Chain sequence(s) |
A: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP B: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
267 | K | A | -3.0335 | |
268 | H | A | -3.0243 | |
269 | Q | A | -2.0165 | |
270 | P | A | -1.2241 | |
271 | G | A | -1.3934 | |
272 | G | A | -1.5611 | |
273 | G | A | -2.1419 | |
274 | K | A | -2.0471 | |
275 | V | A | -0.2057 | |
276 | Q | A | -0.5731 | |
277 | I | A | 1.6682 | |
278 | I | A | 1.6122 | |
279 | N | A | 0.2971 | |
280 | K | A | -0.9839 | |
281 | K | A | -0.9717 | |
282 | L | A | 0.6411 | |
283 | D | A | -0.7027 | |
284 | L | A | -0.6499 | |
285 | S | A | -1.4186 | |
286 | N | A | -2.1206 | |
287 | V | A | -1.0806 | |
288 | Q | A | -1.0248 | |
289 | S | A | -1.7195 | |
290 | K | A | -1.8532 | |
291 | C | A | -0.1653 | |
292 | G | A | 0.0000 | |
293 | S | A | 0.0000 | |
294 | K | A | -1.6232 | |
295 | D | A | -2.4204 | |
296 | N | A | -1.5674 | |
297 | I | A | -0.6809 | |
298 | K | A | -1.5916 | |
299 | H | A | -0.7327 | |
300 | V | A | 0.0000 | |
301 | P | A | 0.0081 | |
302 | G | A | 0.5166 | |
303 | G | A | -0.2103 | |
304 | G | A | -0.7078 | |
305 | S | A | -0.0605 | |
306 | V | A | 1.5646 | |
307 | Q | A | 0.3969 | |
308 | I | A | 1.3001 | |
309 | V | A | 1.7110 | |
310 | Y | A | 1.2487 | |
311 | K | A | -0.9354 | |
312 | P | A | -0.5334 | |
2 | S | B | -1.0976 | |
3 | H | B | -1.4662 | |
4 | P | B | -1.3937 | |
5 | S | B | 0.0000 | |
6 | P | B | -1.3207 | |
7 | Q | B | -1.6725 | |
8 | A | B | -1.4072 | |
9 | K | B | -2.0346 | |
10 | P | B | -1.5202 | |
11 | S | B | -1.3208 | |
12 | N | B | -1.1764 | |
13 | P | B | -1.0430 | |
14 | S | B | -0.9944 | |
15 | N | B | 0.0000 | |
16 | P | B | -1.2474 | |
17 | R | B | -0.9376 | |
18 | V | B | 0.0000 | |
19 | F | B | 0.0000 | |
20 | F | B | 0.0000 | |
21 | D | B | 0.0000 | |
22 | V | B | 0.0000 | |
23 | D | B | 0.0000 | |
24 | I | B | -0.7252 | |
25 | G | B | -1.1277 | |
26 | G | B | -1.6798 | |
27 | E | B | -2.7567 | |
28 | R | B | -2.9920 | |
29 | V | B | -1.2352 | |
30 | G | B | -0.7209 | |
31 | R | B | -0.5784 | |
32 | I | B | 0.0000 | |
33 | V | B | 0.0000 | |
34 | L | B | 0.0000 | |
35 | E | B | 0.0000 | |
36 | L | B | 0.0000 | |
37 | F | B | 0.0000 | |
38 | A | B | -1.1855 | |
39 | D | B | -1.5214 | |
40 | I | B | -0.5334 | |
41 | V | B | 0.0000 | |
42 | P | B | -1.3051 | |
43 | K | B | -1.6965 | |
44 | T | B | 0.0000 | |
45 | A | B | 0.0000 | |
46 | E | B | -1.5182 | |
47 | N | B | 0.0000 | |
48 | F | B | 0.0000 | |
49 | R | B | -1.1537 | |
50 | A | B | 0.0000 | |
51 | L | B | 0.0000 | |
52 | C | B | 0.0000 | |
53 | T | B | -1.5198 | |
54 | G | B | -1.6504 | |
55 | E | B | -2.5592 | |
56 | K | B | -2.2337 | |
57 | G | B | -0.9946 | |
58 | I | B | 0.5809 | |
59 | G | B | 0.0000 | |
60 | P | B | -0.4547 | |
61 | T | B | -0.7580 | |
62 | T | B | -0.8864 | |
63 | G | B | -0.6189 | |
64 | K | B | -1.1593 | |
65 | P | B | -0.8935 | |
66 | L | B | 0.0000 | |
67 | H | B | -1.3424 | |
68 | F | B | 0.0000 | |
69 | K | B | -2.3498 | |
70 | G | B | -1.4933 | |
71 | C | B | 0.0000 | |
72 | P | B | 0.0000 | |
73 | F | B | 0.0000 | |
74 | H | B | 0.0000 | |
75 | R | B | -2.2048 | |
76 | I | B | 0.0000 | |
77 | I | B | -1.3522 | |
78 | K | B | -2.5969 | |
79 | K | B | -2.1739 | |
80 | F | B | -0.0231 | |
81 | M | B | 0.0000 | |
82 | I | B | 0.0000 | |
83 | Q | B | 0.0000 | |
84 | G | B | 0.0000 | |
85 | G | B | 0.0000 | |
86 | D | B | 0.0000 | |
87 | F | B | -1.3378 | |
88 | S | B | -1.5471 | |
89 | N | B | -2.3118 | |
90 | Q | B | -2.3014 | |
91 | N | B | -2.5359 | |
92 | G | B | -1.5609 | |
93 | T | B | -1.0849 | |
94 | G | B | -1.3082 | |
95 | G | B | -1.4990 | |
96 | E | B | 0.0000 | |
97 | S | B | 0.0000 | |
98 | I | B | -0.6283 | |
99 | Y | B | -0.2755 | |
100 | G | B | -1.2277 | |
101 | E | B | -2.6229 | |
102 | K | B | -3.0535 | |
103 | F | B | 0.0000 | |
104 | E | B | -2.8421 | |
105 | D | B | -2.2524 | |
106 | E | B | -1.4930 | |
107 | N | B | -0.9520 | |
108 | F | B | -0.6367 | |
109 | H | B | -0.8019 | |
110 | Y | B | -0.9306 | |
111 | K | B | -1.6247 | |
112 | H | B | 0.0000 | |
113 | D | B | -1.5082 | |
114 | K | B | -1.3276 | |
115 | E | B | -0.9855 | |
116 | G | B | 0.0000 | |
117 | L | B | 0.0000 | |
118 | L | B | 0.0000 | |
119 | S | B | 0.0000 | |
120 | M | B | 0.0000 | |
121 | A | B | -0.3719 | |
122 | N | B | -0.9127 | |
123 | A | B | -0.4439 | |
124 | G | B | -0.7592 | |
125 | S | B | -1.3467 | |
126 | N | B | -2.2831 | |
127 | T | B | -1.8637 | |
128 | N | B | 0.0000 | |
129 | G | B | -1.4467 | |
130 | S | B | 0.0000 | |
131 | Q | B | -0.3316 | |
132 | F | B | 0.0000 | |
133 | F | B | 0.0000 | |
134 | I | B | 0.0000 | |
135 | T | B | 0.0000 | |
136 | T | B | 0.0000 | |
137 | V | B | -0.5628 | |
138 | P | B | -0.9037 | |
139 | T | B | 0.0000 | |
140 | P | B | -1.3750 | |
141 | H | B | -1.6444 | |
142 | L | B | 0.0000 | |
143 | D | B | -1.6774 | |
144 | G | B | -1.6286 | |
145 | K | B | -2.0847 | |
146 | H | B | 0.0000 | |
147 | V | B | 0.0000 | |
148 | V | B | 0.0000 | |
149 | F | B | 0.0000 | |
150 | G | B | 0.0000 | |
151 | Q | B | 0.0000 | |
152 | V | B | 0.0000 | |
153 | I | B | 0.0000 | |
154 | K | B | -0.7057 | |
155 | G | B | 0.0000 | |
156 | M | B | -0.5181 | |
157 | G | B | -0.5482 | |
158 | V | B | 0.0000 | |
159 | A | B | 0.0000 | |
160 | K | B | -1.5595 | |
161 | I | B | -0.1845 | |
162 | L | B | 0.0000 | |
163 | E | B | 0.0000 | |
164 | N | B | -2.1620 | |
165 | V | B | -1.5100 | |
166 | E | B | -2.7141 | |
167 | V | B | -2.3393 | |
168 | K | B | -2.9056 | |
169 | G | B | -2.4309 | |
170 | E | B | -3.2976 | |
171 | K | B | -2.9574 | |
172 | P | B | 0.0000 | |
173 | A | B | -1.2248 | |
174 | K | B | -0.7619 | |
175 | L | B | 0.6595 | |
176 | C | B | 0.0000 | |
177 | V | B | -0.5538 | |
178 | I | B | 0.0000 | |
179 | A | B | -1.7829 | |
180 | E | B | -2.0205 | |
181 | C | B | -1.2847 | |
182 | G | B | -1.1498 | |
183 | E | B | -1.1816 | |
184 | L | B | -2.0705 | |
185 | K | B | -3.4495 | |
186 | E | B | -3.6315 | |
187 | G | B | -2.8566 | |
188 | D | B | -3.5390 | |
189 | D | B | -2.8151 | |
190 | W | B | -1.0608 | |
191 | G | B | -0.4248 | |
192 | I | B | 0.1551 | |
193 | F | B | 0.4557 | |
194 | P | B | -0.7989 | |
195 | K | B | -1.6189 | |
196 | D | B | -1.6089 | |
197 | G | B | -1.2475 | |
198 | S | B | -0.8212 | |
199 | G | B | -0.7937 | |
200 | D | B | 0.0000 | |
201 | S | B | -0.4549 | |
202 | H | B | -0.4691 | |
203 | P | B | -0.4134 | |
204 | D | B | -0.7097 | |
205 | F | B | -0.6754 | |
206 | P | B | 0.0000 | |
207 | E | B | -2.5071 | |
208 | D | B | -1.4463 | |
209 | A | B | -1.7212 | |
210 | D | B | -2.4439 | |
211 | V | B | -2.5218 | |
212 | D | B | -3.3866 | |
213 | L | B | -3.0388 | |
214 | K | B | -3.7361 | |
215 | D | B | -3.5668 | |
216 | V | B | 0.0000 | |
217 | D | B | -2.7896 | |
218 | K | B | -2.1530 | |
219 | I | B | 0.0000 | |
220 | L | B | -1.0118 | |
221 | L | B | -0.0295 | |
222 | I | B | 0.0000 | |
223 | S | B | 0.0000 | |
224 | E | B | -1.9473 | |
225 | D | B | -2.4255 | |
226 | L | B | 0.0000 | |
227 | K | B | -1.7147 | |
228 | N | B | -2.2811 | |
229 | I | B | -1.3031 | |
230 | G | B | 0.0000 | |
231 | N | B | -1.2157 | |
232 | T | B | -1.0770 | |
233 | F | B | -1.1544 | |
234 | F | B | -1.3344 | |
235 | K | B | -2.1003 | |
236 | S | B | -1.5798 | |
237 | Q | B | -2.1792 | |
238 | N | B | -1.5499 | |
239 | W | B | -1.3305 | |
240 | E | B | -1.6135 | |
241 | M | B | -1.0965 | |
242 | A | B | 0.0000 | |
243 | I | B | -0.9776 | |
244 | K | B | -1.7364 | |
245 | K | B | 0.0000 | |
246 | Y | B | 0.0000 | |
247 | T | B | -0.7414 | |
248 | K | B | 0.0000 | |
249 | V | B | 0.0000 | |
250 | L | B | -0.7656 | |
251 | R | B | -1.4397 | |
252 | Y | B | 0.0000 | |
253 | V | B | 0.0000 | |
254 | E | B | -1.8872 | |
255 | G | B | -1.8353 | |
256 | S | B | 0.0000 | |
257 | R | B | -2.7431 | |
258 | A | B | -1.5025 | |
259 | A | B | -1.9125 | |
260 | A | B | -2.7119 | |
261 | E | B | -3.0529 | |
262 | D | B | -2.7599 | |
263 | A | B | -2.1909 | |
264 | D | B | -3.0291 | |
265 | G | B | -2.8911 | |
266 | A | B | -2.0584 | |
267 | K | B | -2.2346 | |
268 | L | B | 0.0000 | |
269 | Q | B | -0.6610 | |
270 | P | B | -0.4948 | |
271 | V | B | 0.0000 | |
272 | A | B | 0.0000 | |
273 | L | B | -0.3751 | |
274 | S | B | -0.1007 | |
275 | C | B | 0.0000 | |
276 | V | B | 0.0000 | |
277 | L | B | -0.4641 | |
278 | N | B | -0.1836 | |
279 | I | B | 0.0000 | |
280 | G | B | 0.0000 | |
281 | A | B | -0.5989 | |
282 | C | B | 0.0000 | |
283 | K | B | -1.1250 | |
284 | L | B | -0.9744 | |
285 | K | B | -1.8017 | |
286 | M | B | -0.6848 | |
287 | S | B | -0.7490 | |
288 | D | B | -0.8303 | |
289 | W | B | -0.9312 | |
290 | Q | B | -1.2409 | |
291 | G | B | -0.9612 | |
292 | A | B | 0.0000 | |
293 | V | B | 0.0000 | |
294 | D | B | -1.6136 | |
295 | S | B | 0.0000 | |
296 | C | B | 0.0000 | |
297 | L | B | -0.9103 | |
298 | E | B | -2.2055 | |
299 | A | B | 0.0000 | |
300 | L | B | -1.2168 | |
301 | E | B | -2.0459 | |
302 | I | B | -0.9161 | |
303 | D | B | -1.0705 | |
304 | P | B | -0.6838 | |
305 | S | B | -0.6329 | |
306 | N | B | 0.0000 | |
307 | T | B | -1.1070 | |
308 | K | B | -1.6531 | |
309 | A | B | 0.0000 | |
310 | L | B | 0.0000 | |
311 | Y | B | -0.8915 | |
312 | R | B | -0.9315 | |
313 | R | B | -0.8744 | |
314 | A | B | 0.0000 | |
315 | Q | B | -0.7087 | |
316 | G | B | 0.0000 | |
317 | W | B | -1.0872 | |
318 | Q | B | 0.0000 | |
319 | G | B | -0.6569 | |
320 | L | B | -0.7368 | |
321 | K | B | -2.1509 | |
322 | E | B | -1.9880 | |
323 | Y | B | -1.9861 | |
324 | D | B | -2.4877 | |
325 | Q | B | -1.9757 | |
326 | A | B | 0.0000 | |
327 | L | B | -1.2244 | |
328 | A | B | -1.2235 | |
329 | D | B | 0.0000 | |
330 | L | B | 0.0000 | |
331 | K | B | -2.2281 | |
332 | K | B | -2.0055 | |
333 | A | B | 0.0000 | |
334 | Q | B | -2.4372 | |
335 | E | B | -2.5077 | |
336 | I | B | -0.6582 | |
337 | A | B | -1.5999 | |
338 | P | B | -2.3387 | |
339 | E | B | -2.8961 | |
340 | D | B | -2.5984 | |
341 | K | B | -2.6934 | |
342 | A | B | -1.3331 | |
343 | I | B | 0.0000 | |
344 | Q | B | -1.6002 | |
345 | A | B | -0.5170 | |
346 | E | B | 0.0000 | |
347 | L | B | -0.5958 | |
348 | L | B | 0.0711 | |
349 | K | B | -1.4446 | |
350 | V | B | 0.0000 | |
351 | K | B | -2.2676 | |
352 | Q | B | -2.6626 | |
353 | K | B | -2.8534 | |
354 | I | B | -3.3773 | |
355 | K | B | -4.0971 | |
356 | A | B | -3.5308 | |
357 | Q | B | -4.1544 | |
358 | K | B | -4.9581 | |
359 | D | B | -5.2004 | |
360 | K | B | -4.8719 | |
361 | E | B | -4.9265 | |
362 | K | B | -4.1532 | |
363 | A | B | -2.2860 | |
364 | A | B | -0.3825 | |
365 | Y | B | 1.3566 |