Project name: 3f93a0df7918a65

Chain sequence(s)	A: QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDLRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4489
• Maximal score value: 1.7558
• Average score: -0.8113
• Total score value: -372.4007

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
68	Q	A	-1.0388
69	A	A	-0.1526
70	A	A	-0.1489
71	H	A	0.0000
72	L	A	-0.0472
73	S	A	-0.5254
74	F	A	0.0000
75	A	A	-1.1796
76	R	A	-2.2440
77	L	A	-1.3205
78	A	A	-1.6785
79	R	A	-3.0196
80	R	A	-2.4545
81	Y	A	-0.4885
82	G	A	-0.9999
83	D	A	-1.4475
84	V	A	0.1388
85	F	A	-0.0045
86	Q	A	-0.8165
87	I	A	-0.9861
88	R	A	-1.9909
89	L	A	-0.9143
90	G	A	-0.8432
91	S	A	-0.7660
92	C	A	-0.6821
93	P	A	-1.0502
94	I	A	0.0000
95	V	A	0.0000
96	V	A	0.0000
97	L	A	0.0000
98	N	A	0.0000
99	G	A	-1.4308
100	E	A	-2.3874
101	R	A	-2.5389
102	A	A	0.0000
103	I	A	0.0000
104	H	A	-1.3567
105	Q	A	-1.3835
106	A	A	0.0000
107	L	A	0.0000
108	V	A	0.0306
109	Q	A	-1.1537
110	Q	A	-0.7109
111	G	A	-0.5208
112	S	A	-0.4275
113	A	A	-0.9578
114	F	A	0.0000
115	A	A	0.0000
116	D	A	-0.8219
117	R	A	0.0000
118	P	A	0.0000
119	A	A	-0.5438
120	F	A	-0.1901
121	A	A	-0.4757
122	S	A	0.0000
123	F	A	0.0000
124	R	A	-2.0952
125	V	A	-1.3978
126	V	A	0.0000
127	S	A	0.0000
128	G	A	-1.6379
129	G	A	-1.5976
130	R	A	-1.7439
131	S	A	0.0000
132	M	A	0.0000
133	A	A	-0.2715
134	F	A	0.0000
135	G	A	-1.0146
136	H	A	-1.4492
137	Y	A	-1.1959
138	S	A	-1.6446
139	E	A	-2.6902
140	H	A	-2.2912
141	W	A	0.0000
142	K	A	-2.5466
143	V	A	-1.8381
144	Q	A	0.0000
145	R	A	-1.8508
146	R	A	-2.3114
147	A	A	0.0000
148	A	A	0.0000
149	H	A	-1.5914
150	S	A	-1.6277
151	M	A	0.0000
152	M	A	0.0000
153	R	A	-2.7891
154	N	A	-2.3721
155	F	A	-1.6512
156	F	A	0.0000
157	T	A	-2.7747
158	R	A	-3.4489
159	Q	A	-3.0434
160	P	A	-2.5084
161	R	A	-3.1230
162	S	A	-2.5687
163	R	A	-3.0007
164	Q	A	-1.9886
165	V	A	0.0330
166	L	A	0.0000
167	E	A	-0.5513
168	G	A	-0.1871
169	H	A	-0.1216
170	V	A	0.0000
171	L	A	-0.2519
172	S	A	-0.4804
173	E	A	0.0000
174	A	A	0.0000
175	R	A	-0.9280
176	E	A	-0.9532
177	L	A	0.0000
178	V	A	0.0000
179	A	A	-0.6213
180	L	A	-0.4482
181	L	A	0.0000
182	V	A	-0.3647
183	R	A	-1.7479
184	G	A	-1.0465
185	S	A	0.0000
186	A	A	-1.4143
187	D	A	-2.1720
188	G	A	-1.3712
189	A	A	-0.8841
190	F	A	-0.3742
191	L	A	-0.3510
192	D	A	-0.8934
193	L	A	0.0000
194	R	A	-0.7997
195	P	A	-0.5255
196	L	A	-0.1746
197	T	A	0.0000
198	V	A	-0.0969
199	V	A	0.0000
200	A	A	0.0000
201	V	A	0.0000
202	A	A	0.0000
203	N	A	0.0000
204	V	A	0.0000
205	M	A	0.0000
206	S	A	0.0000
207	A	A	0.0000
208	V	A	0.0000
209	C	A	0.0000
210	F	A	0.0000
211	G	A	-0.7089
212	C	A	-0.2771
213	R	A	-0.8914
214	Y	A	-1.0315
215	S	A	-1.3886
216	H	A	-1.5574
217	D	A	-2.5551
218	D	A	-2.5145
219	P	A	-2.7337
220	E	A	-3.1958
221	F	A	0.0000
222	R	A	-2.9876
223	E	A	-3.2190
224	L	A	0.0000
225	L	A	0.0000
226	S	A	-1.6286
227	H	A	-1.3482
228	N	A	0.0000
229	E	A	-1.5591
230	E	A	-1.7543
231	F	A	-0.9197
232	G	A	0.0000
233	R	A	-1.4871
234	T	A	0.0000
235	V	A	0.0000
236	G	A	0.0000
237	A	A	-0.0121
238	G	A	-0.3085
239	S	A	-0.1216
240	L	A	0.2508
241	V	A	0.0000
242	D	A	-0.0017
243	V	A	0.0000
244	M	A	0.2389
245	P	A	0.3244
246	W	A	1.2670
247	L	A	0.0000
248	Q	A	0.3545
249	Y	A	1.7558
250	F	A	1.5046
251	P	A	0.2390
252	N	A	-0.1387
253	P	A	-0.5308
254	V	A	-0.4939
255	R	A	-0.5350
256	T	A	-1.0456
257	V	A	0.0000
258	F	A	-1.6589
259	R	A	-2.8241
260	E	A	-2.4808
261	F	A	0.0000
262	E	A	-2.6637
263	Q	A	-3.1217
264	L	A	0.0000
265	N	A	0.0000
266	R	A	-3.2728
267	N	A	-2.6224
268	F	A	0.0000
269	S	A	-1.5677
270	N	A	-2.0880
271	F	A	-1.0845
272	I	A	0.0000
273	L	A	-0.5199
274	D	A	-1.2570
275	K	A	-1.1124
276	F	A	0.0000
277	L	A	-0.4454
278	R	A	-2.1552
279	H	A	-1.7543
280	C	A	-1.3800
281	E	A	-2.5386
282	S	A	-1.9096
283	L	A	-1.9268
284	R	A	-2.3855
285	P	A	-1.3097
286	G	A	-1.0662
287	A	A	-1.0981
288	A	A	-0.8337
289	P	A	-1.2809
290	R	A	-2.0289
291	D	A	-1.1486
292	M	A	0.0000
293	M	A	0.0000
294	D	A	-0.8700
295	A	A	0.0000
296	F	A	0.0000
297	I	A	0.0000
298	L	A	-1.0497
299	S	A	-1.4211
300	A	A	0.0000
301	E	A	-2.8883
302	K	A	-3.4022
303	K	A	-2.9783
304	A	A	-1.9813
305	A	A	-1.9534
306	G	A	-2.0679
307	D	A	-2.8271
312	G	A	-1.0594
313	A	A	-1.1993
314	R	A	-1.5531
315	L	A	0.0000
316	D	A	-2.2605
317	L	A	-1.4199
318	E	A	-2.1172
319	N	A	-1.4947
320	V	A	0.0000
321	P	A	0.0000
322	A	A	0.0000
323	T	A	0.0000
324	I	A	0.0000
325	T	A	0.0000
326	D	A	-0.3048
327	I	A	0.0000
328	F	A	0.0000
329	G	A	-0.1442
330	A	A	-0.0392
331	S	A	-0.1043
332	Q	A	0.0000
333	D	A	0.0000
334	T	A	0.0497
335	L	A	0.0000
336	S	A	0.0000
337	T	A	0.0000
338	A	A	0.0000
339	L	A	0.0000
340	Q	A	0.0000
341	W	A	0.0000
342	L	A	0.0000
343	L	A	0.0000
344	L	A	0.0000
345	L	A	0.0000
346	F	A	0.0000
347	T	A	0.0000
348	R	A	-0.8615
349	Y	A	-0.8040
350	P	A	-1.5321
351	D	A	-2.2758
352	V	A	0.0000
353	Q	A	0.0000
354	T	A	-1.4743
355	R	A	-2.1023
356	V	A	0.0000
357	Q	A	0.0000
358	A	A	-1.2269
359	E	A	-1.3720
360	L	A	0.0000
361	D	A	-2.2953
362	Q	A	-1.8199
363	V	A	-0.9626
364	V	A	0.0000
365	G	A	-2.0531
366	R	A	-2.9017
367	D	A	-3.0686
368	R	A	-2.4899
369	L	A	-1.1882
370	P	A	0.0000
371	C	A	-0.1929
372	M	A	0.0000
373	G	A	-0.7817
374	D	A	-0.8695
375	Q	A	-0.9137
376	P	A	-0.9617
377	N	A	-1.4855
378	L	A	0.0000
379	P	A	-0.0925
380	Y	A	0.0000
381	V	A	0.0000
382	L	A	0.1419
383	A	A	0.0000
384	F	A	0.0000
385	L	A	0.0000
386	Y	A	-0.0753
387	E	A	0.0000
388	A	A	0.0000
389	M	A	0.0000
390	R	A	0.0000
391	F	A	-0.4258
392	S	A	0.0000
393	S	A	0.0000
394	F	A	0.0000
395	V	A	0.4872
396	P	A	0.0000
397	V	A	0.0000
398	T	A	0.0000
399	I	A	0.2564
400	P	A	0.0000
401	H	A	0.0000
402	A	A	0.0000
403	T	A	0.0000
404	T	A	-1.4872
405	A	A	-1.8768
406	N	A	-2.6353
407	T	A	-1.3223
408	S	A	-0.6296
409	V	A	0.0000
410	L	A	-0.1188
411	G	A	-0.0712
412	Y	A	0.2572
413	H	A	-1.1514
414	I	A	0.0000
415	P	A	-2.1651
416	K	A	-3.3169
417	D	A	-2.8991
418	T	A	-1.6221
419	V	A	0.0000
420	V	A	0.0000
421	F	A	0.0000
422	V	A	0.0000
423	N	A	0.0000
424	Q	A	0.0000
425	W	A	0.2617
426	S	A	-0.4173
427	V	A	0.0000
428	N	A	0.0000
429	H	A	0.0000
430	D	A	-0.6035
431	P	A	-0.3453
432	L	A	0.8006
433	K	A	-0.6103
434	W	A	0.0000
435	P	A	-1.0160
436	N	A	-1.8981
437	P	A	-1.7609
438	E	A	-2.7565
439	N	A	-2.5776
440	F	A	0.0000
441	D	A	-1.3192
442	P	A	0.0000
443	A	A	-0.4463
444	R	A	-0.8741
445	F	A	0.0000
446	L	A	-0.6605
447	D	A	-1.6267
448	K	A	-2.5689
449	D	A	-2.4594
450	G	A	-1.1253
451	L	A	-0.2778
452	I	A	-0.6571
453	N	A	-1.7690
454	K	A	-2.8886
455	D	A	-3.0813
456	L	A	-2.0524
457	T	A	0.0000
458	S	A	-2.1104
459	R	A	-2.6242
460	V	A	-1.1001
461	M	A	0.0000
462	I	A	0.0000
463	F	A	0.2169
464	S	A	0.0000
465	V	A	-0.0991
466	G	A	-0.6815
467	K	A	-1.2632
468	R	A	0.0000
469	R	A	-0.8437
470	C	A	-0.3078
471	I	A	-0.8641
472	G	A	-0.9446
473	E	A	-1.2816
474	E	A	-2.2308
475	L	A	0.0000
476	S	A	-0.7876
477	K	A	-1.0331
478	M	A	-0.8623
479	Q	A	0.0000
480	L	A	0.0000
481	F	A	0.0000
482	L	A	0.0000
483	F	A	0.0000
484	I	A	0.0000
485	S	A	0.0000
486	I	A	0.0000
487	L	A	0.0000
488	A	A	0.0000
489	H	A	0.0000
490	Q	A	0.0000
491	C	A	0.0000
492	D	A	-0.7630
493	F	A	0.0000
494	R	A	-1.3340
495	A	A	-1.3473
496	N	A	-1.7556
497	P	A	-1.8477
498	N	A	-2.3926
499	E	A	-3.1346
500	P	A	-1.9426
501	A	A	-1.6857
502	K	A	-2.3148
503	M	A	-1.9234
504	N	A	-1.8687
505	F	A	-0.7812
506	S	A	-0.5514
507	Y	A	0.2474
508	G	A	-0.2978
509	L	A	0.0378
510	T	A	0.0000
511	I	A	0.0000
512	K	A	0.0000
513	P	A	0.0000
514	K	A	-1.7907
515	S	A	-1.4193
516	F	A	0.0000
517	K	A	-1.4851
518	V	A	0.0000
519	N	A	0.0000
520	V	A	0.0000
521	T	A	-1.0710
522	L	A	-1.0994
523	R	A	-2.4348
524	E	A	-2.8782
525	S	A	-1.5135
526	M	A	-1.2038
527	E	A	-2.3388
528	L	A	0.0000
529	L	A	-0.1611
530	D	A	-1.4710