Project name: 297259fd70a4b3d
Status: done
submitted: 2018-03-09 12:47:00, status changed: 2018-03-09 13:37:45
Settings
Chain sequence(s)
|
A: PVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLMPVLKETEKIHNFKVHTFRGPHWCEYCANFMWSLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.6096
-
Maximal score value
-
2.2228
-
Average score
-
-0.8637
-
Total score value
-
-347.225
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
14 |
P |
A |
-0.4930 |
|
15 |
V |
A |
0.2447 |
|
16 |
W |
A |
0.0000 |
|
17 |
K |
A |
-0.9273 |
|
18 |
S |
A |
-0.5931 |
|
19 |
Y |
A |
-0.2200 |
|
20 |
L |
A |
0.0000 |
|
21 |
Y |
A |
-0.7204 |
|
22 |
Q |
A |
-1.6190 |
|
23 |
L |
A |
0.0000 |
|
24 |
Q |
A |
-1.1418 |
|
25 |
Q |
A |
-2.2998 |
|
26 |
E |
A |
-2.0141 |
|
27 |
A |
A |
-1.2495 |
|
28 |
P |
A |
-1.3781 |
|
29 |
H |
A |
-1.9597 |
|
30 |
P |
A |
-1.7982 |
|
31 |
R |
A |
-2.1399 |
|
32 |
R |
A |
-2.1018 |
|
33 |
I |
A |
-0.6592 |
|
34 |
T |
A |
-0.8882 |
|
35 |
C |
A |
-0.6200 |
|
36 |
T |
A |
-0.4042 |
|
37 |
C |
A |
-0.6440 |
|
38 |
E |
A |
-2.2879 |
|
39 |
V |
A |
-2.0647 |
|
40 |
E |
A |
-2.9506 |
|
41 |
N |
A |
-3.0826 |
|
42 |
R |
A |
-2.8820 |
|
43 |
P |
A |
-1.7863 |
|
44 |
K |
A |
-1.9897 |
|
45 |
Y |
A |
-0.7153 |
|
46 |
Y |
A |
0.0000 |
|
47 |
G |
A |
-1.5736 |
|
48 |
R |
A |
-2.1494 |
|
49 |
E |
A |
0.0000 |
|
50 |
F |
A |
0.0000 |
|
51 |
H |
A |
-0.5048 |
|
52 |
G |
A |
0.0000 |
|
53 |
M |
A |
-0.0369 |
|
54 |
I |
A |
-0.4958 |
|
55 |
S |
A |
-1.8115 |
|
56 |
R |
A |
-3.1905 |
|
57 |
E |
A |
-3.0883 |
|
58 |
A |
A |
-1.8068 |
|
59 |
A |
A |
0.0000 |
|
60 |
D |
A |
-1.5584 |
|
61 |
Q |
A |
-0.9822 |
|
62 |
L |
A |
0.4257 |
|
63 |
L |
A |
0.0000 |
|
64 |
I |
A |
1.9554 |
|
65 |
V |
A |
2.2228 |
|
66 |
A |
A |
0.7428 |
|
67 |
E |
A |
-0.9567 |
|
68 |
G |
A |
0.0000 |
|
69 |
S |
A |
0.0000 |
|
70 |
Y |
A |
0.0000 |
|
71 |
L |
A |
0.0000 |
|
72 |
I |
A |
0.0000 |
|
73 |
R |
A |
-0.6525 |
|
74 |
E |
A |
-1.2804 |
|
75 |
S |
A |
-2.2203 |
|
76 |
Q |
A |
-2.7755 |
|
77 |
R |
A |
-3.1762 |
|
78 |
Q |
A |
-2.7458 |
|
79 |
P |
A |
-1.8987 |
|
80 |
G |
A |
-1.3667 |
|
81 |
T |
A |
-1.3160 |
|
82 |
Y |
A |
-0.6830 |
|
83 |
T |
A |
0.0000 |
|
84 |
L |
A |
0.0000 |
|
85 |
A |
A |
0.0000 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
-0.8615 |
|
88 |
F |
A |
0.0000 |
|
89 |
G |
A |
-1.0152 |
|
90 |
S |
A |
-0.7205 |
|
91 |
Q |
A |
-1.6318 |
|
92 |
T |
A |
-1.7502 |
|
93 |
R |
A |
-1.8463 |
|
94 |
N |
A |
-2.2694 |
|
95 |
F |
A |
-1.1032 |
|
96 |
R |
A |
-1.6429 |
|
97 |
L |
A |
0.0000 |
|
98 |
Y |
A |
-0.0656 |
|
99 |
Y |
A |
-0.5278 |
|
100 |
D |
A |
-2.0963 |
|
101 |
G |
A |
-1.9050 |
|
102 |
K |
A |
-2.6777 |
|
103 |
H |
A |
0.0000 |
|
104 |
F |
A |
-1.4162 |
|
105 |
V |
A |
-0.3956 |
|
106 |
G |
A |
-1.4707 |
|
107 |
E |
A |
-2.2376 |
|
108 |
K |
A |
-1.8014 |
|
109 |
R |
A |
-3.1430 |
|
110 |
F |
A |
0.0000 |
|
111 |
E |
A |
-2.8297 |
|
112 |
S |
A |
-1.7299 |
|
113 |
I |
A |
0.0000 |
|
114 |
H |
A |
-1.5425 |
|
115 |
D |
A |
-1.3330 |
|
116 |
L |
A |
0.0000 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.6906 |
|
119 |
D |
A |
0.0000 |
|
120 |
G |
A |
-0.0953 |
|
121 |
L |
A |
0.0000 |
|
122 |
I |
A |
0.0000 |
|
123 |
T |
A |
-0.6159 |
|
124 |
L |
A |
-0.7723 |
|
125 |
Y |
A |
-1.0044 |
|
126 |
I |
A |
0.0000 |
|
127 |
E |
A |
-2.3626 |
|
128 |
T |
A |
-1.8855 |
|
129 |
K |
A |
-2.3669 |
|
130 |
A |
A |
0.0000 |
|
131 |
A |
A |
-1.9993 |
|
132 |
E |
A |
-2.5231 |
|
133 |
Y |
A |
-1.5186 |
|
134 |
I |
A |
-1.2882 |
|
135 |
A |
A |
-1.2019 |
|
136 |
K |
A |
-1.5758 |
|
137 |
M |
A |
0.0000 |
|
138 |
T |
A |
0.0973 |
|
139 |
I |
A |
0.8458 |
|
140 |
N |
A |
-0.6988 |
|
141 |
P |
A |
-0.4279 |
|
142 |
I |
A |
-0.5245 |
|
143 |
Y |
A |
0.0000 |
|
144 |
E |
A |
-2.5779 |
|
145 |
H |
A |
-2.3747 |
|
146 |
V |
A |
-0.9615 |
|
147 |
G |
A |
-0.7187 |
|
148 |
Y |
A |
-0.4898 |
|
149 |
T |
A |
-0.4649 |
|
150 |
T |
A |
0.4695 |
|
151 |
L |
A |
1.5402 |
|
161 |
M |
A |
0.1433 |
|
162 |
P |
A |
-0.1846 |
|
163 |
V |
A |
0.0000 |
|
164 |
L |
A |
-1.6155 |
|
165 |
K |
A |
-3.0946 |
|
166 |
E |
A |
-2.8875 |
|
167 |
T |
A |
-1.5164 |
|
203 |
E |
A |
-2.4415 |
|
204 |
K |
A |
-1.6906 |
|
205 |
I |
A |
0.2302 |
|
206 |
H |
A |
0.0000 |
|
207 |
N |
A |
-1.2080 |
|
208 |
F |
A |
-0.7342 |
|
209 |
K |
A |
-0.7509 |
|
210 |
V |
A |
0.6364 |
|
211 |
H |
A |
-0.0896 |
|
212 |
T |
A |
-0.1790 |
|
213 |
F |
A |
0.0000 |
|
214 |
R |
A |
-1.9201 |
|
215 |
G |
A |
-1.3119 |
|
216 |
P |
A |
-0.6110 |
|
217 |
H |
A |
-0.6556 |
|
218 |
W |
A |
0.0000 |
|
219 |
C |
A |
0.0000 |
|
220 |
E |
A |
-0.4234 |
|
221 |
Y |
A |
0.0000 |
|
222 |
C |
A |
0.0000 |
|
223 |
A |
A |
0.0000 |
|
224 |
N |
A |
0.0000 |
|
225 |
F |
A |
0.0000 |
|
226 |
M |
A |
0.0000 |
|
227 |
W |
A |
0.0000 |
|
228 |
S |
A |
0.0000 |
|
229 |
L |
A |
0.2603 |
|
230 |
I |
A |
0.0513 |
|
231 |
A |
A |
-0.2642 |
|
232 |
Q |
A |
0.0228 |
|
233 |
G |
A |
0.0000 |
|
234 |
V |
A |
0.0000 |
|
235 |
K |
A |
-0.6851 |
|
236 |
C |
A |
0.0000 |
|
237 |
A |
A |
-0.9406 |
|
238 |
D |
A |
-1.4766 |
|
239 |
C |
A |
0.0000 |
|
240 |
G |
A |
-1.5078 |
|
241 |
L |
A |
-0.5611 |
|
242 |
N |
A |
-0.4845 |
|
243 |
V |
A |
0.0000 |
|
244 |
H |
A |
0.0000 |
|
245 |
K |
A |
-2.0802 |
|
246 |
Q |
A |
-1.9138 |
|
247 |
C |
A |
0.0000 |
|
248 |
S |
A |
-1.7420 |
|
249 |
K |
A |
-2.0593 |
|
250 |
M |
A |
-0.8316 |
|
251 |
V |
A |
0.0000 |
|
252 |
P |
A |
-1.1289 |
|
253 |
N |
A |
-1.6163 |
|
254 |
D |
A |
-1.8356 |
|
255 |
C |
A |
0.0000 |
|
256 |
K |
A |
-1.7125 |
|
257 |
P |
A |
-2.1805 |
|
258 |
D |
A |
-2.7363 |
|
259 |
L |
A |
-2.3739 |
|
260 |
K |
A |
-3.2036 |
|
261 |
H |
A |
-2.9866 |
|
262 |
V |
A |
-2.5844 |
|
263 |
K |
A |
-2.9090 |
|
264 |
K |
A |
-2.0893 |
|
265 |
V |
A |
0.0000 |
|
266 |
Y |
A |
0.0000 |
|
267 |
S |
A |
-0.1875 |
|
268 |
C |
A |
-0.0978 |
|
269 |
D |
A |
0.0000 |
|
270 |
L |
A |
0.0000 |
|
271 |
T |
A |
-0.6368 |
|
272 |
T |
A |
-0.9038 |
|
273 |
L |
A |
0.0000 |
|
274 |
V |
A |
-1.1591 |
|
275 |
K |
A |
-1.8775 |
|
276 |
A |
A |
-1.0193 |
|
277 |
H |
A |
-0.9525 |
|
278 |
T |
A |
-1.1402 |
|
279 |
T |
A |
-1.3052 |
|
280 |
K |
A |
-2.3830 |
|
281 |
R |
A |
-1.5981 |
|
282 |
P |
A |
0.0000 |
|
283 |
M |
A |
0.0000 |
|
284 |
V |
A |
0.0000 |
|
285 |
V |
A |
0.0000 |
|
286 |
D |
A |
-1.3782 |
|
287 |
M |
A |
-1.2248 |
|
288 |
C |
A |
0.0000 |
|
289 |
I |
A |
0.0000 |
|
290 |
R |
A |
-2.4204 |
|
291 |
E |
A |
-1.3365 |
|
292 |
I |
A |
0.0000 |
|
293 |
E |
A |
-2.0732 |
|
294 |
S |
A |
-1.3021 |
|
295 |
R |
A |
-0.9678 |
|
296 |
G |
A |
-1.3096 |
|
297 |
L |
A |
0.0000 |
|
298 |
N |
A |
-2.7473 |
|
299 |
S |
A |
-1.9488 |
|
300 |
E |
A |
-2.7222 |
|
301 |
G |
A |
-1.4194 |
|
302 |
L |
A |
0.0000 |
|
303 |
Y |
A |
0.0000 |
|
304 |
R |
A |
-1.5304 |
|
305 |
V |
A |
-0.1415 |
|
306 |
S |
A |
0.1323 |
|
307 |
G |
A |
0.4590 |
|
308 |
F |
A |
1.0828 |
|
309 |
S |
A |
-0.2818 |
|
310 |
D |
A |
-1.6058 |
|
311 |
L |
A |
-0.3492 |
|
312 |
I |
A |
0.0000 |
|
313 |
E |
A |
-1.1781 |
|
314 |
D |
A |
-1.0274 |
|
315 |
V |
A |
0.0000 |
|
316 |
K |
A |
-0.8589 |
|
317 |
M |
A |
-0.9382 |
|
318 |
A |
A |
0.0000 |
|
319 |
F |
A |
0.0000 |
|
320 |
D |
A |
0.0000 |
|
321 |
R |
A |
-2.9273 |
|
322 |
D |
A |
-2.7492 |
|
323 |
G |
A |
-2.6189 |
|
324 |
E |
A |
-3.1778 |
|
325 |
K |
A |
-3.3185 |
|
326 |
A |
A |
0.0000 |
|
327 |
D |
A |
-1.9746 |
|
328 |
I |
A |
0.0000 |
|
329 |
S |
A |
-0.3745 |
|
330 |
V |
A |
0.0738 |
|
331 |
N |
A |
-0.9234 |
|
332 |
M |
A |
-0.2739 |
|
333 |
Y |
A |
0.0000 |
|
334 |
E |
A |
-1.7291 |
|
335 |
D |
A |
-1.0792 |
|
336 |
I |
A |
-0.5253 |
|
337 |
N |
A |
-0.5026 |
|
338 |
I |
A |
0.0000 |
|
339 |
I |
A |
0.0000 |
|
340 |
T |
A |
0.0000 |
|
341 |
G |
A |
-0.0020 |
|
342 |
A |
A |
0.0000 |
|
343 |
L |
A |
0.0000 |
|
344 |
K |
A |
-0.3269 |
|
345 |
L |
A |
-0.3301 |
|
346 |
Y |
A |
0.0000 |
|
347 |
F |
A |
0.0000 |
|
348 |
R |
A |
-1.0152 |
|
349 |
D |
A |
0.0000 |
|
350 |
L |
A |
0.0000 |
|
351 |
P |
A |
0.0000 |
|
352 |
I |
A |
0.0000 |
|
353 |
P |
A |
0.0000 |
|
354 |
L |
A |
0.0000 |
|
355 |
I |
A |
0.0000 |
|
356 |
T |
A |
0.0000 |
|
357 |
Y |
A |
0.0000 |
|
358 |
D |
A |
-1.9653 |
|
359 |
A |
A |
0.0000 |
|
360 |
Y |
A |
0.0000 |
|
361 |
P |
A |
-1.3605 |
|
362 |
K |
A |
-1.8025 |
|
363 |
F |
A |
0.0000 |
|
364 |
I |
A |
0.0000 |
|
365 |
E |
A |
-2.3952 |
|
366 |
S |
A |
0.0000 |
|
367 |
A |
A |
0.0000 |
|
368 |
K |
A |
-1.7502 |
|
369 |
I |
A |
-0.8952 |
|
370 |
M |
A |
-0.0828 |
|
371 |
D |
A |
-1.7777 |
|
372 |
P |
A |
-1.8420 |
|
373 |
D |
A |
-3.1699 |
|
374 |
E |
A |
-3.2021 |
|
375 |
Q |
A |
-2.6518 |
|
376 |
L |
A |
-2.1657 |
|
377 |
E |
A |
-3.6096 |
|
378 |
T |
A |
0.0000 |
|
379 |
L |
A |
0.0000 |
|
380 |
H |
A |
-2.1064 |
|
381 |
E |
A |
-2.9503 |
|
382 |
A |
A |
0.0000 |
|
383 |
L |
A |
0.0000 |
|
384 |
K |
A |
-1.9788 |
|
385 |
L |
A |
-0.8204 |
|
386 |
L |
A |
0.0000 |
|
387 |
P |
A |
-0.5888 |
|
388 |
P |
A |
-0.8592 |
|
389 |
A |
A |
0.0000 |
|
390 |
H |
A |
0.0000 |
|
391 |
C |
A |
-0.9215 |
|
392 |
E |
A |
-1.8357 |
|
393 |
T |
A |
0.0000 |
|
394 |
L |
A |
0.0000 |
|
395 |
R |
A |
-1.4478 |
|
396 |
Y |
A |
-0.7249 |
|
397 |
L |
A |
0.0000 |
|
398 |
M |
A |
0.0000 |
|
399 |
A |
A |
-1.1464 |
|
400 |
H |
A |
0.0000 |
|
401 |
L |
A |
0.0000 |
|
402 |
K |
A |
-1.4477 |
|
403 |
R |
A |
-1.4091 |
|
404 |
V |
A |
0.0000 |
|
405 |
T |
A |
-1.2854 |
|
406 |
L |
A |
-0.2596 |
|
407 |
H |
A |
-1.9505 |
|
408 |
E |
A |
-2.7192 |
|
409 |
K |
A |
-3.1030 |
|
410 |
E |
A |
-3.3049 |
|
411 |
N |
A |
0.0000 |
|
412 |
L |
A |
-0.8170 |
|
413 |
M |
A |
0.0000 |
|
414 |
N |
A |
-1.1459 |
|
415 |
A |
A |
-1.3968 |
|
416 |
E |
A |
-1.6150 |
|
417 |
N |
A |
-0.9446 |
|
418 |
L |
A |
0.0000 |
|
419 |
G |
A |
0.0000 |
|
420 |
I |
A |
-0.6659 |
|
421 |
V |
A |
-0.3730 |
|
422 |
F |
A |
0.0000 |
|
423 |
G |
A |
0.0000 |
|
424 |
P |
A |
-0.4456 |
|
425 |
T |
A |
0.0000 |
|
426 |
L |
A |
0.0000 |
|
427 |
M |
A |
0.0000 |
|
428 |
R |
A |
-0.9911 |
|
429 |
S |
A |
-1.0248 |
|
430 |
P |
A |
-1.4310 |
|
431 |
E |
A |
-1.5477 |
|
432 |
L |
A |
0.1137 |
|
433 |
D |
A |
-0.7367 |
|
434 |
A |
A |
-0.0362 |
|
435 |
M |
A |
0.8688 |
|
436 |
A |
A |
0.0479 |
|
437 |
A |
A |
-0.1534 |
|
438 |
L |
A |
0.4995 |
|
439 |
N |
A |
-0.8772 |
|
440 |
D |
A |
-1.0850 |
|
441 |
I |
A |
-0.8496 |
|
442 |
R |
A |
-1.8765 |
|
443 |
Y |
A |
-1.6003 |
|
444 |
Q |
A |
0.0000 |
|
445 |
R |
A |
-1.2698 |
|
446 |
L |
A |
-0.8843 |
|
447 |
V |
A |
0.0000 |
|
448 |
V |
A |
0.0000 |
|
449 |
E |
A |
-1.1413 |
|
450 |
L |
A |
0.0000 |
|
451 |
L |
A |
0.0000 |
|
452 |
I |
A |
0.0000 |
|
453 |
K |
A |
-1.9392 |
|
454 |
N |
A |
-0.9981 |
|
455 |
E |
A |
-1.0559 |
|
456 |
D |
A |
-1.2290 |
|
457 |
I |
A |
1.0519 |
|
458 |
L |
A |
0.0000 |
|
459 |
F |
A |
0.3593 |
|