Project name: 3N75 [mutate: DA457Y, DA460Y, DA470Y, DB457Y, DB460Y, DB470Y, DC457Y, DC460Y, DC470Y, DD457Y, DD460Y, DD470Y, DE457Y, DE460Y, DE470Y]

Status: done

submitted: 2017-09-13 12:41:42, status changed: 2017-09-13 13:59:12
Settings
Chain sequence(s) A: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
C: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
B: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
E: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
D: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues DA457Y, DA460Y, DA470Y, DB457Y, DB460Y, DB470Y, DC457Y, DC460Y, DC470Y, DD457Y, DD460Y, DD470Y, DE457Y, DE460Y, DE470Y
Energy difference between WT (input) and mutated protein (by FoldX) 1.44843 kcal/mol
Show buried residues

Minimal score value
-4.078
Maximal score value
2.8339
Average score
-0.7014
Total score value
-2490.1321

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3261
2 N A -1.1387
3 V A 0.0000
4 I A 0.0000
5 A A 0.0000
6 I A 0.0000
7 L A 0.0000
8 N A -1.3066
9 H A -1.4140
10 M A -0.6006
11 G A -0.6337
12 V A -0.6902
13 Y A -0.5278
14 F A 0.0000
15 K A 0.0000
16 E A -0.6554
17 E A -0.5920
18 P A 0.0000
19 I A -0.6954
20 R A -1.4210
21 E A -1.6176
22 L A 0.0000
23 H A -1.9910
24 R A -3.1509
25 A A 0.0000
26 L A 0.0000
27 E A -3.7431
28 R A -3.6233
29 L A -2.6756
30 N A -2.8404
31 F A 0.0000
32 Q A -1.4388
33 I A -0.7193
34 V A 0.0000
35 Y A 0.0835
36 P A 0.0000
37 N A -2.1346
38 D A -2.4019
39 R A -2.4279
40 D A -2.5580
41 D A 0.0000
42 L A 0.0000
43 L A -1.5413
44 K A -1.7231
45 L A 0.0000
46 I A 0.0000
47 E A -1.7612
48 N A -1.4999
49 N A 0.0000
50 A A -0.6701
51 R A -0.8825
52 L A 0.0000
53 C A 0.0000
54 G A 0.0000
55 V A 0.0000
56 I A 0.0000
57 F A 0.0000
58 D A 0.0000
59 W A 0.0000
60 D A -1.0630
61 K A -1.5101
62 Y A 0.0000
63 N A 0.0000
64 L A -0.4410
65 E A -1.9570
66 L A 0.0000
67 C A 0.0000
68 E A -2.2014
69 E A -2.0837
70 I A 0.0000
71 S A -2.1675
72 K A -2.7786
73 M A 0.0000
74 N A -1.7206
75 E A -1.7087
76 N A -0.8200
77 L A 0.0000
78 P A 0.0000
79 L A 0.0000
80 Y A 0.0000
81 A A 0.0000
82 F A 0.0000
83 A A 0.0000
84 N A -0.1929
85 T A 0.2101
86 Y A 0.9708
87 S A 0.0000
88 T A -0.0325
89 L A 0.0000
90 D A -0.5471
91 V A -0.7719
92 S A -0.6399
93 L A 0.0000
94 N A -1.6913
95 D A -2.5290
96 L A -2.3482
97 R A -2.8805
98 L A 0.0000
99 Q A -0.7611
100 I A -0.1440
101 S A -0.3496
102 F A 0.0000
103 F A 0.0000
104 E A -0.8198
105 Y A 0.0000
106 A A -0.7379
107 L A 0.0000
108 G A -1.2992
109 A A -1.4058
110 A A 0.0000
111 E A -3.7226
112 D A -3.6989
113 I A 0.0000
114 A A 0.0000
115 N A -3.8110
116 K A -3.8921
117 I A 0.0000
118 K A -3.7292
119 Q A -3.6566
120 T A -2.7570
121 T A 0.0000
122 D A -3.2685
123 E A -2.8823
124 Y A 0.0000
125 I A -0.5745
126 N A -0.8528
127 T A -0.3041
128 I A 0.6836
129 L A 0.7404
130 P A 0.0000
131 P A -0.7115
132 L A 0.0000
133 T A 0.0000
134 K A -0.0813
135 A A -0.5337
136 L A 0.0000
137 F A -0.4662
138 K A -1.3175
139 Y A -1.6564
140 V A 0.0000
141 R A -3.1497
142 E A -3.1334
143 G A -2.0627
144 K A -1.9195
145 Y A 0.5541
146 T A 0.9812
147 F A 2.1301
148 C A 1.3721
149 T A 0.4736
150 P A -0.2352
151 G A -0.1089
152 H A -0.3678
153 M A 0.3995
154 G A -0.7604
155 G A 0.0000
156 T A -0.6512
157 A A -0.6477
158 F A -0.0511
159 Q A -1.2456
160 K A -1.9004
161 S A -0.2891
162 P A 0.5360
163 V A 1.9647
164 G A 0.0000
165 S A 0.7672
166 L A 2.6177
167 F A 2.6713
168 Y A 1.3449
169 D A 0.5236
170 F A 2.4346
171 F A 1.8087
172 G A 0.2705
173 P A -0.9238
174 N A -1.6993
175 T A -0.5686
176 M A 0.0000
177 K A -1.5223
178 S A -1.1523
179 D A -1.0549
180 I A 0.0000
181 S A 0.5894
182 I A 1.6041
183 S A 0.8983
184 V A 0.0000
185 S A -0.5355
186 E A -1.5268
187 L A 0.0000
188 G A -1.1529
189 S A -0.7277
190 L A 0.0000
191 L A -0.7762
192 D A -2.0300
193 H A -1.9317
194 S A -2.0389
195 G A -2.0040
196 P A -1.9511
197 H A 0.0000
198 K A -3.2812
199 E A -3.0647
200 A A 0.0000
201 E A 0.0000
202 Q A -3.0464
203 Y A -2.0082
204 I A 0.0000
205 A A 0.0000
206 R A -2.6883
207 V A 0.0000
208 F A 0.0000
209 N A -1.6116
210 A A -1.9686
211 D A -2.4320
212 R A -2.9869
213 S A 0.0000
214 Y A 0.0000
215 M A 0.0000
216 V A 0.0000
217 T A 0.0000
218 N A -1.7047
219 G A -1.1951
220 T A 0.0000
221 S A -0.8404
222 T A 0.0000
223 A A 0.0000
224 N A 0.0000
225 K A 0.0184
226 I A 0.0000
227 V A 0.0000
228 G A 0.0000
229 M A 0.2523
230 Y A -0.1209
231 S A 0.0109
232 A A 0.0000
233 P A -0.4167
234 A A -0.6812
235 G A -0.9969
236 S A 0.0000
237 T A 0.0000
238 I A 0.0000
239 L A 0.0000
240 I A 0.0000
241 D A 0.0000
242 R A 0.0000
243 N A -0.6863
244 C A 0.0000
245 H A -1.4207
246 K A -1.2781
247 S A 0.0000
248 L A 0.0000
249 T A 0.0000
250 H A -0.4201
251 L A 0.0000
252 M A 0.0000
253 M A 0.2781
254 M A 0.4499
255 S A -0.2377
256 D A -0.9601
257 V A 0.0000
258 T A 0.0000
259 P A 0.0000
260 I A 0.0000
261 Y A 0.0000
262 F A 0.0000
263 R A -1.5842
264 P A 0.0000
265 T A -0.6402
266 R A 0.0000
267 N A 0.0000
268 A A -0.8975
269 Y A -0.0623
270 G A -0.1276
271 I A 0.0000
272 L A 0.0000
273 G A 0.0000
274 G A 0.0000
275 I A 0.0000
276 P A -0.9506
277 Q A -0.6707
278 S A -0.9629
279 E A -1.0018
280 F A 0.0000
281 Q A -1.6131
282 H A -1.7276
283 A A -1.0858
284 T A -1.1537
285 I A 0.0000
286 A A -1.7829
287 K A -2.9383
288 R A -2.1913
289 V A -2.0217
290 K A -3.3465
291 E A -3.3217
292 T A -2.0650
293 P A -1.4618
294 N A -1.8892
295 A A -1.3256
296 T A -0.5052
297 W A 0.0594
298 P A 0.0000
299 V A -0.2932
300 H A 0.0000
301 A A 0.0000
302 V A 0.0000
303 I A 0.0000
304 T A -0.1102
305 N A 0.0000
306 S A 0.0000
307 T A 0.0000
308 Y A 0.2737
309 D A 0.0000
310 G A 0.0000
311 L A 0.0000
312 L A 0.0000
313 Y A 0.0000
314 N A -1.4617
315 T A 0.0000
316 D A -2.4714
317 F A -1.4822
318 I A 0.0000
319 K A 0.0000
320 K A -2.4795
321 T A 0.0000
322 L A 0.0000
323 D A -2.1086
324 V A 0.0000
325 K A -2.2667
326 S A 0.0000
327 I A 0.0000
328 H A 0.0000
329 F A 0.0000
330 D A 0.0000
331 S A 0.0000
332 A A -0.0039
333 W A 0.3626
334 V A 0.0000
335 P A 0.0000
336 Y A 0.0000
337 T A 0.0000
338 N A -1.0708
339 F A 0.0000
340 S A 0.0000
341 P A -1.2051
342 I A -0.8999
343 Y A 0.0000
344 E A -2.3492
345 G A -1.7355
346 K A -1.3008
347 C A 0.0000
348 G A 0.0000
349 M A 0.0000
350 S A -1.6547
351 G A -1.7329
352 G A -1.7706
353 R A -2.6914
354 V A -2.4592
355 E A -3.0382
356 G A -2.3995
357 K A -2.2830
358 V A -1.4294
359 I A 0.0000
360 Y A 0.0000
361 E A 0.0000
362 T A 0.0000
363 Q A 0.0000
364 S A -0.2974
365 T A 0.0000
366 H A -0.3092
368 L A 0.0508
369 L A 0.0000
370 A A 0.2498
371 A A 0.5434
372 F A 1.4622
373 S A -0.0392
374 Q A -1.0638
375 A A 0.0000
376 S A 0.0000
377 M A 0.0000
378 I A 0.0000
379 H A 0.0000
380 V A 0.0000
381 K A 0.0000
382 G A 0.0000
383 D A -2.9724
384 V A -2.3343
385 N A -3.0400
386 E A -4.0780
387 E A -3.6374
388 T A -2.4609
389 F A 0.0000
390 N A -2.2662
391 E A -2.1001
392 A A 0.0000
393 Y A 0.0000
394 M A 0.1037
395 M A 0.6763
396 H A 0.0360
397 T A -0.0679
398 T A -0.1545
399 T A 0.1942
400 S A -0.0600
401 P A 0.0000
402 H A -0.9183
403 Y A 0.0000
404 G A 0.0936
405 I A 0.1188
406 V A 0.0000
407 A A 0.0000
408 S A 0.0000
409 T A 0.0000
410 E A 0.0000
411 T A 0.1007
412 A A 0.0000
413 A A 0.0000
414 A A 0.0969
415 M A 0.0581
416 M A 0.0000
417 K A -1.5490
418 G A -1.4992
419 N A -2.1355
420 A A -1.6145
421 G A 0.0000
422 K A -2.6465
423 R A -2.5771
424 L A -1.1189
425 I A 0.0000
426 N A -2.0214
427 G A -1.5948
428 S A 0.0000
429 I A 0.0000
430 E A -2.2729
431 R A -1.5714
432 A A 0.0000
433 I A 0.0000
434 K A -1.3204
435 F A 0.0000
436 R A 0.0000
437 K A -2.1038
438 E A 0.0000
439 I A 0.0000
440 K A -1.6868
441 R A -1.8740
442 L A 0.0000
443 R A -2.1535
444 T A -1.6921
445 E A -2.3097
446 S A -2.1374
447 D A -2.4317
448 G A -1.7230
449 W A -0.7544
450 F A 0.0000
451 F A 0.0000
452 D A -0.6201
453 V A 0.0000
454 W A 0.0000
455 Q A 0.0000
456 P A 0.3316
457 Y A 0.9883 mutated: DA457Y
458 H A -0.0606
459 I A 0.2313
460 Y A 0.9336 mutated: DA460Y
461 T A 0.2646
462 T A -0.4818
463 E A -0.6463
464 C A 0.0000
465 W A 0.0000
466 P A -1.1889
467 L A 0.0000
468 R A -1.8557
469 S A -1.3687
470 Y A 0.5599 mutated: DA470Y
471 S A 0.0000
472 T A -0.7007
473 W A -0.1114
474 H A 0.0000
475 G A -1.5404
476 F A 0.0000
477 K A -2.4765
478 N A -2.3434
479 I A -1.9191
480 D A -2.2133
481 N A -2.4910
482 E A -2.6281
483 H A 0.0000
484 M A 0.0000
485 Y A 0.0000
486 L A 0.0000
487 D A 0.0000
488 P A 0.0000
489 I A 0.0000
490 K A 0.0000
491 V A 0.0000
492 T A 0.0000
493 L A 0.0000
494 L A 0.0511
495 T A 0.0000
496 P A -0.2456
497 G A 0.0000
498 M A -1.4594
499 E A -3.3318
500 K A -3.4918
501 D A -3.3339
502 G A -2.4095
503 T A -1.9306
504 M A -1.1564
505 S A -1.2082
506 D A -1.6935
507 F A -0.2924
508 G A 0.0000
509 I A 0.0000
510 P A 0.0000
511 A A 0.0000
512 S A -0.1059
513 I A 0.0000
514 V A 0.0000
515 A A -0.5689
516 K A -1.0389
517 Y A 0.0000
518 L A 0.0000
519 D A -2.0023
520 E A -1.8391
521 H A -1.7855
522 G A -1.1784
523 I A -0.3696
524 V A 0.8526
525 V A 0.2041
526 E A -0.5099
527 K A -0.3845
528 T A -0.2981
529 G A -0.0066
530 P A 0.0000
531 Y A 0.0000
532 N A 0.0000
533 L A 0.0000
534 L A 0.0000
535 F A 0.0000
536 L A 0.1550
537 F A 0.0000
538 S A 0.1973
539 I A 0.2214
540 G A -0.2364
541 I A -0.2686
542 D A -1.0703
543 K A -0.9383
544 T A -0.9794
545 K A -1.3516
546 A A 0.0000
547 L A 0.0000
548 S A -0.5757
549 L A 0.0000
550 L A 0.0000
551 R A 0.0000
552 A A 0.0000
553 L A 0.0000
554 T A 0.0000
555 D A -0.9707
556 F A 0.0000
557 K A 0.0000
558 R A -1.2663
559 A A 0.0000
560 F A 0.0000
561 D A -0.9464
562 L A 0.3978
563 N A -0.5425
564 L A -0.6793
565 R A -2.0791
566 V A 0.0000
567 K A -2.4139
568 N A -2.0049
569 M A 0.0000
570 L A 0.0000
571 P A -1.7332
572 S A -1.9808
573 L A 0.0000
574 Y A -2.6032
575 R A -3.3528
576 E A -3.1958
577 D A -2.5510
578 P A -2.6124
579 E A -2.5073
580 F A -1.0719
581 Y A 0.0000
582 E A -2.4669
583 N A -2.1761
584 M A -1.7965
585 R A -2.1383
586 I A 0.0000
587 Q A -1.8041
588 E A -2.2734
589 L A 0.0000
590 A A 0.0000
591 Q A -2.1608
592 N A -1.6475
593 I A -0.8285
594 H A 0.0000
595 K A -1.2588
596 L A -0.8687
597 I A 0.0000
598 V A -0.7775
599 H A -1.0853
600 H A -1.2926
601 N A -1.5063
602 L A 0.0000
603 P A 0.0000
604 D A -2.2330
605 L A -1.5751
606 M A 0.0000
607 Y A -1.0107
608 R A -2.2340
609 A A 0.0000
610 F A -0.4044
611 E A -0.8186
612 V A -0.3786
613 L A 0.3022
614 P A 0.0000
615 T A 0.3590
616 M A 0.7980
617 V A 1.1535
618 M A 0.8168
619 T A 0.2795
620 P A 0.0000
621 Y A 0.0355
622 A A 0.0697
623 A A 0.0000
624 F A 0.1954
625 Q A -0.3517
626 K A -1.1322
627 E A -0.9517
628 L A 0.3774
629 H A -0.8893
630 G A -0.9906
631 M A -1.2377
632 T A -1.7675
633 E A -2.3845
634 E A -2.2919
635 V A -1.5647
636 Y A -1.6332
637 L A 0.0000
638 D A -2.7574
639 E A -2.4695
640 M A 0.0000
641 V A -1.0261
642 G A -0.6721
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32 Q B -1.3228
33 I B 0.0000
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35 Y B -0.0165
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39 R B -2.5260
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60 D B -1.1695
61 K B -1.4129
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100 I B -0.2210
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119 Q B -3.3117
120 T B -2.5731
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126 N B -0.9805
127 T B -0.4314
128 I B 0.5105
129 L B 0.6651
130 P B 0.0000
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132 L B 0.0000
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140 V B -2.0169
141 R B -3.1418
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143 G B -2.2128
144 K B -2.0764
145 Y B 0.2585
146 T B 0.8517
147 F B 2.0879
148 C B 1.3067
149 T B 0.4322
150 P B -0.2806
151 G B -0.0996
152 H B -0.3765
153 M B 0.3487
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155 G B 0.0000
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164 G B 1.1695
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166 L B 2.6635
167 F B 2.7689
168 Y B 1.3638
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170 F B 2.4437
171 F B 1.7826
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178 S B -1.1507
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180 I B 0.0000
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182 I B 1.2423
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187 L B 0.0000
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219 G B 0.0000
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222 T B 0.0000
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225 K B 0.0270
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227 V B 0.0000
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229 M B 0.2538
230 Y B -0.1325
231 S B -0.0144
232 A B 0.0000
233 P B -0.4550
234 A B -0.7844
235 G B -1.0898
236 S B 0.0000
237 T B 0.0000
238 I B 0.0000
239 L B 0.0000
240 I B 0.0000
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242 R B 0.0000
243 N B -0.4813
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245 H B -1.0804
246 K B -1.1642
247 S B 0.0000
248 L B 0.0000
249 T B 0.0000
250 H B -0.3641
251 L B 0.0000
252 M B 0.0000
253 M B 0.3037
254 M B 0.5005
255 S B 0.0000
256 D B -1.2057
257 V B 0.0000
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259 P B 0.0000
260 I B 0.0000
261 Y B 0.0000
262 F B 0.0000
263 R B -0.9907
264 P B -0.6921
265 T B -0.6726
266 R B 0.0000
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270 G B -0.0969
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276 P B -0.8250
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292 T B -2.1372
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297 W B 0.0064
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299 V B -0.2775
300 H B 0.0000
301 A B 0.0000
302 V B 0.0000
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304 T B 0.0000
305 N B 0.0000
306 S B 0.0000
307 T B 0.0000
308 Y B 0.2554
309 D B 0.0000
310 G B 0.0000
311 L B 0.0000
312 L B 0.0000
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314 N B -1.4069
315 T B 0.0000
316 D B -2.4658
317 F B -1.5186
318 I B 0.0000
319 K B 0.0000
320 K B -2.4463
321 T B -1.7287
322 L B 0.0000
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324 V B 0.0000
325 K B -2.3298
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328 H B 0.0000
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330 D B 0.0000
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335 P B 0.0000
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341 P B -1.3707
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345 G B -1.6938
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348 G B 0.0000
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351 G B -1.7822
352 G B -1.8775
353 R B -2.8691
354 V B -2.5609
355 E B -3.1027
356 G B -2.4652
357 K B -2.4075
358 V B 0.0000
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360 Y B 0.0000
361 E B 0.0000
362 T B 0.0000
363 Q B 0.0000
364 S B -0.3083
365 T B 0.0000
366 H B -0.1212
368 L B 0.1276
369 L B 0.0000
370 A B 0.3223
371 A B 0.6169
372 F B 1.5148
373 S B 0.0052
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375 A B 0.0000
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377 M B 0.0000
378 I B 0.0000
379 H B 0.0000
380 V B 0.0000
381 K B 0.0000
382 G B 0.0000
383 D B -3.0561
384 V B -2.3928
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386 E B -4.0664
387 E B -3.6217
388 T B -2.4807
389 F B 0.0000
390 N B -2.3229
391 E B -2.1422
392 A B 0.0000
393 Y B 0.0000
394 M B 0.0106
395 M B 0.6351
396 H B 0.0093
397 T B -0.1206
398 T B -0.1564
399 T B 0.1464
400 S B -0.1147
401 P B 0.0000
402 H B -0.9196
403 Y B 0.0000
404 G B 0.1052
405 I B 0.1387
406 V B 0.0000
407 A B 0.0000
408 S B 0.0000
409 T B 0.0000
410 E B 0.0000
411 T B 0.1268
412 A B 0.0000
413 A B 0.0000
414 A B 0.1588
415 M B 0.2031
416 M B 0.0000
417 K B -1.2095
418 G B -1.1895
419 N B -1.5562
420 A B -1.3142
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423 R B -2.0298
424 L B -0.7702
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427 G B -1.4304
428 S B 0.0000
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430 E B -2.2333
431 R B -1.5611
432 A B 0.0000
433 I B -1.0156
434 K B -1.2466
435 F B 0.0000
436 R B 0.0000
437 K B -2.2578
438 E B 0.0000
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440 K B -2.3584
441 R B -2.1231
442 L B 0.0000
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444 T B -1.8161
445 E B -2.3211
446 S B -2.1069
447 D B -2.3968
448 G B -1.7324
449 W B -0.7809
450 F B 0.0000
451 F B 0.0000
452 D B -0.8548
453 V B 0.0000
454 W B 0.0000
455 Q B 0.0000
456 P B 0.0453
457 Y B 0.4867 mutated: DB457Y
458 H B -0.4441
459 I B 0.0000
460 Y B 0.7638 mutated: DB460Y
461 T B 0.0739
462 T B -0.8074
463 E B -1.3131
464 C B 0.0000
465 W B 0.0000
466 P B -1.3622
467 L B 0.0000
468 R B -2.1585
469 S B -1.4948
470 Y B 0.4456 mutated: DB470Y
471 S B -0.0528
472 T B -0.7065
473 W B -0.1223
474 H B 0.0000
475 G B -1.2264
476 F B 0.0000
477 K B -2.3973
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480 D B -2.2221
481 N B -2.4611
482 E B -2.6522
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484 M B 0.0000
485 Y B 0.0000
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488 P B 0.0000
489 I B 0.0000
490 K B 0.0000
491 V B 0.0000
492 T B 0.0000
493 L B 0.0000
494 L B 0.0147
495 T B 0.0000
496 P B -0.2350
497 G B 0.0000
498 M B -1.4289
499 E B -3.2196
500 K B -3.3715
501 D B -3.2463
502 G B -2.1918
503 T B -1.7750
504 M B -1.3627
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506 D B -1.8625
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510 P B 0.0000
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512 S B -0.1906
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516 K B -1.0844
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519 D B -2.0307
520 E B -1.8326
521 H B -1.7780
522 G B -1.1721
523 I B -0.3354
524 V B 0.8220
525 V B 0.1358
526 E B -0.5800
527 K B -0.3989
528 T B -0.2851
529 G B 0.0158
530 P B 0.0700
531 Y B 0.0000
532 N B 0.0000
533 L B 0.0000
534 L B 0.0000
535 F B 0.0000
536 L B 0.1949
537 F B 0.0000
538 S B 0.2345
539 I B 0.2519
540 G B -0.1950
541 I B -0.2137
542 D B -1.0707
543 K B -0.9146
544 T B -0.9628
545 K B -1.2396
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550 L B 0.0000
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552 A B 0.0000
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562 L B -0.2168
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564 L B -0.7380
565 R B -1.8291
566 V B 0.0000
567 K B -2.2137
568 N B -1.8693
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570 L B 0.0000
571 P B -1.6384
572 S B -1.9513
573 L B 0.0000
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575 R B -3.2636
576 E B -3.1571
577 D B -2.4463
578 P B -2.4972
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580 F B -0.9959
581 Y B 0.0000
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583 N B -2.0418
584 M B -1.6018
585 R B -1.9537
586 I B 0.0000
587 Q B -1.7356
588 E B -2.0576
589 L B 0.0000
590 A B 0.0000
591 Q B -2.3785
592 N B -1.9003
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594 H B 0.0000
595 K B -2.5471
596 L B -1.6064
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599 H B -1.7050
600 H B -1.6585
601 N B -2.0092
602 L B 0.0000
603 P B 0.0000
604 D B -1.8205
605 L B -1.2921
606 M B 0.0000
607 Y B -0.9497
608 R B -1.9960
609 A B 0.0000
610 F B 0.0000
611 E B -1.5361
612 V B -0.6257
613 L B 0.1043
614 P B 0.0000
615 T B 0.3530
616 M B 0.8075
617 V B 1.1080
618 M B 0.8320
619 T B 0.2411
620 P B 0.0000
621 Y B 0.0539
622 A B 0.0992
623 A B 0.0000
624 F B 0.3332
625 Q B -0.1742
626 K B -0.9659
627 E B -0.6864
628 L B 0.5167
629 H B -0.7585
630 G B -0.7851
631 M B -1.0004
632 T B -1.5528
633 E B -2.2545
634 E B -2.2368
635 V B -1.5503
636 Y B -1.2201
637 L B 0.0000
638 D B -2.0092
639 E B -2.1314
640 M B 0.0000
641 V B -0.9540
642 G B -0.6295
643 R B -0.7358
644 I B -0.0512
645 N B 0.0000
646 A B 0.0000
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648 M B 0.0000
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650 L B -0.4243
651 P B 0.0000
652 Y B 0.0576
653 P B 0.1178
654 P B 0.0000
655 G B -0.0729
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658 L B 0.0000
659 V B 0.0000
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661 P B 0.0000
662 G B 0.0000
663 E B 0.0000
664 M B 0.5434
665 I B 0.0000
666 T B -1.6250
667 E B -2.9724
668 E B -2.7582
669 S B 0.0000
670 R B -2.1433
671 P B -1.6691
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673 L B 0.0000
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675 F B 0.0000
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678 M B 0.0000
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680 C B -1.9361
681 E B -2.1338
682 I B -1.0364
683 G B -1.3387
684 A B -1.1504
685 H B -0.9327
686 Y B -0.3357
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689 F B -0.7813
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691 T B -1.8971
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693 I B 0.0000
694 H B -1.1934
695 G B -0.9060
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699 Q B -2.1829
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710 K B -2.6339
711 E B -2.4301
1 M C -0.5072
2 N C -1.2147
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5 A C 0.0000
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7 L C 0.0000
8 N C -1.2539
9 H C -1.3880
10 M C -0.5679
11 G C -0.5705
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20 R C -1.5875
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22 L C 0.0000
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25 A C 0.0000
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27 E C -3.6435
28 R C -3.5149
29 L C -2.3397
30 N C -2.6841
31 F C 0.0000
32 Q C -1.4358
33 I C 0.0000
34 V C 0.0000
35 Y C 0.0238
36 P C 0.0000
37 N C -2.1628
38 D C -2.4798
39 R C -2.4163
40 D C -2.5874
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45 L C 0.0000
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48 N C -1.6752
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50 A C -1.0549
51 R C -1.5380
52 L C 0.0000
53 C C 0.0000
54 G C 0.0000
55 V C 0.0000
56 I C 0.0000
57 F C 0.0000
58 D C 0.0000
59 W C 0.0000
60 D C -1.7702
61 K C -1.8362
62 Y C -1.1818
63 N C 0.0000
64 L C -0.2583
65 E C -1.9627
66 L C 0.0000
67 C C 0.0000
68 E C -2.9612
69 E C -2.2864
70 I C 0.0000
71 S C -2.2742
72 K C -2.8288
73 M C -1.9978
74 N C -1.5317
75 E C -1.6009
76 N C -0.6773
77 L C 0.0000
78 P C 0.0000
79 L C 0.0000
80 Y C 0.0000
81 A C 0.0000
82 F C 0.0000
83 A C 0.0000
84 N C -0.4814
85 T C 0.1804
86 Y C 0.8649
87 S C 0.0000
88 T C -0.1810
89 L C 0.0000
90 D C -0.6060
91 V C -0.9875
92 S C -0.7699
93 L C 0.0000
94 N C -1.5338
95 D C -2.3844
96 L C -2.3762
97 R C -2.6829
98 L C -1.5282
99 Q C -0.6000
100 I C -0.0394
101 S C -0.1843
102 F C 0.0000
103 F C -0.3971
104 E C -0.7807
105 Y C 0.0000
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107 L C 0.0000
108 G C -1.2677
109 A C -1.3759
110 A C 0.0000
111 E C -3.5928
112 D C -3.3985
113 I C 0.0000
114 A C 0.0000
115 N C -3.0206
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