Project name: 34d14e0d934b6f0 [mutate: HA1060L]

Status: done

submitted: 2019-12-03 20:06:34, status changed: 2019-12-24 15:04:55
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Chain sequence(s) A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP
B: RKQLATKAARSAPATG
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues HA1060L
Energy difference between WT (input) and mutated protein (by FoldX) -0.152799 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-4.1357
Maximal score value
2.3641
Average score
-0.7422
Total score value
-388.9152

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
886 S A 0.6911
887 V A 2.1478
888 S A 1.6120
889 I A 2.3641
890 Y A 1.1613
891 P A 0.1172
892 S A -0.8243
893 S A 0.0000
894 A A -1.1223
895 E A -1.3957
896 V A 0.0000
897 L A -1.1173
898 K A -1.8151
899 A A 0.0000
900 C A -1.1725
901 R A -2.1192
902 N A -2.1220
903 L A -0.8541
904 G A -1.5457
905 K A -2.6341
906 N A -2.4151
907 G A -1.1988
908 L A -0.2437
909 S A -1.1653
910 N A -1.5801
911 S A -0.5331
912 S A 0.0886
913 I A 0.5258
914 L A 0.3682
915 L A 0.5079
916 D A -1.7871
917 K A -1.7676
918 C A -0.4208
919 P A -0.6341
920 P A -0.9033
921 P A -1.3262
922 R A -2.1064
923 P A -1.2338
924 P A -0.9203
925 S A -0.5448
926 S A -0.2568
927 P A 0.2262
928 Y A 0.9998
929 P A 0.4352
930 P A -0.2597
931 L A -0.9257
932 P A -1.9764
933 K A -3.4923
934 D A -3.6053
935 K A -3.3114
936 L A 0.0000
937 N A -2.5754
938 P A -1.5533
939 P A -0.8680
940 T A -0.4136
941 P A -0.2071
942 S A 0.0865
943 I A 0.7577
944 Y A 0.6749
945 L A 0.0000
946 E A -2.7004
947 N A -3.0637
948 K A -3.0163
949 R A -2.2278
950 D A -0.9440
951 A A 0.0000
952 F A 1.2289
953 F A 1.7105
954 P A 0.6811
955 P A 0.1640
956 L A 0.0000
957 H A -0.4591
958 Q A -1.3302
959 F A -0.4362
960 C A 0.0000
961 T A -0.7251
962 N A -1.1949
963 P A -1.2175
964 N A -1.5831
965 N A -0.9405
966 P A 0.0000
967 V A 0.0000
968 T A 0.0000
969 V A 0.0000
970 I A 0.0000
971 R A -0.2972
972 G A -1.0149
973 L A 0.0000
974 A A 0.0000
975 G A -2.1044
976 A A 0.0000
977 L A 0.0000
978 K A -2.7717
979 L A 0.0000
980 D A -2.1048
981 L A -1.0509
982 G A -0.9872
983 L A -0.4080
984 F A 0.0000
985 S A -1.0279
986 T A -1.3213
987 K A -2.2778
988 T A -1.5532
989 L A 0.0000
990 V A -2.3328
991 E A -2.7375
992 A A -1.8937
993 N A -1.9181
994 N A -2.8986
995 E A -2.7415
996 H A -1.4181
997 M A -0.5123
998 V A 0.0000
999 E A 0.0000
1000 V A 0.0000
1001 R A 0.0000
1002 T A -1.1588
1003 Q A 0.0000
1004 L A -0.1407
1005 L A 0.2051
1006 Q A -0.3485
1007 P A -0.3752
1008 A A -0.0833
1009 D A -0.6129
1010 E A -0.8716
1011 N A 0.0000
1012 W A -0.8506
1013 D A -0.8526
1014 P A -0.6245
1015 T A -0.7898
1016 G A 0.0000
1017 T A -1.2313
1018 K A -1.8397
1019 K A -1.1921
1020 I A -0.5875
1021 W A 0.0000
1022 H A -0.8797
1023 C A 0.0000
1024 E A -1.0342
1025 S A 0.0000
1026 N A -1.6170
1027 R A -2.4947
1028 S A -1.6906
1029 H A -1.3140
1030 T A -1.0430
1031 T A -1.5659
1032 I A 0.0000
1033 A A -2.3923
1034 K A -2.4501
1035 Y A 0.0000
1036 A A -1.4696
1037 Q A -1.7140
1038 Y A -0.8118
1039 Q A 0.0000
1040 A A -0.6397
1041 S A -0.7880
1042 S A -0.6404
1043 F A -0.1718
1044 Q A -1.5788
1045 E A -2.3042
1046 S A -1.7439
1047 L A -1.9359
1048 R A -3.8306
1049 E A -3.4419
1050 E A -3.6731
1051 N A -4.1357
1052 E A -3.9675
1053 K A -3.4759
1054 R A -3.6682
1055 S A -2.8327
1056 H A -2.7330
1057 H A -2.9604
1058 K A -3.0783
1059 D A -1.7016
1060 L A 0.4395 mutated: HA1060L
1061 S A -0.4401
1062 D A -1.0978
1063 S A -1.1987
1064 E A -2.1140
1065 S A -1.9349
1066 T A -1.9439
1067 S A -1.9825
1068 S A 0.0000
1069 D A -2.8184
1070 N A -2.9714
1071 S A -1.9554
1072 G A -1.8993
1073 R A -3.5268
1074 R A -3.7997
1075 R A -3.7836
1076 K A -3.1790
1077 G A -1.7460
1078 P A -1.1847
1079 F A -0.8803
1080 K A -0.7874
1081 T A -0.4443
1082 I A 0.0000
1083 K A -1.0045
1084 F A 0.0000
1085 G A 0.0000
1086 T A 0.0000
1087 N A 0.0000
1088 I A 0.0000
1089 D A -0.2285
1090 L A 0.0000
1091 S A -1.4264
1092 D A -2.7093
1093 D A -3.8820
1094 K A -3.7138
1095 K A -3.1822
1096 W A 0.0000
1097 K A -3.0046
1098 L A -0.6680
1099 Q A 0.0000
1100 L A -1.3614
1101 H A -1.3695
1102 E A -1.1935
1103 L A 0.0000
1104 T A -0.5666
1105 K A -1.3828
1106 L A 0.0000
1107 P A 0.0000
1108 A A 0.3473
1109 F A 0.3407
1110 V A 0.0000
1111 R A 0.1436
1112 V A 0.8078
1113 V A 1.6327
1114 S A 0.7340
1115 A A 0.2075
1116 G A 0.1818
1117 N A 0.0000
1118 L A 0.0000
1119 L A 0.0000
1120 S A 0.2157
1121 H A -0.4896
1122 V A 0.0000
1123 G A -0.9864
1124 H A 0.0000
1125 T A -0.2710
1126 I A 0.0000
1127 L A 0.0574
1128 G A 0.0000
1129 M A 0.0000
1130 N A 0.1920
1131 T A -0.0649
1132 V A 0.0000
1133 Q A 0.0000
1134 L A 0.0000
1135 Y A 0.1245
1136 M A 0.0000
1137 K A 0.0000
1138 V A 0.0000
1139 P A 0.4458
1140 G A 0.2662
1141 S A 0.0000
1142 R A 0.0000
1143 T A -0.0243
1144 P A 0.0000
1145 G A 0.0000
1146 H A -0.1662
1147 Q A -0.5031
1148 E A -0.6014
1149 N A -0.7349
1150 N A 0.0000
1151 N A 0.0000
1152 F A 0.0000
1153 C A 0.0000
1154 S A 0.0000
1155 V A 0.0000
1156 N A 0.0000
1157 I A 0.0000
1158 N A 0.0000
1159 I A 0.0000
1160 G A 0.0000
1161 P A -0.5706
1162 G A -0.3966
1163 D A -0.5359
1164 C A 0.0000
1165 E A -0.0184
1166 W A 0.0000
1167 F A 0.0000
1168 V A 0.0000
1169 V A 0.0000
1170 P A -0.5600
1171 E A -0.8226
1172 G A -0.3450
1173 Y A 0.0000
1174 W A 0.0000
1175 G A 0.0000
1176 V A -0.3804
1177 L A 0.0000
1178 N A -1.2160
1179 D A -2.1464
1180 F A -1.6487
1181 C A 0.0000
1182 E A -2.8616
1183 K A -3.1114
1184 N A -2.4402
1185 N A -2.6934
1186 L A -1.5894
1187 N A -1.1403
1188 F A 0.0000
1189 L A 0.2801
1190 M A 0.9925
1191 G A -0.0474
1192 S A 0.0000
1193 W A 0.0000
1194 W A 0.0000
1195 P A 0.0000
1196 N A -1.0782
1197 L A 0.0000
1198 E A -2.6018
1199 D A -2.1474
1200 L A 0.0000
1201 Y A -2.1927
1202 E A -2.6673
1203 A A -1.4627
1204 N A -2.0408
1205 V A 0.0000
1206 P A 0.0000
1207 V A 0.0000
1208 Y A -0.8022
1209 R A -0.8048
1210 F A 0.0000
1211 I A 0.2491
1212 Q A 0.0000
1213 R A -1.2836
1214 P A -0.9007
1215 G A 0.0000
1216 D A 0.0000
1217 L A 0.0000
1218 V A 0.0000
1219 W A 0.0000
1220 I A 0.0000
1221 N A 0.0000
1222 A A 0.0000
1223 G A 0.0000
1224 T A 0.0000
1225 V A 0.0000
1226 H A 0.0000
1227 W A 0.0000
1228 V A 0.0000
1229 Q A 0.0000
1230 A A 0.0000
1231 I A 1.0894
1232 G A 0.3038
1233 W A 0.3581
1234 C A 0.0000
1235 N A 0.0000
1236 N A 0.0000
1237 I A 0.0000
1238 A A 0.0000
1239 W A 0.0000
1240 N A 0.0000
1241 V A 0.0000
1242 G A 0.0000
1243 P A 0.0000
1244 L A 0.3407
1245 T A -0.2894
1246 A A -0.7848
1247 C A -0.3308
1248 Q A 0.0000
1249 Y A 0.0000
1250 K A -1.3398
1251 L A 0.0000
1252 A A 0.0000
1253 V A -1.0148
1254 E A -2.3958
1255 R A 0.0000
1256 Y A 0.0000
1257 E A -0.9441
1258 W A -0.8085
1259 N A 0.0000
1260 K A -0.5031
1261 L A 0.4482
1262 Q A -0.2126
1263 S A -0.0536
1264 V A 0.0150
1265 K A -0.4800
1266 S A 0.0000
1267 I A 0.0000
1268 V A 0.0000
1269 P A 0.0000
1270 M A 0.0000
1271 V A 0.0000
1272 H A 0.0000
1273 L A 0.0000
1274 S A 0.0000
1275 W A 0.0000
1276 N A -0.8917
1277 M A 0.0000
1278 A A 0.0000
1279 R A -2.0672
1280 N A -2.0078
1281 I A 0.0000
1282 K A -2.1379
1283 V A 0.0000
1284 S A -1.2514
1285 D A -1.9094
1286 P A -1.5995
1287 K A -2.2295
1288 L A 0.0000
1289 F A -1.0591
1290 E A -0.7807
1291 M A -0.4707
1292 I A 0.0000
1293 K A 0.0000
1294 Y A 0.7685
1295 C A 0.0000
1296 L A 0.0000
1297 L A 0.0000
1298 R A -1.1108
1299 T A -0.6795
1300 L A 0.0000
1301 K A -1.3193
1302 Q A -1.6932
1303 C A 0.0000
1304 Q A 0.0000
1305 T A -0.6778
1306 L A -0.4283
1307 R A -0.4080
1308 E A -0.4530
1309 A A 0.0312
1310 L A 0.0000
1311 I A 0.9505
1312 A A 0.5283
1313 A A -0.1796
1314 G A -0.2841
1315 K A -1.0640
1316 E A -1.3058
1317 I A 0.2145
1318 I A 0.9579
1319 W A 0.7018
1320 H A 0.0000
1321 G A 0.0000
1322 R A -0.9878
1323 T A -1.3384
1324 K A -2.2532
1325 E A -1.7549
1326 E A 0.0000
1327 P A -0.8866
1328 A A -0.3236
1329 H A 0.0000
1330 Y A 0.0000
1331 C A 0.0000
1332 S A 0.6783
1333 I A 1.5925
1334 C A 0.5176
1335 E A 0.1116
1336 V A 0.3988
1337 E A 0.0000
1338 V A 0.0000
1339 F A 0.2002
1340 D A 0.0000
1341 L A 0.0000
1342 L A 0.0000
1343 F A 0.0000
1344 V A 0.0000
1345 T A -1.0279
1346 N A -2.2160
1347 E A -1.9910
1348 S A -1.6862
1349 N A -2.2579
1350 S A -2.4722
1351 R A -3.5049
1352 K A -3.5748
1353 T A -2.2302
1354 Y A -1.1948
1355 I A 0.0128
1356 V A 0.0000
1357 H A 0.0000
1358 C A -0.4280
1359 Q A -1.6488
1360 D A -2.4604
1361 C A 0.0000
1362 A A 0.0000
1363 R A -2.9593
1364 K A -2.8857
1365 T A -2.0930
1366 S A -2.4426
1367 G A -2.5242
1368 N A -2.5717
1369 L A 0.0000
1370 E A -3.1432
1371 N A -2.3601
1372 F A 0.0000
1373 V A -0.6032
1374 V A 0.0000
1375 L A 0.0000
1376 E A 0.1207
1377 Q A 0.0000
1378 Y A 0.0000
1379 K A -2.1933
1380 M A 0.0000
1381 E A -2.7514
1382 D A -2.2320
1383 L A 0.0000
1384 M A -1.8575
1385 Q A -2.5724
1386 V A 0.0000
1387 Y A 0.0000
1388 D A -1.7173
1389 Q A -1.9637
1390 F A 0.0000
1391 T A -0.7618
1392 L A -0.3320
1393 A A -0.6183
1394 P A -0.5777
17 R B -2.5126
18 K B -2.6629
19 Q B -2.5209
20 L B -0.9770
21 A B -0.7707
22 T B -0.8777
23 K B -1.7587
24 A B -0.8592
25 A B 0.0000
26 R B -0.5953
28 S B -0.3535
29 A B -0.2796
30 P B -0.1910
31 A B -0.6931
32 T B -0.8262

 

Laboratory of Theory of Biopolymers 2015