Project name: AD_44

Chain sequence(s)	A: MERRRITSAARREYVSEGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAAEYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDEKEVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVMEKLEENLIETSDEKSEVKSH
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.5401
• Maximal score value: 1.7739
• Average score: -0.285
• Total score value: -126.239

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.5374
2	E	A	-1.0736
3	R	A	-0.6515
4	R	A	-2.2336
5	R	A	-2.1879
6	I	A	0.0236
7	T	A	-0.7650
8	S	A	-0.8233
9	A	A	-0.2381
10	A	A	-0.3152
11	R	A	-2.1925
12	R	A	-2.2680
13	E	A	-0.6298
14	Y	A	1.3422
15	V	A	0.9031
16	S	A	-0.3641
17	E	A	-1.8676
18	G	A	-0.7783
19	E	A	-1.2670
20	M	A	0.4004
21	M	A	-0.0481
22	V	A	0.0000
23	G	A	0.0000
24	G	A	0.0061
25	L	A	0.2226
26	A	A	0.0000
27	P	A	0.0000
28	G	A	0.0000
29	R	A	0.0000
30	R	A	0.0000
31	L	A	0.0000
32	G	A	0.0000
33	P	A	0.0000
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	0.0000
42	M	A	0.0000
43	P	A	0.0000
44	P	A	0.0000
45	P	A	0.0951
46	L	A	0.7245
47	P	A	0.0000
48	T	A	-0.3899
49	R	A	-1.7998
50	V	A	-0.2846
51	D	A	-1.0744
52	F	A	0.0997
53	S	A	0.1341
54	L	A	1.3892
55	A	A	0.2009
56	G	A	-0.4544
57	A	A	-0.0260
58	L	A	0.0000
59	N	A	-0.2064
60	A	A	0.0112
61	G	A	0.0000
62	F	A	0.0000
63	K	A	-2.0336
64	E	A	-2.1315
65	T	A	0.0000
66	R	A	-1.2271
67	A	A	-0.2993
68	S	A	0.0000
69	E	A	0.0000
70	R	A	-1.0338
71	A	A	-0.1813
72	E	A	0.0000
73	M	A	0.5505
74	M	A	0.9910
75	E	A	-0.4906
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.1696
79	R	A	-0.9879
80	F	A	0.0000
81	A	A	-0.1284
82	S	A	-0.0885
83	Y	A	0.0000
84	I	A	0.0000
85	E	A	-0.5289
86	K	A	-1.3071
87	V	A	0.0000
88	R	A	-0.0721
89	F	A	0.9104
90	L	A	0.0000
91	E	A	0.0000
92	Q	A	-1.3269
93	Q	A	-0.9220
94	N	A	0.0000
95	K	A	-0.3785
96	A	A	-0.0457
97	L	A	0.2407
98	A	A	0.0594
99	A	A	-0.1556
100	E	A	-1.1828
101	L	A	0.0000
102	N	A	-0.3861
103	Q	A	-1.1390
104	L	A	-0.0838
105	R	A	-0.2150
106	A	A	-0.1153
107	K	A	-0.4811
108	E	A	0.0000
109	P	A	-0.0873
110	T	A	-0.3490
111	K	A	-0.7783
112	L	A	1.3529
113	A	A	0.0618
114	D	A	-1.6574
115	V	A	0.4247
116	Y	A	0.2460
117	Q	A	-0.4376
118	A	A	-0.0599
119	E	A	-0.5195
120	L	A	0.0000
121	R	A	-2.0638
122	E	A	-1.5852
123	L	A	0.0000
124	R	A	-0.1085
125	L	A	1.1026
126	R	A	-1.1592
127	L	A	0.0000
128	D	A	-1.1725
129	Q	A	-1.3969
130	L	A	0.0000
131	T	A	0.0000
132	A	A	-0.1338
133	N	A	-0.3679
134	S	A	0.0000
135	A	A	-0.3379
136	R	A	-1.8588
137	L	A	0.0000
138	E	A	0.0736
139	V	A	1.5073
140	E	A	-0.8907
141	R	A	0.0000
142	D	A	-1.3508
143	N	A	-1.4764
144	L	A	0.0000
145	A	A	0.0000
146	Q	A	-1.3059
147	D	A	-0.8205
148	L	A	0.0000
149	A	A	-0.0454
150	T	A	-0.0272
151	V	A	0.1455
152	R	A	-0.4488
153	Q	A	-0.7563
154	K	A	-0.7740
155	L	A	0.0000
156	Q	A	-0.6612
157	D	A	-1.5361
158	E	A	-0.4753
159	T	A	0.0000
160	N	A	-0.7288
161	L	A	1.3668
162	R	A	0.0000
163	L	A	0.0315
164	E	A	-1.7521
165	A	A	-0.3248
166	E	A	0.0000
167	N	A	-0.7369
168	N	A	-0.8777
169	L	A	0.0393
170	A	A	0.0000
171	A	A	0.2636
172	Y	A	1.3201
173	R	A	0.0000
174	Q	A	-0.6449
175	E	A	-1.8740
176	A	A	-0.8046
177	D	A	-2.0290
178	E	A	-1.6650
179	A	A	0.0000
180	T	A	0.0857
181	L	A	1.5471
182	A	A	0.2890
183	R	A	0.0000
184	L	A	0.5025
185	D	A	-0.8303
186	L	A	0.0000
187	E	A	-0.4540
188	R	A	-1.9971
189	K	A	-0.5132
190	I	A	-0.1629
191	E	A	-1.7894
192	S	A	-0.3915
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-0.4160
196	E	A	-0.2459
197	I	A	0.0000
198	R	A	-0.2951
199	F	A	0.2841
200	L	A	0.0000
201	R	A	0.0000
202	K	A	-0.2110
203	I	A	0.0712
204	H	A	-0.7192
205	E	A	0.0000
206	E	A	-2.0854
207	E	A	-1.7054
208	V	A	0.0000
209	R	A	-0.3460
210	E	A	0.0000
211	L	A	0.0000
212	Q	A	0.0000
213	E	A	0.0000
214	Q	A	0.0000
215	L	A	0.7454
216	A	A	0.1591
217	R	A	-0.3909
218	Q	A	-1.2300
219	Q	A	0.0000
220	V	A	1.5884
221	H	A	0.1343
222	V	A	0.0000
223	E	A	-1.7682
224	L	A	-0.2645
225	D	A	-1.0207
226	V	A	0.0000
227	A	A	-0.1383
228	K	A	0.0000
229	P	A	0.0000
230	D	A	0.0000
231	L	A	0.1767
232	T	A	0.0204
233	A	A	0.0052
234	A	A	0.0000
235	L	A	0.1903
236	K	A	-0.4713
237	E	A	-0.4595
238	I	A	0.0000
239	R	A	-0.4761
240	T	A	-0.1712
241	Q	A	0.0660
242	Y	A	1.1557
243	E	A	-0.4788
244	A	A	0.0278
245	M	A	0.6043
246	A	A	0.0000
247	S	A	-0.0977
248	S	A	-0.1417
249	N	A	-0.1812
250	M	A	0.0000
251	H	A	-0.6698
252	E	A	-0.7213
253	A	A	0.0000
254	E	A	-1.0660
255	E	A	-1.3604
256	W	A	0.3271
257	Y	A	-0.0392
258	R	A	-1.8235
259	S	A	-0.3527
260	K	A	0.0000
261	F	A	1.7505
262	A	A	0.3241
263	D	A	-0.2637
264	L	A	0.0000
265	T	A	-0.1619
266	D	A	-0.7140
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-0.1274
270	R	A	-0.7464
271	N	A	0.0000
272	A	A	-0.2321
273	E	A	-1.5297
274	L	A	1.4190
275	L	A	1.0769
276	R	A	-1.8864
277	Q	A	-1.5815
278	A	A	-0.2408
279	K	A	-0.5924
280	H	A	-0.5992
281	E	A	-0.4665
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-0.2081
285	Y	A	0.0000
286	R	A	0.0000
287	R	A	0.0000
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0000
293	T	A	0.0000
294	C	A	0.0000
295	D	A	-0.1914
296	L	A	0.0000
297	E	A	-0.3748
298	S	A	-0.1062
299	L	A	0.0000
300	R	A	-0.3758
301	G	A	-0.1370
302	T	A	0.0000
303	N	A	0.0000
304	E	A	-0.4317
305	S	A	-0.1009
306	L	A	0.0000
307	E	A	0.0000
308	R	A	-1.8441
309	Q	A	0.0000
310	M	A	0.0000
311	R	A	-1.4270
312	E	A	-0.6181
313	Q	A	0.0000
314	E	A	-0.6989
315	E	A	-1.9461
316	R	A	-0.7941
317	H	A	0.0000
318	V	A	0.7702
319	R	A	-1.6070
320	E	A	0.0000
321	A	A	0.0000
322	A	A	-0.1760
323	E	A	-1.3833
324	Y	A	0.0000
325	Q	A	-0.8626
326	E	A	-2.0379
327	A	A	0.0000
328	L	A	0.1980
329	A	A	-0.3332
330	R	A	-1.6628
331	L	A	0.0000
332	E	A	-2.0212
333	E	A	-2.5401
334	E	A	-1.9675
335	G	A	-0.7744
336	Q	A	-0.5444
337	E	A	-1.5639
338	L	A	1.2197
339	K	A	0.0000
340	D	A	-1.9716
341	E	A	-1.3380
342	M	A	0.0000
343	A	A	-0.4488
344	R	A	-1.3491
345	H	A	-0.4734
346	L	A	0.0000
347	Q	A	-0.7275
348	E	A	-1.0346
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-0.6353
352	L	A	0.0000
353	L	A	0.0000
354	N	A	-0.7858
355	V	A	0.1717
356	K	A	0.0000
357	L	A	0.3149
358	A	A	0.1194
359	L	A	0.0000
360	D	A	0.0000
361	I	A	0.5631
362	E	A	-0.0956
363	I	A	0.0000
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	0.0000
367	R	A	0.0000
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	0.0000
372	G	A	0.0000
373	E	A	0.0000
374	E	A	0.0000
375	N	A	0.0000
376	R	A	-0.1269
377	I	A	0.0000
378	T	A	0.0000
379	I	A	0.0736
380	P	A	-0.1822
381	V	A	0.4290
382	Q	A	-0.2579
383	T	A	0.2784
384	F	A	1.7739
385	S	A	0.2863
386	N	A	0.0000
387	L	A	0.7947
388	Q	A	-0.5510
389	I	A	-0.2412
390	R	A	-1.9525
391	E	A	-0.6048
392	T	A	0.0000
393	S	A	0.0000
394	L	A	-0.0131
395	D	A	0.0000
396	E	A	-0.2941
397	K	A	-0.8360
398	E	A	-0.5140
399	V	A	0.0359
400	S	A	0.0000
401	E	A	-0.8529
402	G	A	0.0000
403	H	A	-0.3964
404	L	A	1.0963
405	K	A	-1.4793
406	R	A	-0.7635
407	N	A	-1.1699
408	I	A	0.1094
409	V	A	0.1812
410	V	A	0.0000
411	K	A	0.0000
412	T	A	-0.1818
413	V	A	-0.0031
414	E	A	-0.3123
415	M	A	0.0000
416	R	A	0.0000
417	D	A	0.0000
418	G	A	0.0000
419	E	A	0.0000
420	V	A	0.0000
421	I	A	0.0000
422	K	A	-0.5836
423	E	A	-1.2693
424	S	A	0.0000
425	K	A	-1.5770
426	Q	A	-0.9600
427	E	A	0.0000
428	H	A	0.0000
429	K	A	-1.2157
430	D	A	-0.4487
431	V	A	0.0000
432	M	A	0.3430
396	E	A	-0.2941
369	L	A	0.0000
386	N	A	0.0000
391	E	A	-0.6048
392	T	A	0.0000
393	S	A	0.0000
395	D	A	0.0000
396	E	A	-0.2941
400	S	A	0.0000
411	K	A	0.0000
424	S	A	0.0000