Chain sequence(s) |
A: VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR C: VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR B: VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH D: VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | V | A | 1.5271 | |
2 | L | A | 0.4956 | |
3 | S | A | 0.1032 | |
4 | P | A | -0.2427 | |
5 | A | A | -0.2807 | |
6 | D | A | 0.0000 | |
7 | K | A | -1.0389 | |
8 | T | A | -0.7688 | |
9 | N | A | -0.8770 | |
10 | V | A | 0.0000 | |
11 | K | A | -1.5966 | |
12 | A | A | -1.3174 | |
13 | A | A | 0.0000 | |
14 | W | A | 0.0000 | |
15 | G | A | -1.7811 | |
16 | K | A | -2.4103 | |
17 | V | A | 0.0000 | |
18 | G | A | -1.3702 | |
19 | A | A | -1.0409 | |
20 | H | A | -1.7990 | |
21 | A | A | -2.0980 | |
22 | G | A | -3.0728 | |
23 | E | A | -2.8613 | |
24 | Y | A | 0.0000 | |
25 | G | A | 0.0000 | |
26 | A | A | 0.0000 | |
27 | E | A | -1.2515 | |
28 | A | A | 0.0000 | |
29 | L | A | 0.0000 | |
30 | E | A | -0.6602 | |
31 | R | A | 0.0000 | |
32 | M | A | 0.0000 | |
33 | F | A | 0.0000 | |
34 | L | A | 0.3687 | |
35 | S | A | 0.1938 | |
36 | F | A | 0.2102 | |
37 | P | A | -0.2084 | |
38 | T | A | -0.3056 | |
39 | T | A | 0.0000 | |
40 | K | A | -0.4356 | |
41 | T | A | 0.0000 | |
42 | Y | A | 0.0639 | |
43 | F | A | -0.2296 | |
44 | P | A | -0.9610 | |
45 | H | A | -1.1161 | |
46 | F | A | -0.8332 | |
47 | D | A | -1.6339 | |
48 | L | A | -0.9196 | |
49 | S | A | -1.0809 | |
50 | H | A | -1.5979 | |
51 | G | A | -1.4433 | |
52 | S | A | 0.0000 | |
53 | A | A | -1.3987 | |
54 | Q | A | -1.7749 | |
55 | V | A | 0.0000 | |
56 | K | A | -3.3423 | |
57 | G | A | -2.6437 | |
58 | H | A | -2.2751 | |
59 | G | A | 0.0000 | |
60 | K | A | -4.0080 | |
61 | K | A | -3.3917 | |
62 | V | A | -1.9079 | |
63 | A | A | 0.0000 | |
64 | D | A | -3.0443 | |
65 | A | A | -1.7136 | |
66 | L | A | 0.0000 | |
67 | T | A | -1.5582 | |
68 | N | A | -1.5548 | |
69 | A | A | 0.0000 | |
70 | V | A | 0.0000 | |
71 | A | A | -1.1562 | |
72 | H | A | -1.9566 | |
73 | V | A | -1.7265 | |
74 | D | A | -2.7361 | |
75 | D | A | -2.7900 | |
76 | M | A | 0.0000 | |
77 | P | A | -1.4920 | |
78 | N | A | -2.0184 | |
79 | A | A | -1.5174 | |
80 | L | A | 0.0000 | |
81 | S | A | -0.7524 | |
82 | A | A | -0.3411 | |
83 | L | A | -0.1871 | |
84 | S | A | 0.0000 | |
85 | D | A | -1.6084 | |
86 | L | A | -0.8785 | |
87 | H | A | -0.8962 | |
88 | A | A | 0.0000 | |
89 | H | A | -2.2855 | |
90 | K | A | -2.2184 | |
91 | L | A | -0.8924 | |
92 | R | A | -1.0255 | |
93 | V | A | -0.0486 | |
94 | D | A | 0.0000 | |
95 | P | A | -0.0122 | |
96 | V | A | 0.2770 | |
97 | N | A | 0.0000 | |
98 | F | A | -0.1784 | |
99 | K | A | -1.0350 | |
100 | L | A | -0.0846 | |
101 | L | A | 0.0577 | |
102 | S | A | -0.3505 | |
103 | H | A | 0.0000 | |
104 | C | A | 0.0000 | |
105 | L | A | 0.0000 | |
106 | L | A | 0.0000 | |
107 | V | A | 0.0000 | |
108 | T | A | 0.0000 | |
109 | L | A | 0.0000 | |
110 | A | A | 0.0000 | |
111 | A | A | 0.0000 | |
112 | H | A | -1.1359 | |
113 | L | A | 0.0000 | |
114 | P | A | -0.6202 | |
115 | A | A | -0.3567 | |
116 | E | A | -0.9074 | |
117 | F | A | 0.0000 | |
118 | T | A | -0.2944 | |
119 | P | A | -0.3566 | |
120 | A | A | -0.3267 | |
121 | V | A | 0.0000 | |
122 | H | A | 0.0000 | |
123 | A | A | -0.1799 | |
124 | S | A | 0.0000 | |
125 | L | A | 0.0000 | |
126 | D | A | -0.2899 | |
127 | K | A | -0.1199 | |
128 | F | A | 0.0000 | |
129 | L | A | 0.0000 | |
130 | A | A | -0.3740 | |
131 | S | A | 0.2051 | |
132 | V | A | 0.0000 | |
133 | S | A | 0.0000 | |
134 | T | A | -0.1124 | |
135 | V | A | -0.3198 | |
136 | L | A | 0.0000 | |
137 | T | A | -0.4010 | |
138 | S | A | -0.3673 | |
139 | K | A | -0.9116 | |
140 | Y | A | 0.0000 | |
141 | R | A | -0.5266 | |
144 | V | B | -0.5451 | |
145 | H | B | -0.9372 | |
146 | L | B | -1.1914 | |
147 | T | B | -1.2223 | |
148 | P | B | -1.9191 | |
149 | E | B | -2.5196 | |
150 | E | B | -2.1194 | |
151 | K | B | -2.0429 | |
152 | S | B | -1.5747 | |
153 | A | B | -1.1254 | |
154 | V | B | 0.0000 | |
155 | T | B | -0.9310 | |
156 | A | B | -0.6493 | |
157 | L | B | 0.0000 | |
158 | W | B | -0.7352 | |
159 | G | B | -1.3310 | |
160 | K | B | -2.0436 | |
161 | V | B | 0.0000 | |
162 | N | B | -2.5135 | |
163 | V | B | -2.2226 | |
164 | D | B | -3.4432 | |
165 | E | B | -3.2515 | |
166 | V | B | 0.0000 | |
167 | G | B | 0.0000 | |
168 | G | B | 0.0000 | |
169 | E | B | -1.3664 | |
170 | A | B | 0.0000 | |
171 | L | B | 0.0000 | |
172 | G | B | 0.0000 | |
173 | R | B | 0.0000 | |
174 | L | B | 0.0000 | |
175 | L | B | 0.0000 | |
176 | V | B | -0.1134 | |
177 | V | B | 0.0000 | |
178 | Y | B | 0.0263 | |
179 | P | B | -0.3762 | |
180 | W | B | 0.0000 | |
181 | T | B | 0.0000 | |
182 | Q | B | -0.6080 | |
183 | R | B | -1.1580 | |
184 | F | B | -0.1472 | |
185 | F | B | -1.0576 | |
186 | E | B | -2.1133 | |
187 | S | B | -1.4414 | |
188 | F | B | -1.5355 | |
189 | G | B | -1.9970 | |
190 | D | B | -2.6982 | |
191 | L | B | -1.5028 | |
192 | S | B | -1.0817 | |
193 | T | B | -0.9549 | |
194 | P | B | -1.1697 | |
195 | D | B | -2.1486 | |
196 | A | B | -1.6572 | |
197 | V | B | 0.0000 | |
198 | M | B | -1.2045 | |
199 | G | B | -1.6999 | |
200 | N | B | -1.8663 | |
201 | P | B | -1.5572 | |
202 | K | B | -2.4002 | |
203 | V | B | 0.0000 | |
204 | K | B | -2.6531 | |
205 | A | B | -2.2713 | |
206 | H | B | -1.9290 | |
207 | G | B | 0.0000 | |
208 | K | B | -2.9860 | |
209 | K | B | -2.3600 | |
210 | V | B | -0.8571 | |
211 | L | B | 0.0000 | |
212 | G | B | -1.4701 | |
213 | A | B | -1.0232 | |
214 | F | B | 0.0000 | |
215 | S | B | -1.0352 | |
216 | D | B | -1.9416 | |
217 | G | B | 0.0000 | |
218 | L | B | -1.1374 | |
219 | A | B | -1.2420 | |
220 | H | B | -2.1145 | |
221 | L | B | 0.0000 | |
222 | D | B | -2.6724 | |
223 | N | B | -2.7111 | |
224 | L | B | 0.0000 | |
225 | K | B | -2.4823 | |
226 | G | B | -1.7671 | |
227 | T | B | -1.5768 | |
228 | F | B | 0.0000 | |
229 | A | B | -0.9564 | |
230 | T | B | -0.5321 | |
231 | L | B | -0.1360 | |
232 | S | B | 0.0000 | |
233 | E | B | -2.2389 | |
234 | L | B | -1.0865 | |
235 | H | B | -0.9572 | |
236 | C | B | 0.0000 | |
237 | D | B | -3.0040 | |
238 | K | B | -2.4608 | |
239 | L | B | -0.7518 | |
240 | H | B | -0.9664 | |
241 | V | B | -0.2689 | |
242 | D | B | 0.0000 | |
243 | P | B | -0.7313 | |
244 | E | B | -0.9340 | |
245 | N | B | 0.0000 | |
246 | F | B | -0.6968 | |
247 | R | B | -1.5865 | |
248 | L | B | -0.5058 | |
249 | L | B | -0.1860 | |
250 | G | B | 0.0000 | |
251 | N | B | -0.4601 | |
252 | V | B | 0.0000 | |
253 | L | B | 0.0000 | |
254 | V | B | 0.0000 | |
255 | C | B | 0.0000 | |
256 | V | B | 0.0000 | |
257 | L | B | 0.0000 | |
258 | A | B | 0.0000 | |
259 | H | B | -1.0199 | |
260 | H | B | -1.5900 | |
261 | F | B | -1.6806 | |
262 | G | B | -1.8684 | |
263 | K | B | -2.7932 | |
264 | E | B | -2.7473 | |
265 | F | B | 0.0000 | |
266 | T | B | -1.1686 | |
267 | P | B | -0.5408 | |
268 | P | B | -0.1828 | |
269 | V | B | 0.0000 | |
270 | Q | B | 0.0000 | |
271 | A | B | 0.0000 | |
272 | A | B | 0.0000 | |
273 | Y | B | 0.0000 | |
274 | Q | B | 0.0000 | |
275 | K | B | -0.6372 | |
276 | V | B | 0.0000 | |
277 | V | B | 0.0000 | |
278 | A | B | -0.7094 | |
279 | G | B | 0.0000 | |
280 | V | B | 0.0000 | |
281 | A | B | 0.0000 | |
282 | N | B | -1.7889 | |
283 | A | B | 0.0000 | |
284 | L | B | -0.9619 | |
285 | A | B | -1.4607 | |
286 | H | B | -1.9359 | |
287 | K | B | -1.9148 | |
288 | Y | B | -1.4890 | |
289 | H | B | -1.5476 | |
401 | V | C | 1.4930 | |
402 | L | C | 0.5178 | |
403 | S | C | 0.1316 | |
404 | P | C | -0.2468 | |
405 | A | C | -0.4358 | |
406 | D | C | 0.0000 | |
407 | K | C | -1.0054 | |
408 | T | C | -0.9573 | |
409 | N | C | -0.9344 | |
410 | V | C | 0.0000 | |
411 | K | C | -2.1030 | |
412 | A | C | -1.4824 | |
413 | A | C | 0.0000 | |
414 | W | C | 0.0000 | |
415 | G | C | -1.8229 | |
416 | K | C | -2.3965 | |
417 | V | C | 0.0000 | |
418 | G | C | -1.1916 | |
419 | A | C | -0.9208 | |
420 | H | C | -1.7195 | |
421 | A | C | -2.0048 | |
422 | G | C | -2.7546 | |
423 | E | C | -2.6256 | |
424 | Y | C | 0.0000 | |
425 | G | C | 0.0000 | |
426 | A | C | -1.9701 | |
427 | E | C | -1.1246 | |
428 | A | C | 0.0000 | |
429 | L | C | 0.0000 | |
430 | E | C | -0.6207 | |
431 | R | C | 0.0000 | |
432 | M | C | 0.0000 | |
433 | F | C | 0.0000 | |
434 | L | C | 0.4834 | |
435 | S | C | 0.2810 | |
436 | F | C | 0.2611 | |
437 | P | C | -0.1374 | |
438 | T | C | -0.2461 | |
439 | T | C | 0.0000 | |
440 | K | C | -0.2845 | |
441 | T | C | 0.0000 | |
442 | Y | C | 0.1113 | |
443 | F | C | -0.2493 | |
444 | P | C | -1.0338 | |
445 | H | C | -1.1906 | |
446 | F | C | -0.9885 | |
447 | D | C | -1.9055 | |
448 | L | C | -1.1083 | |
449 | S | C | -1.1851 | |
450 | H | C | -1.5987 | |
451 | G | C | -1.4355 | |
452 | S | C | 0.0000 | |
453 | A | C | -1.1754 | |
454 | Q | C | -1.5366 | |
455 | V | C | 0.0000 | |
456 | K | C | -2.6687 | |
457 | G | C | -2.0902 | |
458 | H | C | -1.9666 | |
459 | G | C | 0.0000 | |
460 | K | C | -3.6001 | |
461 | K | C | -3.1753 | |
462 | V | C | -1.6309 | |
463 | A | C | 0.0000 | |
464 | D | C | -3.0362 | |
465 | A | C | -1.7218 | |
466 | L | C | -1.1844 | |
467 | T | C | -1.6428 | |
468 | N | C | -1.7819 | |
469 | A | C | 0.0000 | |
470 | V | C | 0.0000 | |
471 | A | C | -1.4354 | |
472 | H | C | -2.2503 | |
473 | V | C | -1.9805 | |
474 | D | C | -2.9616 | |
475 | D | C | -3.2436 | |
476 | M | C | 0.0000 | |
477 | P | C | -1.7406 | |
478 | N | C | -2.1740 | |
479 | A | C | -1.6860 | |
480 | L | C | 0.0000 | |
481 | S | C | -0.6021 | |
482 | A | C | -0.1184 | |
483 | L | C | -0.0187 | |
484 | S | C | 0.0000 | |
485 | D | C | -1.0001 | |
486 | L | C | -0.3812 | |
487 | H | C | -0.6297 | |
488 | A | C | 0.0000 | |
489 | H | C | -1.8302 | |
490 | K | C | -1.8861 | |
491 | L | C | -0.4977 | |
492 | R | C | -0.9122 | |
493 | V | C | -0.0374 | |
494 | D | C | 0.0000 | |
495 | P | C | -0.2150 | |
496 | V | C | -0.0146 | |
497 | N | C | 0.0000 | |
498 | F | C | -0.2745 | |
499 | K | C | -1.2672 | |
500 | L | C | -0.1531 | |
501 | L | C | 0.1748 | |
502 | S | C | -0.3358 | |
503 | H | C | 0.0000 | |
504 | C | C | 0.0000 | |
505 | L | C | 0.0000 | |
506 | L | C | 0.0000 | |
507 | V | C | 0.0000 | |
508 | T | C | 0.0000 | |
509 | L | C | 0.0000 | |
510 | A | C | 0.0000 | |
511 | A | C | -1.0406 | |
512 | H | C | -1.1441 | |
513 | L | C | 0.0000 | |
514 | P | C | -0.5724 | |
515 | A | C | -0.3403 | |
516 | E | C | -0.7312 | |
517 | F | C | 0.0000 | |
518 | T | C | -0.1819 | |
519 | P | C | -0.2474 | |
520 | A | C | -0.2317 | |
521 | V | C | -0.0557 | |
522 | H | C | 0.0000 | |
523 | A | C | -0.0952 | |
524 | S | C | 0.0000 | |
525 | L | C | 0.0000 | |
526 | D | C | -0.3977 | |
527 | K | C | -0.0215 | |
528 | F | C | 0.0000 | |
529 | L | C | 0.0000 | |
530 | A | C | -0.1992 | |
531 | S | C | 0.2633 | |
532 | V | C | 0.0000 | |
533 | S | C | -0.2354 | |
534 | T | C | -0.1406 | |
535 | V | C | -0.2882 | |
536 | L | C | 0.0000 | |
537 | T | C | -0.3357 | |
538 | S | C | -0.4316 | |
539 | K | C | -0.8186 | |
540 | Y | C | 0.0000 | |
541 | R | C | -0.6485 | |
544 | V | D | 0.1311 | |
545 | H | D | -0.7601 | |
546 | L | D | -1.0546 | |
547 | T | D | -1.2783 | |
548 | P | D | -1.8689 | |
549 | E | D | -2.5342 | |
550 | E | D | -2.0689 | |
551 | K | D | -2.0701 | |
552 | S | D | -1.5286 | |
553 | A | D | -1.0088 | |
554 | V | D | 0.0000 | |
555 | T | D | -0.9165 | |
556 | A | D | -0.6582 | |
557 | L | D | 0.0000 | |
558 | W | D | -0.7022 | |
559 | G | D | -1.3145 | |
560 | K | D | -2.0009 | |
561 | V | D | -1.6873 | |
562 | N | D | -2.6559 | |
563 | V | D | -2.2535 | |
564 | D | D | -3.4740 | |
565 | E | D | -3.2430 | |
566 | V | D | 0.0000 | |
567 | G | D | 0.0000 | |
568 | G | D | 0.0000 | |
569 | E | D | -1.2179 | |
570 | A | D | 0.0000 | |
571 | L | D | 0.0000 | |
572 | G | D | 0.0000 | |
573 | R | D | 0.0000 | |
574 | L | D | 0.0000 | |
575 | L | D | 0.0000 | |
576 | V | D | -0.1193 | |
577 | V | D | 0.0000 | |
578 | Y | D | 0.0719 | |
579 | P | D | -0.4134 | |
580 | W | D | 0.0000 | |
581 | T | D | 0.0000 | |
582 | Q | D | -0.7758 | |
583 | R | D | -1.3659 | |
584 | F | D | -0.0512 | |
585 | F | D | -1.0215 | |
586 | E | D | -2.2246 | |
587 | S | D | -1.4377 | |
588 | F | D | -1.3464 | |
589 | G | D | -2.0091 | |
590 | D | D | -2.5827 | |
591 | L | D | 0.0000 | |
592 | S | D | -1.1415 | |
593 | T | D | -1.0547 | |
594 | P | D | -0.9402 | |
595 | D | D | -2.1060 | |
596 | A | D | -1.5848 | |
597 | V | D | 0.0000 | |
598 | M | D | -1.0548 | |
599 | G | D | -1.5490 | |
600 | N | D | -1.6014 | |
601 | P | D | -1.2108 | |
602 | K | D | -1.5811 | |
603 | V | D | 0.0000 | |
604 | K | D | -2.2795 | |
605 | A | D | -1.7893 | |
606 | H | D | -1.6703 | |
607 | G | D | 0.0000 | |
608 | K | D | -2.8039 | |
609 | K | D | -2.1817 | |
610 | V | D | -0.4161 | |
611 | L | D | 0.0000 | |
612 | G | D | -1.3516 | |
613 | A | D | -0.8754 | |
614 | F | D | 0.0000 | |
615 | S | D | -0.8746 | |
616 | D | D | -1.9141 | |
617 | G | D | 0.0000 | |
618 | L | D | -1.0599 | |
619 | A | D | -1.1647 | |
620 | H | D | -2.1265 | |
621 | L | D | -1.6576 | |
622 | D | D | -2.5728 | |
623 | N | D | -2.6384 | |
624 | L | D | 0.0000 | |
625 | K | D | -2.6893 | |
626 | G | D | -1.9216 | |
627 | T | D | -1.5429 | |
628 | F | D | 0.0000 | |
629 | A | D | -0.9837 | |
630 | T | D | -0.5035 | |
631 | L | D | -0.0080 | |
632 | S | D | 0.0000 | |
633 | E | D | -1.8904 | |
634 | L | D | -0.9276 | |
635 | H | D | -0.8986 | |
636 | C | D | 0.0000 | |
637 | D | D | -2.7336 | |
638 | K | D | -2.2835 | |
639 | L | D | -0.6813 | |
640 | H | D | -0.9133 | |
641 | V | D | -0.3025 | |
642 | D | D | 0.0000 | |
643 | P | D | -0.8067 | |
644 | E | D | -0.8753 | |
645 | N | D | -0.5589 | |
646 | F | D | -0.7472 | |
647 | R | D | -1.5362 | |
648 | L | D | -0.4771 | |
649 | L | D | -0.1718 | |
650 | G | D | 0.0000 | |
651 | N | D | -0.4645 | |
652 | V | D | 0.0000 | |
653 | L | D | 0.0000 | |
654 | V | D | 0.0000 | |
655 | C | D | 0.0000 | |
656 | V | D | 0.0000 | |
657 | L | D | 0.0000 | |
658 | A | D | 0.0000 | |
659 | H | D | -0.6820 | |
660 | H | D | -1.1422 | |
661 | F | D | -1.3168 | |
662 | G | D | -1.6097 | |
663 | K | D | -2.6166 | |
664 | E | D | -2.4511 | |
665 | F | D | 0.0000 | |
666 | T | D | -1.0058 | |
667 | P | D | -0.2532 | |
668 | P | D | -0.0973 | |
669 | V | D | -0.3121 | |
670 | Q | D | 0.0000 | |
671 | A | D | -0.0110 | |
672 | A | D | 0.0000 | |
673 | Y | D | 0.0000 | |
674 | Q | D | 0.0000 | |
675 | K | D | -0.5434 | |
676 | V | D | 0.0000 | |
677 | V | D | 0.0000 | |
678 | A | D | -0.6764 | |
679 | G | D | -0.7933 | |
680 | V | D | 0.0000 | |
681 | A | D | 0.0000 | |
682 | N | D | -1.9009 | |
683 | A | D | 0.0000 | |
684 | L | D | -1.0448 | |
685 | A | D | -1.6618 | |
686 | H | D | -2.2960 | |
687 | K | D | -2.3391 | |
688 | Y | D | -1.6218 | |
689 | H | D | -1.6630 |