| Chain sequence(s) |
A: GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC B: VDPSTGEL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 325 | G | A | -1.6523 | |
| 326 | R | A | -2.5054 | |
| 327 | L | A | 0.0000 | |
| 328 | I | A | 0.0000 | |
| 329 | Y | A | 0.0000 | |
| 330 | T | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | G | A | 0.0000 | |
| 333 | G | A | 0.0000 | |
| 334 | Y | A | 0.0000 | |
| 335 | F | A | -0.4597 | |
| 336 | R | A | -1.6622 | |
| 337 | Q | A | -1.3282 | |
| 338 | S | A | 0.0000 | |
| 339 | L | A | 0.0000 | |
| 340 | S | A | -0.4004 | |
| 341 | Y | A | -0.5984 | |
| 342 | L | A | 0.0000 | |
| 343 | E | A | 0.0000 | |
| 344 | A | A | 0.0000 | |
| 345 | Y | A | 0.0000 | |
| 346 | N | A | -1.2641 | |
| 347 | P | A | -1.0455 | |
| 348 | S | A | -1.3072 | |
| 349 | N | A | -1.5731 | |
| 350 | G | A | -1.1208 | |
| 351 | S | A | -0.6932 | |
| 352 | W | A | -0.4444 | |
| 353 | L | A | -0.3874 | |
| 354 | R | A | -1.5721 | |
| 355 | L | A | -1.1056 | |
| 356 | A | A | -1.4943 | |
| 357 | D | A | -1.7803 | |
| 358 | L | A | 0.0000 | |
| 359 | Q | A | -1.1241 | |
| 360 | V | A | 0.2976 | |
| 361 | P | A | -0.1433 | |
| 362 | R | A | 0.0000 | |
| 363 | S | A | 0.0000 | |
| 364 | G | A | -0.3272 | |
| 365 | L | A | 0.0000 | |
| 366 | A | A | 0.0092 | |
| 367 | G | A | 0.1321 | |
| 368 | C | A | 0.0000 | |
| 369 | V | A | 0.5439 | |
| 370 | V | A | -0.0461 | |
| 371 | G | A | -0.3042 | |
| 372 | G | A | 0.1238 | |
| 373 | L | A | 0.4046 | |
| 374 | L | A | 0.0000 | |
| 375 | Y | A | 0.0000 | |
| 376 | A | A | 0.0000 | |
| 377 | V | A | 0.0000 | |
| 378 | G | A | 0.0000 | |
| 379 | G | A | 0.0000 | |
| 380 | R | A | -0.8332 | |
| 381 | N | A | -1.0646 | |
| 382 | N | A | -1.4489 | |
| 383 | S | A | -1.6376 | |
| 384 | P | A | -1.8043 | |
| 385 | D | A | -2.3403 | |
| 386 | G | A | -1.9518 | |
| 387 | N | A | -2.1670 | |
| 388 | T | A | -1.3807 | |
| 389 | D | A | -0.9586 | |
| 390 | S | A | -0.3871 | |
| 391 | S | A | -0.2174 | |
| 392 | A | A | -0.0178 | |
| 393 | L | A | 0.0000 | |
| 394 | D | A | 0.0000 | |
| 395 | C | A | -0.1152 | |
| 396 | Y | A | 0.0000 | |
| 397 | N | A | -0.2414 | |
| 398 | P | A | 0.0000 | |
| 399 | M | A | 0.6758 | |
| 400 | T | A | -0.0384 | |
| 401 | N | A | -0.7759 | |
| 402 | Q | A | -1.6150 | |
| 403 | W | A | -1.1890 | |
| 404 | S | A | -0.7420 | |
| 405 | P | A | -0.4012 | |
| 406 | C | A | -0.4748 | |
| 407 | A | A | -1.0983 | |
| 408 | S | A | -0.5920 | |
| 409 | M | A | 0.0000 | |
| 410 | S | A | -0.0698 | |
| 411 | V | A | 0.0171 | |
| 412 | P | A | -0.3027 | |
| 413 | R | A | 0.0000 | |
| 414 | N | A | 0.0000 | |
| 415 | R | A | -0.3643 | |
| 416 | I | A | 0.0000 | |
| 417 | G | A | 0.0000 | |
| 418 | V | A | 0.2501 | |
| 419 | G | A | 0.0000 | |
| 420 | V | A | -0.1882 | |
| 421 | I | A | 0.0000 | |
| 422 | D | A | -2.1881 | |
| 423 | G | A | -1.3734 | |
| 424 | H | A | -1.2031 | |
| 425 | I | A | 0.0000 | |
| 426 | Y | A | 0.0000 | |
| 427 | A | A | 0.0000 | |
| 428 | V | A | 0.0000 | |
| 429 | G | A | 0.0000 | |
| 430 | G | A | 0.0000 | |
| 431 | S | A | 0.0000 | |
| 432 | H | A | 0.1085 | |
| 433 | G | A | 0.0915 | |
| 434 | C | A | 1.2942 | |
| 435 | I | A | 1.7187 | |
| 436 | H | A | 0.2133 | |
| 437 | H | A | -0.2779 | |
| 438 | S | A | -0.4239 | |
| 439 | S | A | -0.0081 | |
| 440 | V | A | 0.0000 | |
| 441 | E | A | 0.0000 | |
| 442 | R | A | -0.8332 | |
| 443 | Y | A | 0.0000 | |
| 444 | E | A | -3.0147 | |
| 445 | P | A | -2.7353 | |
| 446 | E | A | -3.5921 | |
| 447 | R | A | -4.0030 | |
| 448 | D | A | -3.6267 | |
| 449 | E | A | -3.6496 | |
| 450 | W | A | -1.8135 | |
| 451 | H | A | -0.9868 | |
| 452 | L | A | 0.6411 | |
| 453 | V | A | -0.0583 | |
| 454 | A | A | -0.4790 | |
| 455 | P | A | -0.2510 | |
| 456 | M | A | 0.0000 | |
| 457 | L | A | 0.7204 | |
| 458 | T | A | 0.0025 | |
| 459 | R | A | -1.1135 | |
| 460 | R | A | 0.0000 | |
| 461 | I | A | 0.0000 | |
| 462 | G | A | 0.0000 | |
| 463 | V | A | 0.0000 | |
| 464 | G | A | 0.0000 | |
| 465 | V | A | 0.0000 | |
| 466 | A | A | 0.0000 | |
| 467 | V | A | -0.0815 | |
| 468 | L | A | -0.9488 | |
| 469 | N | A | -2.0709 | |
| 470 | R | A | -2.4304 | |
| 471 | L | A | -0.9305 | |
| 472 | L | A | 0.0000 | |
| 473 | Y | A | 0.0000 | |
| 474 | A | A | 0.0000 | |
| 475 | V | A | 0.0000 | |
| 476 | G | A | 0.0000 | |
| 477 | G | A | 0.0000 | |
| 478 | F | A | -0.6564 | |
| 479 | D | A | -0.9579 | |
| 480 | G | A | -0.4651 | |
| 481 | T | A | -0.8571 | |
| 482 | N | A | -1.5178 | |
| 483 | R | A | -0.9377 | |
| 484 | L | A | -0.4461 | |
| 485 | N | A | -0.6175 | |
| 486 | S | A | -0.1827 | |
| 487 | A | A | 0.0000 | |
| 488 | E | A | 0.0000 | |
| 489 | C | A | 0.0000 | |
| 490 | Y | A | 0.0000 | |
| 491 | Y | A | -2.0985 | |
| 492 | P | A | -2.3156 | |
| 493 | E | A | -3.1429 | |
| 494 | R | A | -3.6312 | |
| 495 | N | A | -2.9918 | |
| 496 | E | A | -3.2471 | |
| 497 | W | A | 0.0000 | |
| 498 | R | A | -1.4827 | |
| 499 | M | A | 0.1135 | |
| 500 | I | A | -0.2407 | |
| 501 | T | A | -0.4854 | |
| 502 | P | A | -0.5362 | |
| 503 | M | A | 0.0000 | |
| 504 | N | A | -1.0513 | |
| 505 | T | A | -0.3977 | |
| 506 | I | A | -0.3709 | |
| 507 | R | A | 0.0000 | |
| 508 | S | A | 0.0000 | |
| 509 | G | A | 0.0000 | |
| 510 | A | A | 0.0491 | |
| 511 | G | A | 0.0000 | |
| 512 | V | A | 0.0000 | |
| 513 | C | A | 0.0000 | |
| 514 | V | A | -0.0933 | |
| 515 | L | A | 0.0000 | |
| 516 | H | A | -1.4551 | |
| 517 | N | A | -1.6725 | |
| 518 | C | A | 0.0000 | |
| 519 | I | A | 0.0000 | |
| 520 | Y | A | 0.0000 | |
| 521 | A | A | 0.0000 | |
| 522 | A | A | 0.0000 | |
| 523 | G | A | 0.0000 | |
| 524 | G | A | 0.0000 | |
| 525 | Y | A | 0.0000 | |
| 526 | D | A | -1.4703 | |
| 527 | G | A | -1.7731 | |
| 528 | Q | A | -2.2349 | |
| 529 | D | A | -2.5228 | |
| 530 | Q | A | 0.0000 | |
| 531 | L | A | -0.9316 | |
| 532 | N | A | -1.2013 | |
| 533 | S | A | -0.1737 | |
| 534 | V | A | 0.0000 | |
| 535 | E | A | 0.0000 | |
| 536 | R | A | -0.2385 | |
| 537 | Y | A | 0.0000 | |
| 538 | D | A | -1.7854 | |
| 539 | V | A | -1.6970 | |
| 540 | E | A | -2.4793 | |
| 541 | T | A | -1.7976 | |
| 542 | E | A | -2.3062 | |
| 543 | T | A | -1.4490 | |
| 544 | W | A | 0.0000 | |
| 545 | T | A | 0.3474 | |
| 546 | F | A | 1.2817 | |
| 547 | V | A | 0.5859 | |
| 548 | A | A | -0.2283 | |
| 549 | P | A | -0.6091 | |
| 550 | M | A | 0.0000 | |
| 551 | R | A | -2.4925 | |
| 552 | H | A | -1.7025 | |
| 553 | H | A | -1.5012 | |
| 554 | R | A | 0.0000 | |
| 555 | S | A | 0.0000 | |
| 556 | A | A | 0.0000 | |
| 557 | L | A | 0.0000 | |
| 558 | G | A | 0.0000 | |
| 559 | I | A | 0.3629 | |
| 560 | T | A | 0.3422 | |
| 561 | V | A | 0.0743 | |
| 562 | H | A | 0.0000 | |
| 563 | Q | A | -1.6515 | |
| 564 | G | A | -1.4918 | |
| 565 | K | A | -1.3449 | |
| 566 | I | A | 0.0000 | |
| 567 | Y | A | 0.0000 | |
| 568 | V | A | 0.0000 | |
| 569 | L | A | 0.0000 | |
| 570 | G | A | 0.0000 | |
| 571 | G | A | 0.0000 | |
| 572 | Y | A | -0.4480 | |
| 573 | D | A | -1.2296 | |
| 574 | G | A | -1.0756 | |
| 575 | H | A | -1.1724 | |
| 576 | T | A | -0.5338 | |
| 577 | F | A | -0.2623 | |
| 578 | L | A | -0.4416 | |
| 579 | D | A | -0.8528 | |
| 580 | S | A | -1.3761 | |
| 581 | V | A | 0.0000 | |
| 582 | E | A | 0.0000 | |
| 583 | C | A | 0.0000 | |
| 584 | Y | A | 0.0000 | |
| 585 | D | A | -1.7513 | |
| 586 | P | A | -1.8122 | |
| 587 | D | A | -2.4418 | |
| 588 | S | A | -1.6594 | |
| 589 | D | A | -1.6961 | |
| 590 | T | A | -1.1833 | |
| 591 | W | A | -1.1586 | |
| 592 | S | A | -1.2519 | |
| 593 | E | A | -2.1846 | |
| 594 | V | A | -0.6890 | |
| 595 | T | A | -1.2298 | |
| 596 | R | A | -2.1479 | |
| 597 | M | A | 0.0000 | |
| 598 | T | A | -0.7611 | |
| 599 | S | A | -0.4682 | |
| 600 | G | A | -0.2942 | |
| 601 | R | A | 0.0000 | |
| 602 | S | A | 0.0000 | |
| 603 | G | A | -0.0483 | |
| 604 | V | A | 0.0000 | |
| 605 | G | A | 0.0000 | |
| 606 | V | A | 0.3340 | |
| 607 | A | A | 0.0000 | |
| 608 | V | A | -0.1617 | |
| 609 | T | A | 0.0000 | |
| 610 | M | A | -1.0439 | |
| 611 | E | A | -1.8647 | |
| 612 | P | A | 0.0000 | |
| 613 | C | A | 0.6083 | |
| 348 | V | B | 2.0050 | |
| 349 | D | B | 0.5293 | |
| 350 | P | B | -0.5636 | |
| 351 | S | B | 0.0000 | |
| 352 | T | B | 0.0000 | |
| 353 | G | B | 0.0000 | |
| 354 | E | B | 0.5774 | |
| 355 | L | B | 1.6478 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine