Project name: hDASPO

Chain sequence(s)	A: MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3594
• Maximal score value: 1.0552
• Average score: -0.6709
• Total score value: -228.7692

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.6643
2	D	A	-0.3473
3	T	A	-0.4630
4	A	A	0.0000
5	R	A	-0.8257
6	I	A	0.0000
7	A	A	0.0000
8	V	A	0.0000
9	V	A	0.0000
10	G	A	-0.7787
11	A	A	0.0000
12	G	A	-0.4505
13	V	A	0.0000
14	V	A	0.1649
15	G	A	0.0000
16	L	A	0.0000
17	S	A	0.0000
18	T	A	0.0000
19	A	A	0.0000
20	V	A	0.0000
21	C	A	0.0000
22	I	A	0.0000
23	S	A	0.0000
24	K	A	-1.8018
25	L	A	0.0000
26	V	A	0.0000
27	P	A	-1.6020
28	R	A	-2.1171
29	C	A	-1.2363
30	S	A	-0.3846
31	V	A	0.0000
32	T	A	0.0000
33	I	A	0.0000
34	I	A	0.0000
35	S	A	0.0000
36	D	A	-3.2083
37	K	A	-2.6886
38	F	A	-1.3802
39	T	A	-1.0037
40	P	A	-1.2664
41	D	A	-2.3363
42	T	A	-1.3828
43	T	A	-0.6141
44	S	A	-0.3781
45	D	A	0.0000
46	V	A	-0.3646
47	A	A	-0.0524
48	A	A	0.0300
49	G	A	0.0000
50	M	A	0.0516
51	L	A	0.0000
52	I	A	0.1083
53	P	A	0.0000
54	H	A	-0.0663
55	T	A	0.0502
56	Y	A	0.4218
57	P	A	-0.7558
58	D	A	-1.8555
59	T	A	-0.9242
60	P	A	-0.9137
61	I	A	-1.0175
62	H	A	-1.8841
63	T	A	-1.4990
64	Q	A	-1.5376
65	K	A	-2.0717
66	Q	A	-2.4315
67	W	A	0.0000
68	F	A	0.0000
69	R	A	-3.2452
70	E	A	-2.6257
71	T	A	0.0000
72	F	A	0.0000
73	N	A	-1.5231
74	H	A	-0.9085
75	L	A	0.0000
76	F	A	0.0256
77	A	A	-0.2047
78	I	A	-0.3583
79	A	A	0.0000
80	N	A	-1.3250
81	S	A	-0.7743
82	A	A	-0.8791
83	E	A	-1.4034
84	A	A	-1.3526
85	G	A	-1.7629
86	D	A	-1.9984
87	A	A	0.0000
88	G	A	0.0000
89	V	A	0.0000
90	H	A	-0.9637
91	L	A	-0.0615
92	V	A	0.0000
93	S	A	-0.2303
94	G	A	0.0000
95	W	A	-0.2058
96	Q	A	0.0000
97	I	A	0.0000
98	F	A	-0.0264
99	Q	A	-0.6842
100	S	A	-0.1549
101	T	A	-0.1151
102	P	A	-0.5786
103	T	A	-0.6355
104	E	A	-1.1184
105	E	A	0.0000
106	V	A	-0.3664
107	P	A	-0.4007
108	F	A	-0.8097
109	W	A	0.0000
110	A	A	-0.5038
111	D	A	-1.5529
112	V	A	-1.1876
113	V	A	0.0000
114	L	A	1.0029
115	G	A	-0.0834
116	F	A	-0.2580
117	R	A	-0.8650
118	K	A	-1.0081
119	M	A	0.0000
120	T	A	-1.4095
121	E	A	-2.2923
122	A	A	-1.9838
123	E	A	-1.9966
124	L	A	0.0000
125	K	A	-2.9821
126	K	A	-3.0644
127	F	A	0.0000
128	P	A	-1.3867
129	Q	A	-1.1669
130	Y	A	0.0000
131	V	A	0.7911
132	F	A	0.3442
133	G	A	0.0000
134	Q	A	0.0000
135	A	A	0.0000
136	F	A	0.0000
137	T	A	0.4330
138	T	A	0.0000
139	L	A	0.0000
140	K	A	0.0000
141	C	A	0.0000
142	E	A	-0.6653
143	C	A	0.0000
144	P	A	-0.5155
145	A	A	-0.5811
146	Y	A	0.0000
147	L	A	0.0000
148	P	A	-0.7613
149	W	A	-1.0619
150	L	A	0.0000
151	E	A	-1.2408
152	K	A	-2.1539
153	R	A	-1.9599
154	I	A	0.0000
155	K	A	-1.8287
156	G	A	-1.6367
157	S	A	-1.4084
158	G	A	-0.8007
159	G	A	0.0000
160	W	A	0.8533
161	T	A	0.4925
162	L	A	0.0327
163	T	A	-1.2560
164	R	A	-2.4115
165	R	A	-3.2268
166	I	A	0.0000
167	E	A	-2.6595
168	D	A	-1.6236
169	L	A	0.0000
170	W	A	-0.2568
171	E	A	-0.6269
172	L	A	0.0000
173	H	A	-0.8822
174	P	A	-0.5220
175	S	A	-0.6384
176	F	A	-0.7886
177	D	A	-1.7165
178	I	A	0.0000
179	V	A	0.0000
180	V	A	0.0000
181	N	A	0.0000
182	C	A	0.0000
183	S	A	-0.4650
184	G	A	-0.0894
185	L	A	0.0892
186	G	A	-0.6410
187	S	A	0.0000
188	R	A	-1.4475
189	Q	A	-1.6279
190	L	A	-1.1144
191	A	A	-1.0318
192	G	A	-1.2175
193	D	A	-1.2598
194	S	A	-1.0863
195	K	A	-1.4713
196	I	A	0.0000
197	F	A	-0.0233
198	P	A	0.0000
199	V	A	0.0000
200	R	A	0.0000
201	G	A	0.0000
202	Q	A	0.0000
203	V	A	-0.4051
204	L	A	0.0000
205	Q	A	-1.4606
206	V	A	0.0000
207	Q	A	-1.1597
208	A	A	0.0000
209	P	A	-0.4208
210	W	A	0.2984
211	V	A	-0.5569
212	E	A	-1.6708
213	H	A	-0.9962
214	F	A	0.0000
215	I	A	0.0000
216	R	A	-0.2880
217	D	A	-0.4405
218	G	A	-0.6013
219	S	A	-0.9036
220	G	A	-0.8757
221	L	A	-0.2526
222	T	A	0.0000
223	Y	A	-0.0512
224	I	A	0.0000
225	Y	A	0.0000
226	P	A	0.0000
227	G	A	-0.8835
228	T	A	-0.8157
229	S	A	-0.6392
230	H	A	-0.8668
231	V	A	0.0000
232	T	A	-0.6450
233	L	A	0.0000
234	G	A	0.0000
235	G	A	0.0000
236	T	A	-1.3897
237	R	A	-2.8130
238	Q	A	-2.5971
239	K	A	-2.3930
240	G	A	-1.3221
241	D	A	-0.9478
242	W	A	0.5143
243	N	A	-0.0644
244	L	A	1.0552
245	S	A	0.0351
246	P	A	-0.9093
247	D	A	-1.8831
248	A	A	-1.9895
249	E	A	-3.0309
250	N	A	0.0000
251	S	A	-2.2418
252	R	A	-3.2029
253	E	A	-2.6973
254	I	A	0.0000
255	L	A	-1.3371
256	S	A	-1.3559
257	R	A	-0.9737
258	C	A	0.0000
259	C	A	-0.7065
260	A	A	-0.5438
261	L	A	0.0000
262	E	A	-0.8905
263	P	A	-0.8590
264	S	A	-0.5939
265	L	A	0.0000
266	H	A	-1.3462
267	G	A	-1.0776
268	A	A	-0.6967
269	C	A	-0.5462
270	N	A	-1.6331
271	I	A	-1.0937
272	R	A	-2.3449
273	E	A	-1.8817
274	K	A	-1.1076
275	V	A	-0.0776
276	G	A	0.0000
277	L	A	0.0000
278	R	A	-0.5930
279	P	A	0.0609
280	Y	A	0.0648
281	R	A	-0.4597
282	P	A	-0.5208
283	G	A	-0.4354
284	V	A	0.0000
285	R	A	-0.6938
286	L	A	-0.5914
287	Q	A	-1.1865
288	T	A	-0.8059
289	E	A	-0.5851
290	L	A	0.1016
291	L	A	-0.3644
292	A	A	-1.8395
293	R	A	-3.1692
294	D	A	-3.3594
295	G	A	-2.8290
296	Q	A	-3.3386
297	R	A	-3.0002
298	L	A	0.0000
299	P	A	0.0000
300	V	A	0.0000
301	V	A	0.0000
302	H	A	0.0000
303	H	A	0.0000
304	Y	A	0.0000
305	G	A	0.0000
306	H	A	0.0000
307	G	A	-0.0118
308	S	A	-0.5633
309	G	A	-0.2152
310	G	A	-0.1707
311	I	A	0.0000
312	S	A	0.0000
313	V	A	0.0000
314	H	A	0.0000
315	W	A	-0.4260
316	G	A	0.0000
317	T	A	0.0000
318	A	A	0.0000
319	L	A	-0.1880
320	E	A	-0.8346
321	A	A	0.0000
322	A	A	0.0000
323	R	A	-1.5201
324	L	A	-1.2076
325	V	A	0.0000
326	S	A	-1.3837
327	E	A	-2.3222
328	C	A	-1.3872
329	V	A	0.0000
330	H	A	-2.0248
331	A	A	-1.2247
332	L	A	-0.8587
333	R	A	-2.0449
334	T	A	-1.1866
335	P	A	-1.2261
336	I	A	-0.7281
337	P	A	-0.9611
338	K	A	-1.1702
339	S	A	-0.9374
340	N	A	-0.9836
341	L	A	0.1653