Project name: 2IV1 [mutate: KA64L, DA66L, DA68L, EA69L, DA70L, KB64L, DB66L, DB68L, EB69L, DB70L, KC64L, DC66L, DC68L, EC69L, DC70L, KD64L, DD66L, DD68L, ED69L, DD70L, KE64L, DE66L, DE68L, EE69L, DE70L, KF64L, DF66L, DF68L, EF69L, DF70L, KG64L, DG66L, DG68L, EG69L

Status: done

submitted: 2017-09-13 10:36:10, status changed: 2017-09-13 12:13:20
Settings
Chain sequence(s) A: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
C: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
B: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
E: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
D: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
G: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
F: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
I: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
H: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
J: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues KA64L, DA66L, DA68L, EA69L, DA70L, KB64L, DB66L, DB68L, EB69L, DB70L, KC64L, DC66L, DC68L, EC69L, DC70L, KD64L, DD66L, DD68L, ED69L, DD70L, KE64L, DE66L, DE68L, EE69L, DE70L, KF64L, DF66L, DF68L, EF69L, DF70L, KG64L, DG66L, DG68L, EG69L, DG70L, KH64L, DH66L, DH68L, EH69L, DH70L, KI64L, DI66L, DI68L, DI70L, EI69L, KJ64L, DJ66L, DJ68L, EJ69L, DJ70L
Energy difference between WT (input) and mutated protein (by FoldX) 70.2763 kcal/mol
Show buried residues

Minimal score value
-3.3692
Maximal score value
3.0191
Average score
-0.4421
Total score value
-689.6588

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 0.4327
2 I A 0.4527
3 Q A 0.0000
4 S A 0.0000
5 Q A 0.0000
6 I A -0.2033
7 N A -0.9883
8 R A -1.1370
9 N A -1.6809
10 I A -0.7686
11 R A 0.0000
12 L A -1.1184
13 D A -2.0164
14 L A 0.0000
15 A A 0.0000
16 D A -0.7767
17 A A -0.3764
18 I A 0.0000
19 L A 0.0000
20 L A -0.6056
21 S A -0.7817
22 K A 0.0000
23 A A 0.0000
24 K A -2.5263
25 K A -2.5256
26 D A -2.4730
27 L A -1.4493
28 S A 0.0000
29 F A 0.0000
30 A A -1.7170
31 E A -2.4598
32 I A 0.0000
33 A A 0.0000
34 D A -2.8081
35 G A -1.5967
36 T A -1.6296
37 G A -0.9656
38 L A -0.5767
39 A A -1.1033
40 E A -1.9417
41 A A 0.0000
42 F A 0.0000
43 V A 0.0000
44 T A 0.0000
45 A A 0.0000
46 A A 0.0000
47 L A 0.0000
48 L A 0.0000
49 G A 0.0000
50 Q A 0.0000
51 Q A 0.0000
52 A A -0.3592
53 L A 0.0000
54 P A -0.9421
55 A A -1.2872
56 D A -2.2829
57 A A 0.0000
58 A A 0.0000
59 R A -1.6448
60 L A -0.6760
61 V A 0.0000
62 G A 0.0000
63 A A 0.7881
64 L A 0.4575 mutated: KA64L
65 L A 0.0000
66 L A 2.0673 mutated: DA66L
67 L A 2.0733
68 L A 3.0191 mutated: DA68L
69 L A 2.5061 mutated: EA69L
70 L A 1.7338 mutated: DA70L
71 S A 0.0000
72 I A 1.0257
73 L A 0.5753
74 L A 0.0000
75 L A 0.0000
76 Q A -0.4893
77 M A 0.0000
78 I A 0.0000
79 P A 0.0000
80 L A 0.0000
81 R A 0.0000
82 G A 0.0000
83 C A 0.0000
84 I A 0.0000
85 D A -2.8445
86 D A -3.3692
87 R A -2.0568
88 I A 0.0000
89 P A 0.0000
90 T A -0.8391
91 D A 0.0000
92 P A 0.0000
93 T A 0.0000
94 M A 0.0000
95 Y A 0.0000
96 Q A 0.0000
97 F A 0.0000
98 Y A 0.0000
99 E A 0.0000
100 M A 0.0000
101 L A 0.0000
102 Q A 0.0000
103 V A 0.0000
104 Y A 0.0000
105 G A 0.0000
106 T A 0.0000
107 T A 0.0000
108 L A 0.0000
109 K A 0.0000
110 A A 0.0000
111 L A 0.0000
112 V A 0.0000
113 H A 0.0000
114 E A -0.1468
115 K A -1.0911
116 F A -0.6824
117 G A -0.2619
118 D A -0.5417
119 G A 0.0000
120 I A 0.0000
121 I A 0.0000
122 S A 0.0000
123 A A 0.0000
124 I A -0.6913
125 N A -1.3585
126 F A 0.0000
127 K A -1.9381
128 L A 0.0000
129 D A -2.5679
130 V A 0.0000
131 K A -2.7187
132 K A -2.3069
133 V A -0.9326
134 A A -0.8917
135 D A 0.0000
136 P A -1.3693
137 E A -2.2886
138 G A -1.6939
139 G A -1.3640
140 E A -1.5079
141 R A 0.0000
142 A A 0.0000
143 V A -1.1246
144 I A 0.0000
145 T A -1.1644
146 L A 0.0000
147 D A -1.2530
148 G A 0.0000
149 K A -1.0518
150 Y A -0.6226
151 L A -0.5506
152 P A -0.8941
153 T A -1.0336
154 K A -1.9235
155 P A -0.8358
156 F A -0.3210
1 M B 0.4271
2 I B 0.4214
3 Q B 0.0000
4 S B 0.0000
5 Q B 0.0000
6 I B -0.3000
7 N B -1.1409
8 R B -1.2721
9 N B -1.7704
10 I B -0.9660
11 R B 0.0000
12 L B -1.1351
13 D B -2.0291
14 L B 0.0000
15 A B 0.0000
16 D B 0.0000
17 A B -0.2823
18 I B 0.0000
19 L B 0.0000
20 L B -0.4974
21 S B -0.7520
22 K B 0.0000
23 A B 0.0000
24 K B -2.4623
25 K B -2.4900
26 D B -2.4751
27 L B 0.0000
28 S B 0.0000
29 F B 0.0000
30 A B -1.4145
31 E B -1.9842
32 I B 0.0000
33 A B 0.0000
34 D B -2.6162
35 G B -1.5324
36 T B -1.5969
37 G B -0.9162
38 L B -0.4967
39 A B -1.0067
40 E B -1.7504
41 A B 0.0000
42 F B 0.0000
43 V B 0.0000
44 T B 0.0000
45 A B 0.0000
46 A B 0.0000
47 L B 0.0000
48 L B 0.0000
49 G B 0.0000
50 Q B 0.0000
51 Q B 0.0000
52 A B -0.4002
53 L B 0.0000
54 P B -1.1235
55 A B -1.3544
56 D B -2.3353
57 A B 0.0000
58 A B 0.0000
59 R B -1.7556
60 L B -0.8120
61 V B 0.0000
62 G B 0.0000
63 A B 0.7331
64 L B 0.4873 mutated: KB64L
65 L B 0.0000
66 L B 2.0406 mutated: DB66L
67 L B 1.9719
68 L B 2.9103 mutated: DB68L
69 L B 2.3450 mutated: EB69L
70 L B 1.4951 mutated: DB70L
71 S B 0.0000
72 I B 0.0000
73 L B 0.3295
74 L B 0.0000
75 L B 0.0000
76 Q B -0.6276
77 M B 0.0000
78 I B 0.0000
79 P B 0.0000
80 L B -0.0760
81 R B 0.0000
82 G B 0.0000
83 C B 0.0000
84 I B 0.0000
85 D B -2.2980
86 D B -3.1225
87 R B -1.9985
88 I B 0.0000
89 P B 0.0000
90 T B 0.0000
91 D B 0.0000
92 P B 0.0000
93 T B 0.0000
94 M B 0.0000
95 Y B 0.0000
96 Q B 0.0000
97 F B 0.0000
98 Y B 0.0000
99 E B 0.0000
100 M B 0.0000
101 L B 0.0000
102 Q B 0.0000
103 V B 0.0000
104 Y B 0.0000
105 G B 0.0000
106 T B 0.0000
107 T B 0.0000
108 L B 0.0000
109 K B 0.0000
110 A B 0.0000
111 L B 0.0000
112 V B 0.0000
113 H B 0.0000
114 E B -0.2859
115 K B -1.3051
116 F B -0.8508
117 G B -0.3455
118 D B -0.5804
119 G B 0.0000
120 I B 0.0000
121 I B 0.0000
122 S B 0.0000
123 A B 0.0000
124 I B -0.6519
125 N B -1.2776
126 F B 0.0000
127 K B -1.7929
128 L B 0.0000
129 D B -2.5546
130 V B 0.0000
131 K B -2.6150
132 K B -2.1084
133 V B -0.8578
134 A B -0.9215
135 D B 0.0000
136 P B -1.3913
137 E B -2.3157
138 G B -1.7857
139 G B -1.4408
140 E B -1.5704
141 R B -1.3327
142 A B 0.0000
143 V B -1.1263
144 I B 0.0000
145 T B -0.9203
146 L B 0.0000
147 D B 0.0000
148 G B 0.0000
149 K B -1.0082
150 Y B 0.0000
151 L B -0.5999
152 P B -0.9202
153 T B -1.0474
154 K B -1.9119
155 P B -0.8023
156 F B -0.2454
1 M C 0.6176
2 I C 0.6339
3 Q C 0.0000
4 S C 0.0000
5 Q C 0.0000
6 I C 0.0000
7 N C -1.2303
8 R C -1.3053
9 N C -1.7852
10 I C -0.9864
11 R C 0.0000
12 L C -1.1301
13 D C -2.0222
14 L C 0.0000
15 A C 0.0000
16 D C 0.0000
17 A C -0.2810
18 I C 0.0000
19 L C 0.0000
20 L C -0.4857
21 S C -0.6575
22 K C 0.0000
23 A C 0.0000
24 K C -2.2914
25 K C -2.0904
26 D C -2.2567
27 L C 0.0000
28 S C 0.0000
29 F C 0.0000
30 A C -1.4602
31 E C -2.0301
32 I C 0.0000
33 A C 0.0000
34 D C -2.6307
35 G C -1.5236
36 T C -1.6174
37 G C -0.9497
38 L C -0.5033
39 A C -1.0272
40 E C -1.8441
41 A C 0.0000
42 F C 0.0000
43 V C 0.0000
44 T C 0.0000
45 A C 0.0000
46 A C 0.0000
47 L C 0.0000
48 L C 0.0000
49 G C 0.0000
50 Q C 0.0000
51 Q C 0.0000
52 A C -0.3725
53 L C 0.0000
54 P C -1.0705
55 A C -1.2830
56 D C -2.2642
57 A C 0.0000
58 A C 0.0000
59 R C -1.4999
60 L C -0.7116
61 V C 0.0000
62 G C 0.0000
63 A C 0.7500
64 L C 0.5306 mutated: KC64L
65 L C 0.0000
66 L C 2.0970 mutated: DC66L
67 L C 2.0104
68 L C 2.7918 mutated: DC68L
69 L C 2.4514 mutated: EC69L
70 L C 1.6969 mutated: DC70L
71 S C 0.0000
72 I C 0.0000
73 L C 0.4724
74 L C 0.0000
75 L C 0.0000
76 Q C -0.5090
77 M C 0.0000
78 I C 0.0000
79 P C 0.0000
80 L C -0.1420
81 R C 0.0000
82 G C 0.0000
83 C C 0.0000
84 I C 0.0000
85 D C -1.6117
86 D C -2.2268
87 R C -1.3017
88 I C 0.0000
89 P C 0.0000
90 T C -0.5816
91 D C 0.0000
92 P C 0.0000
93 T C 0.0000
94 M C 0.0000
95 Y C 0.0000
96 Q C 0.0000
97 F C 0.0000
98 Y C 0.0000
99 E C 0.0000
100 M C 0.0000
101 L C 0.0000
102 Q C 0.0000
103 V C 0.0000
104 Y C 0.0000
105 G C 0.0000
106 T C 0.0000
107 T C 0.0000
108 L C 0.0000
109 K C 0.0000
110 A C 0.0000
111 L C 0.0000
112 V C 0.0000
113 H C 0.0000
114 E C -0.0913
115 K C -0.9045
116 F C -0.6272
117 G C -0.2253
118 D C -0.5282
119 G C 0.0000
120 I C 0.0000
121 I C 0.0000
122 S C 0.0000
123 A C 0.0000
124 I C -0.6623
125 N C -1.2198
126 F C 0.0000
127 K C -1.7641
128 L C 0.0000
129 D C -2.5932
130 V C 0.0000
131 K C -2.5855
132 K C -1.9942
133 V C -0.8131
134 A C -0.8510
135 D C 0.0000
136 P C -1.3852
137 E C -2.2849
138 G C -1.7100
139 G C -1.3849
140 E C -1.4705
141 R C -1.1701
142 A C 0.0000
143 V C -1.0878
144 I C 0.0000
145 T C -1.0723
146 L C 0.0000
147 D C 0.0000
148 G C 0.0000
149 K C -0.9953
150 Y C 0.0000
151 L C -0.4959
152 P C -0.7603
153 T C -0.9711
154 K C -1.7771
155 P C -0.9361
156 F C -0.3714
1 M D 0.6287
2 I D 0.5508
3 Q D 0.0000
4 S D 0.0000
5 Q D 0.0000
6 I D 0.0000
7 N D -1.2373
8 R D -1.3161
9 N D -1.8419
10 I D -1.2228
11 R D 0.0000
12 L D -1.2103
13 D D -2.0985
14 L D 0.0000
15 A D 0.0000
16 D D -0.6718
17 A D -0.3701
18 I D 0.0000
19 L D 0.0000
20 L D -0.5818
21 S D -0.7708
22 K D 0.0000
23 A D 0.0000
24 K D -2.5440
25 K D -2.5194
26 D D -2.4217
27 L D -1.2989
28 S D 0.0000
29 F D 0.0000
30 A D -1.5721
31 E D -2.2010
32 I D 0.0000
33 A D 0.0000
34 D D -2.7299
35 G D -1.5910
36 T D -1.6331
37 G D -1.1058
38 L D -0.4927
39 A D -1.0587
40 E D -1.8234
41 A D 0.0000
42 F D 0.0000
43 V D 0.0000
44 T D 0.0000
45 A D 0.0000
46 A D 0.0000
47 L D 0.0000
48 L D 0.0000
49 G D 0.0000
50 Q D 0.0000
51 Q D 0.0000
52 A D -0.3973
53 L D 0.0000
54 P D -1.1224
55 A D -1.3347
56 D D -2.3798
57 A D 0.0000
58 A D 0.0000
59 R D -1.5741
60 L D -0.8041
61 V D 0.0000
62 G D 0.0000
63 A D 0.7879
64 L D 0.6135 mutated: KD64L
65 L D 0.0000
66 L D 2.0825 mutated: DD66L
67 L D 2.0733
68 L D 2.7576 mutated: DD68L
69 L D 2.3807 mutated: ED69L
70 L D 1.5519 mutated: DD70L
71 S D 0.0000
72 I D 0.0000
73 L D 0.3979
74 L D 0.0000
75 L D 0.0000
76 Q D -0.6230
77 M D 0.0000
78 I D 0.0000
79 P D 0.0000
80 L D 0.0000
81 R D 0.0000
82 G D 0.0000
83 C D 0.0000
84 I D 0.0000
85 D D -1.8657
86 D D -2.8066
87 R D -1.5849
88 I D 0.0000
89 P D 0.0000
90 T D 0.0000
91 D D 0.0000
92 P D 0.0000
93 T D 0.0000
94 M D 0.0000
95 Y D 0.0000
96 Q D 0.0000
97 F D 0.0000
98 Y D 0.0000
99 E D 0.0000
100 M D 0.0000
101 L D 0.0000
102 Q D 0.0000
103 V D 0.0000
104 Y D 0.0000
105 G D 0.0000
106 T D 0.0000
107 T D 0.0000
108 L D 0.0000
109 K D 0.0000
110 A D 0.0000
111 L D 0.0000
112 V D 0.0000
113 H D 0.0000
114 E D -0.2771
115 K D -1.2617
116 F D -0.7882
117 G D -0.4367
118 D D -0.5826
119 G D 0.0000
120 I D 0.0000
121 I D 0.0000
122 S D 0.0000
123 A D 0.0000
124 I D -0.6250
125 N D -1.1874
126 F D 0.0000
127 K D -1.7049
128 L D 0.0000
129 D D -2.5670
130 V D 0.0000
131 K D -2.6709
132 K D -2.2907
133 V D -0.9962
134 A D -0.9903
135 D D 0.0000
136 P D -1.3982
137 E D -2.3035
138 G D -1.7340
139 G D -1.4195
140 E D -1.6670
141 R D -1.3636
142 A D 0.0000
143 V D -1.2801
144 I D 0.0000
145 T D -1.1209
146 L D 0.0000
147 D D 0.0000
148 G D 0.0000
149 K D -0.8912
150 Y D 0.0000
151 L D -0.5765
152 P D -0.8799
153 T D -1.0574
154 K D -1.9252
155 P D -0.8222
156 F D -0.2642
1 M E 0.5049
2 I E 0.6977
3 Q E 0.0000
4 S E 0.0000
5 Q E 0.0000
6 I E -0.2685
7 N E -1.0913
8 R E -1.2204
9 N E -1.6953
10 I E -0.7823
11 R E 0.0000
12 L E -1.1378
13 D E -2.0231
14 L E 0.0000
15 A E 0.0000
16 D E -0.7989
17 A E -0.3761
18 I E 0.0000
19 L E 0.0000
20 L E -0.5869
21 S E -0.7535
22 K E 0.0000
23 A E 0.0000
24 K E -2.4647
25 K E -2.3200
26 D E -2.3433
27 L E 0.0000
28 S E -0.9364
29 F E 0.0000
30 A E -1.6541
31 E E -2.2648
32 I E 0.0000
33 A E 0.0000
34 D E -2.7451
35 G E -1.5905
36 T E -1.6735
37 G E -0.9662
38 L E -0.5495
39 A E -1.1118
40 E E -1.8761
41 A E 0.0000
42 F E 0.0000
43 V E 0.0000
44 T E 0.0000
45 A E 0.0000
46 A E 0.0000
47 L E 0.0000
48 L E 0.0000
49 G E 0.0000
50 Q E 0.0000
51 Q E 0.0000
52 A E -0.3634
53 L E 0.0000
54 P E -1.1078
55 A E -1.3086
56 D E -2.3280
57 A E 0.0000
58 A E 0.0000
59 R E -1.5602
60 L E -0.8409
61 V E 0.0000
62 G E 0.0000
63 A E 0.7524
64 L E 0.4931 mutated: KE64L
65 L E 0.0000
66 L E 2.0893 mutated: DE66L
67 L E 2.1285
68 L E 2.8664 mutated: DE68L
69 L E 2.5585 mutated: EE69L
70 L E 1.8489 mutated: DE70L
71 S E 0.0000
72 I E 1.0239
73 L E 0.6220
74 L E 0.0000
75 L E 0.0000
76 Q E -0.4215
77 M E 0.0000
78 I E 0.0000
79 P E 0.0000
80 L E 0.0000
81 R E 0.0000
82 G E 0.0000
83 C E 0.0000
84 I E 0.0000
85 D E -2.7197
86 D E -3.0564
87 R E -1.6630
88 I E -0.8602
89 P E 0.0000
90 T E -0.6395
91 D E 0.0000
92 P E 0.0000
93 T E 0.0000
94 M E 0.0000
95 Y E 0.0000
96 Q E 0.0000
97 F E 0.0000
98 Y E 0.0000
99 E E 0.0000
100 M E 0.0000
101 L E 0.0000
102 Q E 0.0000
103 V E 0.0000
104 Y E 0.0000
105 G E 0.0000
106 T E 0.0000
107 T E 0.0000
108 L E 0.0000
109 K E 0.0000
110 A E 0.0000
111 L E 0.0000
112 V E 0.0000
113 H E 0.0000
114 E E -0.2451
115 K E -1.1841
116 F E -0.7293
117 G E -0.4004
118 D E -0.5557
119 G E 0.0000
120 I E 0.0000
121 I E 0.0000
122 S E 0.0000
123 A E -0.3926
124 I E -0.6710
125 N E -1.2872
126 F E 0.0000
127 K E -2.1925
128 L E 0.0000
129 D E -2.6660
130 V E 0.0000
131 K E -2.4732
132 K E -1.8129
133 V E -0.6709
134 A E -0.8159
135 D E 0.0000
136 P E -1.3814
137 E E -2.3005
138 G E -1.7402
139 G E -1.3766
140 E E -1.4030
141 R E -1.0889
142 A E 0.0000
143 V E -1.0619
144 I E 0.0000
145 T E -1.0814
146 L E 0.0000
147 D E -1.4570
148 G E 0.0000
149 K E -1.0366
150 Y E -0.5812
151 L E -0.5283
152 P E -0.8846
153 T E -0.9930
154 K E -1.8735
155 P E -0.8067
156 F E -0.1857
1 M F 0.5934
2 I F 0.6604
3 Q F 0.0000
4 S F 0.0000
5 Q F 0.0000
6 I F 0.0000
7 N F -1.1330
8 R F -1.2681
9 N F -1.6972
10 I F -0.8002
11 R F 0.0000
12 L F -1.1684
13 D F -2.0264
14 L F 0.0000
15 A F 0.0000
16 D F -0.8603
17 A F -0.3685
18 I F 0.0000
19 L F 0.0000
20 L F -0.4970
21 S F -0.6868
22 K F 0.0000
23 A F 0.0000
24 K F -2.4745
25 K F -2.4430
26 D F -2.4037
27 L F -1.2952
28 S F 0.0000
29 F F 0.0000
30 A F -1.6109
31 E F -2.1494
32 I F 0.0000
33 A F 0.0000
34 D F -2.7172
35 G F -1.5479
36 T F -1.5785
37 G F -0.9367
38 L F -0.5319
39 A F -1.1073
40 E F -1.9432
41 A F 0.0000
42 F F 0.0000
43 V F 0.0000
44 T F 0.0000
45 A F 0.0000
46 A F 0.0000
47 L F 0.0000
48 L F 0.0000
49 G F 0.0000
50 Q F 0.0000
51 Q F 0.0000
52 A F -0.4095
53 L F 0.0000
54 P F -1.1200
55 A F -1.3373
56 D F -2.2934
57 A F 0.0000
58 A F 0.0000
59 R F -1.5200
60 L F -0.6495
61 V F 0.0000
62 G F 0.0000
63 A F 0.7640
64 L F 0.5047 mutated: KF64L
65 L F 0.0000
66 L F 2.0346 mutated: DF66L
67 L F 2.0663
68 L F 2.7944 mutated: DF68L
69 L F 2.4601 mutated: EF69L
70 L F 1.7338 mutated: DF70L
71 S F 0.0000
72 I F 0.0000
73 L F 0.4053
74 L F 0.0000
75 L F 0.0000
76 Q F -0.6281
77 M F 0.0000
78 I F 0.0000
79 P F 0.0000
80 L F -0.1163
81 R F 0.0000
82 G F 0.0000
83 C F 0.0000
84 I F 0.0000
85 D F -2.1640
86 D F -3.0306
87 R F -2.0210
88 I F 0.0000
89 P F 0.0000
90 T F 0.0000
91 D F 0.0000
92 P F 0.0000
93 T F 0.0000
94 M F 0.0000
95 Y F 0.0000
96 Q F 0.0000
97 F F 0.0000
98 Y F 0.0000
99 E F 0.0000
100 M F 0.0000
101 L F 0.0000
102 Q F 0.0000
103 V F 0.0000
104 Y F 0.0000
105 G F 0.0000
106 T F 0.0000
107 T F 0.0000
108 L F 0.0000
109 K F 0.0000
110 A F 0.0000
111 L F 0.0000
112 V F 0.0000
113 H F 0.0000
114 E F -0.2451
115 K F -1.2371
116 F F -0.7758
117 G F -0.4343
118 D F -0.5870
119 G F 0.0000
120 I F 0.0000
121 I F 0.0000
122 S F 0.0000
123 A F 0.0000
124 I F -0.5925
125 N F -1.1666
126 F F 0.0000
127 K F -1.8742
128 L F 0.0000
129 D F -2.6262
130 V F 0.0000
131 K F -2.7390
132 K F -2.3316
133 V F -0.9939
134 A F -0.9341
135 D F 0.0000
136 P F -1.3830
137 E F -2.2744
138 G F -1.6813
139 G F -1.3626
140 E F -1.5958
141 R F -1.3339
142 A F 0.0000
143 V F -1.1719
144 I F 0.0000
145 T F -0.9590
146 L F 0.0000
147 D F -1.1991
148 G F 0.0000
149 K F -1.1967
150 Y F 0.0000
151 L F 0.0000
152 P F -1.0207
153 T F -1.0909
154 K F -1.9916
155 P F -0.9149
156 F F -0.4788
1 M G 0.6555
2 I G 0.5529
3 Q G 0.0000
4 S G 0.0000
5 Q G 0.0000
6 I G -0.2506
7 N G -1.0796
8 R G -1.2285
9 N G -1.7647
10 I G -0.9274
11 R G 0.0000
12 L G -1.1423
13 D G -1.9887
14 L G 0.0000
15 A G 0.0000
16 D G 0.0000
17 A G -0.2834
18 I G 0.0000
19 L G 0.0000
20 L G -0.4627
21 S G -0.6267
22 K G 0.0000
23 A G 0.0000
24 K G -2.2904
25 K G -2.1112
26 D G -2.2500
27 L G -1.1313
28 S G -0.7363
29 F G 0.0000
30 A G -1.4423
31 E G -1.8706
32 I G 0.0000
33 A G 0.0000
34 D G -2.6151
35 G G -1.5313
36 T G -1.5955
37 G G -0.9508
38 L G -0.5202
39 A G -1.0547
40 E G -1.8209
41 A G 0.0000
42 F G 0.0000
43 V G 0.0000
44 T G 0.0000
45 A G 0.0000
46 A G 0.0000
47 L G 0.0000
48 L G 0.0000
49 G G 0.0000
50 Q G 0.0000
51 Q G 0.0000
52 A G -0.3635
53 L G 0.0000
54 P G -0.9153
55 A G -1.2907
56 D G -2.2815
57 A G 0.0000
58 A G 0.0000
59 R G -1.6194
60 L G -0.7236
61 V G 0.0000
62 G G 0.0000
63 A G 0.8111
64 L G 0.6534 mutated: KG64L
65 L G 0.0000
66 L G 2.1097 mutated: DG66L
67 L G 2.0410
68 L G 2.9632 mutated: DG68L
69 L G 2.4390 mutated: EG69L
70 L G 1.6400 mutated: DG70L
71 S G 0.0000
72 I G 0.0000
73 L G 0.4611
74 L G 0.0000
75 L G 0.0000
76 Q G -0.5245
77 M G 0.0000
78 I G 0.0000
79 P G 0.0000
80 L G 0.0000
81 R G 0.0000
82 G G 0.0000
83 C G 0.0000
84 I G 0.0000
85 D G -2.8238
86 D G -3.2679
87 R G -1.7882
88 I G 0.0000
89 P G 0.0000
90 T G -0.8310
91 D G 0.0000
92 P G 0.0000
93 T G 0.0000
94 M G 0.0000
95 Y G 0.0000
96 Q G 0.0000
97 F G 0.0000
98 Y G 0.0000
99 E G 0.0000
100 M G 0.0000
101 L G 0.0000
102 Q G 0.0000
103 V G 0.0000
104 Y G 0.0000
105 G G 0.0000
106 T G 0.0000
107 T G 0.0000
108 L G 0.0000
109 K G 0.0000
110 A G 0.0000
111 L G 0.0000
112 V G 0.0000
113 H G 0.0000
114 E G -0.2201
115 K G -1.2020
116 F G -0.5085
117 G G -0.3612
118 D G -0.5046
119 G G 0.0000
120 I G 0.0000
121 I G 0.0000
122 S G 0.0000
123 A G 0.0000
124 I G -0.5959
125 N G -1.1533
126 F G 0.0000
127 K G -1.8793
128 L G 0.0000
129 D G -2.6303
130 V G 0.0000
131 K G -2.6161
132 K G -1.9960
133 V G -0.9078
134 A G -0.9570
135 D G -1.5361
136 P G -1.4858
137 E G -2.3684
138 G G -1.8203
139 G G -1.5206
140 E G -1.6045
141 R G -1.3188
142 A G 0.0000
143 V G -1.3049
144 I G 0.0000
145 T G -1.1939
146 L G 0.0000
147 D G 0.0000
148 G G 0.0000
149 K G -0.8520
150 Y G -0.4046
151 L G -0.4222
152 P G -0.6127
153 T G -0.9761
154 K G -1.9020
155 P G -0.8375
156 F G -0.1696
1 M H 0.7165
2 I H 0.7353
3 Q H 0.0000
4 S H 0.0000
5 Q H 0.0000
6 I H -0.2986
7 N H -1.1387
8 R H -1.2319
9 N H -1.7347
10 I H -0.9097
11 R H 0.0000
12 L H -1.1086
13 D H -1.9952
14 L H 0.0000
15 A H 0.0000
16 D H 0.0000
17 A H -0.2812
18 I H 0.0000
19 L H 0.0000
20 L H -0.5168
21 S H -0.7432
22 K H 0.0000
23 A H 0.0000
24 K H -2.4480
25 K H -2.4425
26 D H -2.4087
27 L H -1.4289
28 S H 0.0000
29 F H 0.0000
30 A H -1.5831
31 E H -2.4967
32 I H 0.0000
33 A H 0.0000
34 D H -2.7451
35 G H -1.6192
36 T H -1.6057
37 G H -0.8856
38 L H -0.3721
39 A H -0.7386
40 E H -1.3447
41 A H 0.0000
42 F H 0.0000
43 V H 0.0000
44 T H 0.0000
45 A H 0.0000
46 A H 0.0000
47 L H 0.0000
48 L H 0.0000
49 G H 0.0000
50 Q H 0.0000
51 Q H 0.0000
52 A H -0.4008
53 L H 0.0000
54 P H -1.1262
55 A H -1.3172
56 D H -2.3013
57 A H 0.0000
58 A H 0.0000
59 R H -1.7232
60 L H -0.7636
61 V H 0.0000
62 G H 0.0000
63 A H 0.7591
64 L H 0.4295 mutated: KH64L
65 L H 0.0000
66 L H 2.0512 mutated: DH66L
67 L H 1.9757
68 L H 2.8950 mutated: DH68L
69 L H 2.3218 mutated: EH69L
70 L H 1.4298 mutated: DH70L
71 S H 0.0000
72 I H 0.0000
73 L H 0.3188
74 L H 0.0000
75 L H 0.0000
76 Q H -0.5752
77 M H 0.0000
78 I H 0.0000
79 P H 0.0000
80 L H -0.0676
81 R H 0.0000
82 G H 0.0000
83 C H 0.0000
84 I H 0.0000
85 D H -2.3699
86 D H -2.3606
87 R H -1.5440
88 I H 0.0000
89 P H 0.0000
90 T H -0.6245
91 D H 0.0000
92 P H 0.0000
93 T H 0.0000
94 M H 0.0000
95 Y H 0.0000
96 Q H 0.0000
97 F H 0.0000
98 Y H 0.0000
99 E H 0.0000
100 M H 0.0000
101 L H 0.0000
102 Q H 0.0000
103 V H 0.0000
104 Y H 0.0000
105 G H 0.0000
106 T H 0.0000
107 T H 0.0000
108 L H 0.0000
109 K H 0.0000
110 A H 0.0000
111 L H 0.0000
112 V H 0.0000
113 H H 0.0000
114 E H -0.2769
115 K H -1.2381
116 F H -0.7388
117 G H -0.4170
118 D H -0.5554
119 G H 0.0000
120 I H 0.0000
121 I H 0.0000
122 S H 0.0000
123 A H -0.3208
124 I H -0.6226
125 N H -1.1958
126 F H 0.0000
127 K H -1.7078
128 L H 0.0000
129 D H -2.2433
130 V H 0.0000
131 K H -2.6405
132 K H -2.3060
133 V H -1.0347
134 A H -0.9988
135 D H -1.5158
136 P H -1.4494
137 E H -2.3134
138 G H -1.7115
139 G H -1.3961
140 E H -1.6293
141 R H -1.3605
142 A H 0.0000
143 V H -1.1489
144 I H 0.0000
145 T H -1.0112
146 L H 0.0000
147 D H 0.0000
148 G H 0.0000
149 K H -0.8863
150 Y H -0.4887
151 L H -0.4798
152 P H -0.8568
153 T H -1.0038
154 K H -1.8944
155 P H -0.8197
156 F H -0.2476
1 M I 0.5199
2 I I 0.6558
3 Q I 0.0000
4 S I 0.0000
5 Q I 0.0000
6 I I -0.2553
7 N I -1.0761
8 R I -1.1997
9 N I -1.6609
10 I I -0.7660
11 R I 0.0000
12 L I -1.0724
13 D I -1.9646
14 L I 0.0000
15 A I 0.0000
16 D I 0.0000
17 A I -0.2897
18 I I 0.0000
19 L I 0.0000
20 L I -0.4935
21 S I -0.7677
22 K I 0.0000
23 A I 0.0000
24 K I -2.5421
25 K I -2.6334
26 D I -2.5253
27 L I -1.3359
28 S I 0.0000
29 F I 0.0000
30 A I -1.4835
31 E I -1.9340
32 I I 0.0000
33 A I 0.0000
34 D I -2.7159
35 G I -1.5567
36 T I -1.5907
37 G I -0.9896
38 L I -0.5946
39 A I -1.0774
40 E I -1.8202
41 A I 0.0000
42 F I 0.0000
43 V I 0.0000
44 T I 0.0000
45 A I 0.0000
46 A I 0.0000
47 L I 0.0000
48 L I 0.0000
49 G I 0.0000
50 Q I 0.0000
51 Q I 0.0000
52 A I -0.3915
53 L I 0.0000
54 P I -1.0867
55 A I -1.3141
56 D I -2.3102
57 A I 0.0000
58 A I 0.0000
59 R I -1.5507
60 L I -0.5775
61 V I 0.0000
62 G I 0.0000
63 A I 0.7557
64 L I 0.5177 mutated: KI64L
65 L I 0.0000
66 L I 2.0321 mutated: DI66L
67 L I 2.0169
68 L I 2.7817 mutated: DI68L
69 L I 2.4371 mutated: EI69L
70 L I 1.6579 mutated: DI70L
71 S I 1.3935
72 I I 0.0000
73 L I 0.4565
74 L I 0.0000
75 L I 0.0000
76 Q I -0.5252
77 M I 0.0000
78 I I 0.0000
79 P I 0.0000
80 L I -0.0603
81 R I 0.0000
82 G I 0.0000
83 C I 0.0000
84 I I 0.0000
85 D I -1.6444
86 D I -2.3338
87 R I -1.3386
88 I I 0.0000
89 P I 0.0000
90 T I -0.6368
91 D I 0.0000
92 P I 0.0000
93 T I 0.0000
94 M I 0.0000
95 Y I 0.0000
96 Q I 0.0000
97 F I 0.0000
98 Y I 0.0000
99 E I 0.0000
100 M I 0.0000
101 L I 0.0000
102 Q I 0.0000
103 V I 0.0000
104 Y I 0.0000
105 G I 0.0000
106 T I 0.0000
107 T I 0.0000
108 L I 0.0000
109 K I 0.0000
110 A I 0.0000
111 L I 0.0000
112 V I 0.0000
113 H I 0.0000
114 E I -0.2422
115 K I -1.2208
116 F I -0.7591
117 G I -0.4598
118 D I -0.6356
119 G I 0.0000
120 I I 0.0000
121 I I 0.0000
122 S I 0.0000
123 A I 0.0000
124 I I -0.5519
125 N I -1.1749
126 F I 0.0000
127 K I -1.7895
128 L I 0.0000
129 D I -1.8907
130 V I 0.0000
131 K I -1.9894
132 K I -2.1555
133 V I -0.7307
134 A I -0.8778
135 D I 0.0000
136 P I -1.3612
137 E I -2.2876
138 G I -1.7060
139 G I -1.3405
140 E I -1.5642
141 R I -1.2057
142 A I 0.0000
143 V I -0.8962
144 I I 0.0000
145 T I -0.9444
146 L I 0.0000
147 D I -1.3959
148 G I 0.0000
149 K I -1.2348
150 Y I -0.7626
151 L I 0.0000
152 P I -1.0120
153 T I -1.0868
154 K I -1.9315
155 P I -0.8147
156 F I -0.2280
1 M J 0.6449
2 I J 0.6018
3 Q J 0.0000
4 S J 0.0000
5 Q J 0.0000
6 I J -0.2947
7 N J -1.1293
8 R J -1.2690
9 N J -1.8085
10 I J -1.0266
11 R J 0.0000
12 L J -1.2413
13 D J -2.0861
14 L J 0.0000
15 A J 0.0000
16 D J -0.8231
17 A J -0.3791
18 I J 0.0000
19 L J 0.0000
20 L J -0.5885
21 S J -0.8052
22 K J 0.0000
23 A J 0.0000
24 K J -2.5366
25 K J -2.6009
26 D J -2.4650
27 L J -1.3622
28 S J 0.0000
29 F J 0.0000
30 A J -1.5926
31 E J -2.2688
32 I J 0.0000
33 A J 0.0000
34 D J -2.7308
35 G J -1.5974
36 T J -1.6197
37 G J -0.9266
38 L J -0.4821
39 A J -0.9968
40 E J -1.7129
41 A J 0.0000
42 F J 0.0000
43 V J 0.0000
44 T J 0.0000
45 A J 0.0000
46 A J 0.0000
47 L J 0.0000
48 L J 0.0000
49 G J 0.0000
50 Q J 0.0000
51 Q J 0.0000
52 A J -0.3665
53 L J 0.0000
54 P J -1.0522
55 A J -1.1977
56 D J -2.1914
57 A J 0.0000
58 A J 0.0000
59 R J -1.3689
60 L J -0.6769
61 V J 0.0000
62 G J 0.0000
63 A J 0.8341
64 L J 0.5175 mutated: KJ64L
65 L J 0.0000
66 L J 2.0893 mutated: DJ66L
67 L J 2.0940
68 L J 2.9707 mutated: DJ68L
69 L J 2.5012 mutated: EJ69L
70 L J 1.5921 mutated: DJ70L
71 S J 0.0000
72 I J 1.0244
73 L J 0.5614
74 L J 0.0000
75 L J 0.0000
76 Q J -0.4505
77 M J 0.0000
78 I J 0.0000
79 P J 0.0000
80 L J 0.0000
81 R J 0.0000
82 G J 0.0000
83 C J 0.0000
84 I J 0.0000
85 D J -2.8108
86 D J -3.2067
87 R J -1.8400
88 I J 0.0000
89 P J 0.0000
90 T J -0.6990
91 D J 0.0000
92 P J 0.0000
93 T J 0.0000
94 M J 0.0000
95 Y J 0.0000
96 Q J 0.0000
97 F J 0.0000
98 Y J 0.0000
99 E J 0.0000
100 M J 0.0000
101 L J 0.0000
102 Q J 0.0000
103 V J 0.0000
104 Y J 0.0000
105 G J 0.0000
106 T J 0.0000
107 T J 0.0000
108 L J 0.0000
109 K J 0.0000
110 A J 0.0000
111 L J 0.0000
112 V J 0.0000
113 H J 0.0000
114 E J -0.2972
115 K J -1.2255
116 F J -0.8120
117 G J -0.4490
118 D J -0.5992
119 G J 0.0000
120 I J 0.0000
121 I J 0.0000
122 S J 0.0000
123 A J -0.3220
124 I J -0.5904
125 N J -1.2127
126 F J 0.0000
127 K J -1.8509
128 L J 0.0000
129 D J -2.5984
130 V J 0.0000
131 K J -2.6615
132 K J -2.1604
133 V J -0.9219
134 A J -0.9591
135 D J 0.0000
136 P J -1.4162
137 E J -2.3346
138 G J -1.8259
139 G J -1.4574
140 E J -1.6559
141 R J -1.4249
142 A J 0.0000
143 V J -1.3245
144 I J 0.0000
145 T J -1.1454
146 L J 0.0000
147 D J -1.1420
148 G J 0.0000
149 K J -0.9998
150 Y J 0.0000
151 L J -0.6070
152 P J -0.9503
153 T J -1.0904
154 K J -1.9535
155 P J -0.8885
156 F J -0.3642

 

Laboratory of Theory of Biopolymers 2015