| Chain sequence(s) |
A: PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLAFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLAQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR B: PQLKPIEASILAARRV |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 11 | P | A | -1.0572 | |
| 12 | E | A | -1.3344 | |
| 13 | M | A | -0.2973 | |
| 14 | V | A | 0.0000 | |
| 15 | R | A | -1.9640 | |
| 16 | G | A | -1.3539 | |
| 17 | Q | A | -1.1749 | |
| 18 | V | A | -0.4992 | |
| 19 | F | A | 0.0000 | |
| 20 | D | A | -1.9895 | |
| 21 | V | A | 0.0000 | |
| 22 | G | A | -1.6730 | |
| 23 | P | A | -0.9820 | |
| 24 | R | A | -0.8670 | |
| 25 | Y | A | 0.0000 | |
| 26 | T | A | -1.5767 | |
| 27 | N | A | -1.6717 | |
| 28 | L | A | 0.0000 | |
| 29 | S | A | -0.1193 | |
| 30 | Y | A | 0.3930 | |
| 31 | I | A | 1.0558 | |
| 32 | G | A | -0.3116 | |
| 33 | E | A | -1.7158 | |
| 34 | G | A | -1.2418 | |
| 35 | A | A | -0.4435 | |
| 36 | Y | A | -0.4750 | |
| 37 | G | A | -0.6626 | |
| 38 | M | A | 0.0000 | |
| 39 | V | A | 0.1488 | |
| 40 | C | A | 0.0000 | |
| 41 | S | A | -0.4387 | |
| 42 | A | A | 0.0000 | |
| 43 | Y | A | -1.1050 | |
| 44 | D | A | 0.0000 | |
| 45 | N | A | -1.0900 | |
| 46 | V | A | 0.3821 | |
| 47 | N | A | -1.3300 | |
| 48 | K | A | -1.8013 | |
| 49 | V | A | -0.7487 | |
| 50 | R | A | -1.9902 | |
| 51 | V | A | 0.0000 | |
| 52 | A | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | K | A | -0.2075 | |
| 55 | K | A | -0.5811 | |
| 56 | I | A | -0.2345 | |
| 57 | S | A | -0.8639 | |
| 58 | P | A | 0.0000 | |
| 59 | F | A | -1.7818 | |
| 60 | E | A | -2.5818 | |
| 61 | H | A | -1.8795 | |
| 62 | Q | A | -2.2512 | |
| 63 | T | A | -1.5580 | |
| 64 | Y | A | -0.5424 | |
| 65 | C | A | 0.0000 | |
| 66 | Q | A | 0.0000 | |
| 67 | R | A | -1.0538 | |
| 68 | T | A | 0.0000 | |
| 69 | L | A | 0.0000 | |
| 70 | R | A | 0.0000 | |
| 71 | E | A | 0.0000 | |
| 72 | I | A | 0.0000 | |
| 73 | K | A | -0.3576 | |
| 74 | I | A | 0.0000 | |
| 75 | L | A | 0.0000 | |
| 76 | L | A | -0.3681 | |
| 77 | A | A | -0.4859 | |
| 78 | F | A | 0.0000 | |
| 79 | R | A | -2.1658 | |
| 80 | H | A | 0.0000 | |
| 81 | E | A | -1.9426 | |
| 82 | N | A | 0.0000 | |
| 83 | I | A | 0.0000 | |
| 84 | I | A | 0.0000 | |
| 85 | G | A | -1.1401 | |
| 86 | I | A | -0.7988 | |
| 87 | N | A | -1.2663 | |
| 88 | D | A | -0.7302 | |
| 89 | I | A | 0.0000 | |
| 90 | I | A | -0.1360 | |
| 91 | R | A | -0.7564 | |
| 92 | A | A | -1.2418 | |
| 93 | P | A | -0.7372 | |
| 94 | T | A | -0.8758 | |
| 95 | I | A | -1.6578 | |
| 96 | E | A | -2.5179 | |
| 97 | Q | A | -2.5337 | |
| 98 | M | A | 0.0000 | |
| 99 | K | A | -2.6620 | |
| 100 | D | A | -1.4444 | |
| 101 | V | A | 0.0000 | |
| 102 | Y | A | 0.0000 | |
| 103 | I | A | 0.0000 | |
| 104 | V | A | 0.0000 | |
| 105 | Q | A | 0.0000 | |
| 106 | D | A | -1.5450 | |
| 107 | L | A | -0.8121 | |
| 108 | M | A | -1.1740 | |
| 109 | E | A | -1.9159 | |
| 110 | T | A | -0.9742 | |
| 111 | D | A | 0.0000 | |
| 112 | L | A | 0.0000 | |
| 113 | Y | A | -0.7103 | |
| 114 | K | A | -1.7080 | |
| 115 | L | A | 0.0000 | |
| 116 | L | A | 0.0000 | |
| 117 | K | A | -2.5902 | |
| 118 | T | A | -1.6852 | |
| 119 | Q | A | -1.7646 | |
| 120 | H | A | -1.6250 | |
| 121 | L | A | -1.0753 | |
| 122 | S | A | -1.2705 | |
| 123 | N | A | -1.9769 | |
| 124 | D | A | -2.2031 | |
| 125 | H | A | -1.4239 | |
| 126 | I | A | 0.0000 | |
| 127 | C | A | -0.9305 | |
| 128 | Y | A | 0.0000 | |
| 129 | F | A | 0.0000 | |
| 130 | L | A | 0.0000 | |
| 131 | Y | A | 0.0000 | |
| 132 | Q | A | 0.0000 | |
| 133 | I | A | 0.0000 | |
| 134 | L | A | 0.0000 | |
| 135 | R | A | 0.0000 | |
| 136 | G | A | 0.0000 | |
| 137 | L | A | 0.0000 | |
| 138 | K | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | I | A | 0.0000 | |
| 141 | H | A | 0.0000 | |
| 142 | S | A | -0.2138 | |
| 143 | A | A | 0.0000 | |
| 144 | N | A | -1.0022 | |
| 145 | V | A | 0.0000 | |
| 146 | L | A | 0.0000 | |
| 147 | H | A | 0.0000 | |
| 148 | R | A | -0.2636 | |
| 149 | D | A | -0.2973 | |
| 150 | L | A | 0.0000 | |
| 151 | K | A | 0.0000 | |
| 152 | P | A | 0.0000 | |
| 153 | S | A | -0.2259 | |
| 154 | N | A | 0.0000 | |
| 155 | L | A | 0.0000 | |
| 156 | L | A | -0.3758 | |
| 157 | L | A | 0.0000 | |
| 158 | N | A | -1.2508 | |
| 159 | T | A | -1.3164 | |
| 160 | T | A | -0.8482 | |
| 161 | C | A | 0.0000 | |
| 162 | D | A | -0.5125 | |
| 163 | L | A | 0.0000 | |
| 164 | K | A | -0.7294 | |
| 165 | I | A | 0.0000 | |
| 166 | C | A | 0.0000 | |
| 167 | D | A | -0.8702 | |
| 168 | F | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | L | A | -0.4108 | |
| 171 | A | A | 0.0000 | |
| 172 | R | A | -0.6346 | |
| 173 | V | A | -0.7850 | |
| 174 | A | A | -1.2111 | |
| 175 | D | A | -2.5352 | |
| 176 | P | A | -2.4148 | |
| 177 | D | A | -3.1340 | |
| 178 | H | A | -2.2384 | |
| 186 | E | A | -1.6051 | |
| 187 | Y | A | 0.5154 | |
| 188 | V | A | 0.5423 | |
| 189 | A | A | 0.3429 | |
| 190 | T | A | -0.3912 | |
| 191 | R | A | -0.8342 | |
| 192 | W | A | -0.4355 | |
| 193 | Y | A | 0.0000 | |
| 194 | R | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | P | A | 0.0000 | |
| 197 | E | A | 0.0000 | |
| 198 | I | A | -0.2997 | |
| 199 | M | A | 0.0000 | |
| 200 | L | A | 0.1033 | |
| 201 | N | A | 0.2152 | |
| 202 | S | A | -0.7637 | |
| 203 | K | A | -2.2839 | |
| 204 | G | A | 0.0000 | |
| 205 | Y | A | -1.5009 | |
| 206 | T | A | -1.2600 | |
| 207 | K | A | -0.6932 | |
| 208 | S | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | D | A | 0.0000 | |
| 211 | I | A | 0.0000 | |
| 212 | W | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | V | A | 0.0000 | |
| 215 | G | A | 0.0000 | |
| 216 | C | A | 0.0000 | |
| 217 | I | A | 0.0000 | |
| 218 | L | A | 0.0000 | |
| 219 | A | A | 0.0000 | |
| 220 | E | A | 0.0000 | |
| 221 | M | A | 0.0000 | |
| 222 | L | A | -0.5541 | |
| 223 | S | A | -0.8384 | |
| 224 | N | A | -1.5596 | |
| 225 | R | A | -2.0577 | |
| 226 | P | A | -0.8153 | |
| 227 | I | A | -0.2348 | |
| 228 | F | A | 0.0000 | |
| 229 | P | A | -1.0208 | |
| 230 | G | A | 0.0000 | |
| 231 | K | A | -2.0537 | |
| 232 | H | A | -1.3691 | |
| 233 | Y | A | -0.1562 | |
| 234 | L | A | 0.1229 | |
| 235 | D | A | -0.9138 | |
| 236 | Q | A | 0.0000 | |
| 237 | L | A | 0.0000 | |
| 238 | N | A | -0.8097 | |
| 239 | H | A | -0.7837 | |
| 240 | I | A | 0.0000 | |
| 241 | L | A | 0.0000 | |
| 242 | G | A | -1.2017 | |
| 243 | I | A | -0.7606 | |
| 244 | L | A | 0.0000 | |
| 245 | G | A | 0.0000 | |
| 246 | S | A | -1.4618 | |
| 247 | P | A | -1.2891 | |
| 248 | S | A | -1.6351 | |
| 249 | Q | A | -2.5185 | |
| 250 | E | A | -2.8386 | |
| 251 | D | A | -2.1172 | |
| 252 | L | A | 0.0000 | |
| 253 | N | A | -1.2375 | |
| 254 | C | A | -0.4428 | |
| 255 | I | A | 0.4850 | |
| 256 | I | A | 1.7895 | |
| 257 | N | A | 0.3842 | |
| 258 | L | A | 0.3810 | |
| 259 | K | A | -1.2743 | |
| 260 | A | A | -0.5595 | |
| 261 | R | A | -0.6398 | |
| 262 | N | A | -1.0708 | |
| 263 | Y | A | -0.1032 | |
| 264 | L | A | 0.0000 | |
| 265 | L | A | 0.7426 | |
| 266 | S | A | 0.1681 | |
| 267 | L | A | -0.0791 | |
| 268 | P | A | -0.8086 | |
| 269 | H | A | -1.8706 | |
| 270 | K | A | -2.4973 | |
| 271 | N | A | -2.8133 | |
| 272 | K | A | -2.5730 | |
| 273 | V | A | -1.6674 | |
| 274 | P | A | -1.6183 | |
| 275 | W | A | 0.0000 | |
| 276 | N | A | -2.5377 | |
| 277 | R | A | -2.4758 | |
| 278 | L | A | -1.0363 | |
| 279 | F | A | -1.1182 | |
| 280 | P | A | -1.7936 | |
| 281 | N | A | -1.9327 | |
| 282 | A | A | -1.3341 | |
| 283 | D | A | -1.5603 | |
| 284 | S | A | -1.5371 | |
| 285 | K | A | -1.6462 | |
| 286 | A | A | 0.0000 | |
| 287 | L | A | 0.0000 | |
| 288 | D | A | -2.0429 | |
| 289 | L | A | 0.0000 | |
| 290 | L | A | 0.0000 | |
| 291 | D | A | -1.3248 | |
| 292 | K | A | -1.4925 | |
| 293 | M | A | 0.0000 | |
| 294 | L | A | 0.0000 | |
| 295 | T | A | -0.7622 | |
| 296 | F | A | -0.5172 | |
| 297 | N | A | -1.2256 | |
| 298 | P | A | -1.1506 | |
| 299 | H | A | -1.8679 | |
| 300 | K | A | -2.3388 | |
| 301 | R | A | 0.0000 | |
| 302 | I | A | -1.3829 | |
| 303 | E | A | -1.7135 | |
| 304 | V | A | 0.0000 | |
| 305 | E | A | -2.4001 | |
| 306 | Q | A | -2.1636 | |
| 307 | A | A | 0.0000 | |
| 308 | L | A | 0.0000 | |
| 309 | A | A | -1.0023 | |
| 310 | H | A | 0.0000 | |
| 311 | P | A | -0.6712 | |
| 312 | Y | A | 0.0000 | |
| 313 | L | A | 0.0000 | |
| 314 | A | A | -0.4858 | |
| 315 | Q | A | -1.1615 | |
| 316 | Y | A | 0.0000 | |
| 317 | Y | A | -0.2331 | |
| 318 | D | A | -0.6940 | |
| 319 | P | A | -0.5653 | |
| 320 | S | A | -0.3600 | |
| 321 | D | A | -0.5655 | |
| 322 | E | A | 0.0000 | |
| 323 | P | A | -0.1053 | |
| 324 | I | A | 0.9121 | |
| 325 | A | A | -0.4572 | |
| 326 | E | A | -1.6180 | |
| 327 | A | A | -0.9662 | |
| 328 | P | A | -1.0559 | |
| 329 | F | A | -1.2928 | |
| 330 | K | A | -2.2820 | |
| 331 | F | A | -1.7046 | |
| 332 | D | A | -2.3383 | |
| 333 | M | A | -1.8162 | |
| 334 | E | A | -2.6993 | |
| 335 | L | A | 0.0000 | |
| 336 | D | A | -3.4834 | |
| 337 | D | A | -3.1726 | |
| 338 | L | A | -2.2950 | |
| 339 | P | A | -2.2029 | |
| 340 | K | A | -3.0917 | |
| 341 | E | A | -3.3962 | |
| 342 | K | A | -2.8623 | |
| 343 | L | A | 0.0000 | |
| 344 | K | A | -2.6053 | |
| 345 | E | A | -2.8074 | |
| 346 | L | A | -1.7963 | |
| 347 | I | A | 0.0000 | |
| 348 | F | A | -1.4241 | |
| 349 | E | A | -2.2751 | |
| 350 | E | A | -1.4158 | |
| 351 | T | A | 0.0000 | |
| 352 | A | A | -1.1982 | |
| 353 | R | A | -1.4123 | |
| 354 | F | A | -0.3320 | |
| 355 | Q | A | -0.7628 | |
| 356 | P | A | -0.7162 | |
| 357 | G | A | -0.7234 | |
| 358 | Y | A | -0.4806 | |
| 359 | R | A | -1.6927 | |
| 712 | P | B | -1.7397 | |
| 713 | Q | B | -1.7669 | |
| 714 | L | B | -1.2804 | |
| 715 | K | B | -2.1921 | |
| 716 | P | B | -1.8317 | |
| 717 | I | B | -1.2641 | |
| 718 | E | B | -1.7346 | |
| 719 | A | B | -0.7482 | |
| 720 | S | B | 0.0000 | |
| 721 | I | B | 0.9886 | |
| 722 | L | B | 0.0000 | |
| 723 | A | B | 0.0000 | |
| 724 | A | B | -0.1668 | |
| 725 | R | B | -1.1542 | |
| 726 | R | B | -0.5395 | |
| 727 | V | B | 0.8135 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine