Project name: 10%_pro_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1398
• Maximal score value: 1.9825
• Average score: -0.7602
• Total score value: -327.6476

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6476
3	E	A	-2.4655
4	L	A	0.0000
5	T	A	-1.3787
6	Q	A	-1.6228
7	D	A	-2.2545
8	P	A	-1.6716
9	A	A	0.0000
10	V	A	-0.6137
11	S	A	-0.0742
12	V	A	-0.1780
13	A	A	0.0581
14	L	A	-0.2489
15	G	A	-0.9096
16	Q	A	-1.3144
17	T	A	-1.1882
18	V	A	0.0000
19	R	A	-1.8144
20	V	A	0.0000
21	T	A	-1.0891
22	C	A	0.0000
23	Q	A	-2.0073
24	G	A	-2.4161
25	D	A	-3.1398
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.8448
29	S	A	-1.4018
30	Y	A	-0.9131
31	Y	A	-0.7240
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	-0.2624
37	Q	A	0.0000
38	K	A	-1.3761
39	P	A	-1.3568
40	G	A	-1.3088
41	Q	A	-1.6528
42	A	A	-0.9402
43	P	A	-0.1367
44	V	A	1.1327
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.3008
49	G	A	0.0000
50	K	A	-2.7234
51	N	A	-2.6241
52	N	A	-2.6686
53	R	A	-2.1648
54	P	A	-0.7751
55	S	A	-0.6902
56	G	A	-0.7609
57	I	A	-0.5583
58	P	A	-1.3040
59	D	A	-2.1890
60	R	A	-1.3794
61	F	A	0.0000
62	S	A	-1.3987
63	G	A	-1.2253
64	S	A	-0.8085
65	S	A	-1.0912
66	S	A	-1.0559
67	G	A	-1.9374
68	N	A	-2.2651
69	T	A	-1.4724
70	A	A	0.0000
71	S	A	-0.7473
72	L	A	0.0000
73	T	A	-1.1491
74	I	A	0.0000
75	T	A	-1.2871
76	G	A	-0.9662
77	A	A	0.0000
78	Q	A	-1.5563
79	A	A	0.0000
80	E	A	-2.6584
81	D	A	0.0000
82	E	A	-1.8609
83	A	A	0.0000
84	D	A	-1.7939
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.5241
89	S	A	0.0000
90	R	A	-0.6481
91	D	A	-1.3004
92	S	A	-1.4551
93	S	A	-0.7162
94	G	A	-0.5329
95	N	A	-0.9063
96	H	A	-0.7376
97	W	A	0.0000
98	V	A	0.0000
99	F	A	-0.9780
100	G	A	0.0000
101	G	A	-1.8239
102	G	A	-1.5063
103	T	A	0.0000
104	E	A	-2.4003
105	L	A	0.0000
106	T	A	-0.2985
107	V	A	0.0000
108	L	A	0.8114
109	G	A	-0.2203
110	Q	A	0.0000
111	P	A	-0.9651
112	K	A	-2.1768
113	A	A	-1.3394
114	A	A	-0.6932
115	P	A	-0.3434
116	S	A	-0.2297
117	V	A	-0.4234
118	T	A	-0.3625
119	L	A	0.0000
120	F	A	0.0000
121	P	A	-0.2198
122	P	A	-0.5297
123	S	A	-1.1999
124	S	A	-1.7309
125	E	A	-2.7178
126	E	A	0.0000
127	L	A	-2.2730
128	Q	A	-2.5233
129	A	A	-2.0903
130	N	A	-2.8463
131	K	A	-3.1276
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.5814
140	D	A	-1.1753
141	F	A	0.0000
142	Y	A	-1.2028
143	P	A	-1.0143
144	G	A	-0.9575
145	A	A	-0.3815
146	V	A	-0.1185
147	T	A	-0.0915
148	V	A	-0.0942
149	A	A	-0.3710
150	W	A	0.0000
151	K	A	-0.9172
152	A	A	0.0000
153	D	A	-1.3729
154	S	A	-0.8733
155	S	A	-0.5608
156	P	A	-0.7742
157	V	A	-0.6054
158	K	A	-1.4445
159	A	A	-0.6536
160	G	A	-0.3526
161	V	A	0.1057
162	E	A	0.0586
163	T	A	0.2830
164	T	A	0.0000
165	T	A	-0.1090
166	P	A	-0.3614
167	S	A	-0.6778
168	K	A	-1.2684
169	Q	A	-1.3848
170	S	A	-1.3418
171	N	A	-1.8484
172	N	A	-1.9134
173	K	A	-1.8762
174	Y	A	-0.9474
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.0164
181	S	A	-0.0230
182	L	A	0.0000
183	T	A	-2.0591
184	P	A	-2.5632
185	E	A	-3.1120
186	Q	A	-2.4062
187	W	A	0.0000
188	K	A	-3.0196
189	S	A	0.0000
190	H	A	-2.4209
191	R	A	-2.5622
192	S	A	-1.5986
193	Y	A	0.0000
194	S	A	0.0000
195	C	A	0.0000
196	Q	A	-1.0373
197	V	A	0.0000
198	T	A	-0.6608
199	H	A	0.0000
200	E	A	-2.2937
201	G	A	-1.4419
202	S	A	-0.8946
203	T	A	-0.7384
204	V	A	-0.7008
205	E	A	-2.1359
206	K	A	-1.7262
207	T	A	-1.0575
208	V	A	0.0000
209	A	A	-0.9893
210	P	A	-1.2534
2	V	A	1.0686
3	Q	A	-1.1262
4	L	A	0.0000
5	Q	A	-1.5605
6	Q	A	-1.3026
7	S	A	-1.0294
8	G	A	-0.8398
9	A	A	0.0000
10	E	A	-1.4084
11	V	A	-1.0409
12	K	A	-1.8352
13	K	A	-2.4894
14	P	A	-2.1925
15	G	A	-1.5922
16	S	A	-1.3055
17	S	A	-1.5172
18	V	A	0.0000
19	R	A	-2.4357
20	V	A	0.0000
21	S	A	-0.9783
22	C	A	0.0000
23	K	A	-1.4267
24	A	A	0.0000
25	S	A	-0.7186
26	G	A	-0.7663
27	G	A	-1.2717
28	T	A	-1.6201
29	F	A	0.0000
30	N	A	-2.0920
31	N	A	-1.9541
32	N	A	-1.7118
33	A	A	-0.9441
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-1.0103
39	Q	A	-1.0420
40	A	A	-1.2785
41	P	A	-1.1313
42	G	A	-1.2934
43	Q	A	-1.9109
44	G	A	-1.5635
45	L	A	0.0000
46	E	A	-2.1433
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.0000
52	I	A	0.2788
53	P	A	0.0000
54	M	A	0.1710
55	F	A	1.6557
56	G	A	0.5925
57	T	A	0.0968
58	A	A	-0.0053
59	K	A	-0.7059
60	Y	A	-0.6359
61	S	A	-1.4238
62	Q	A	-2.2306
63	N	A	-2.2304
64	F	A	-1.5248
65	Q	A	-2.1747
66	G	A	-1.6147
67	R	A	-1.3018
68	V	A	0.0000
69	A	A	-0.6974
70	I	A	0.0000
71	T	A	-0.3474
72	A	A	-0.6656
73	D	A	-1.9780
74	E	A	-2.3502
75	S	A	-1.4293
76	T	A	-1.2501
77	G	A	0.0000
78	T	A	-1.2572
79	A	A	0.0000
80	S	A	0.0000
81	M	A	0.0000
82	E	A	-1.8042
83	L	A	0.0000
84	S	A	-1.1946
85	S	A	-1.1577
86	L	A	0.0000
87	R	A	-2.8673
88	S	A	-2.3159
89	E	A	-2.5288
90	D	A	0.0000
91	T	A	-1.0396
92	A	A	0.0000
93	V	A	0.0120
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.9414
99	S	A	0.0000
100	R	A	-1.5734
101	D	A	-0.5191
102	L	A	0.5286
103	L	A	1.9710
104	L	A	1.9825
105	F	A	0.8743
106	P	A	0.1333
107	H	A	-0.9627
108	H	A	-1.1811
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.3904
112	P	A	-0.0781
113	W	A	-0.5705
114	G	A	-1.5257
115	R	A	-2.3954
116	G	A	0.0000
117	T	A	0.0000
118	M	A	0.0301
119	V	A	0.0000
120	T	A	0.0000
121	V	A	0.0000
122	S	A	-1.1399
123	S	A	-0.8904
124	A	A	-0.5225
125	S	A	-0.4750
126	T	A	-0.7039
127	K	A	-1.3808
128	G	A	-1.5778
129	P	A	0.0000
130	S	A	-0.7460
131	V	A	0.0000
132	F	A	-0.7573
133	P	A	-1.1842
134	L	A	0.0000
135	A	A	-0.7111
136	P	A	-0.8350
137	S	A	-0.7642
138	S	A	-1.2248
139	K	A	-2.0295
140	S	A	-1.3681
141	T	A	-0.8335
142	S	A	-0.8883
143	G	A	-0.8520
144	G	A	-1.1802
145	T	A	-0.8839
146	A	A	0.0000
147	A	A	0.0000
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.3096
154	D	A	-0.6399
155	Y	A	0.0000
156	F	A	-0.3309
157	P	A	0.0000
158	E	A	-0.5713
159	P	A	-0.6845
160	V	A	-0.6233
161	T	A	-0.6397
162	V	A	-0.2074
163	S	A	-0.4547
164	W	A	0.0000
165	N	A	-0.7208
166	S	A	-0.6483
167	G	A	-0.3817
168	A	A	-0.1899
169	L	A	0.0502
170	T	A	-0.1316
171	S	A	-0.2418
172	G	A	-0.3122
173	V	A	0.1164
174	H	A	-0.1531
175	T	A	-0.0176
176	F	A	0.0000
177	P	A	-0.1480
178	A	A	0.2888
179	V	A	0.7564
180	L	A	1.2229
181	Q	A	0.2531
182	S	A	-0.1605
183	S	A	-0.2704
184	G	A	-0.0054
185	L	A	0.0598
186	Y	A	0.3462
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.1658
192	V	A	0.0000
193	T	A	-0.2169
194	V	A	0.0000
195	P	A	-0.7032
196	S	A	-0.9348
197	S	A	-0.7871
198	S	A	-0.6323
199	L	A	-1.0365
200	G	A	-1.1521
201	T	A	-0.8586
202	Q	A	-1.6013
203	T	A	-1.2270
204	Y	A	0.0000
205	I	A	-1.2259
206	C	A	0.0000
207	N	A	-1.6123
208	V	A	0.0000
209	N	A	-2.0591
210	H	A	0.0000
211	K	A	-2.7793
212	P	A	-1.7719
213	S	A	-1.8433
214	N	A	-2.4073
215	T	A	-2.1463
216	K	A	-2.7574
217	V	A	-1.5486
218	D	A	-2.6198
219	K	A	-1.9353
220	K	A	-2.6077
221	V	A	0.0000
222	E	A	-2.4667
223	P	A	-1.4752