B	-1.3212