Project name: 46f7d95ab1283ab

Chain sequence(s)	A: EEDELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCAMGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGRGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSENSKEAEILEVLRHPRDWVR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.4072
• Maximal score value: 1.9895
• Average score: -1.0119
• Total score value: -339.9944

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
119	E	A	-3.3409
120	E	A	-4.1102
121	D	A	-3.7423
122	E	A	-3.6757
123	L	A	-2.3881
124	A	A	-2.3643
125	H	A	-3.2949
126	R	A	-2.8589
127	C	A	-1.4869
128	S	A	-0.9714
129	S	A	-1.3963
130	F	A	0.0000
131	M	A	-0.4852
132	A	A	-0.3416
133	P	A	-0.5126
134	P	A	0.0000
135	V	A	-0.6783
136	T	A	-1.2330
137	D	A	-2.4355
138	L	A	-1.8866
139	G	A	-2.6867
140	E	A	-3.8952
141	L	A	0.0000
142	R	A	-4.1289
143	R	A	-4.4072
144	R	A	-4.3998
145	P	A	-3.0483
146	G	A	-2.2449
147	D	A	-2.1958
148	M	A	0.0000
149	K	A	-1.1981
150	T	A	0.0000
151	K	A	-1.7289
152	M	A	0.0000
153	E	A	0.0000
154	L	A	-0.6631
155	L	A	0.0000
156	I	A	0.0000
157	L	A	0.0000
158	E	A	-1.9324
159	T	A	0.0000
160	Q	A	0.0000
161	A	A	0.0000
162	Q	A	-2.0877
163	V	A	0.0000
164	C	A	0.0000
165	Q	A	-1.7861
166	A	A	-1.1766
167	L	A	0.0000
168	A	A	-1.2738
169	Q	A	-1.4758
170	V	A	-0.9116
171	D	A	0.0000
172	G	A	-0.9983
173	G	A	-1.1592
174	A	A	-1.3810
175	N	A	-1.5306
176	F	A	-0.5151
177	S	A	-0.4483
178	V	A	-0.3080
179	D	A	-1.8680
180	R	A	-1.7693
181	W	A	-1.8066
182	E	A	-3.5480
183	R	A	-4.1090
184	K	A	-4.0302
185	E	A	-3.7543
186	G	A	-2.6988
187	G	A	-2.3568
188	G	A	0.0000
189	G	A	0.0000
190	I	A	0.0000
191	S	A	-0.4430
192	C	A	0.0000
193	V	A	0.1236
194	L	A	0.0000
195	Q	A	-1.7317
196	D	A	-2.3956
197	G	A	-1.5797
198	C	A	-0.4187
199	V	A	0.0000
200	F	A	0.0000
201	E	A	0.0000
202	K	A	-0.7693
203	A	A	0.0000
204	G	A	0.0000
205	V	A	0.0000
206	S	A	-0.3008
207	I	A	0.0000
208	S	A	0.0000
209	V	A	0.0000
210	V	A	-1.2517
211	H	A	-1.4703
212	G	A	-1.6311
213	N	A	-1.8957
214	L	A	-1.5022
215	S	A	-1.7921
216	E	A	-2.9175
217	E	A	-2.3211
218	A	A	0.0000
219	A	A	0.0000
220	K	A	-3.1416
221	Q	A	-2.7655
222	M	A	0.0000
223	R	A	-2.1851
224	S	A	-2.1842
225	R	A	-2.6995
226	G	A	-1.5395
227	K	A	-0.8670
228	V	A	0.4186
229	L	A	0.0000
230	K	A	-2.5089
231	T	A	-2.4828
232	K	A	-3.3251
233	D	A	-3.2417
234	G	A	-2.6415
235	K	A	-3.4137
236	L	A	0.0000
237	P	A	-1.6739
238	F	A	-0.8555
239	C	A	0.0000
240	A	A	0.0000
241	M	A	0.0000
242	G	A	0.0000
243	V	A	0.0000
244	S	A	-0.1551
245	S	A	0.0000
246	V	A	0.0000
247	I	A	0.0000
248	H	A	0.0000
249	P	A	0.0000
250	K	A	-1.3106
251	N	A	0.0000
252	P	A	0.0000
253	H	A	-1.0433
254	A	A	0.0000
255	P	A	0.0000
256	T	A	0.0000
257	I	A	0.0000
258	H	A	-0.1888
259	F	A	0.0000
260	N	A	-0.2189
261	Y	A	0.0000
262	R	A	0.0000
263	Y	A	0.0000
264	F	A	0.0000
265	E	A	0.0000
266	V	A	0.0000
267	E	A	-2.5916
268	E	A	0.0000
269	A	A	-2.9927
270	D	A	-3.1907
271	G	A	-2.3692
272	N	A	-3.0131
273	K	A	-2.7741
274	Q	A	-1.3533
275	W	A	-1.0039
276	W	A	0.0000
277	F	A	0.0000
278	G	A	0.0000
279	R	A	0.0000
280	G	A	0.0000
281	C	A	0.0000
282	D	A	0.0000
283	L	A	0.0000
284	T	A	0.0000
285	P	A	0.0000
286	T	A	0.0000
287	Y	A	-0.5254
288	L	A	0.0000
289	N	A	-1.3085
290	Q	A	-1.6243
291	E	A	-2.1789
292	D	A	0.0000
293	A	A	0.0000
294	V	A	-1.4326
295	H	A	-1.3501
296	F	A	0.0000
297	H	A	0.0000
298	R	A	-2.5967
299	T	A	-1.5920
300	L	A	0.0000
301	K	A	-2.5859
302	E	A	-3.0447
303	A	A	0.0000
304	C	A	0.0000
305	D	A	-2.5499
306	Q	A	-2.4383
307	H	A	-2.2539
308	G	A	-1.4670
309	P	A	-2.0622
310	D	A	-2.4430
311	L	A	-1.6300
312	Y	A	0.0000
313	P	A	-2.2597
314	K	A	-2.4528
315	F	A	0.0000
316	K	A	0.0000
317	K	A	-2.7603
318	W	A	-1.5275
319	C	A	0.0000
320	D	A	-1.7966
321	D	A	-1.8963
322	Y	A	-0.5396
323	F	A	0.0000
324	F	A	-0.2106
325	I	A	0.0000
326	A	A	-0.6121
327	H	A	-1.0679
328	R	A	-1.2402
329	G	A	-1.1557
330	E	A	0.0000
331	R	A	-0.9006
332	R	A	0.0000
333	G	A	0.0000
334	I	A	0.0000
335	G	A	0.0000
336	G	A	0.0000
337	I	A	0.0000
338	F	A	0.0000
339	F	A	0.0000
340	D	A	-0.9020
341	D	A	-1.5695
342	L	A	-1.1776
343	D	A	-1.9350
344	S	A	-1.6348
345	P	A	-1.4079
346	S	A	-1.8112
347	K	A	-2.3273
348	E	A	-3.4098
349	E	A	-3.6049
350	V	A	0.0000
351	F	A	0.0000
352	R	A	-3.0844
353	F	A	0.0000
354	V	A	0.0000
355	Q	A	-1.7692
356	S	A	-1.8265
357	C	A	0.0000
358	A	A	0.0000
359	R	A	-2.2416
360	A	A	0.0000
361	V	A	0.0000
362	V	A	-0.5709
363	P	A	-0.4056
364	S	A	0.0000
365	Y	A	0.0000
366	I	A	0.0000
367	P	A	-1.1853
368	L	A	0.0000
369	V	A	0.0000
370	K	A	-2.8652
371	K	A	-3.0652
372	H	A	-2.3525
373	C	A	-2.1136
374	D	A	-2.8163
375	D	A	-2.0631
376	S	A	-0.6820
377	F	A	-0.1229
378	T	A	-0.2966
379	P	A	-0.7318
380	Q	A	-1.2555
381	E	A	-0.9611
382	K	A	-0.7163
383	L	A	-0.4575
384	W	A	0.0000
385	Q	A	0.0000
386	Q	A	0.0000
387	L	A	-0.3802
388	R	A	0.0000
389	R	A	0.0000
390	G	A	0.0000
391	R	A	-0.2767
392	Y	A	0.0000
393	V	A	0.0000
394	E	A	0.0000
395	F	A	0.0000
396	N	A	0.0000
397	L	A	1.1863
398	L	A	0.9908
399	Y	A	0.7323
400	D	A	-0.2704
401	R	A	-1.0741
402	G	A	-0.9189
403	T	A	-1.1077
404	K	A	-1.5782
405	F	A	-0.8944
406	G	A	-0.4860
407	L	A	-0.2066
408	F	A	0.0000
409	T	A	-0.7562
410	P	A	-0.3477
411	G	A	-0.5861
412	S	A	-0.5373
413	R	A	-0.4017
414	I	A	0.9959
415	E	A	0.2229
416	S	A	0.6651
417	I	A	1.1273
418	L	A	1.9895
419	M	A	1.2119
420	S	A	0.0000
421	L	A	1.2464
422	P	A	0.0000
423	L	A	0.0998
424	T	A	-0.1143
425	A	A	-0.3866
426	R	A	-1.6131
427	W	A	-0.3390
428	E	A	-0.9975
429	Y	A	0.7203
430	M	A	0.3164
431	H	A	-0.7709
432	S	A	-0.7620
433	P	A	-1.3578
434	S	A	-1.9575
435	E	A	-2.8481
436	N	A	-2.6341
437	S	A	-2.0260
438	K	A	-2.1792
439	E	A	-1.7080
440	A	A	-2.0333
441	E	A	-2.2520
442	I	A	0.0000
443	L	A	-1.6877
444	E	A	-2.9676
445	V	A	0.0000
446	L	A	0.0000
447	R	A	-2.9887
448	H	A	-2.4190
449	P	A	-2.6281
450	R	A	-2.7399
451	D	A	-2.8198
452	W	A	-1.9437
453	V	A	-1.9771
454	R	A	-2.3255