Chain sequence(s) |
A: MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKT B: MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKT |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | TA27A, TB27A |
Energy difference between WT (input) and mutated protein (by FoldX) | -1.12521 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
0 | M | A | -0.0315 | |
1 | Q | A | -1.7773 | |
2 | D | A | -2.4148 | |
3 | P | A | -1.6213 | |
4 | Y | A | 0.0000 | |
5 | V | A | -1.7115 | |
6 | K | A | -2.3732 | |
7 | E | A | 0.0000 | |
8 | A | A | 0.0000 | |
9 | E | A | -2.4832 | |
10 | N | A | -2.0570 | |
11 | L | A | 0.0000 | |
12 | K | A | -2.2806 | |
13 | K | A | -2.6142 | |
14 | Y | A | -0.7668 | |
15 | F | A | -1.0830 | |
16 | N | A | -2.0944 | |
17 | A | A | 0.0000 | |
18 | G | A | -2.1823 | |
19 | H | A | -2.1103 | |
20 | S | A | -1.6106 | |
21 | D | A | -2.1878 | |
22 | V | A | 0.0000 | |
23 | A | A | -1.8528 | |
24 | D | A | -2.8223 | |
25 | N | A | -2.4783 | |
26 | G | A | -1.5340 | |
27 | A | A | -0.8091 | mutated: TA27A |
28 | L | A | 0.0000 | |
29 | F | A | 0.0000 | |
30 | L | A | -0.6434 | |
31 | G | A | -0.9516 | |
32 | I | A | 0.0000 | |
33 | L | A | 0.0000 | |
34 | K | A | -2.5184 | |
35 | N | A | -2.3027 | |
36 | W | A | 0.0000 | |
37 | K | A | -3.8376 | |
38 | E | A | -3.7747 | |
39 | E | A | -3.4941 | |
40 | S | A | -2.2754 | |
41 | D | A | -1.9222 | |
42 | R | A | -2.4117 | |
43 | K | A | 0.0000 | |
44 | I | A | 0.0000 | |
45 | M | A | 0.0000 | |
46 | Q | A | 0.0000 | |
47 | S | A | 0.0000 | |
48 | Q | A | 0.0000 | |
49 | I | A | 0.0000 | |
50 | V | A | 0.0000 | |
51 | S | A | -0.5647 | |
52 | F | A | 0.0000 | |
53 | Y | A | 0.0000 | |
54 | F | A | -1.2636 | |
55 | K | A | -2.1636 | |
56 | L | A | 0.0000 | |
57 | F | A | 0.0000 | |
58 | K | A | -3.3042 | |
59 | N | A | -2.9678 | |
60 | F | A | -2.6062 | |
61 | K | A | -3.3022 | |
62 | D | A | -3.3442 | |
63 | D | A | -2.7343 | |
64 | Q | A | -2.5922 | |
65 | S | A | -1.5251 | |
66 | I | A | 0.0000 | |
67 | Q | A | -2.4918 | |
68 | K | A | -2.6397 | |
69 | S | A | 0.0000 | |
70 | V | A | 0.0000 | |
71 | E | A | -3.2260 | |
72 | T | A | -2.3700 | |
73 | I | A | 0.0000 | |
74 | K | A | -2.2772 | |
75 | E | A | -2.5241 | |
76 | D | A | -1.7159 | |
77 | M | A | 0.0000 | |
78 | N | A | -1.4704 | |
79 | V | A | -0.6370 | |
80 | K | A | -0.9077 | |
81 | F | A | 0.0000 | |
82 | F | A | 0.0000 | |
83 | N | A | -1.6682 | |
84 | S | A | -1.7709 | |
85 | N | A | -2.6011 | |
86 | K | A | -3.3666 | |
87 | K | A | -3.3688 | |
88 | K | A | 0.0000 | |
89 | R | A | -2.9080 | |
90 | D | A | -3.2528 | |
91 | D | A | 0.0000 | |
92 | F | A | 0.0000 | |
93 | E | A | -2.6325 | |
94 | K | A | -2.7276 | |
95 | L | A | 0.0000 | |
96 | T | A | -1.6638 | |
97 | N | A | -1.9051 | |
98 | Y | A | -0.9573 | |
99 | S | A | -0.5046 | |
100 | V | A | -0.5258 | |
101 | T | A | -0.4374 | |
102 | D | A | -0.5750 | |
103 | L | A | 0.4466 | |
104 | N | A | -1.0270 | |
105 | V | A | -0.3861 | |
106 | Q | A | 0.0000 | |
107 | R | A | -1.2558 | |
108 | K | A | -1.3340 | |
109 | A | A | 0.0000 | |
110 | I | A | 0.0000 | |
111 | H | A | -1.3918 | |
112 | E | A | 0.0000 | |
113 | L | A | 0.0000 | |
114 | I | A | -0.9253 | |
115 | Q | A | -1.3096 | |
116 | V | A | 0.0000 | |
117 | M | A | 0.0000 | |
118 | A | A | -1.1147 | |
119 | E | A | -1.4662 | |
120 | L | A | 0.0000 | |
121 | S | A | -0.7093 | |
122 | P | A | -0.7310 | |
123 | A | A | -1.1520 | |
124 | A | A | -1.2898 | |
125 | K | A | -1.6943 | |
126 | T | A | -0.8798 | |
0 | M | B | -0.0072 | |
1 | Q | B | -1.9368 | |
2 | D | B | -2.5378 | |
3 | P | B | -1.7621 | |
4 | Y | B | 0.0000 | |
5 | V | B | 0.0000 | |
6 | K | B | -2.7798 | |
7 | E | B | 0.0000 | |
8 | A | B | 0.0000 | |
9 | E | B | -2.4450 | |
10 | N | B | -1.9359 | |
11 | L | B | 0.0000 | |
12 | K | B | 0.0000 | |
13 | K | B | -2.4281 | |
14 | Y | B | -0.6134 | |
15 | F | B | -0.9015 | |
16 | N | B | -2.2217 | |
17 | A | B | 0.0000 | |
18 | G | B | -2.1925 | |
19 | H | B | -2.3855 | |
20 | S | B | -1.8917 | |
21 | D | B | -3.0511 | |
22 | V | B | 0.0000 | |
23 | A | B | -2.1284 | |
24 | D | B | -3.0873 | |
25 | N | B | -2.5826 | |
26 | G | B | -1.5283 | |
27 | A | B | -0.8014 | mutated: TB27A |
28 | L | B | 0.0000 | |
29 | F | B | 0.0000 | |
30 | L | B | -0.8069 | |
31 | G | B | -0.9560 | |
32 | I | B | 0.0000 | |
33 | L | B | 0.0000 | |
34 | K | B | -2.4181 | |
35 | N | B | -2.3767 | |
36 | W | B | 0.0000 | |
37 | K | B | -3.2346 | |
38 | E | B | -2.9660 | |
39 | E | B | -2.0684 | |
40 | S | B | -1.8415 | |
41 | D | B | -1.5105 | |
42 | R | B | 0.0000 | |
43 | K | B | 0.0000 | |
44 | I | B | 0.0000 | |
45 | M | B | 0.0000 | |
46 | Q | B | 0.0000 | |
47 | S | B | 0.0000 | |
48 | Q | B | 0.0000 | |
49 | I | B | 0.0000 | |
50 | V | B | 0.0000 | |
51 | S | B | -0.5315 | |
52 | F | B | 0.0000 | |
53 | Y | B | 0.0000 | |
54 | F | B | -1.1716 | |
55 | K | B | -2.0312 | |
56 | L | B | 0.0000 | |
57 | F | B | 0.0000 | |
58 | K | B | -3.3595 | |
59 | N | B | -2.8572 | |
60 | F | B | -2.7446 | |
61 | K | B | -3.9573 | |
62 | D | B | -3.5419 | |
63 | D | B | -2.8035 | |
64 | Q | B | -2.6484 | |
65 | S | B | -1.5464 | |
66 | I | B | 0.0000 | |
67 | Q | B | -2.8351 | |
68 | K | B | -2.7904 | |
69 | S | B | 0.0000 | |
70 | V | B | 0.0000 | |
71 | E | B | -3.4841 | |
72 | T | B | -2.5665 | |
73 | I | B | 0.0000 | |
74 | K | B | -2.5175 | |
75 | E | B | -2.6210 | |
76 | D | B | -1.7481 | |
77 | M | B | 0.0000 | |
78 | N | B | -1.4652 | |
79 | V | B | -0.5416 | |
80 | K | B | -0.8735 | |
81 | F | B | 0.0000 | |
82 | F | B | 0.0000 | |
83 | N | B | -1.6398 | |
84 | S | B | -1.7041 | |
85 | N | B | -2.6253 | |
86 | K | B | -3.3732 | |
87 | K | B | -3.2986 | |
88 | K | B | 0.0000 | |
89 | R | B | -3.0085 | |
90 | D | B | -3.5728 | |
91 | D | B | 0.0000 | |
92 | F | B | 0.0000 | |
93 | E | B | -2.7555 | |
94 | K | B | -2.7726 | |
95 | L | B | 0.0000 | |
96 | T | B | -1.6794 | |
97 | N | B | -1.8821 | |
98 | Y | B | -0.9576 | |
99 | S | B | -0.5009 | |
100 | V | B | -0.5644 | |
101 | T | B | -0.4729 | |
102 | D | B | -0.5642 | |
103 | L | B | 0.4686 | |
104 | N | B | -0.8450 | |
105 | V | B | -0.4001 | |
106 | Q | B | -0.3470 | |
107 | R | B | -1.2256 | |
108 | K | B | -1.2752 | |
109 | A | B | 0.0000 | |
110 | I | B | 0.0000 | |
111 | H | B | -1.4480 | |
112 | E | B | 0.0000 | |
113 | L | B | 0.0000 | |
114 | I | B | -0.5510 | |
115 | Q | B | -0.6950 | |
116 | V | B | 0.0000 | |
117 | M | B | 0.0000 | |
118 | A | B | -0.7633 | |
119 | E | B | -1.4433 | |
120 | L | B | 0.0000 | |
121 | S | B | -0.8648 | |
122 | P | B | -1.5981 | |
123 | A | B | -1.4166 | |
124 | A | B | -0.8173 | |
125 | K | B | -1.7182 | |
126 | T | B | -1.8765 |