Project name: full

Chain sequence(s)	A: RDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0137
• Maximal score value: 2.2534
• Average score: -0.7523
• Total score value: -269.3135

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
40	R	A	-3.0789
41	D	A	-3.4280
42	R	A	-2.8817
43	L	A	-1.8620
44	N	A	-2.4857
45	T	A	-2.2227
46	E	A	0.0000
47	L	A	0.0000
48	D	A	-2.3566
49	R	A	-2.1942
50	L	A	0.0000
51	A	A	-1.2283
52	S	A	-0.8274
53	L	A	0.4303
54	L	A	0.0000
55	P	A	-0.1708
56	F	A	0.0000
57	P	A	-1.2266
58	Q	A	-2.2205
59	D	A	-2.5632
60	V	A	-1.6338
61	I	A	0.0000
62	N	A	-2.9950
63	K	A	-2.9721
64	L	A	-1.8088
65	D	A	-2.0656
66	K	A	-1.3867
67	L	A	-0.2449
68	S	A	-1.0180
69	V	A	0.0000
70	L	A	-0.2039
71	R	A	-1.2002
72	L	A	0.0000
73	S	A	0.0000
74	V	A	0.7829
75	S	A	-0.0816
76	Y	A	0.0000
77	L	A	0.8568
78	R	A	-0.9627
79	A	A	0.0000
80	K	A	-0.6133
81	S	A	-0.7036
82	F	A	0.0000
83	F	A	0.0000
84	D	A	-1.2914
85	V	A	0.5823
86	A	A	-0.5355
87	L	A	-0.7349
88	K	A	-2.6214
89	S	A	0.0000
90	S	A	0.0000
91	P	A	-0.7053
92	T	A	-1.4676
93	E	A	0.0000
94	R	A	-3.2106
95	N	A	-3.2194
96	G	A	-2.6230
97	G	A	-2.1737
98	Q	A	-1.8222
99	D	A	-1.2580
100	N	A	-0.6683
101	C	A	-0.3072
102	R	A	-1.5410
103	A	A	-0.9623
104	A	A	-0.9176
105	N	A	-1.6651
106	F	A	-1.9456
107	R	A	-3.1667
108	E	A	-2.8052
109	G	A	0.0000
110	L	A	-1.5218
111	N	A	-1.6917
112	L	A	-0.3080
113	Q	A	-0.1740
114	E	A	-0.6682
115	G	A	0.0000
116	E	A	0.8536
117	F	A	2.2534
118	L	A	2.1161
119	L	A	1.2361
120	Q	A	0.3660
121	A	A	0.0633
122	L	A	0.3842
123	N	A	-0.3213
124	G	A	0.0000
125	F	A	0.0000
126	V	A	0.0000
127	L	A	0.0000
128	V	A	0.0000
129	V	A	0.0000
130	T	A	0.0000
131	T	A	-0.9011
132	D	A	-1.8356
133	A	A	0.0000
134	L	A	-0.4971
135	V	A	0.0000
136	F	A	-0.2604
137	Y	A	0.0000
138	A	A	0.0000
139	S	A	0.0000
140	S	A	-0.3494
141	T	A	0.0000
142	I	A	0.0000
143	Q	A	-0.7017
144	D	A	-1.3948
145	Y	A	0.0000
146	L	A	0.0000
147	G	A	-0.2200
148	F	A	-0.0635
149	Q	A	-0.5547
150	Q	A	0.0000
151	S	A	0.0000
152	D	A	-1.6119
153	V	A	0.0000
154	I	A	0.0000
155	H	A	-1.1593
156	Q	A	-1.5978
157	S	A	-1.2446
158	V	A	0.0000
159	Y	A	-1.1249
160	E	A	-2.2389
161	L	A	0.0000
162	I	A	0.0000
163	H	A	-1.4529
164	T	A	-1.5999
165	E	A	-2.3914
166	D	A	0.0000
167	R	A	-2.4717
168	A	A	-1.9164
169	E	A	-2.1284
170	F	A	0.0000
171	Q	A	-2.1131
172	R	A	-2.8427
173	Q	A	-1.7416
174	L	A	0.0000
175	H	A	-1.3165
176	W	A	0.0000
177	A	A	0.0000
178	L	A	1.2876
179	N	A	-0.4948
180	P	A	-1.0425
181	S	A	0.0000
182	Q	A	-1.8440
183	C	A	-0.4502
184	T	A	-1.1087
185	E	A	-2.5777
186	S	A	-1.3193
187	G	A	-1.5358
188	Q	A	-2.0034
189	G	A	-1.5745
190	I	A	-1.5480
191	E	A	-2.6375
192	E	A	-1.8711
193	A	A	-0.9930
194	T	A	-0.3545
195	G	A	0.7326
196	L	A	1.2932
197	P	A	0.5605
198	Q	A	-0.6438
199	T	A	0.0895
200	V	A	1.2134
201	V	A	0.5183
202	C	A	0.7938
203	Y	A	-0.1352
204	N	A	-1.4451
205	P	A	-1.8047
206	D	A	-2.6526
207	Q	A	-2.1382
208	I	A	-1.2818
209	P	A	-1.4332
210	P	A	-2.0203
211	E	A	-2.8655
212	N	A	-2.6929
213	S	A	-1.0504
214	P	A	0.0000
215	L	A	-0.2776
216	M	A	0.0000
217	E	A	-2.2454
218	R	A	-1.4303
219	C	A	-0.4694
220	F	A	0.0000
221	I	A	-0.0413
222	C	A	0.0000
223	R	A	-0.7416
224	L	A	0.0000
225	R	A	-0.4584
226	C	A	0.0000
227	L	A	1.0030
228	L	A	-0.3788
229	D	A	-1.5419
230	N	A	-0.8561
231	S	A	-0.5136
232	S	A	-0.3637
233	G	A	-0.0941
234	F	A	0.1418
235	L	A	0.0000
236	A	A	0.0000
237	M	A	0.0000
238	N	A	0.0000
239	F	A	0.0000
240	Q	A	-0.6573
241	G	A	-1.1034
242	K	A	-1.8704
243	L	A	0.0000
244	K	A	-1.0706
245	Y	A	0.0000
246	L	A	0.0000
247	H	A	-1.5136
248	G	A	-1.7005
249	Q	A	-2.2886
250	K	A	-3.6489
251	K	A	-3.9456
252	K	A	-4.0137
253	G	A	-3.0927
254	K	A	-2.9478
255	D	A	-3.3751
256	G	A	0.0000
257	S	A	-1.7986
258	I	A	0.6757
259	L	A	-0.4861
260	P	A	0.0000
261	P	A	0.2624
262	Q	A	0.0000
263	L	A	0.0000
264	A	A	0.0000
265	L	A	0.0000
266	F	A	-0.2348
267	A	A	0.0000
268	I	A	0.2574
269	A	A	0.0000
270	T	A	0.0000
271	P	A	0.0000
272	L	A	0.0000
273	Q	A	0.0372
274	P	A	0.0000
275	P	A	-0.7619
276	S	A	-0.1347
277	I	A	0.6370
278	L	A	0.0000
279	E	A	-2.1942
280	I	A	-1.9595
281	R	A	-2.7081
282	T	A	-1.9002
283	K	A	-2.1055
284	N	A	-1.2117
285	F	A	0.8226
286	I	A	0.0000
287	F	A	0.0000
288	R	A	-2.2143
289	T	A	0.0000
290	K	A	-1.1397
291	H	A	0.0000
292	K	A	-1.1072
293	L	A	-0.2129
294	D	A	-1.5539
295	F	A	-0.8924
296	T	A	-0.9567
297	P	A	0.0000
298	I	A	-0.0582
299	G	A	-0.6044
300	C	A	-1.4250
301	D	A	-1.5440
302	A	A	-1.0068
303	K	A	-0.7822
304	G	A	0.0000
305	R	A	-1.5385
306	I	A	0.8630
307	V	A	0.0000
308	L	A	0.0000
309	G	A	-0.8949
310	Y	A	-1.0574
311	T	A	-1.4101
312	E	A	-1.8363
313	A	A	-0.8297
314	E	A	-1.5385
315	L	A	0.0000
316	C	A	-0.7007
317	T	A	-0.7905
318	R	A	-1.2766
319	G	A	-1.1493
320	S	A	-0.9033
321	G	A	-0.6681
322	Y	A	-0.1861
323	Q	A	0.0000
324	F	A	-0.1406
325	I	A	-0.1548
326	H	A	-0.8881
327	A	A	0.0656
328	A	A	0.0000
329	D	A	0.1989
330	M	A	1.1731
331	L	A	1.7103
332	Y	A	0.8984
333	C	A	0.0000
334	A	A	-0.0900
335	E	A	-0.8870
336	S	A	0.0000
337	H	A	-0.0051
338	I	A	0.8979
339	R	A	-0.1766
340	M	A	0.0000
341	I	A	1.4288
342	K	A	-0.5905
343	T	A	-0.4273
344	G	A	0.0924
345	E	A	-0.2668
346	S	A	0.0000
347	G	A	0.0000
348	M	A	0.0000
349	I	A	1.1916
350	V	A	1.2202
351	F	A	0.0000
352	R	A	-0.2208
353	L	A	0.0000
354	L	A	-0.7854
355	T	A	0.0000
356	K	A	-2.2119
357	N	A	-2.5196
358	N	A	-2.6934
359	R	A	-2.9329
360	W	A	-1.8103
361	T	A	0.0000
362	W	A	0.1459
363	V	A	0.0000
364	Q	A	0.0000
365	S	A	0.0000
366	N	A	0.0000
367	A	A	0.0000
368	R	A	0.0283
369	L	A	0.0000
370	L	A	0.5083
371	Y	A	-0.5587
372	K	A	-2.4828
373	N	A	-2.7142
374	G	A	-2.2044
375	R	A	-2.6719
376	P	A	-0.7585
377	D	A	-0.9616
378	Y	A	-0.2905
379	I	A	0.0000
380	I	A	-0.3256
381	V	A	0.0000
382	T	A	0.0000
383	Q	A	0.0000
384	R	A	-0.1194
385	P	A	0.1030
386	L	A	0.3652
387	T	A	-0.9694
388	D	A	-2.1834
389	E	A	-2.4995
390	E	A	-2.9979
391	G	A	0.0000
392	T	A	-2.1874
393	E	A	-2.8346
394	H	A	-2.1068
395	L	A	-0.7407
396	R	A	-2.7354
397	K	A	-2.6854