Project name: 2BQ8
Status: done
submitted: 2018-02-20 14:31:34, status changed: 2018-02-20 14:47:35
Settings
Chain sequence(s)
|
X: ATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.8273
-
Maximal score value
-
2.443
-
Average score
-
-0.6616
-
Total score value
-
-201.1198
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
A |
X |
0.0033 |
|
2 |
T |
X |
-0.4299 |
|
3 |
P |
X |
-0.5329 |
|
4 |
A |
X |
-1.0215 |
|
5 |
L |
X |
0.0000 |
|
6 |
R |
X |
-0.7516 |
|
7 |
F |
X |
0.0000 |
|
8 |
V |
X |
0.0000 |
|
9 |
A |
X |
0.0000 |
|
10 |
V |
X |
0.0000 |
|
11 |
G |
X |
0.0000 |
|
12 |
D |
X |
0.0000 |
|
13 |
W |
X |
0.0000 |
|
14 |
G |
X |
0.0000 |
|
15 |
G |
X |
0.0000 |
|
16 |
V |
X |
-0.0523 |
|
17 |
P |
X |
-0.4021 |
|
18 |
N |
X |
-1.2657 |
|
19 |
A |
X |
-0.7096 |
|
20 |
P |
X |
-0.5925 |
|
21 |
F |
X |
-0.9708 |
|
22 |
H |
X |
-0.6316 |
|
23 |
T |
X |
-0.1641 |
|
24 |
A |
X |
-0.0027 |
|
25 |
R |
X |
-0.3007 |
|
26 |
E |
X |
0.0000 |
|
27 |
M |
X |
-0.5390 |
|
28 |
A |
X |
-0.5823 |
|
29 |
N |
X |
0.0000 |
|
30 |
A |
X |
0.0000 |
|
31 |
K |
X |
-2.3461 |
|
32 |
E |
X |
0.0000 |
|
33 |
I |
X |
0.0000 |
|
34 |
A |
X |
0.0000 |
|
35 |
R |
X |
-2.1160 |
|
36 |
T |
X |
0.0000 |
|
37 |
V |
X |
0.0000 |
|
38 |
Q |
X |
-0.8541 |
|
39 |
I |
X |
1.2976 |
|
40 |
L |
X |
0.9942 |
|
41 |
G |
X |
-0.0815 |
|
42 |
A |
X |
-0.7011 |
|
43 |
D |
X |
-1.4114 |
|
44 |
F |
X |
0.0000 |
|
45 |
I |
X |
0.0000 |
|
46 |
L |
X |
0.0000 |
|
47 |
S |
X |
0.0000 |
|
48 |
L |
X |
0.0000 |
|
49 |
G |
X |
0.0000 |
|
50 |
D |
X |
0.0000 |
|
51 |
N |
X |
0.0000 |
|
52 |
F |
X |
0.0000 |
|
53 |
Y |
X |
0.0000 |
|
54 |
F |
X |
1.2398 |
|
55 |
T |
X |
0.3778 |
|
56 |
G |
X |
0.0000 |
|
57 |
V |
X |
0.0000 |
|
58 |
Q |
X |
-2.0229 |
|
59 |
D |
X |
-1.5416 |
|
60 |
I |
X |
-0.2315 |
|
61 |
N |
X |
-1.8083 |
|
62 |
D |
X |
-2.1287 |
|
63 |
K |
X |
-2.7241 |
|
64 |
R |
X |
0.0000 |
|
65 |
F |
X |
0.0000 |
|
66 |
Q |
X |
-2.7356 |
|
67 |
E |
X |
-2.1101 |
|
68 |
T |
X |
0.0000 |
|
69 |
F |
X |
0.0000 |
|
70 |
E |
X |
-2.2046 |
|
71 |
D |
X |
-2.3054 |
|
72 |
V |
X |
0.0000 |
|
73 |
F |
X |
0.0000 |
|
74 |
S |
X |
-2.2892 |
|
75 |
D |
X |
-3.1542 |
|
76 |
R |
X |
-3.4112 |
|
77 |
S |
X |
0.0000 |
|
78 |
L |
X |
0.0000 |
|
79 |
R |
X |
-3.8273 |
|
80 |
K |
X |
-3.5170 |
|
81 |
V |
X |
0.0000 |
|
82 |
P |
X |
-1.4051 |
|
83 |
W |
X |
0.0000 |
|
84 |
Y |
X |
-0.0431 |
|
85 |
V |
X |
0.0000 |
|
86 |
L |
X |
0.0000 |
|
87 |
A |
X |
0.0000 |
|
88 |
G |
X |
0.0000 |
|
89 |
N |
X |
0.0000 |
|
90 |
H |
X |
0.0000 |
|
91 |
D |
X |
0.0000 |
|
92 |
H |
X |
0.0463 |
|
93 |
L |
X |
0.5833 |
|
94 |
G |
X |
-0.5359 |
|
95 |
N |
X |
-1.2528 |
|
96 |
V |
X |
-0.5388 |
|
97 |
S |
X |
-0.5023 |
|
98 |
A |
X |
0.0000 |
|
99 |
Q |
X |
0.0000 |
|
100 |
I |
X |
0.0720 |
|
101 |
A |
X |
0.1032 |
|
102 |
Y |
X |
0.0000 |
|
103 |
S |
X |
-0.5615 |
|
104 |
K |
X |
-0.9752 |
|
105 |
I |
X |
0.9851 |
|
106 |
S |
X |
-0.6769 |
|
107 |
K |
X |
-2.1571 |
|
108 |
R |
X |
0.0000 |
|
109 |
W |
X |
0.0000 |
|
110 |
N |
X |
-0.9550 |
|
111 |
F |
X |
0.0000 |
|
112 |
P |
X |
-0.4796 |
|
113 |
S |
X |
-0.1331 |
|
114 |
P |
X |
0.0657 |
|
115 |
F |
X |
0.1084 |
|
116 |
Y |
X |
0.0000 |
|
117 |
R |
X |
-0.7591 |
|
118 |
L |
X |
0.0000 |
|
119 |
H |
X |
-0.9946 |
|
120 |
F |
X |
-1.0216 |
|
121 |
K |
X |
-2.2684 |
|
122 |
I |
X |
0.0000 |
|
123 |
P |
X |
-1.4750 |
|
124 |
Q |
X |
-1.8383 |
|
125 |
T |
X |
-1.6548 |
|
126 |
N |
X |
-2.0132 |
|
127 |
V |
X |
0.0000 |
|
128 |
S |
X |
0.0000 |
|
129 |
V |
X |
0.0000 |
|
130 |
A |
X |
0.0000 |
|
131 |
I |
X |
0.0000 |
|
132 |
F |
X |
0.0000 |
|
133 |
M |
X |
0.0000 |
|
134 |
L |
X |
0.0000 |
|
135 |
D |
X |
0.0000 |
|
136 |
T |
X |
0.0000 |
|
137 |
V |
X |
0.0000 |
|
138 |
T |
X |
-1.1298 |
|
139 |
L |
X |
0.0000 |
|
140 |
C |
X |
0.0000 |
|
141 |
G |
X |
0.0000 |
|
142 |
N |
X |
-1.4301 |
|
143 |
S |
X |
0.0000 |
|
144 |
D |
X |
0.6510 |
|
145 |
D |
X |
0.0000 |
|
146 |
F |
X |
2.4430 |
|
147 |
L |
X |
1.9390 |
|
148 |
S |
X |
0.3873 |
|
149 |
Q |
X |
-0.8373 |
|
150 |
Q |
X |
-1.9754 |
|
151 |
P |
X |
0.0000 |
|
152 |
E |
X |
-3.4429 |
|
153 |
R |
X |
-3.3173 |
|
154 |
P |
X |
-2.7712 |
|
155 |
R |
X |
-3.0972 |
|
156 |
D |
X |
-2.7033 |
|
157 |
V |
X |
-1.6332 |
|
158 |
K |
X |
-2.2199 |
|
159 |
L |
X |
-1.1970 |
|
160 |
A |
X |
0.0000 |
|
161 |
R |
X |
-2.1268 |
|
162 |
T |
X |
-1.0479 |
|
163 |
Q |
X |
0.0000 |
|
164 |
L |
X |
-1.1542 |
|
165 |
S |
X |
-1.2451 |
|
166 |
W |
X |
-0.9526 |
|
167 |
L |
X |
0.0000 |
|
168 |
K |
X |
-1.8181 |
|
169 |
K |
X |
-2.1898 |
|
170 |
Q |
X |
-1.5369 |
|
171 |
L |
X |
0.0000 |
|
172 |
A |
X |
-1.1209 |
|
173 |
A |
X |
-1.1352 |
|
174 |
A |
X |
0.0000 |
|
175 |
R |
X |
-2.0157 |
|
176 |
E |
X |
0.0000 |
|
177 |
D |
X |
-1.4887 |
|
178 |
Y |
X |
0.0000 |
|
179 |
V |
X |
0.0000 |
|
180 |
L |
X |
0.0000 |
|
181 |
V |
X |
0.0000 |
|
182 |
A |
X |
0.0000 |
|
183 |
G |
X |
0.0000 |
|
184 |
H |
X |
0.0000 |
|
185 |
Y |
X |
0.0000 |
|
186 |
P |
X |
0.0000 |
|
187 |
V |
X |
0.0000 |
|
188 |
W |
X |
0.0000 |
|
189 |
S |
X |
0.0000 |
|
190 |
I |
X |
0.0000 |
|
191 |
A |
X |
0.0000 |
|
192 |
E |
X |
-1.0499 |
|
193 |
H |
X |
0.0000 |
|
194 |
G |
X |
0.0000 |
|
195 |
P |
X |
0.0000 |
|
196 |
T |
X |
0.0000 |
|
197 |
H |
X |
-1.9112 |
|
198 |
C |
X |
-1.9331 |
|
199 |
L |
X |
0.0000 |
|
200 |
V |
X |
-1.4995 |
|
201 |
K |
X |
-2.4399 |
|
202 |
Q |
X |
-1.9239 |
|
203 |
L |
X |
0.0000 |
|
204 |
R |
X |
-1.6798 |
|
205 |
P |
X |
-1.0987 |
|
206 |
L |
X |
0.0000 |
|
207 |
L |
X |
0.0000 |
|
208 |
A |
X |
-0.8325 |
|
209 |
T |
X |
-0.3679 |
|
210 |
Y |
X |
-0.1232 |
|
211 |
G |
X |
0.0000 |
|
212 |
V |
X |
0.0000 |
|
213 |
T |
X |
0.0000 |
|
214 |
A |
X |
0.0000 |
|
215 |
Y |
X |
0.0000 |
|
216 |
L |
X |
0.0000 |
|
217 |
C |
X |
0.0000 |
|
218 |
G |
X |
0.0000 |
|
219 |
H |
X |
0.0000 |
|
220 |
D |
X |
0.0000 |
|
221 |
H |
X |
0.0000 |
|
222 |
N |
X |
0.0000 |
|
223 |
L |
X |
0.0000 |
|
224 |
Q |
X |
0.0000 |
|
225 |
Y |
X |
0.0000 |
|
226 |
L |
X |
0.0000 |
|
227 |
Q |
X |
-1.2014 |
|
228 |
D |
X |
-1.9153 |
|
229 |
E |
X |
-2.6596 |
|
230 |
N |
X |
-2.3094 |
|
231 |
G |
X |
-1.5004 |
|
232 |
V |
X |
0.0000 |
|
233 |
G |
X |
0.0000 |
|
234 |
Y |
X |
0.0000 |
|
235 |
V |
X |
0.0000 |
|
236 |
L |
X |
0.0000 |
|
237 |
S |
X |
0.0000 |
|
238 |
G |
X |
0.0000 |
|
239 |
A |
X |
0.0000 |
|
240 |
G |
X |
0.0000 |
|
241 |
N |
X |
0.0000 |
|
242 |
F |
X |
0.0751 |
|
243 |
M |
X |
-0.6430 |
|
244 |
D |
X |
-1.0213 |
|
245 |
P |
X |
-1.6891 |
|
246 |
S |
X |
0.0000 |
|
247 |
K |
X |
-3.1909 |
|
248 |
R |
X |
-3.4905 |
|
249 |
H |
X |
-2.9882 |
|
250 |
Q |
X |
-3.1166 |
|
251 |
R |
X |
-3.6969 |
|
252 |
K |
X |
-3.2216 |
|
253 |
V |
X |
0.0000 |
|
254 |
P |
X |
-1.8034 |
|
255 |
N |
X |
-2.0299 |
|
256 |
G |
X |
-1.5870 |
|
257 |
Y |
X |
-1.1959 |
|
258 |
L |
X |
-0.8861 |
|
259 |
R |
X |
-1.5502 |
|
260 |
F |
X |
-0.6186 |
|
261 |
H |
X |
-0.4262 |
|
262 |
Y |
X |
-0.0048 |
|
263 |
G |
X |
0.0000 |
|
264 |
T |
X |
-1.4651 |
|
265 |
E |
X |
-2.6791 |
|
266 |
D |
X |
-2.5558 |
|
267 |
S |
X |
0.0000 |
|
268 |
L |
X |
-0.2327 |
|
269 |
G |
X |
0.0000 |
|
270 |
G |
X |
0.0000 |
|
271 |
F |
X |
0.0000 |
|
272 |
A |
X |
0.0000 |
|
273 |
Y |
X |
0.0000 |
|
274 |
V |
X |
0.0000 |
|
275 |
E |
X |
-0.7866 |
|
276 |
I |
X |
0.0000 |
|
277 |
S |
X |
0.0000 |
|
278 |
S |
X |
-1.6374 |
|
279 |
K |
X |
-2.6389 |
|
280 |
E |
X |
-2.3883 |
|
281 |
M |
X |
0.0000 |
|
282 |
T |
X |
-1.5576 |
|
283 |
V |
X |
0.0000 |
|
284 |
T |
X |
0.0000 |
|
285 |
Y |
X |
0.0000 |
|
286 |
I |
X |
0.0000 |
|
287 |
E |
X |
0.0000 |
|
288 |
A |
X |
0.0000 |
|
289 |
S |
X |
-0.9578 |
|
290 |
G |
X |
-1.5818 |
|
291 |
K |
X |
-1.8592 |
|
292 |
S |
X |
-1.1227 |
|
293 |
L |
X |
-0.3759 |
|
294 |
F |
X |
-0.5342 |
|
295 |
K |
X |
-1.5268 |
|
296 |
T |
X |
-1.7221 |
|
297 |
R |
X |
-2.6579 |
|
298 |
L |
X |
0.0000 |
|
299 |
P |
X |
-2.0394 |
|
300 |
R |
X |
-2.4283 |
|
301 |
R |
X |
-1.5081 |
|
302 |
A |
X |
-0.6691 |
|
303 |
R |
X |
-0.9690 |
|
304 |
P |
X |
-0.6931 |
|