Project name: 5TF2
Status: done
submitted: 2018-02-20 14:32:41, status changed: 2018-02-20 14:47:16
Settings
Chain sequence(s)
|
A: ELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPPDDGKLVTVGRDLKASVWQKDQLVTQLHWQEPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSR
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.6607
-
Maximal score value
-
1.6767
-
Average score
-
-0.6822
-
Total score value
-
-230.5848
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
8 |
E |
A |
-2.1813 |
|
9 |
L |
A |
-1.1153 |
|
10 |
Y |
A |
-1.2203 |
|
11 |
R |
A |
-2.2644 |
|
12 |
A |
A |
0.0000 |
|
13 |
P |
A |
-0.9051 |
|
14 |
F |
A |
0.0000 |
|
15 |
P |
A |
-0.5151 |
|
16 |
L |
A |
0.0000 |
|
17 |
Y |
A |
0.3088 |
|
18 |
A |
A |
0.0000 |
|
19 |
L |
A |
0.0000 |
|
20 |
Q |
A |
-0.2567 |
|
21 |
V |
A |
0.0000 |
|
22 |
D |
A |
0.0000 |
|
23 |
P |
A |
-1.7417 |
|
24 |
S |
A |
-1.1419 |
|
25 |
T |
A |
-0.7701 |
|
26 |
G |
A |
0.0000 |
|
27 |
L |
A |
0.0000 |
|
28 |
L |
A |
0.0000 |
|
29 |
I |
A |
0.0000 |
|
30 |
A |
A |
0.0000 |
|
31 |
A |
A |
0.0000 |
|
32 |
G |
A |
0.0000 |
|
33 |
G |
A |
0.0000 |
|
34 |
G |
A |
-0.8626 |
|
35 |
G |
A |
0.0000 |
|
36 |
A |
A |
-0.7891 |
|
37 |
A |
A |
-1.2526 |
|
38 |
K |
A |
-1.9500 |
|
39 |
T |
A |
-1.2280 |
|
40 |
G |
A |
-1.2098 |
|
41 |
I |
A |
-1.6300 |
|
42 |
K |
A |
-2.2922 |
|
43 |
N |
A |
0.0000 |
|
44 |
G |
A |
0.0000 |
|
45 |
V |
A |
0.0000 |
|
46 |
H |
A |
0.0000 |
|
47 |
F |
A |
0.0000 |
|
48 |
L |
A |
0.0000 |
|
49 |
Q |
A |
-0.1541 |
|
50 |
L |
A |
0.0000 |
|
51 |
E |
A |
-1.8299 |
|
52 |
L |
A |
-0.7102 |
|
53 |
I |
A |
-0.4794 |
|
54 |
N |
A |
-1.4616 |
|
56 |
R |
A |
-1.9725 |
|
57 |
L |
A |
0.0000 |
|
58 |
S |
A |
-0.9064 |
|
59 |
A |
A |
-0.2075 |
|
60 |
S |
A |
0.0639 |
|
61 |
L |
A |
0.8353 |
|
62 |
L |
A |
0.5684 |
|
63 |
H |
A |
-0.5293 |
|
64 |
S |
A |
-0.2894 |
|
65 |
H |
A |
-1.4164 |
|
66 |
D |
A |
-2.4463 |
|
67 |
T |
A |
0.0000 |
|
68 |
E |
A |
-2.6745 |
|
69 |
T |
A |
-1.8787 |
|
70 |
R |
A |
-1.9312 |
|
71 |
A |
A |
-1.2866 |
|
72 |
T |
A |
0.0000 |
|
73 |
M |
A |
-0.0290 |
|
74 |
N |
A |
-0.1576 |
|
75 |
L |
A |
0.1030 |
|
76 |
A |
A |
0.0000 |
|
77 |
L |
A |
0.0325 |
|
78 |
A |
A |
0.0000 |
|
79 |
G |
A |
-1.1767 |
|
80 |
D |
A |
-1.2328 |
|
81 |
I |
A |
-1.1543 |
|
82 |
L |
A |
0.0000 |
|
83 |
A |
A |
0.0000 |
|
84 |
A |
A |
0.0000 |
|
85 |
G |
A |
0.0000 |
|
86 |
Q |
A |
0.0000 |
|
87 |
D |
A |
-1.8637 |
|
88 |
A |
A |
0.0000 |
|
89 |
H |
A |
-0.7183 |
|
90 |
C |
A |
0.0000 |
|
91 |
Q |
A |
-0.5446 |
|
92 |
L |
A |
0.0000 |
|
93 |
L |
A |
0.0000 |
|
94 |
R |
A |
-2.9798 |
|
95 |
F |
A |
0.0000 |
|
96 |
Q |
A |
-2.7153 |
|
97 |
A |
A |
-1.5830 |
|
98 |
H |
A |
-1.7634 |
|
137 |
L |
A |
0.4304 |
|
138 |
E |
A |
-1.8959 |
|
139 |
L |
A |
-1.9729 |
|
140 |
R |
A |
-3.3163 |
|
141 |
V |
A |
-2.7175 |
|
142 |
E |
A |
-3.3279 |
|
143 |
N |
A |
-2.5277 |
|
144 |
L |
A |
-1.5518 |
|
145 |
Q |
A |
-0.9400 |
|
146 |
A |
A |
-0.5718 |
|
147 |
V |
A |
-0.6158 |
|
148 |
Q |
A |
-0.2959 |
|
149 |
T |
A |
0.0000 |
|
150 |
D |
A |
0.0000 |
|
151 |
F |
A |
1.4336 |
|
152 |
S |
A |
0.0655 |
|
153 |
S |
A |
-0.6755 |
|
154 |
D |
A |
-1.7159 |
|
155 |
P |
A |
-0.7703 |
|
156 |
L |
A |
-0.5107 |
|
157 |
Q |
A |
0.0000 |
|
158 |
K |
A |
-0.6892 |
|
159 |
V |
A |
0.0000 |
|
160 |
V |
A |
0.0000 |
|
161 |
C |
A |
-0.0120 |
|
162 |
F |
A |
0.0000 |
|
163 |
N |
A |
-1.5488 |
|
164 |
H |
A |
-2.3476 |
|
165 |
D |
A |
-2.6369 |
|
166 |
N |
A |
-1.8951 |
|
167 |
T |
A |
-1.2724 |
|
168 |
L |
A |
-1.0719 |
|
169 |
L |
A |
0.0000 |
|
170 |
A |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
G |
A |
0.0000 |
|
173 |
G |
A |
0.0000 |
|
174 |
T |
A |
-0.8445 |
|
175 |
D |
A |
-0.6759 |
|
176 |
G |
A |
0.0000 |
|
177 |
Y |
A |
-0.7306 |
|
178 |
V |
A |
0.0000 |
|
179 |
R |
A |
0.0000 |
|
180 |
V |
A |
0.0000 |
|
181 |
W |
A |
0.0000 |
|
182 |
K |
A |
-1.7567 |
|
183 |
V |
A |
-1.0293 |
|
184 |
P |
A |
-0.9236 |
|
185 |
S |
A |
-1.3003 |
|
186 |
L |
A |
0.0000 |
|
187 |
E |
A |
-2.5704 |
|
188 |
K |
A |
-2.1920 |
|
189 |
V |
A |
-0.8292 |
|
190 |
L |
A |
-1.2218 |
|
191 |
E |
A |
-1.7118 |
|
192 |
F |
A |
-1.7540 |
|
193 |
K |
A |
-2.2935 |
|
194 |
A |
A |
-1.6403 |
|
195 |
H |
A |
0.0000 |
|
196 |
E |
A |
-2.7164 |
|
197 |
G |
A |
-2.1549 |
|
198 |
E |
A |
-1.7354 |
|
199 |
I |
A |
0.0000 |
|
200 |
E |
A |
-1.1290 |
|
201 |
D |
A |
-0.6047 |
|
202 |
L |
A |
0.0000 |
|
203 |
A |
A |
0.0000 |
|
204 |
L |
A |
-0.4815 |
|
205 |
G |
A |
0.0000 |
|
206 |
P |
A |
-1.3641 |
|
207 |
D |
A |
-2.3142 |
|
208 |
G |
A |
-2.0503 |
|
209 |
K |
A |
-1.2648 |
|
210 |
L |
A |
0.0000 |
|
211 |
V |
A |
0.0000 |
|
212 |
T |
A |
0.0000 |
|
213 |
V |
A |
0.0000 |
|
214 |
G |
A |
0.0000 |
|
215 |
R |
A |
-2.3724 |
|
216 |
D |
A |
-1.8525 |
|
217 |
L |
A |
-1.4122 |
|
218 |
K |
A |
-1.7164 |
|
219 |
A |
A |
0.0000 |
|
220 |
S |
A |
0.0000 |
|
221 |
V |
A |
0.0000 |
|
222 |
W |
A |
0.0000 |
|
223 |
Q |
A |
-2.4484 |
|
224 |
K |
A |
-3.1018 |
|
225 |
D |
A |
-3.3118 |
|
226 |
Q |
A |
-2.1209 |
|
227 |
L |
A |
-0.2583 |
|
228 |
V |
A |
0.1353 |
|
229 |
T |
A |
-0.0208 |
|
230 |
Q |
A |
-0.4074 |
|
231 |
L |
A |
0.0000 |
|
232 |
H |
A |
-1.4321 |
|
233 |
W |
A |
-0.7916 |
|
234 |
Q |
A |
-1.3332 |
|
235 |
E |
A |
-2.1792 |
|
238 |
P |
A |
-0.0395 |
|
239 |
T |
A |
0.6633 |
|
240 |
F |
A |
1.6767 |
|
241 |
S |
A |
0.5204 |
|
242 |
S |
A |
-0.1225 |
|
243 |
T |
A |
0.0000 |
|
244 |
P |
A |
-0.9145 |
|
245 |
Y |
A |
-0.8754 |
|
246 |
R |
A |
-0.9744 |
|
247 |
Y |
A |
0.0000 |
|
248 |
Q |
A |
-0.5451 |
|
249 |
A |
A |
0.0000 |
|
250 |
C |
A |
0.0000 |
|
251 |
R |
A |
-0.3417 |
|
252 |
F |
A |
-0.1947 |
|
253 |
G |
A |
0.0000 |
|
254 |
Q |
A |
-1.4704 |
|
255 |
V |
A |
0.0000 |
|
256 |
P |
A |
-1.3521 |
|
257 |
D |
A |
-2.2620 |
|
258 |
Q |
A |
-1.4508 |
|
259 |
P |
A |
-0.8563 |
|
260 |
A |
A |
-0.5043 |
|
261 |
G |
A |
-0.7790 |
|
262 |
L |
A |
-0.3898 |
|
263 |
R |
A |
0.0000 |
|
264 |
L |
A |
0.0000 |
|
265 |
F |
A |
0.0000 |
|
266 |
T |
A |
0.0000 |
|
267 |
V |
A |
0.0000 |
|
268 |
Q |
A |
0.0000 |
|
269 |
I |
A |
0.0000 |
|
270 |
P |
A |
0.0000 |
|
271 |
H |
A |
-1.6296 |
|
272 |
K |
A |
-2.6113 |
|
273 |
R |
A |
-2.6007 |
|
274 |
L |
A |
-2.1146 |
|
275 |
R |
A |
-2.7242 |
|
276 |
Q |
A |
-2.3747 |
|
277 |
P |
A |
-1.9716 |
|
278 |
P |
A |
-1.2039 |
|
279 |
P |
A |
-0.7746 |
|
280 |
C |
A |
0.0000 |
|
281 |
Y |
A |
-0.4221 |
|
282 |
L |
A |
0.0000 |
|
283 |
T |
A |
0.0000 |
|
284 |
A |
A |
0.0000 |
|
285 |
W |
A |
0.0000 |
|
286 |
D |
A |
-0.0656 |
|
287 |
G |
A |
0.0000 |
|
288 |
S |
A |
-0.7933 |
|
289 |
N |
A |
-0.8847 |
|
290 |
F |
A |
0.1220 |
|
291 |
L |
A |
1.0474 |
|
292 |
P |
A |
0.3429 |
|
293 |
L |
A |
0.5722 |
|
294 |
R |
A |
-1.1952 |
|
295 |
T |
A |
-1.0781 |
|
296 |
K |
A |
-1.5645 |
|
297 |
S |
A |
-0.6850 |
|
298 |
C |
A |
0.0000 |
|
299 |
G |
A |
-0.8354 |
|
300 |
H |
A |
-1.2777 |
|
301 |
E |
A |
-0.7527 |
|
302 |
V |
A |
0.0000 |
|
303 |
V |
A |
0.0000 |
|
304 |
S |
A |
0.1773 |
|
305 |
C |
A |
0.0000 |
|
306 |
L |
A |
0.0000 |
|
307 |
D |
A |
-0.4885 |
|
308 |
V |
A |
-0.5352 |
|
309 |
S |
A |
0.0000 |
|
310 |
E |
A |
-2.6780 |
|
311 |
S |
A |
-1.8147 |
|
312 |
G |
A |
0.0000 |
|
313 |
T |
A |
-0.4102 |
|
314 |
F |
A |
0.0000 |
|
315 |
L |
A |
0.0000 |
|
316 |
G |
A |
0.0000 |
|
317 |
L |
A |
0.0000 |
|
318 |
G |
A |
0.0000 |
|
319 |
T |
A |
0.0000 |
|
320 |
V |
A |
0.9333 |
|
321 |
T |
A |
-0.1618 |
|
322 |
G |
A |
0.0000 |
|
323 |
S |
A |
0.0000 |
|
324 |
V |
A |
0.0000 |
|
325 |
A |
A |
0.0000 |
|
326 |
I |
A |
0.0000 |
|
327 |
Y |
A |
0.0000 |
|
328 |
I |
A |
0.5865 |
|
329 |
A |
A |
0.0000 |
|
330 |
F |
A |
0.5541 |
|
331 |
S |
A |
-0.1494 |
|
332 |
L |
A |
0.0000 |
|
333 |
Q |
A |
-0.6902 |
|
334 |
C |
A |
0.2885 |
|
335 |
L |
A |
0.9096 |
|
336 |
Y |
A |
1.0308 |
|
337 |
Y |
A |
0.4830 |
|
338 |
V |
A |
-0.4672 |
|
339 |
R |
A |
-2.3974 |
|
340 |
E |
A |
-2.3032 |
|
341 |
A |
A |
-1.3904 |
|
342 |
H |
A |
0.0000 |
|
343 |
G |
A |
-0.5592 |
|
344 |
I |
A |
0.8471 |
|
345 |
V |
A |
0.9530 |
|
346 |
V |
A |
0.0000 |
|
347 |
T |
A |
0.3584 |
|
348 |
D |
A |
-0.1987 |
|
349 |
V |
A |
0.0000 |
|
350 |
A |
A |
0.0000 |
|
351 |
F |
A |
0.0000 |
|
352 |
L |
A |
0.0000 |
|
353 |
P |
A |
0.0000 |
|
354 |
E |
A |
-3.6607 |
|
355 |
K |
A |
-3.6062 |
|
356 |
G |
A |
-2.5916 |
|
357 |
R |
A |
-2.7456 |
|
358 |
G |
A |
0.0000 |
|
359 |
P |
A |
-2.5419 |
|
360 |
E |
A |
-2.7381 |
|
361 |
L |
A |
-1.4575 |
|
362 |
L |
A |
-1.3326 |
|
363 |
G |
A |
-1.4122 |
|
364 |
S |
A |
-1.4489 |
|
365 |
H |
A |
-1.5411 |
|
366 |
E |
A |
-2.1497 |
|
367 |
T |
A |
0.0000 |
|
368 |
A |
A |
0.0000 |
|
369 |
L |
A |
0.0000 |
|
370 |
F |
A |
0.0000 |
|
371 |
S |
A |
0.0000 |
|
372 |
V |
A |
0.0000 |
|
373 |
A |
A |
0.0000 |
|
374 |
V |
A |
0.4968 |
|
375 |
D |
A |
-0.3847 |
|
376 |
S |
A |
-0.6791 |
|
377 |
R |
A |
-1.6467 |
|
378 |
C |
A |
0.0000 |
|
379 |
Q |
A |
-0.9830 |
|
380 |
L |
A |
-0.0901 |
|
381 |
H |
A |
0.0000 |
|
382 |
L |
A |
0.1953 |
|
383 |
L |
A |
0.0000 |
|
384 |
P |
A |
-1.0048 |
|
385 |
S |
A |
-1.7396 |
|
386 |
R |
A |
-2.3432 |
|