Chain sequence(s) |
A: SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL B: VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL E: SRHKKLMFK |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
0 | S | A | -0.8157 | |
1 | M | A | -1.1740 | |
2 | E | A | -2.3098 | |
3 | N | A | -1.9348 | |
4 | F | A | -2.1953 | |
5 | Q | A | -2.9345 | |
6 | K | A | -2.6514 | |
7 | V | A | -1.1216 | |
8 | E | A | -2.2673 | |
9 | K | A | -2.0871 | |
10 | I | A | -0.7345 | |
11 | G | A | -1.3365 | |
12 | E | A | -1.9649 | |
13 | G | A | -1.2437 | |
14 | T | A | -0.2850 | |
15 | Y | A | 0.2413 | |
16 | G | A | -0.5617 | |
17 | V | A | -0.8121 | |
18 | V | A | -0.8361 | |
19 | Y | A | -1.3946 | |
20 | K | A | -1.3847 | |
21 | A | A | 0.0000 | |
22 | R | A | -2.4767 | |
23 | N | A | -2.3194 | |
24 | K | A | -2.3885 | |
25 | L | A | 0.0867 | |
26 | T | A | -0.5697 | |
27 | G | A | -1.2617 | |
28 | E | A | -1.8940 | |
29 | V | A | -0.9637 | |
30 | V | A | 0.0000 | |
31 | A | A | -0.2423 | |
32 | L | A | 0.0000 | |
33 | K | A | -0.5038 | |
34 | K | A | -0.8587 | |
35 | I | A | 0.0000 | |
36 | R | A | -2.5129 | |
37 | L | A | 0.0000 | |
38 | D | A | -3.4680 | |
39 | T | A | -3.1377 | |
40 | E | A | -2.8404 | |
41 | T | A | -2.1475 | |
42 | E | A | -1.9478 | |
43 | G | A | 0.0000 | |
44 | V | A | 0.0000 | |
45 | P | A | -0.3083 | |
46 | S | A | -0.1293 | |
47 | T | A | 0.1151 | |
48 | A | A | 0.0000 | |
49 | I | A | 0.0000 | |
50 | R | A | -0.2180 | |
51 | E | A | 0.0000 | |
52 | I | A | 0.0000 | |
53 | S | A | 0.0000 | |
54 | L | A | 0.0000 | |
55 | L | A | 0.0000 | |
56 | K | A | -1.7167 | |
57 | E | A | -1.1378 | |
58 | L | A | 0.0000 | |
59 | N | A | -1.8316 | |
60 | H | A | -1.0742 | |
61 | P | A | -0.8364 | |
62 | N | A | 0.0000 | |
63 | I | A | 0.0000 | |
64 | V | A | 0.0000 | |
65 | K | A | -1.5695 | |
66 | L | A | -0.9882 | |
67 | L | A | -0.5796 | |
68 | D | A | -1.4896 | |
69 | V | A | -0.3334 | |
70 | I | A | -0.4406 | |
71 | H | A | -1.1491 | |
72 | T | A | -1.6078 | |
73 | E | A | -3.1387 | |
74 | N | A | -3.3831 | |
75 | K | A | -2.8299 | |
76 | L | A | 0.0000 | |
77 | Y | A | 0.0000 | |
78 | L | A | 0.0000 | |
79 | V | A | 0.0000 | |
80 | F | A | 0.0000 | |
81 | E | A | -0.5099 | |
82 | F | A | -0.2991 | |
83 | L | A | 0.0000 | |
84 | H | A | -1.3670 | |
85 | Q | A | -1.1660 | |
86 | D | A | 0.0000 | |
87 | L | A | 0.0000 | |
88 | K | A | -2.1401 | |
89 | K | A | -2.7491 | |
90 | F | A | 0.0000 | |
91 | M | A | 0.0000 | |
92 | D | A | -2.4977 | |
93 | A | A | -0.7410 | |
94 | S | A | 0.0000 | |
95 | A | A | -0.2385 | |
96 | L | A | 1.1873 | |
97 | T | A | 0.6080 | |
98 | G | A | 0.0862 | |
99 | I | A | 0.0000 | |
100 | P | A | -0.0121 | |
101 | L | A | 0.3469 | |
102 | P | A | -0.3703 | |
103 | L | A | 0.0000 | |
104 | I | A | 0.0000 | |
105 | K | A | -0.5251 | |
106 | S | A | 0.0000 | |
107 | Y | A | 0.0000 | |
108 | L | A | 0.0000 | |
109 | F | A | 0.2566 | |
110 | Q | A | 0.0000 | |
111 | L | A | 0.0000 | |
112 | L | A | 0.0000 | |
113 | Q | A | -0.2278 | |
114 | G | A | 0.0000 | |
115 | L | A | 0.0000 | |
116 | A | A | -0.1065 | |
117 | F | A | -0.0575 | |
118 | C | A | 0.0000 | |
119 | H | A | 0.0000 | |
120 | S | A | -0.6397 | |
121 | H | A | -0.1813 | |
122 | R | A | 0.0000 | |
123 | V | A | 0.0000 | |
124 | L | A | 0.0000 | |
125 | H | A | 0.0000 | |
126 | R | A | 0.0000 | |
127 | D | A | -0.4058 | |
128 | L | A | 0.0000 | |
129 | K | A | -0.6708 | |
130 | P | A | 0.0000 | |
131 | Q | A | -1.4766 | |
132 | N | A | 0.0000 | |
133 | L | A | 0.0000 | |
134 | L | A | -0.5420 | |
135 | I | A | 0.0000 | |
136 | N | A | -0.8284 | |
137 | T | A | -0.7133 | |
138 | E | A | -1.6743 | |
139 | G | A | 0.0000 | |
140 | A | A | -0.6440 | |
141 | I | A | 0.0000 | |
142 | K | A | -0.3195 | |
143 | L | A | 0.0000 | |
144 | A | A | 0.0000 | |
145 | D | A | -1.0661 | |
146 | F | A | 0.0000 | |
147 | G | A | -0.2836 | |
148 | L | A | 0.2204 | |
149 | A | A | 0.0000 | |
150 | R | A | 0.0000 | |
151 | A | A | -0.0329 | |
152 | F | A | 0.0000 | |
153 | G | A | -0.1951 | |
154 | V | A | 0.0000 | |
155 | P | A | 0.2548 | |
156 | V | A | 0.0674 | |
157 | R | A | -0.5029 | |
158 | T | A | -0.4384 | |
159 | Y | A | 0.0000 | |
161 | H | A | -1.9266 | |
162 | E | A | -2.2952 | |
163 | V | A | 0.0000 | |
164 | V | A | 0.0000 | |
165 | T | A | -0.1721 | |
166 | L | A | -0.5932 | |
167 | W | A | -0.0042 | |
168 | Y | A | 0.0000 | |
169 | R | A | -0.3303 | |
170 | A | A | 0.0000 | |
171 | P | A | 0.0000 | |
172 | E | A | 0.0000 | |
173 | I | A | 0.0000 | |
174 | L | A | 0.0000 | |
175 | L | A | 0.0000 | |
176 | G | A | -1.1838 | |
177 | C | A | -0.7231 | |
178 | K | A | -1.2854 | |
179 | Y | A | 0.2831 | |
180 | Y | A | 0.0000 | |
181 | S | A | 0.0000 | |
182 | T | A | 0.0000 | |
183 | A | A | 0.0000 | |
184 | V | A | 0.0000 | |
185 | D | A | 0.0000 | |
186 | I | A | 0.0000 | |
187 | W | A | 0.0000 | |
188 | S | A | 0.0000 | |
189 | L | A | 0.0000 | |
190 | G | A | 0.0000 | |
191 | C | A | 0.0000 | |
192 | I | A | 0.0000 | |
193 | F | A | 0.0000 | |
194 | A | A | 0.0000 | |
195 | E | A | 0.0000 | |
196 | M | A | 0.0000 | |
197 | V | A | 0.0000 | |
198 | T | A | -0.9577 | |
199 | R | A | -1.7231 | |
200 | R | A | -2.3061 | |
201 | A | A | -0.8863 | |
202 | L | A | -0.4327 | |
203 | F | A | 0.0000 | |
204 | P | A | -0.9268 | |
205 | G | A | 0.0000 | |
206 | D | A | -2.3228 | |
207 | S | A | -1.9020 | |
208 | E | A | -2.1860 | |
209 | I | A | -1.0543 | |
210 | D | A | -2.2241 | |
211 | Q | A | 0.0000 | |
212 | L | A | 0.0000 | |
213 | F | A | -1.3656 | |
214 | R | A | -2.1879 | |
215 | I | A | 0.0000 | |
216 | F | A | 0.0000 | |
217 | R | A | -2.8038 | |
218 | T | A | -2.0993 | |
219 | L | A | 0.0000 | |
220 | G | A | 0.0000 | |
221 | T | A | -1.6101 | |
222 | P | A | 0.0000 | |
223 | D | A | -1.6807 | |
224 | E | A | -0.9856 | |
225 | V | A | 0.9700 | |
226 | V | A | 0.4936 | |
227 | W | A | 0.0000 | |
228 | P | A | -0.4945 | |
229 | G | A | -0.6113 | |
230 | V | A | 0.0000 | |
231 | T | A | -1.2992 | |
232 | S | A | -0.8565 | |
233 | M | A | -1.0000 | |
234 | P | A | -1.4275 | |
235 | D | A | -1.9133 | |
236 | Y | A | 0.0000 | |
237 | K | A | -1.6689 | |
238 | P | A | -1.2574 | |
239 | S | A | -0.9480 | |
240 | F | A | 0.0000 | |
241 | P | A | -1.2460 | |
242 | K | A | -2.2871 | |
243 | W | A | -1.5143 | |
244 | A | A | -1.7341 | |
245 | R | A | -2.7682 | |
246 | Q | A | -2.8491 | |
247 | D | A | -2.8903 | |
248 | F | A | -1.9933 | |
249 | S | A | -2.0409 | |
250 | K | A | -2.4076 | |
251 | V | A | -1.2193 | |
252 | V | A | 0.0000 | |
253 | P | A | -1.2871 | |
254 | P | A | -0.9823 | |
255 | L | A | 0.0000 | |
256 | D | A | -2.3182 | |
257 | E | A | -2.9433 | |
258 | D | A | -2.5147 | |
259 | G | A | 0.0000 | |
260 | R | A | -1.9040 | |
261 | S | A | -1.4086 | |
262 | L | A | 0.0000 | |
263 | L | A | 0.0000 | |
264 | S | A | -0.5246 | |
265 | Q | A | -0.8958 | |
266 | M | A | 0.0000 | |
267 | L | A | 0.0000 | |
268 | H | A | -0.8857 | |
269 | Y | A | 0.0000 | |
270 | D | A | 0.0000 | |
271 | P | A | -1.1484 | |
272 | N | A | -1.9952 | |
273 | K | A | -2.3488 | |
274 | R | A | 0.0000 | |
275 | I | A | -0.8855 | |
276 | S | A | -0.6641 | |
277 | A | A | 0.0000 | |
278 | K | A | -0.7011 | |
279 | A | A | -0.2551 | |
280 | A | A | 0.0000 | |
281 | L | A | 0.0595 | |
282 | A | A | -0.0805 | |
283 | H | A | 0.0000 | |
284 | P | A | -1.2822 | |
285 | F | A | 0.0000 | |
286 | F | A | 0.0000 | |
287 | Q | A | -2.1285 | |
288 | D | A | -2.3050 | |
289 | V | A | -1.2672 | |
290 | T | A | -1.1617 | |
291 | K | A | -1.5597 | |
292 | P | A | -0.5080 | |
293 | V | A | 0.7325 | |
294 | P | A | 0.0000 | |
295 | H | A | 0.8065 | |
296 | L | A | 1.6253 | |
175 | V | B | 0.0854 | |
176 | P | B | -0.9712 | |
177 | D | B | -1.4414 | |
178 | Y | B | 0.0000 | |
179 | H | B | -1.4366 | |
180 | E | B | -2.5437 | |
181 | D | B | -1.8455 | |
182 | I | B | 0.0000 | |
183 | H | B | 0.0000 | |
184 | T | B | -1.4513 | |
185 | Y | B | -1.1761 | |
186 | L | B | 0.0000 | |
187 | R | B | -1.2179 | |
188 | E | B | -1.8242 | |
189 | M | B | -0.9818 | |
190 | E | B | 0.0000 | |
191 | V | B | 0.2715 | |
192 | K | B | -1.3434 | |
193 | C | B | -0.8754 | |
194 | K | B | -0.5421 | |
195 | P | B | -0.7673 | |
196 | K | B | -0.9773 | |
197 | V | B | -0.0581 | |
198 | G | B | -1.0227 | |
199 | Y | B | 0.0000 | |
200 | M | B | -1.6376 | |
201 | K | B | -2.4170 | |
202 | K | B | -2.6814 | |
203 | Q | B | 0.0000 | |
204 | P | B | -1.0714 | |
205 | D | B | -0.5187 | |
206 | I | B | 0.0000 | |
207 | T | B | -0.8207 | |
208 | N | B | -0.9500 | |
209 | S | B | -0.4582 | |
210 | M | B | 0.0000 | |
211 | R | B | 0.0000 | |
212 | A | B | 0.0000 | |
213 | I | B | 0.5086 | |
214 | L | B | 0.0000 | |
215 | V | B | 0.0000 | |
216 | D | B | -0.1577 | |
217 | W | B | 0.0000 | |
218 | L | B | 0.0000 | |
219 | V | B | 0.0000 | |
220 | E | B | -1.4021 | |
221 | V | B | 0.0000 | |
222 | G | B | 0.0000 | |
223 | E | B | -1.9312 | |
224 | E | B | -1.4967 | |
225 | Y | B | -1.1204 | |
226 | K | B | -2.0257 | |
227 | L | B | -0.9560 | |
228 | Q | B | -0.9112 | |
229 | N | B | -0.6654 | |
230 | E | B | 0.0000 | |
231 | T | B | 0.0000 | |
232 | L | B | 0.0000 | |
233 | H | B | 0.0000 | |
234 | L | B | 0.0000 | |
235 | A | B | 0.0000 | |
236 | V | B | 0.0000 | |
237 | N | B | -0.2585 | |
238 | Y | B | 0.0000 | |
239 | I | B | 0.0000 | |
240 | D | B | 0.0000 | |
241 | R | B | -0.3818 | |
242 | F | B | 0.0000 | |
243 | L | B | 0.0000 | |
244 | S | B | -0.6105 | |
245 | S | B | -0.4814 | |
246 | M | B | 0.1189 | |
247 | S | B | -0.2315 | |
248 | V | B | 0.0000 | |
249 | L | B | 0.6602 | |
250 | R | B | -0.5561 | |
251 | G | B | -0.8787 | |
252 | K | B | -0.7255 | |
253 | L | B | 0.0000 | |
254 | Q | B | 0.0000 | |
255 | L | B | 0.0000 | |
256 | V | B | 0.0000 | |
257 | G | B | 0.0000 | |
258 | T | B | 0.0000 | |
259 | A | B | 0.0000 | |
260 | A | B | 0.0000 | |
261 | M | B | 0.0000 | |
262 | L | B | 0.0000 | |
263 | L | B | 0.0000 | |
264 | A | B | 0.0000 | |
265 | S | B | 0.0000 | |
266 | K | B | 0.0000 | |
267 | F | B | 0.0000 | |
268 | E | B | 0.0000 | |
269 | E | B | 0.0000 | |
270 | I | B | 1.1595 | |
271 | Y | B | 1.2459 | |
272 | P | B | 0.0750 | |
273 | P | B | 0.0000 | |
274 | E | B | -2.0676 | |
275 | V | B | 0.0000 | |
276 | A | B | -1.1800 | |
277 | E | B | -0.8314 | |
278 | F | B | 0.0000 | |
279 | V | B | 0.0000 | |
280 | Y | B | -0.6276 | |
281 | I | B | 0.0000 | |
282 | T | B | 0.0000 | |
283 | D | B | -3.3425 | |
284 | D | B | -2.8529 | |
285 | T | B | -2.2179 | |
286 | Y | B | 0.0000 | |
287 | T | B | -1.4853 | |
288 | K | B | -2.3649 | |
289 | K | B | -3.0036 | |
290 | Q | B | -2.2681 | |
291 | V | B | 0.0000 | |
292 | L | B | 0.0000 | |
293 | R | B | -2.7451 | |
294 | M | B | 0.0000 | |
295 | E | B | 0.0000 | |
296 | H | B | -1.0749 | |
297 | L | B | -0.5047 | |
298 | V | B | 0.0000 | |
299 | L | B | 0.0000 | |
300 | K | B | -0.6846 | |
301 | V | B | -0.0061 | |
302 | L | B | 0.0000 | |
303 | T | B | -0.4890 | |
304 | F | B | 0.0000 | |
305 | D | B | -0.9060 | |
306 | L | B | 0.0000 | |
307 | A | B | 0.0000 | |
308 | A | B | 0.0000 | |
309 | P | B | 0.0000 | |
310 | T | B | 0.0000 | |
311 | V | B | 0.0000 | |
312 | N | B | 0.0000 | |
313 | Q | B | -0.1720 | |
314 | F | B | 0.0000 | |
315 | L | B | 0.0000 | |
316 | T | B | 0.1576 | |
317 | Q | B | 0.0000 | |
318 | Y | B | 0.0000 | |
319 | F | B | 0.3742 | |
320 | L | B | 0.8340 | |
321 | H | B | -0.2157 | |
322 | Q | B | -0.6179 | |
323 | Q | B | -1.3262 | |
324 | P | B | -0.9209 | |
325 | A | B | -0.4450 | |
326 | N | B | -0.5538 | |
327 | C | B | -0.1069 | |
328 | K | B | -0.6571 | |
329 | V | B | 0.0000 | |
330 | E | B | -0.5355 | |
331 | S | B | 0.0000 | |
332 | L | B | 0.0000 | |
333 | A | B | 0.0000 | |
334 | M | B | -0.0748 | |
335 | F | B | 0.0000 | |
336 | L | B | 0.0000 | |
337 | G | B | 0.0000 | |
338 | E | B | 0.0000 | |
339 | L | B | 0.0000 | |
340 | S | B | 0.0000 | |
341 | L | B | -0.1440 | |
342 | I | B | 0.0000 | |
343 | D | B | -0.8272 | |
344 | A | B | 0.0000 | |
345 | D | B | -2.0763 | |
346 | P | B | -1.4975 | |
347 | Y | B | 0.0000 | |
348 | L | B | 0.0000 | |
349 | K | B | -1.6366 | |
350 | Y | B | -0.4659 | |
351 | L | B | 0.3222 | |
352 | P | B | 0.1465 | |
353 | S | B | 0.0000 | |
354 | V | B | 0.2206 | |
355 | I | B | 0.0000 | |
356 | A | B | 0.0000 | |
357 | G | B | 0.0000 | |
358 | A | B | 0.0000 | |
359 | A | B | 0.0000 | |
360 | F | B | 0.0000 | |
361 | H | B | 0.0000 | |
362 | L | B | 0.0000 | |
363 | A | B | 0.0000 | |
364 | L | B | 0.0000 | |
365 | Y | B | -0.1837 | |
366 | T | B | -0.3773 | |
367 | V | B | -0.0153 | |
368 | T | B | -0.3898 | |
369 | G | B | -0.7090 | |
370 | Q | B | -1.0483 | |
371 | S | B | -0.8413 | |
372 | W | B | 0.0000 | |
373 | P | B | -1.3908 | |
374 | E | B | -2.2432 | |
375 | S | B | -1.6159 | |
376 | L | B | 0.0000 | |
377 | I | B | -1.2201 | |
378 | R | B | -2.3919 | |
379 | K | B | -1.9191 | |
380 | T | B | 0.0000 | |
381 | G | B | -1.1240 | |
382 | Y | B | -0.7416 | |
383 | T | B | -1.1319 | |
384 | L | B | -0.7370 | |
385 | E | B | -1.9930 | |
386 | S | B | -1.3764 | |
387 | L | B | 0.0000 | |
388 | K | B | -1.6957 | |
389 | P | B | -1.0832 | |
390 | C | B | 0.0000 | |
391 | L | B | 0.0000 | |
392 | M | B | -0.5332 | |
393 | D | B | -1.2308 | |
394 | L | B | 0.0000 | |
395 | H | B | -1.1286 | |
396 | Q | B | -1.5857 | |
397 | T | B | 0.0000 | |
398 | Y | B | 0.0000 | |
399 | L | B | -1.0515 | |
400 | K | B | -1.4908 | |
401 | A | B | 0.0000 | |
402 | P | B | -1.0524 | |
403 | Q | B | -1.6791 | |
404 | H | B | -1.1591 | |
405 | A | B | -0.4974 | |
406 | Q | B | -0.5982 | |
407 | Q | B | -1.2385 | |
408 | S | B | 0.0000 | |
409 | I | B | 0.0000 | |
410 | R | B | -1.8134 | |
411 | E | B | -2.7933 | |
412 | K | B | -2.4880 | |
413 | Y | B | 0.0000 | |
414 | K | B | -2.9769 | |
415 | N | B | -3.1123 | |
416 | S | B | -2.3855 | |
417 | K | B | -2.6653 | |
418 | Y | B | -1.9944 | |
419 | H | B | -1.9839 | |
420 | G | B | -1.8484 | |
421 | V | B | 0.0000 | |
422 | S | B | 0.0000 | |
423 | L | B | 0.4364 | |
424 | L | B | 0.1716 | |
425 | N | B | -0.8490 | |
426 | P | B | -0.8770 | |
427 | P | B | -1.2355 | |
428 | E | B | -2.2256 | |
429 | T | B | -1.0433 | |
430 | L | B | 0.0000 | |
431 | N | B | -0.7441 | |
432 | L | B | 0.5378 | |
378 | S | E | -1.1212 | |
379 | R | E | -1.7133 | |
380 | H | E | -2.3419 | |
381 | K | E | -2.9025 | |
382 | K | E | -2.9104 | |
383 | L | E | 0.0000 | |
384 | M | E | -0.1146 | |
385 | F | E | -0.4968 | |
386 | K | E | -1.4028 |