Chain sequence(s) |
A: AGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRSD C: AGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRS B: GWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRS D: AGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRSD |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | A | A | -0.5110 | |
2 | G | A | -0.5518 | |
3 | W | A | -0.4279 | |
4 | Q | A | -1.5334 | |
5 | S | A | -1.5195 | |
6 | Y | A | -0.7984 | |
7 | V | A | 0.0000 | |
8 | D | A | -1.8398 | |
9 | N | A | -1.1228 | |
10 | L | A | 0.0000 | |
11 | M | A | -0.6556 | |
12 | C | A | -0.6398 | |
13 | D | A | -1.4553 | |
14 | G | A | -0.9314 | |
15 | C | A | -1.2198 | |
16 | C | A | 0.0000 | |
17 | Q | A | -0.8799 | |
18 | E | A | 0.0000 | |
19 | A | A | 0.0000 | |
20 | A | A | 0.0000 | |
21 | I | A | 0.0000 | |
22 | V | A | 0.0000 | |
23 | G | A | 0.0000 | |
24 | Y | A | -0.7673 | |
25 | C | A | -1.0202 | |
26 | D | A | -1.7646 | |
27 | A | A | -0.7295 | |
28 | K | A | -0.3261 | |
29 | Y | A | 1.1403 | |
30 | V | A | 0.6782 | |
31 | W | A | 0.2833 | |
32 | A | A | 0.0000 | |
33 | A | A | -0.7319 | |
34 | T | A | -0.7930 | |
35 | A | A | -0.3834 | |
36 | G | A | -0.6392 | |
37 | G | A | -0.5343 | |
38 | V | A | -0.3334 | |
39 | F | A | 0.0000 | |
40 | Q | A | -0.8855 | |
41 | S | A | -0.5172 | |
42 | I | A | 0.0000 | |
43 | T | A | 0.4146 | |
44 | P | A | 0.6788 | |
45 | I | A | 1.5236 | |
46 | E | A | 0.0000 | |
47 | I | A | 0.0000 | |
48 | D | A | -1.0470 | |
49 | M | A | -0.4628 | |
50 | I | A | 0.0000 | |
51 | V | A | -0.7256 | |
52 | G | A | -1.9207 | |
53 | K | A | -2.7575 | |
54 | D | A | -2.9696 | |
55 | R | A | -2.0103 | |
56 | E | A | -2.5265 | |
57 | G | A | -1.6856 | |
58 | F | A | 0.0000 | |
59 | F | A | -0.1310 | |
60 | T | A | -0.6966 | |
61 | N | A | -1.4364 | |
62 | G | A | -0.9480 | |
63 | L | A | 0.0000 | |
64 | T | A | -0.5089 | |
65 | L | A | 0.0000 | |
66 | G | A | -0.5704 | |
67 | A | A | -0.5450 | |
68 | K | A | -1.3071 | |
69 | K | A | -2.2643 | |
70 | C | A | 0.0000 | |
71 | S | A | -0.7077 | |
72 | V | A | 0.0000 | |
73 | I | A | 0.3014 | |
74 | R | A | 0.0304 | |
75 | D | A | 0.0000 | |
76 | S | A | 0.0000 | |
77 | L | A | 0.0000 | |
78 | Y | A | 0.3474 | |
79 | V | A | -0.2577 | |
80 | D | A | -1.6794 | |
81 | G | A | -1.4073 | |
82 | D | A | 0.0000 | |
83 | C | A | -0.0652 | |
84 | T | A | 0.0000 | |
85 | M | A | 0.0000 | |
86 | D | A | 0.0000 | |
87 | I | A | 0.0000 | |
88 | R | A | -1.1275 | |
89 | T | A | 0.0000 | |
90 | K | A | -2.1069 | |
91 | S | A | -1.9506 | |
92 | Q | A | -2.1623 | |
93 | G | A | -1.6332 | |
94 | G | A | -1.5513 | |
95 | E | A | -1.5632 | |
96 | P | A | -1.5180 | |
97 | T | A | -1.4448 | |
98 | Y | A | -1.2909 | |
99 | N | A | -1.0349 | |
100 | V | A | 0.0000 | |
101 | A | A | 0.0000 | |
102 | V | A | 0.0000 | |
103 | G | A | 0.0000 | |
104 | R | A | -0.6831 | |
105 | A | A | 0.0000 | |
106 | G | A | -1.9965 | |
107 | R | A | -2.1052 | |
108 | A | A | 0.0000 | |
109 | L | A | 0.0000 | |
110 | V | A | 0.0000 | |
111 | I | A | 0.0000 | |
112 | V | A | 0.0000 | |
113 | M | A | 0.0000 | |
114 | G | A | 0.0000 | |
115 | K | A | -2.1314 | |
116 | E | A | -2.5582 | |
117 | G | A | -1.5976 | |
118 | V | A | -1.2042 | |
119 | H | A | -1.0601 | |
120 | G | A | -0.5273 | |
121 | G | A | 0.0000 | |
122 | T | A | 0.0000 | |
123 | L | A | 0.0000 | |
124 | N | A | 0.0000 | |
125 | K | A | 0.0000 | |
126 | K | A | -0.5430 | |
127 | A | A | 0.0000 | |
128 | Y | A | 0.0000 | |
129 | E | A | 0.0000 | |
130 | L | A | 0.0000 | |
131 | A | A | 0.0000 | |
132 | L | A | -0.5289 | |
133 | Y | A | -0.5765 | |
134 | L | A | -1.4241 | |
135 | R | A | -2.9982 | |
136 | R | A | -1.9659 | |
137 | S | A | -1.8649 | |
138 | D | A | -2.8680 | |
2 | G | B | -0.7824 | |
3 | W | B | -0.6517 | |
4 | Q | B | -1.1851 | |
5 | S | B | -1.4380 | |
6 | Y | B | -0.8058 | |
7 | V | B | 0.0000 | |
8 | D | B | -1.4333 | |
9 | N | B | -1.0205 | |
10 | L | B | 0.0000 | |
11 | M | B | -0.5770 | |
12 | C | B | -0.5411 | |
13 | D | B | -1.5314 | |
14 | G | B | -0.9847 | |
15 | C | B | -1.1383 | |
16 | C | B | 0.0000 | |
17 | Q | B | -0.8291 | |
18 | E | B | 0.0000 | |
19 | A | B | 0.0000 | |
20 | A | B | 0.0000 | |
21 | I | B | 0.0000 | |
22 | V | B | 0.0000 | |
23 | G | B | 0.0000 | |
24 | Y | B | -0.5701 | |
25 | C | B | -0.7933 | |
26 | D | B | -1.7001 | |
27 | A | B | -0.6917 | |
28 | K | B | -0.2102 | |
29 | Y | B | 1.2189 | |
30 | V | B | 0.7021 | |
31 | W | B | 0.3523 | |
32 | A | B | 0.0000 | |
33 | A | B | -0.6485 | |
34 | T | B | 0.0000 | |
35 | A | B | -0.3997 | |
36 | G | B | -0.6583 | |
37 | G | B | -0.4958 | |
38 | V | B | -0.2417 | |
39 | F | B | 0.0000 | |
40 | Q | B | -0.9971 | |
41 | S | B | -0.5419 | |
42 | I | B | 0.0000 | |
43 | T | B | 0.5135 | |
44 | P | B | 0.8585 | |
45 | I | B | 1.6968 | |
46 | E | B | 0.0000 | |
47 | I | B | 0.0000 | |
48 | D | B | -0.6401 | |
49 | M | B | -0.3127 | |
50 | I | B | 0.0000 | |
51 | V | B | -0.5712 | |
52 | G | B | -1.9109 | |
53 | K | B | -2.8946 | |
54 | D | B | -3.4205 | |
55 | R | B | -2.2457 | |
56 | E | B | -2.6620 | |
57 | G | B | -1.7465 | |
58 | F | B | 0.0000 | |
59 | F | B | 0.1113 | |
60 | T | B | -0.6068 | |
61 | N | B | -1.3975 | |
62 | G | B | -0.8769 | |
63 | L | B | 0.0000 | |
64 | T | B | -0.5679 | |
65 | L | B | 0.0000 | |
66 | G | B | -0.5413 | |
67 | A | B | -0.4658 | |
68 | K | B | -1.2745 | |
69 | K | B | -2.1909 | |
70 | C | B | 0.0000 | |
71 | S | B | -0.6216 | |
72 | V | B | 0.0000 | |
73 | I | B | 0.6147 | |
74 | R | B | 0.1287 | |
75 | D | B | -0.0877 | |
76 | S | B | 0.0000 | |
77 | L | B | 0.0000 | |
78 | Y | B | 0.3059 | |
79 | V | B | -0.2818 | |
80 | D | B | -1.7056 | |
81 | G | B | -1.5044 | |
82 | D | B | 0.0000 | |
83 | C | B | 0.0000 | |
84 | T | B | 0.0000 | |
85 | M | B | 0.0000 | |
86 | D | B | 0.0000 | |
87 | I | B | 0.0000 | |
88 | R | B | -1.2197 | |
89 | T | B | 0.0000 | |
90 | K | B | -2.2168 | |
91 | S | B | -2.2876 | |
92 | Q | B | -2.4942 | |
93 | G | B | -1.9884 | |
94 | G | B | -1.9286 | |
95 | E | B | -2.7125 | |
96 | P | B | -2.0891 | |
97 | T | B | -1.7576 | |
98 | Y | B | -1.4572 | |
99 | N | B | -1.0411 | |
100 | V | B | 0.0000 | |
101 | A | B | 0.0000 | |
102 | V | B | 0.0000 | |
103 | G | B | 0.0000 | |
104 | R | B | -0.5871 | |
105 | A | B | 0.0000 | |
106 | G | B | -1.5739 | |
107 | R | B | -2.3261 | |
108 | A | B | 0.0000 | |
109 | L | B | 0.0000 | |
110 | V | B | 0.0000 | |
111 | I | B | 0.0000 | |
112 | V | B | 0.0000 | |
113 | M | B | 0.0000 | |
114 | G | B | 0.0000 | |
115 | K | B | -1.8631 | |
116 | E | B | -2.4384 | |
117 | G | B | -1.5279 | |
118 | V | B | -1.1123 | |
119 | H | B | -1.0026 | |
120 | G | B | -0.4701 | |
121 | G | B | 0.0000 | |
122 | T | B | 0.0000 | |
123 | L | B | 0.0000 | |
124 | N | B | 0.0000 | |
125 | K | B | 0.0000 | |
126 | K | B | -0.5243 | |
127 | A | B | 0.0000 | |
128 | Y | B | 0.0000 | |
129 | E | B | 0.0000 | |
130 | L | B | 0.0000 | |
131 | A | B | 0.0000 | |
132 | L | B | -0.3339 | |
133 | Y | B | 0.0000 | |
134 | L | B | -0.7075 | |
135 | R | B | -1.6579 | |
136 | R | B | -1.0472 | |
137 | S | B | -0.7192 | |
1 | A | C | -1.0212 | |
2 | G | C | -0.6524 | |
3 | W | C | -0.5824 | |
4 | Q | C | -1.5303 | |
5 | S | C | -1.6162 | |
6 | Y | C | -0.8974 | |
7 | V | C | 0.0000 | |
8 | D | C | -2.2426 | |
9 | N | C | -1.8256 | |
10 | L | C | 0.0000 | |
11 | M | C | -0.9863 | |
12 | C | C | -1.2703 | |
13 | D | C | -2.0217 | |
14 | G | C | -1.2247 | |
15 | C | C | -1.4683 | |
16 | C | C | 0.0000 | |
17 | Q | C | -1.1293 | |
18 | E | C | 0.0000 | |
19 | A | C | 0.0000 | |
20 | A | C | 0.0000 | |
21 | I | C | 0.0000 | |
22 | V | C | 0.0000 | |
23 | G | C | 0.0000 | |
24 | Y | C | 0.0000 | |
25 | C | C | -1.4223 | |
26 | D | C | -1.9963 | |
27 | A | C | -1.0112 | |
28 | K | C | -0.7678 | |
29 | Y | C | 0.9457 | |
30 | V | C | 0.5431 | |
31 | W | C | 0.2489 | |
32 | A | C | 0.0000 | |
33 | A | C | -0.6756 | |
34 | T | C | -0.7388 | |
35 | A | C | -0.5019 | |
36 | G | C | -0.6423 | |
37 | G | C | -0.4845 | |
38 | V | C | -0.1480 | |
39 | F | C | 0.0000 | |
40 | Q | C | -1.0095 | |
41 | S | C | -0.5594 | |
42 | I | C | 0.0000 | |
43 | T | C | 0.2733 | |
44 | P | C | 0.5182 | |
45 | I | C | 1.3257 | |
46 | E | C | 0.3991 | |
47 | I | C | 0.0000 | |
48 | D | C | -1.4116 | |
49 | M | C | -0.6153 | |
50 | I | C | 0.0000 | |
51 | V | C | -0.8671 | |
52 | G | C | -1.8407 | |
53 | K | C | -2.8141 | |
54 | D | C | -3.1565 | |
55 | R | C | -2.0813 | |
56 | E | C | -2.5468 | |
57 | G | C | -1.6112 | |
58 | F | C | 0.0000 | |
59 | F | C | 0.0288 | |
60 | T | C | -0.5925 | |
61 | N | C | -1.4596 | |
62 | G | C | -1.1042 | |
63 | L | C | 0.0000 | |
64 | T | C | -0.8473 | |
65 | L | C | 0.0000 | |
66 | G | C | -0.5676 | |
67 | A | C | -0.4939 | |
68 | K | C | -1.1990 | |
69 | K | C | -2.6402 | |
70 | C | C | 0.0000 | |
71 | S | C | -0.9972 | |
72 | V | C | 0.0000 | |
73 | I | C | 0.0842 | |
74 | R | C | -0.2360 | |
75 | D | C | -0.2476 | |
76 | S | C | 0.0000 | |
77 | L | C | 0.0000 | |
78 | Y | C | 0.3093 | |
79 | V | C | -0.2637 | |
80 | D | C | -1.6742 | |
81 | G | C | -1.2743 | |
82 | D | C | 0.0000 | |
83 | C | C | 0.0000 | |
84 | T | C | 0.0000 | |
85 | M | C | 0.0000 | |
86 | D | C | 0.0000 | |
87 | I | C | 0.0000 | |
88 | R | C | -1.5243 | |
89 | T | C | 0.0000 | |
90 | K | C | -2.5570 | |
91 | S | C | -2.1639 | |
92 | Q | C | -2.3421 | |
93 | G | C | -1.4994 | |
94 | G | C | -1.3782 | |
95 | E | C | -1.7164 | |
96 | P | C | -1.5883 | |
97 | T | C | -1.6447 | |
98 | Y | C | -1.5257 | |
99 | N | C | -1.2437 | |
100 | V | C | 0.0000 | |
101 | A | C | 0.0000 | |
102 | V | C | 0.0000 | |
103 | G | C | 0.0000 | |
104 | R | C | -0.7829 | |
105 | A | C | 0.0000 | |
106 | G | C | -2.1138 | |
107 | R | C | -2.6595 | |
108 | A | C | 0.0000 | |
109 | L | C | 0.0000 | |
110 | V | C | 0.0000 | |
111 | I | C | 0.0000 | |
112 | V | C | 0.0000 | |
113 | M | C | 0.0000 | |
114 | G | C | 0.0000 | |
115 | K | C | -2.4350 | |
116 | E | C | -2.7649 | |
117 | G | C | -1.6675 | |
118 | V | C | -1.3462 | |
119 | H | C | -1.1269 | |
120 | G | C | -0.5715 | |
121 | G | C | 0.0000 | |
122 | T | C | 0.0000 | |
123 | L | C | 0.0000 | |
124 | N | C | 0.0000 | |
125 | K | C | 0.0000 | |
126 | K | C | -0.6394 | |
127 | A | C | 0.0000 | |
128 | Y | C | 0.0000 | |
129 | E | C | -0.5220 | |
130 | L | C | -0.2804 | |
131 | A | C | 0.0000 | |
132 | L | C | 0.0000 | |
133 | Y | C | -0.7841 | |
134 | L | C | -1.5475 | |
135 | R | C | -3.0338 | |
136 | R | C | -2.8943 | |
137 | S | C | -2.0291 | |
1 | A | D | -0.9445 | |
2 | G | D | -0.5888 | |
3 | W | D | -0.4808 | |
4 | Q | D | -1.5400 | |
5 | S | D | -1.6092 | |
6 | Y | D | -1.0823 | |
7 | V | D | 0.0000 | |
8 | D | D | -2.5535 | |
9 | N | D | -1.8767 | |
10 | L | D | 0.0000 | |
11 | M | D | -1.1106 | |
12 | C | D | -1.3320 | |
13 | D | D | -2.0810 | |
14 | G | D | -1.1903 | |
15 | C | D | -1.4358 | |
16 | C | D | 0.0000 | |
17 | Q | D | -1.0808 | |
18 | E | D | 0.0000 | |
19 | A | D | 0.0000 | |
20 | A | D | 0.0000 | |
21 | I | D | 0.0000 | |
22 | V | D | 0.0000 | |
23 | G | D | 0.0000 | |
24 | Y | D | -0.6039 | |
25 | C | D | -0.8915 | |
26 | D | D | -1.7077 | |
27 | A | D | -0.6560 | |
28 | K | D | -0.2124 | |
29 | Y | D | 1.1877 | |
30 | V | D | 0.6466 | |
31 | W | D | 0.3676 | |
32 | A | D | 0.0000 | |
33 | A | D | -0.7510 | |
34 | T | D | -0.8599 | |
35 | A | D | -0.5479 | |
36 | G | D | -0.7140 | |
37 | G | D | -0.6527 | |
38 | V | D | -0.3638 | |
39 | F | D | 0.0000 | |
40 | Q | D | -1.0909 | |
41 | S | D | -0.6141 | |
42 | I | D | 0.0000 | |
43 | T | D | 0.4712 | |
44 | P | D | 0.8985 | |
45 | I | D | 1.6356 | |
46 | E | D | 0.0000 | |
47 | I | D | 0.0000 | |
48 | D | D | -0.9180 | |
49 | M | D | -0.3761 | |
50 | I | D | 0.0000 | |
51 | V | D | -0.7037 | |
52 | G | D | -1.8008 | |
53 | K | D | -2.9205 | |
54 | D | D | -3.4313 | |
55 | R | D | -2.1911 | |
56 | E | D | -2.6401 | |
57 | G | D | -1.7120 | |
58 | F | D | 0.0000 | |
59 | F | D | 0.3165 | |
60 | T | D | -0.5756 | |
61 | N | D | -1.4376 | |
62 | G | D | -0.9918 | |
63 | L | D | 0.0000 | |
64 | T | D | -0.7970 | |
65 | L | D | 0.0000 | |
66 | G | D | 0.0000 | |
67 | A | D | -0.4724 | |
68 | K | D | -1.3575 | |
69 | K | D | -2.6166 | |
70 | C | D | 0.0000 | |
71 | S | D | -0.7419 | |
72 | V | D | 0.0000 | |
73 | I | D | 1.1290 | |
74 | R | D | 0.0000 | |
75 | D | D | 0.1163 | |
76 | S | D | 0.0000 | |
77 | L | D | 0.0000 | |
78 | Y | D | 0.3996 | |
79 | V | D | -0.2424 | |
80 | D | D | -1.8335 | |
81 | G | D | -1.5695 | |
82 | D | D | 0.0000 | |
83 | C | D | 0.0000 | |
84 | T | D | 0.0000 | |
85 | M | D | 0.0000 | |
86 | D | D | 0.0000 | |
87 | I | D | 0.0000 | |
88 | R | D | -1.3820 | |
89 | T | D | 0.0000 | |
90 | K | D | -2.7535 | |
91 | S | D | -2.2473 | |
92 | Q | D | -2.4201 | |
93 | G | D | -1.6633 | |
94 | G | D | -1.3894 | |
95 | E | D | -1.7745 | |
96 | P | D | -1.6274 | |
97 | T | D | -1.7003 | |
98 | Y | D | -1.5316 | |
99 | N | D | -1.1501 | |
100 | V | D | 0.0000 | |
101 | A | D | 0.0000 | |
102 | V | D | 0.0000 | |
103 | G | D | 0.0000 | |
104 | R | D | -0.4474 | |
105 | A | D | 0.0000 | |
106 | G | D | -1.9427 | |
107 | R | D | -2.2668 | |
108 | A | D | 0.0000 | |
109 | L | D | 0.0000 | |
110 | V | D | 0.0000 | |
111 | I | D | 0.0000 | |
112 | V | D | 0.0000 | |
113 | M | D | 0.0000 | |
114 | G | D | 0.0000 | |
115 | K | D | -2.2786 | |
116 | E | D | -2.6880 | |
117 | G | D | -1.6199 | |
118 | V | D | -1.3291 | |
119 | H | D | -1.0798 | |
120 | G | D | -0.4729 | |
121 | G | D | 0.0000 | |
122 | T | D | 0.0000 | |
123 | L | D | 0.0000 | |
124 | N | D | 0.0000 | |
125 | K | D | 0.0000 | |
126 | K | D | -0.7268 | |
127 | A | D | 0.0000 | |
128 | Y | D | 0.0000 | |
129 | E | D | -0.6121 | |
130 | L | D | 0.0000 | |
131 | A | D | 0.0000 | |
132 | L | D | -0.8696 | |
133 | Y | D | -0.7480 | |
134 | L | D | 0.0000 | |
135 | R | D | -2.6073 | |
136 | R | D | -2.9568 | |
137 | S | D | -2.1263 | |
138 | D | D | -3.0151 |