Project name: 3N75 [mutate: KA437Y, KA440Y, EA445Y, DA457Y, DA460Y, DA470Y, KB437Y, KB440Y, EB445Y, DB457Y, DB460Y, DB470Y, KC437Y, KC440Y, EC445Y, DC457Y, DC460Y, DC470Y, KD437Y, KD440Y, ED445Y, DD457Y, DD460Y, DD470Y, KE437Y, KE440Y, EE445Y, DE457Y, DE460Y, DE47

Status: done

submitted: 2017-09-13 12:59:48, status changed: 2017-09-13 15:17:48
Settings
Chain sequence(s) A: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
C: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
B: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
E: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
D: MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNARLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQISFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTHLMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWFFDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEKDGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLLRALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHHNLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKE
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues KA437Y, KA440Y, EA445Y, DA457Y, DA460Y, DA470Y, KB437Y, KB440Y, EB445Y, DB457Y, DB460Y, DB470Y, KC437Y, KC440Y, EC445Y, DC457Y, DC460Y, DC470Y, KD437Y, KD440Y, ED445Y, DD457Y, DD460Y, DD470Y, KE437Y, KE440Y, EE445Y, DE457Y, DE460Y, DE470Y
Energy difference between WT (input) and mutated protein (by FoldX) -7.04762 kcal/mol
Show buried residues

Minimal score value
-4.078
Maximal score value
2.8408
Average score
-0.6762
Total score value
-2400.3863

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3122
2 N A -1.1162
3 V A 0.0000
4 I A 0.0000
5 A A 0.0000
6 I A 0.0000
7 L A 0.0000
8 N A -1.3066
9 H A -1.4140
10 M A -0.6006
11 G A -0.6337
12 V A -0.6902
13 Y A -0.5278
14 F A 0.0000
15 K A 0.0000
16 E A -0.6554
17 E A -0.5920
18 P A 0.0000
19 I A -0.6954
20 R A -1.4210
21 E A -1.6176
22 L A 0.0000
23 H A -1.9910
24 R A -3.1509
25 A A 0.0000
26 L A 0.0000
27 E A -3.7431
28 R A -3.6233
29 L A -2.6501
30 N A -2.8253
31 F A 0.0000
32 Q A -1.4388
33 I A -0.7193
34 V A 0.0000
35 Y A 0.0835
36 P A 0.0000
37 N A -2.1346
38 D A -2.4019
39 R A -2.4279
40 D A -2.5580
41 D A 0.0000
42 L A 0.0000
43 L A -1.5428
44 K A -1.7261
45 L A 0.0000
46 I A 0.0000
47 E A -1.7664
48 N A -1.5031
49 N A 0.0000
50 A A -0.6620
51 R A -0.8618
52 L A 0.0000
53 C A 0.0000
54 G A 0.0000
55 V A 0.0000
56 I A 0.0000
57 F A 0.0000
58 D A 0.0000
59 W A 0.0000
60 D A -1.0638
61 K A -1.5110
62 Y A 0.0000
63 N A 0.0000
64 L A -0.4453
65 E A -1.9596
66 L A 0.0000
67 C A 0.0000
68 E A -2.2147
69 E A -2.0897
70 I A 0.0000
71 S A -2.1802
72 K A -2.7856
73 M A 0.0000
74 N A -1.7206
75 E A -1.7167
76 N A -0.8177
77 L A 0.0000
78 P A 0.0000
79 L A 0.0000
80 Y A 0.0000
81 A A 0.0000
82 F A 0.0000
83 A A 0.0000
84 N A -0.1929
85 T A 0.2079
86 Y A 0.9636
87 S A 0.0000
88 T A -0.0571
89 L A 0.0000
90 D A -0.3754
91 V A -0.4054
92 S A -0.4902
93 L A 0.0000
94 N A -1.8255
95 D A -2.6241
96 L A -2.4226
97 R A -2.9219
98 L A 0.0000
99 Q A -0.7668
100 I A -0.1440
101 S A -0.3496
102 F A 0.0000
103 F A 0.0000
104 E A -0.8198
105 Y A 0.0000
106 A A -0.7379
107 L A 0.0000
108 G A -1.2992
109 A A -1.4058
110 A A 0.0000
111 E A -3.7226
112 D A -3.6844
113 I A 0.0000
114 A A 0.0000
115 N A -3.7607
116 K A -3.8454
117 I A 0.0000
118 K A -3.5853
119 Q A -3.5829
120 T A -2.7097
121 T A 0.0000
122 D A -3.2236
123 E A -2.8616
124 Y A 0.0000
125 I A -0.5637
126 N A -0.8673
127 T A -0.3092
128 I A 0.6821
129 L A 0.7373
130 P A 0.0000
131 P A -0.7151
132 L A 0.0000
133 T A 0.0000
134 K A -0.0835
135 A A -0.5327
136 L A 0.0000
137 F A -0.4648
138 K A -1.3148
139 Y A -1.6550
140 V A 0.0000
141 R A -3.1488
142 E A -3.1326
143 G A -2.0622
144 K A -1.9195
145 Y A 0.5541
146 T A 0.9812
147 F A 2.1301
148 C A 1.3721
149 T A 0.4736
150 P A -0.2352
151 G A -0.1089
152 H A -0.3678
153 M A 0.3995
154 G A -0.7604
155 G A 0.0000
156 T A -0.6512
157 A A -0.6477
158 F A -0.0511
159 Q A -1.2456
160 K A -1.9004
161 S A -0.2891
162 P A 0.5360
163 V A 1.9647
164 G A 0.0000
165 S A 0.7672
166 L A 2.6177
167 F A 2.6713
168 Y A 1.3449
169 D A 0.5236
170 F A 2.4346
171 F A 1.8087
172 G A 0.2705
173 P A -0.9238
174 N A -1.6993
175 T A -0.5686
176 M A 0.0000
177 K A -1.5223
178 S A -1.1520
179 D A -1.0549
180 I A 0.0000
181 S A 0.5894
182 I A 1.6041
183 S A 0.8983
184 V A 0.0000
185 S A -0.5355
186 E A -1.5268
187 L A 0.0000
188 G A -1.1529
189 S A -0.7277
190 L A 0.0000
191 L A -0.7762
192 D A -2.0300
193 H A -1.9317
194 S A -2.0389
195 G A -2.0040
196 P A -1.9511
197 H A 0.0000
198 K A -3.2812
199 E A -3.0647
200 A A 0.0000
201 E A 0.0000
202 Q A -3.0464
203 Y A -2.0082
204 I A 0.0000
205 A A 0.0000
206 R A -2.6883
207 V A 0.0000
208 F A 0.0000
209 N A -1.6115
210 A A -1.9686
211 D A -2.4320
212 R A -2.9869
213 S A 0.0000
214 Y A 0.0000
215 M A 0.0000
216 V A 0.0000
217 T A 0.0000
218 N A -1.7047
219 G A -1.1951
220 T A 0.0000
221 S A -0.8404
222 T A 0.0000
223 A A 0.0000
224 N A 0.0000
225 K A 0.0184
226 I A 0.0000
227 V A 0.0000
228 G A 0.0000
229 M A 0.2523
230 Y A -0.1209
231 S A 0.0109
232 A A 0.0000
233 P A -0.4167
234 A A -0.6812
235 G A -0.9969
236 S A 0.0000
237 T A 0.0000
238 I A 0.0000
239 L A 0.0000
240 I A 0.0000
241 D A 0.0000
242 R A 0.0000
243 N A -0.6864
244 C A 0.0000
245 H A -1.4207
246 K A -1.2780
247 S A 0.0000
248 L A 0.0000
249 T A 0.0000
250 H A -0.4201
251 L A 0.0000
252 M A 0.0000
253 M A 0.2781
254 M A 0.4499
255 S A -0.2377
256 D A -0.9601
257 V A 0.0000
258 T A 0.0000
259 P A 0.0000
260 I A 0.0000
261 Y A 0.0000
262 F A 0.0000
263 R A -1.5842
264 P A 0.0000
265 T A -0.6405
266 R A 0.0000
267 N A 0.0000
268 A A -0.8921
269 Y A -0.0618
270 G A -0.1277
271 I A 0.0000
272 L A 0.0000
273 G A 0.0000
274 G A 0.0000
275 I A 0.0000
276 P A -0.9467
277 Q A -0.6650
278 S A -0.9636
279 E A -1.0025
280 F A 0.0000
281 Q A -1.6149
282 H A -1.7288
283 A A -1.0858
284 T A -1.1537
285 I A 0.0000
286 A A -1.7829
287 K A -2.9383
288 R A -2.1913
289 V A -2.0217
290 K A -3.3465
291 E A -3.3217
292 T A -2.0650
293 P A -1.4618
294 N A -1.8892
295 A A -1.3256
296 T A -0.5052
297 W A 0.0594
298 P A 0.0000
299 V A -0.2932
300 H A 0.0000
301 A A 0.0000
302 V A 0.0000
303 I A 0.0000
304 T A -0.1102
305 N A 0.0000
306 S A 0.0000
307 T A 0.0000
308 Y A 0.2736
309 D A 0.0000
310 G A 0.0000
311 L A 0.0000
312 L A 0.0000
313 Y A 0.0000
314 N A -1.4556
315 T A 0.0000
316 D A -2.4664
317 F A -1.4707
318 I A 0.0000
319 K A 0.0000
320 K A -2.4779
321 T A -1.6877
322 L A 0.0000
323 D A -2.1104
324 V A 0.0000
325 K A -2.2667
326 S A 0.0000
327 I A 0.0000
328 H A 0.0000
329 F A 0.0000
330 D A 0.0000
331 S A 0.0000
332 A A -0.0039
333 W A 0.3626
334 V A 0.0000
335 P A 0.0000
336 Y A 0.0000
337 T A 0.0000
338 N A -1.0707
339 F A 0.0000
340 S A 0.0000
341 P A -1.2051
342 I A -0.8999
343 Y A 0.0000
344 E A -2.3496
345 G A -1.7342
346 K A -1.3002
347 C A 0.0000
348 G A 0.0000
349 M A 0.0000
350 S A -1.6545
351 G A -1.7328
352 G A -1.7706
353 R A -2.6914
354 V A -2.4592
355 E A -3.0382
356 G A -2.3995
357 K A -2.2830
358 V A -1.4294
359 I A 0.0000
360 Y A 0.0000
361 E A 0.0000
362 T A 0.0000
363 Q A 0.0000
364 S A -0.2974
365 T A 0.0000
366 H A -0.3092
368 L A 0.0509
369 L A 0.0000
370 A A 0.2498
371 A A 0.5434
372 F A 1.4622
373 S A -0.0392
374 Q A -1.0638
375 A A 0.0000
376 S A 0.0000
377 M A 0.0000
378 I A 0.0000
379 H A 0.0000
380 V A 0.0000
381 K A 0.0000
382 G A 0.0000
383 D A -2.9724
384 V A -2.3343
385 N A -3.0400
386 E A -4.0780
387 E A -3.6374
388 T A -2.4609
389 F A 0.0000
390 N A -2.2662
391 E A -2.1001
392 A A 0.0000
393 Y A 0.0000
394 M A 0.1037
395 M A 0.6763
396 H A 0.0360
397 T A -0.0679
398 T A -0.1545
399 T A 0.1942
400 S A -0.0600
401 P A 0.0000
402 H A -0.9183
403 Y A 0.0000
404 G A 0.0936
405 I A 0.1188
406 V A 0.0000
407 A A 0.0000
408 S A 0.0000
409 T A 0.0000
410 E A 0.0000
411 T A 0.1007
412 A A 0.0000
413 A A 0.0000
414 A A 0.0969
415 M A 0.0581
416 M A 0.0000
417 K A -1.5490
418 G A -1.4992
419 N A -2.1355
420 A A -1.6145
421 G A 0.0000
422 K A -2.6446
423 R A -2.5734
424 L A -1.1145
425 I A 0.0000
426 N A -2.0341
427 G A -1.5864
428 S A 0.0000
429 I A 0.0000
430 E A -2.2859
431 R A -1.4104
432 A A 0.0000
433 I A -0.4303
434 K A -0.5577
435 F A 0.0000
436 R A 0.0000
437 Y A 0.5055 mutated: KA437Y
438 E A 0.0000
439 I A 0.0000
440 Y A 0.1710 mutated: KA440Y
441 R A -0.2069
442 L A 0.0000
443 R A -0.8933
444 T A -0.2388
445 Y A 0.4508 mutated: EA445Y
446 S A -0.8138
447 D A -1.8156
448 G A -1.3907
449 W A -0.7628
450 F A 0.0000
451 F A 0.0000
452 D A -0.4919
453 V A 0.0000
454 W A 0.0000
455 Q A 0.0000
456 P A 0.2218
457 Y A 0.9041 mutated: DA457Y
458 H A 0.0584
459 I A 0.0000
460 Y A 1.1412 mutated: DA460Y
461 T A 0.2273
462 T A -0.4834
463 E A -0.6737
464 C A 0.0000
465 W A 0.0000
466 P A -1.1874
467 L A 0.0000
468 R A -1.8624
469 S A -1.3648
470 Y A 0.5600 mutated: DA470Y
471 S A 0.0000
472 T A -0.7142
473 W A -0.1334
474 H A 0.0000
475 G A -1.5390
476 F A 0.0000
477 K A -2.4763
478 N A -2.3408
479 I A -1.9139
480 D A -2.1967
481 N A -2.4547
482 E A -2.6098
483 H A 0.0000
484 M A 0.0000
485 Y A 0.0000
486 L A 0.0000
487 D A 0.0000
488 P A 0.0000
489 I A 0.0000
490 K A 0.0000
491 V A 0.0000
492 T A 0.0000
493 L A 0.0000
494 L A 0.0433
495 T A 0.0000
496 P A -0.2424
497 G A 0.0000
498 M A -1.4338
499 E A -3.2797
500 K A -3.4657
501 D A -3.3161
502 G A -2.3929
503 T A -1.9129
504 M A -1.1420
505 S A -1.1933
506 D A -1.6877
507 F A -0.2926
508 G A 0.0000
509 I A 0.0000
510 P A 0.0000
511 A A 0.0000
512 S A -0.1064
513 I A 0.0000
514 V A 0.0000
515 A A -0.5698
516 K A -1.0408
517 Y A 0.0000
518 L A 0.0000
519 D A -2.0029
520 E A -1.8396
521 H A -1.7858
522 G A -1.1786
523 I A -0.3698
524 V A 0.8523
525 V A 0.2039
526 E A -0.5099
527 K A -0.3858
528 T A -0.2993
529 G A -0.0081
530 P A 0.0000
531 Y A 0.0000
532 N A 0.0000
533 L A 0.0000
534 L A 0.0000
535 F A 0.0000
536 L A 0.1446
537 F A 0.0000
538 S A 0.1750
539 I A 0.2060
540 G A -0.2419
541 I A -0.2998
542 D A -1.0378
543 K A -0.9115
544 T A -0.9786
545 K A -1.3579
546 A A 0.0000
547 L A 0.0000
548 S A -0.5934
549 L A 0.0000
550 L A 0.0000
551 R A 0.0000
552 A A 0.0000
553 L A 0.0000
554 T A 0.0000
555 D A -0.9673
556 F A 0.0000
557 K A 0.0000
558 R A -1.2648
559 A A 0.0000
560 F A 0.0000
561 D A -0.9456
562 L A 0.3978
563 N A -0.5461
564 L A -0.6791
565 R A -2.0855
566 V A 0.0000
567 K A -2.4157
568 N A -2.0058
569 M A 0.0000
570 L A 0.0000
571 P A -1.7334
572 S A -1.9811
573 L A 0.0000
574 Y A -2.6032
575 R A -3.3528
576 E A -3.1958
577 D A -2.5510
578 P A -2.6124
579 E A -2.5073
580 F A -1.0719
581 Y A 0.0000
582 E A -2.4687
583 N A -2.1795
584 M A -1.8076
585 R A -2.1573
586 I A 0.0000
587 Q A -1.8156
588 E A -2.2988
589 L A 0.0000
590 A A 0.0000
591 Q A -2.1682
592 N A -1.6535
593 I A -0.8315
594 H A 0.0000
595 K A -1.2589
596 L A -0.8687
597 I A 0.0000
598 V A -0.7777
599 H A -1.0853
600 H A -1.2926
601 N A -1.5064
602 L A 0.0000
603 P A 0.0000
604 D A -2.2330
605 L A -1.5751
606 M A 0.0000
607 Y A -1.0107
608 R A -2.2340
609 A A 0.0000
610 F A -0.4044
611 E A -0.8186
612 V A -0.3786
613 L A 0.3022
614 P A 0.0000
615 T A 0.3590
616 M A 0.7980
617 V A 1.1535
618 M A 0.8168
619 T A 0.2795
620 P A 0.0000
621 Y A 0.0355
622 A A 0.0697
623 A A 0.0000
624 F A 0.1954
625 Q A -0.3517
626 K A -1.1322
627 E A -0.9517
628 L A 0.3774
629 H A -0.8893
630 G A -0.9906
631 M A -1.2377
632 T A -1.7675
633 E A -2.3845
634 E A -2.2919
635 V A -1.5647
636 Y A -1.6332
637 L A 0.0000
638 D A -2.7574
639 E A -2.4695
640 M A 0.0000
641 V A -1.0261
642 G A -0.6721
643 R A -0.7571
644 I A -0.0818
645 N A 0.0000
646 A A 0.0000
647 N A -0.4989
648 M A 0.0000
649 I A 0.0000
650 L A -0.4273
651 P A 0.0000
652 Y A -0.0484
653 P A 0.0521
654 P A 0.0000
655 G A -0.1171
656 V A 0.0000
657 P A 0.0000
658 L A 0.0000
659 V A 0.0000
660 M A 0.0000
661 P A 0.0000
662 G A 0.0000
663 E A 0.0000
664 M A 0.5757
665 I A 0.0000
666 T A -1.5598
667 E A -2.9013
668 E A -2.7149
669 S A 0.0000
670 R A -2.0578
671 P A -1.6143
672 V A 0.0000
673 L A 0.0000
674 E A -1.7454
675 F A 0.0000
676 L A 0.0000
677 Q A -1.5777
678 M A 0.0000
679 L A 0.0000
680 C A -1.9388
681 E A -2.2178
682 I A -1.0607
683 G A -1.4510
684 A A -1.2667
685 H A -0.9933
686 Y A -0.3978
687 P A -1.0536
688 G A -1.2491
689 F A -0.9006
690 E A -2.2524
691 T A -2.0527
692 D A -2.2445
693 I A 0.0000
694 H A -1.1926
695 G A -0.7017
696 A A -1.1017
697 Y A -1.1761
698 R A -2.7025
699 Q A -2.4073
700 A A -1.8333
701 D A -2.8548
702 G A -2.7461
703 R A -3.0534
704 Y A 0.0000
705 T A 0.0000
706 V A 0.0000
707 K A -1.5256
708 V A 0.0000
709 L A 0.0000
710 K A -3.0343
711 E A -2.6051
1 M B -0.1476
2 N B -1.0350
3 V B 0.0000
4 I B 0.0000
5 A B 0.0000
6 I B 0.0000
7 L B 0.0000
8 N B -1.2728
9 H B -1.3813
10 M B -0.5433
11 G B -0.5834
12 V B -0.6447
13 Y B -0.4692
14 F B 0.0000
15 K B 0.0000
16 E B -0.6116
17 E B -0.5734
18 P B 0.0000
19 I B -0.7204
20 R B -1.4729
21 E B -1.6703
22 L B 0.0000
23 H B -2.1107
24 R B -3.3780
25 A B 0.0000
26 L B 0.0000
27 E B -3.7705
28 R B -3.5770
29 L B -2.4115
30 N B -2.7566
31 F B 0.0000
32 Q B -1.4141
33 I B 0.0000
34 V B 0.0000
35 Y B -0.0165
36 P B 0.0000
37 N B -2.2359
38 D B -2.5903
39 R B -2.5277
40 D B -2.7145
41 D B 0.0000
42 L B 0.0000
43 L B -1.7660
44 K B -2.0257
45 L B 0.0000
46 I B 0.0000
47 E B -2.3674
48 N B -1.7996
49 N B 0.0000
50 A B -0.8258
51 R B -0.8453
52 L B 0.0000
53 C B 0.0000
54 G B 0.0000
55 V B 0.0000
56 I B 0.0000
57 F B 0.0000
58 D B 0.0000
59 W B 0.0000
60 D B -1.1528
61 K B -1.4035
62 Y B 0.0000
63 N B 0.0000
64 L B 0.0394
65 E B -1.6173
66 L B 0.0000
67 C B 0.0000
68 E B -2.6219
69 E B -2.1885
70 I B 0.0000
71 S B 0.0000
72 K B -2.7342
73 M B 0.0000
74 N B -1.6700
75 E B -1.7809
76 N B -1.0208
77 L B 0.0000
78 P B 0.0000
79 L B 0.0000
80 Y B 0.0000
81 A B 0.0000
82 F B 0.0000
83 A B 0.0000
84 N B -0.1332
85 T B 0.2198
86 Y B 0.9288
87 S B 0.0000
88 T B -0.0541
89 L B 0.0000
90 D B -0.0921
91 V B -0.0739
92 S B -0.2962
93 L B 0.0000
94 N B -1.4990
95 D B -2.4672
96 L B -2.3858
97 R B -2.7124
98 L B 0.0000
99 Q B -0.9417
100 I B -0.2227
101 S B -0.3383
102 F B 0.0000
103 F B 0.0000
104 E B -0.7981
105 Y B 0.0000
106 A B -0.6538
107 L B 0.0000
108 G B -1.2141
109 A B -1.3742
110 A B 0.0000
111 E B -3.5736
112 D B -3.4585
113 I B 0.0000
114 A B 0.0000
115 N B -3.1546
116 K B -3.4086
117 I B 0.0000
118 K B -3.3108
119 Q B -3.4087
120 T B -2.6387
121 T B 0.0000
122 D B -3.2229
123 E B -2.9973
124 Y B 0.0000
125 I B -0.6367
126 N B -0.9574
127 T B -0.4211
128 I B 0.5235
129 L B 0.6788
130 P B 0.0000
131 P B -0.6864
132 L B 0.0000
133 T B 0.0000
134 K B -0.0930
135 A B -0.5547
136 L B 0.0000
137 F B -0.4839
138 K B -1.3765
139 Y B -1.7135
140 V B -2.0148
141 R B -3.1394
142 E B -3.1480
143 G B -2.2116
144 K B -2.0764
145 Y B 0.2585
146 T B 0.8517
147 F B 2.0879
148 C B 1.3067
149 T B 0.4322
150 P B -0.2805
151 G B -0.0994
152 H B -0.3755
153 M B 0.3490
154 G B -0.8034
155 G B 0.0000
156 T B -0.6653
157 A B -0.6611
158 F B -0.0817
159 Q B -1.2928
160 K B -1.9311
161 S B -0.3040
162 P B 0.5502
163 V B 1.9698
164 G B 1.1711
165 S B 0.7665
166 L B 2.6643
167 F B 2.7696
168 Y B 1.3651
169 D B 0.5163
170 F B 2.4437
171 F B 1.7826
172 G B 0.2187
173 P B -0.9825
174 N B -1.7155
175 T B -0.5777
176 M B 0.0000
177 K B -1.6078
178 S B -1.1500
179 D B -1.0053
180 I B 0.0000
181 S B 0.0000
182 I B 1.2428
183 S B 0.6646
184 V B 0.0000
185 S B -0.7424
186 E B -1.7543
187 L B 0.0000
188 G B -1.2827
189 S B -0.8297
190 L B 0.0000
191 L B -0.6712
192 D B -2.0399
193 H B -1.9137
194 S B -2.0359
195 G B -2.0138
196 P B -1.9168
197 H B 0.0000
198 K B -3.2700
199 E B -2.9965
200 A B 0.0000
201 E B 0.0000
202 Q B -3.0343
203 Y B -1.9791
204 I B 0.0000
205 A B 0.0000
206 R B -2.7577
207 V B 0.0000
208 F B 0.0000
209 N B -1.8982
210 A B -2.1171
211 D B -2.5048
212 R B -3.0251
213 S B 0.0000
214 Y B 0.0000
215 M B 0.0000
216 V B 0.0000
217 T B 0.0000
218 N B -1.6985
219 G B 0.0000
220 T B 0.0000
221 S B -0.7841
222 T B 0.0000
223 A B 0.0000
224 N B 0.0000
225 K B 0.0271
226 I B 0.0000
227 V B 0.0000
228 G B 0.0000
229 M B 0.2541
230 Y B -0.1321
231 S B -0.0125
232 A B 0.0000
233 P B -0.4540
234 A B -0.7844
235 G B -1.0897
236 S B 0.0000
237 T B 0.0000
238 I B 0.0000
239 L B 0.0000
240 I B 0.0000
241 D B 0.0000
242 R B 0.0000
243 N B -0.4813
244 C B 0.0000
245 H B -1.0804
246 K B -1.1642
247 S B 0.0000
248 L B 0.0000
249 T B 0.0000
250 H B -0.3641
251 L B 0.0000
252 M B 0.0000
253 M B 0.3037
254 M B 0.5005
255 S B 0.0000
256 D B -1.2057
257 V B 0.0000
258 T B 0.0000
259 P B 0.0000
260 I B 0.0000
261 Y B 0.0000
262 F B 0.0000
263 R B -0.9894
264 P B -0.6913
265 T B -0.6714
266 R B 0.0000
267 N B 0.0000
268 A B -0.7810
269 Y B 0.0168
270 G B -0.0969
271 I B 0.0000
272 L B 0.0000
273 G B 0.0000
274 G B 0.0000
275 I B 0.0000
276 P B -0.8339
277 Q B -0.8652
278 S B -0.8788
279 E B -0.8606
280 F B 0.0000
281 Q B -1.4331
282 H B -1.7430
283 A B -1.0958
284 T B -1.1718
285 I B 0.0000
286 A B -1.8436
287 K B -2.9962
288 R B -2.2884
289 V B 0.0000
290 K B -3.4390
291 E B -3.3847
292 T B -2.1373
293 P B -1.4973
294 N B -1.9189
295 A B -1.3765
296 T B -0.5495
297 W B 0.0078
298 P B 0.0000
299 V B -0.2717
300 H B 0.0000
301 A B 0.0000
302 V B 0.0000
303 I B 0.0000
304 T B 0.0000
305 N B 0.0000
306 S B 0.0000
307 T B 0.0000
308 Y B 0.2554
309 D B 0.0000
310 G B 0.0000
311 L B 0.0000
312 L B 0.0000
313 Y B 0.0000
314 N B -1.4199
315 T B 0.0000
316 D B -2.4661
317 F B -1.5188
318 I B 0.0000
319 K B 0.0000
320 K B -2.4463
321 T B -1.7252
322 L B 0.0000
323 D B -2.2217
324 V B 0.0000
325 K B -2.3283
326 S B 0.0000
327 I B 0.0000
328 H B 0.0000
329 F B 0.0000
330 D B 0.0000
331 S B 0.0000
332 A B 0.0137
333 W B 0.2829
334 V B 0.0000
335 P B 0.0000
336 Y B 0.0000
337 T B 0.0000
338 N B -1.1810
339 F B 0.0000
340 S B 0.0000
341 P B -1.3926
342 I B 0.0000
343 Y B 0.0000
344 E B -2.3697
345 G B -1.6940
346 K B 0.0000
347 C B 0.0000
348 G B 0.0000
349 M B 0.0000
350 S B -1.6949
351 G B -1.7822
352 G B -1.8775
353 R B -2.8691
354 V B -2.5609
355 E B -3.1027
356 G B -2.4652
357 K B -2.4075
358 V B 0.0000
359 I B 0.0000
360 Y B 0.0000
361 E B 0.0000
362 T B 0.0000
363 Q B 0.0000
364 S B -0.3043
365 T B 0.0000
366 H B -0.1044
368 L B 0.1324
369 L B 0.0000
370 A B 0.3275
371 A B 0.6235
372 F B 1.5194
373 S B 0.0089
374 Q B -1.0465
375 A B 0.0000
376 S B 0.0000
377 M B 0.0000
378 I B 0.0000
379 H B 0.0000
380 V B 0.0000
381 K B 0.0000
382 G B 0.0000
383 D B -3.0561
384 V B -2.3927
385 N B -3.0570
386 E B -4.0664
387 E B -3.6217
388 T B -2.4807
389 F B 0.0000
390 N B -2.3246
391 E B -2.1434
392 A B 0.0000
393 Y B 0.0000
394 M B 0.0077
395 M B 0.6347
396 H B 0.0088
397 T B -0.1234
398 T B -0.1599
399 T B 0.1440
400 S B -0.1159
401 P B 0.0000
402 H B -0.9202
403 Y B 0.0000
404 G B 0.1052
405 I B 0.1398
406 V B 0.0000
407 A B 0.0000
408 S B 0.0000
409 T B 0.0000
410 E B 0.0000
411 T B 0.1268
412 A B 0.0000
413 A B 0.0000
414 A B 0.1588
415 M B 0.2031
416 M B 0.0000
417 K B -1.2172
418 G B -1.1993
419 N B -1.5761
420 A B -1.3420
421 G B 0.0000
422 K B -2.1767
423 R B -2.1059
424 L B -0.8071
425 I B 0.0000
426 N B -1.9120
427 G B -1.4474
428 S B 0.0000
429 I B 0.0000
430 E B -2.2450
431 R B -1.3353
432 A B 0.0000
433 I B -0.4049
434 K B -0.5293
435 F B 0.0000
436 R B 0.0000
437 Y B 0.4979 mutated: KB437Y
438 E B 0.0000
439 I B 0.0000
440 Y B 0.0800 mutated: KB440Y
441 R B -0.1429
442 L B 0.0000
443 R B -0.9787
444 T B -0.2679
445 Y B 0.4526 mutated: EB445Y
446 S B -0.8351
447 D B -1.8154
448 G B -1.4181
449 W B -0.7866
450 F B 0.0000
451 F B 0.0000
452 D B -0.5027
453 V B 0.0000
454 W B 0.0000
455 Q B 0.0000
456 P B 0.0000
457 Y B 1.0413 mutated: DB457Y
458 H B 0.1448
459 I B 0.0000
460 Y B 1.0752 mutated: DB460Y
461 T B 0.0351
462 T B -0.8780
463 E B -1.4655
464 C B 0.0000
465 W B 0.0000
466 P B -1.1688
467 L B 0.0000
468 R B -1.3015
469 S B -1.0877
470 Y B 0.7407 mutated: DB470Y
471 S B 0.0000
472 T B -0.4874
473 W B 0.1182
474 H B 0.0000
475 G B -1.2095
476 F B 0.0000
477 K B -2.3943
478 N B -2.2335
479 I B -1.7835
480 D B -2.1100
481 N B -2.2947
482 E B -2.5422
483 H B 0.0000
484 M B 0.0000
485 Y B 0.0000
486 L B 0.0000
487 D B 0.0000
488 P B 0.0000
489 I B 0.0000
490 K B 0.0000
491 V B 0.0000
492 T B 0.0000
493 L B 0.0000
494 L B 0.0429
495 T B 0.0000
496 P B -0.2251
497 G B 0.0000
498 M B -1.4369
499 E B -3.2360
500 K B -3.3723
501 D B -3.2518
502 G B -2.1967
503 T B -1.7797
504 M B -1.3673
505 S B -1.4942
506 D B -1.8644
507 F B -0.3968
508 G B 0.0000
509 I B 0.0000
510 P B 0.0000
511 A B 0.0000
512 S B -0.1906
513 I B 0.0000
514 V B 0.0000
515 A B -0.5069
516 K B -1.0842
517 Y B 0.0000
518 L B 0.0000
519 D B -2.0305
520 E B -1.8323
521 H B -1.7780
522 G B -1.1721
523 I B -0.3354
524 V B 0.8220
525 V B 0.1358
526 E B -0.5800
527 K B -0.3989
528 T B -0.2852
529 G B 0.0157
530 P B 0.0699
531 Y B 0.0000
532 N B 0.0000
533 L B 0.0000
534 L B 0.0000
535 F B 0.0000
536 L B 0.1949
537 F B 0.0000
538 S B 0.2357
539 I B 0.2532
540 G B -0.1928
541 I B -0.2084
542 D B -1.0637
543 K B -0.8910
544 T B -0.9411
545 K B -1.2348
546 A B 0.0000
547 L B 0.0000
548 S B -0.5378
549 L B 0.0000
550 L B 0.0000
551 R B 0.0000
552 A B 0.0000
553 L B 0.0000
554 T B 0.0000
555 D B -1.3159
556 F B 0.0000
557 K B 0.0000
558 R B -1.5545
559 A B 0.0000
560 F B 0.0000
561 D B -1.3646
562 L B -0.2168
563 N B -0.7629
564 L B -0.7380
565 R B -1.8291
566 V B 0.0000
567 K B -2.2134
568 N B -1.8691
569 M B 0.0000
570 L B 0.0000
571 P B -1.6375
572 S B -1.9496
573 L B 0.0000
574 Y B -2.3435
575 R B -3.2630
576 E B -3.1567
577 D B -2.4461
578 P B -2.4970
579 E B -2.4310
580 F B -0.9959
581 Y B 0.0000
582 E B -2.2631
583 N B -2.0418
584 M B -1.6018
585 R B -1.9537
586 I B 0.0000
587 Q B -1.7356
588 E B -2.0576
589 L B 0.0000
590 A B 0.0000
591 Q B -2.3785
592 N B -1.9003
593 I B 0.0000
594 H B 0.0000
595 K B -2.5471
596 L B -1.6063
597 I B 0.0000
598 V B -1.5563
599 H B -1.7050
600 H B -1.6603
601 N B -2.0121
602 L B 0.0000
603 P B 0.0000
604 D B -1.8262
605 L B -1.3079
606 M B 0.0000
607 Y B -0.9519
608 R B -1.9984
609 A B 0.0000
610 F B 0.0000
611 E B -1.5283
612 V B -0.6192
613 L B 0.1102
614 P B 0.0000
615 T B 0.3535
616 M B 0.8078
617 V B 1.1079
618 M B 0.8320
619 T B 0.2411
620 P B 0.0000
621 Y B 0.0539
622 A B 0.0992
623 A B 0.0000
624 F B 0.3332
625 Q B -0.1742
626 K B -0.9659
627 E B -0.6864
628 L B 0.5167
629 H B -0.7585
630 G B -0.7851
631 M B -1.0004
632 T B -1.5528
633 E B -2.2545
634 E B -2.2368
635 V B -1.5503
636 Y B -1.2201
637 L B 0.0000
638 D B -2.0110
639 E B -2.1314
640 M B 0.0000
641 V B -0.9512
642 G B -0.6296
643 R B -0.7358
644 I B -0.0512
645 N B 0.0000
646 A B 0.0000
647 N B -0.5220
648 M B 0.0000
649 I B 0.0000
650 L B -0.4243
651 P B 0.0000
652 Y B 0.0576
653 P B 0.1178
654 P B 0.0000
655 G B -0.0729
656 V B 0.0000
657 P B 0.0000
658 L B 0.0000
659 V B 0.0000
660 M B 0.0000
661 P B 0.0000
662 G B 0.0000
663 E B 0.0000
664 M B 0.5437
665 I B 0.0000
666 T B -1.6208
667 E B -2.9674
668 E B -2.7539
669 S B 0.0000
670 R B -2.1336
671 P B -1.6723
672 V B 0.0000
673 L B 0.0000
674 E B -1.6017
675 F B 0.0000
676 L B 0.0000
677 Q B -1.3777
678 M B 0.0000
679 L B 0.0000
680 C B -1.9370
681 E B -2.1332
682 I B -1.0359
683 G B -1.3380
684 A B -1.1500
685 H B -0.9325
686 Y B -0.3356
687 P B -0.7756
688 G B -1.1458
689 F B -0.7811
690 E B -1.9192
691 T B -1.8969
692 D B -2.1777
693 I B 0.0000
694 H B -1.1934
695 G B -0.9060
696 A B -1.0563
697 Y B -1.0860
698 R B -2.5550
699 Q B -2.1829
700 A B -1.7245
701 D B -2.7314
702 G B -2.5362
703 R B -2.4878
704 Y B 0.0000
705 T B 0.0000
706 V B 0.0000
707 K B -1.5139
708 V B 0.0000
709 L B 0.0000
710 K B -2.6339
711 E B -2.4301
1 M C -0.5243
2 N C -1.2202
3 V C 0.0000
4 I C 0.0000
5 A C 0.0000
6 I C 0.0000
7 L C 0.0000
8 N C -1.2607
9 H C -1.3880
10 M C -0.5757
11 G C -0.5705
12 V C -0.6384
13 Y C -0.4900
14 F C 0.0000
15 K C 0.0000
16 E C -0.6432
17 E C -0.6421
18 P C 0.0000
19 I C -0.7892
20 R C -1.5875
21 E C -1.7354
22 L C 0.0000
23 H C -2.2944
24 R C -3.3322
25 A C 0.0000
26 L C 0.0000
27 E C -3.6435
28 R C -3.5149
29 L C -2.3438
30 N C -2.6891
31 F C 0.0000
32 Q C -1.4358
33 I C 0.0000
34 V C 0.0000
35 Y C 0.0238
36 P C 0.0000
37 N C -2.1640
38 D C -2.4818
39 R C -2.4360
40 D C -2.5973
41 D C 0.0000
42 L C 0.0000
43 L C -1.5752
44 K C -1.8681
45 L C 0.0000
46 I C 0.0000
47 E C -1.8977
48 N C -1.6752
49 N C 0.0000
50 A C -1.0549
51 R C -1.5380
52 L C 0.0000
53 C C 0.0000
54 G C 0.0000
55 V C 0.0000
56 I C 0.0000
57 F C 0.0000
58 D C 0.0000
59 W C 0.0000
60 D C -1.2223
61 K C -1.6253
62 Y C -1.0752
63 N C 0.0000
64 L C -0.2268
65 E C -1.9951
66 L C 0.0000
67 C C 0.0000
68 E C -2.9670
69 E C -2.2894
70 I C 0.0000
71 S C -2.2637
72 K C -2.8215
73 M C -1.9951
74 N C -1.5278
75 E C -1.5942
76 N C -0.6735
77 L C 0.0000
78 P C 0.0000
79 L C 0.0000
80 Y C 0.0000
81 A C 0.0000
82 F C 0.0000
83 A C 0.0000
84 N C -0.2443
85 T C 0.2277
86 Y C 0.9480
87 S C 0.0000
88 T C -0.0864
89 L C 0.0000
90 D C -0.3287
91 V C -0.2860
92 S C -0.4423
93 L C 0.0000
94 N C -1.5123
95 D C -2.3631
96 L C -2.3594
97 R C -2.6620
98 L C -1.5199
99 Q C -0.6008
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