Chain sequence(s) |
A: MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTS B: MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTS |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | -0.0869 | |
2 | E | A | -1.7932 | |
3 | K | A | -1.4659 | |
4 | T | A | -1.1557 | |
5 | E | A | -1.7479 | |
6 | L | A | 0.0000 | |
7 | I | A | -1.0765 | |
8 | Q | A | -1.4492 | |
9 | K | A | -1.4603 | |
10 | A | A | 0.0000 | |
11 | K | A | -2.1037 | |
12 | L | A | 0.0000 | |
13 | A | A | 0.0000 | |
14 | E | A | -2.7603 | |
15 | Q | A | -2.3911 | |
16 | A | A | 0.0000 | |
17 | E | A | -3.0865 | |
18 | R | A | -2.1981 | |
19 | Y | A | -2.0880 | |
20 | D | A | -2.2690 | |
21 | D | A | -1.6520 | |
22 | M | A | 0.0000 | |
23 | A | A | 0.0000 | |
24 | T | A | -0.8192 | |
25 | C | A | 0.0000 | |
26 | M | A | 0.0000 | |
27 | K | A | -1.1162 | |
28 | A | A | -1.0925 | |
29 | V | A | 0.0000 | |
30 | T | A | 0.0000 | |
31 | E | A | -2.3706 | |
32 | Q | A | -2.4795 | |
33 | G | A | -2.0696 | |
34 | A | A | -1.7695 | |
35 | E | A | -2.5541 | |
36 | L | A | 0.0000 | |
37 | S | A | -1.8108 | |
38 | N | A | -2.5461 | |
39 | E | A | -2.6849 | |
40 | E | A | -1.7997 | |
41 | R | A | 0.0000 | |
42 | N | A | -1.5317 | |
43 | L | A | -1.1796 | |
44 | L | A | 0.0000 | |
45 | S | A | -0.5147 | |
46 | V | A | -0.3449 | |
47 | A | A | 0.0000 | |
48 | Y | A | 0.0000 | |
49 | K | A | -1.7495 | |
50 | N | A | -1.7545 | |
51 | V | A | -1.2735 | |
52 | V | A | 0.0000 | |
53 | G | A | -1.3275 | |
54 | G | A | -1.5410 | |
55 | R | A | -1.7108 | |
56 | R | A | -1.4405 | |
57 | S | A | -1.2952 | |
58 | A | A | 0.0000 | |
59 | W | A | -1.3337 | |
60 | R | A | -1.3072 | |
61 | V | A | -0.7434 | |
62 | I | A | 0.0000 | |
63 | S | A | -1.1628 | |
64 | S | A | -1.2301 | |
65 | I | A | -1.2545 | |
66 | E | A | 0.0000 | |
67 | Q | A | -2.7609 | |
68 | K | A | -2.8757 | |
69 | T | A | -2.0632 | |
70 | D | A | -3.2975 | |
71 | T | A | -2.2181 | |
72 | S | A | -2.3636 | |
73 | D | A | -3.3820 | |
74 | K | A | -3.5681 | |
75 | K | A | -3.6652 | |
76 | L | A | -3.2271 | |
77 | Q | A | -3.1869 | |
78 | L | A | 0.0000 | |
79 | I | A | 0.0000 | |
80 | K | A | -3.0902 | |
81 | D | A | -3.6096 | |
82 | Y | A | 0.0000 | |
83 | R | A | -2.7664 | |
84 | E | A | -3.6758 | |
85 | K | A | -3.3445 | |
86 | V | A | 0.0000 | |
87 | E | A | -2.1144 | |
88 | S | A | -1.7735 | |
89 | E | A | -1.4615 | |
90 | L | A | 0.0000 | |
91 | R | A | -1.0593 | |
92 | S | A | -0.6654 | |
93 | I | A | 0.0000 | |
94 | C | A | 0.0000 | |
95 | T | A | -0.7196 | |
96 | T | A | -0.8322 | |
97 | V | A | 0.0000 | |
98 | L | A | -1.5079 | |
99 | E | A | -2.8533 | |
100 | L | A | 0.0000 | |
101 | L | A | 0.0000 | |
102 | D | A | -3.2069 | |
103 | K | A | -3.2717 | |
104 | Y | A | -2.4145 | |
105 | L | A | 0.0000 | |
106 | I | A | -1.2150 | |
107 | A | A | -1.2903 | |
108 | N | A | -2.0109 | |
109 | A | A | -1.2177 | |
110 | T | A | -1.0945 | |
111 | N | A | -1.2527 | |
112 | P | A | -1.5003 | |
113 | E | A | -1.6424 | |
114 | S | A | 0.0000 | |
115 | K | A | -1.3765 | |
116 | V | A | 0.0000 | |
117 | F | A | 0.0000 | |
118 | Y | A | 0.0000 | |
119 | L | A | 0.0000 | |
120 | K | A | -0.8085 | |
121 | M | A | 0.0000 | |
122 | K | A | -0.9491 | |
123 | G | A | 0.0000 | |
124 | D | A | 0.0000 | |
125 | Y | A | 0.0000 | |
126 | F | A | -0.5414 | |
127 | R | A | 0.0000 | |
128 | Y | A | 0.0000 | |
129 | L | A | -0.2898 | |
130 | A | A | 0.0000 | |
131 | E | A | -0.5207 | |
132 | V | A | 0.0000 | |
133 | A | A | -1.1837 | |
134 | C | A | -1.0762 | |
135 | G | A | -2.2865 | |
136 | D | A | -3.8289 | |
137 | D | A | -4.1931 | |
138 | R | A | -3.6366 | |
139 | K | A | -4.3316 | |
140 | Q | A | -4.1828 | |
141 | T | A | 0.0000 | |
142 | I | A | -2.3735 | |
143 | D | A | -3.4420 | |
144 | N | A | -2.5126 | |
145 | S | A | 0.0000 | |
146 | Q | A | -1.9420 | |
147 | G | A | -2.1357 | |
148 | A | A | 0.0000 | |
149 | Y | A | 0.0000 | |
150 | Q | A | -2.0774 | |
151 | E | A | -2.6264 | |
152 | A | A | 0.0000 | |
153 | F | A | -1.6674 | |
154 | D | A | -2.5800 | |
155 | I | A | -2.5044 | |
156 | S | A | 0.0000 | |
157 | K | A | -3.3924 | |
158 | K | A | -3.6564 | |
159 | E | A | -3.6357 | |
160 | M | A | 0.0000 | |
161 | Q | A | -2.4441 | |
162 | P | A | -1.4115 | |
163 | T | A | 0.0000 | |
164 | H | A | -0.8059 | |
165 | P | A | -0.5976 | |
166 | I | A | 0.0000 | |
167 | R | A | 0.0000 | |
168 | L | A | 0.0000 | |
169 | G | A | 0.1942 | |
170 | L | A | 0.0000 | |
171 | A | A | 0.0000 | |
172 | L | A | 0.0037 | |
173 | N | A | -0.0271 | |
174 | F | A | 0.0000 | |
175 | S | A | 0.0000 | |
176 | V | A | -0.3037 | |
177 | F | A | 0.0000 | |
178 | Y | A | -0.5639 | |
179 | Y | A | -1.0317 | |
180 | E | A | -1.8429 | |
181 | I | A | -0.7907 | |
182 | L | A | -0.4663 | |
183 | N | A | -1.7775 | |
184 | N | A | -1.4264 | |
185 | P | A | -1.2999 | |
186 | E | A | -1.7332 | |
187 | L | A | -0.5003 | |
188 | A | A | 0.0000 | |
189 | C | A | -0.6009 | |
190 | T | A | -0.6209 | |
191 | L | A | 0.0000 | |
192 | A | A | 0.0000 | |
193 | K | A | -1.5252 | |
194 | T | A | -0.8677 | |
195 | A | A | 0.0000 | |
196 | F | A | -0.7654 | |
197 | D | A | -1.1218 | |
198 | E | A | -0.9854 | |
199 | A | A | 0.0000 | |
200 | I | A | 0.4165 | |
201 | A | A | -0.4050 | |
202 | E | A | -1.4536 | |
203 | L | A | -0.7113 | |
204 | D | A | -1.8709 | |
205 | T | A | -1.3011 | |
206 | L | A | -2.1201 | |
207 | N | A | -2.8948 | |
208 | E | A | -3.2755 | |
209 | D | A | -3.3929 | |
210 | S | A | -2.3815 | |
211 | Y | A | -1.7163 | |
212 | K | A | -2.4673 | |
213 | D | A | -2.0971 | |
214 | S | A | 0.0000 | |
215 | T | A | 0.1007 | |
216 | L | A | 0.4933 | |
217 | I | A | -0.0073 | |
218 | M | A | 0.0000 | |
219 | Q | A | -0.7945 | |
220 | L | A | -0.1938 | |
221 | L | A | 0.0000 | |
222 | R | A | -1.7825 | |
223 | D | A | -1.4694 | |
224 | N | A | -0.5523 | |
225 | L | A | -0.5653 | |
226 | T | A | -0.0203 | |
227 | L | A | 0.9623 | |
228 | W | A | 0.2759 | |
229 | T | A | 0.0308 | |
230 | S | A | 0.2820 | |
1 | M | B | -0.1507 | |
2 | E | B | -1.9724 | |
3 | K | B | -1.8345 | |
4 | T | B | -1.3047 | |
5 | E | B | -1.7195 | |
6 | L | B | 0.0000 | |
7 | I | B | -1.1781 | |
8 | Q | B | -1.3424 | |
9 | K | B | -1.5359 | |
10 | A | B | 0.0000 | |
11 | K | B | -2.1782 | |
12 | L | B | 0.0000 | |
13 | A | B | 0.0000 | |
14 | E | B | -2.4947 | |
15 | Q | B | -2.2892 | |
16 | A | B | 0.0000 | |
17 | E | B | -3.0303 | |
18 | R | B | -2.3661 | |
19 | Y | B | -2.1070 | |
20 | D | B | -2.3565 | |
21 | D | B | -1.9209 | |
22 | M | B | 0.0000 | |
23 | A | B | 0.0000 | |
24 | T | B | -0.8413 | |
25 | C | B | 0.0000 | |
26 | M | B | 0.0000 | |
27 | K | B | -1.1551 | |
28 | A | B | -1.2191 | |
29 | V | B | 0.0000 | |
30 | T | B | 0.0000 | |
31 | E | B | -2.4911 | |
32 | Q | B | -2.5844 | |
33 | G | B | -1.9507 | |
34 | A | B | -1.6808 | |
35 | E | B | -2.3599 | |
36 | L | B | -1.6123 | |
37 | S | B | -1.7658 | |
38 | N | B | -2.4697 | |
39 | E | B | -2.6849 | |
40 | E | B | -1.7818 | |
41 | R | B | 0.0000 | |
42 | N | B | -1.4860 | |
43 | L | B | -1.1349 | |
44 | L | B | 0.0000 | |
45 | S | B | -0.4730 | |
46 | V | B | -0.2251 | |
47 | A | B | 0.0000 | |
48 | Y | B | 0.0000 | |
49 | K | B | -1.6548 | |
50 | N | B | -1.6520 | |
51 | V | B | 0.0000 | |
52 | V | B | 0.0000 | |
53 | G | B | -1.1938 | |
54 | G | B | -1.4562 | |
55 | R | B | -1.6041 | |
56 | R | B | -0.9771 | |
57 | S | B | -1.0579 | |
58 | A | B | 0.0000 | |
59 | W | B | -1.0004 | |
60 | R | B | -0.9075 | |
61 | V | B | -0.6910 | |
62 | I | B | 0.0000 | |
63 | S | B | -0.9735 | |
64 | S | B | -1.0355 | |
65 | I | B | -1.4244 | |
66 | E | B | -2.1869 | |
67 | Q | B | -2.5620 | |
68 | K | B | -2.8209 | |
69 | T | B | -2.2985 | |
70 | D | B | -3.0378 | |
71 | T | B | -2.0352 | |
73 | D | B | -3.5028 | |
74 | K | B | -3.6144 | |
75 | K | B | -3.5116 | |
76 | L | B | 0.0000 | |
77 | Q | B | -3.3490 | |
78 | L | B | -2.6630 | |
79 | I | B | 0.0000 | |
80 | K | B | -2.9739 | |
81 | D | B | -3.4214 | |
82 | Y | B | 0.0000 | |
83 | R | B | -2.5864 | |
84 | E | B | -3.3595 | |
85 | K | B | -2.9013 | |
86 | V | B | 0.0000 | |
87 | E | B | -2.3028 | |
88 | S | B | -2.0590 | |
89 | E | B | -1.7461 | |
90 | L | B | 0.0000 | |
91 | R | B | -2.1894 | |
92 | S | B | -1.2665 | |
93 | I | B | 0.0000 | |
94 | C | B | 0.0000 | |
95 | T | B | -1.0594 | |
96 | T | B | -1.0317 | |
97 | V | B | 0.0000 | |
98 | L | B | 0.0000 | |
99 | E | B | -2.8483 | |
100 | L | B | 0.0000 | |
101 | L | B | 0.0000 | |
102 | D | B | -3.0622 | |
103 | K | B | -3.1333 | |
104 | Y | B | -2.1782 | |
105 | L | B | 0.0000 | |
106 | I | B | -1.2675 | |
107 | A | B | -1.2820 | |
108 | N | B | -1.6152 | |
109 | A | B | -0.9694 | |
110 | T | B | -1.0606 | |
111 | N | B | -1.5518 | |
112 | P | B | -1.5166 | |
113 | E | B | -1.1473 | |
114 | S | B | -1.1372 | |
115 | K | B | -1.1344 | |
116 | V | B | 0.0000 | |
117 | F | B | -0.2328 | |
118 | Y | B | 0.0000 | |
119 | L | B | 0.0000 | |
120 | K | B | -0.6549 | |
121 | M | B | 0.0000 | |
122 | K | B | -0.8474 | |
123 | G | B | 0.0000 | |
124 | D | B | 0.0000 | |
125 | Y | B | 0.0000 | |
126 | F | B | -0.5161 | |
127 | R | B | 0.0000 | |
128 | Y | B | -0.0839 | |
129 | L | B | -0.4179 | |
130 | A | B | 0.0000 | |
131 | E | B | -0.4324 | |
132 | V | B | -0.4629 | |
133 | A | B | -1.1741 | |
134 | C | B | -1.0847 | |
135 | G | B | -2.3070 | |
136 | D | B | -3.7262 | |
137 | D | B | -3.7612 | |
138 | R | B | -3.3666 | |
139 | K | B | -3.9110 | |
140 | Q | B | -3.6317 | |
141 | T | B | 0.0000 | |
142 | I | B | -1.8562 | |
143 | D | B | -2.3298 | |
144 | N | B | -1.8574 | |
145 | S | B | 0.0000 | |
146 | Q | B | -1.5691 | |
147 | G | B | -1.7784 | |
148 | A | B | 0.0000 | |
149 | Y | B | 0.0000 | |
150 | Q | B | -1.8679 | |
151 | E | B | -2.2913 | |
152 | A | B | 0.0000 | |
153 | F | B | -1.5293 | |
154 | D | B | -2.4277 | |
155 | I | B | -2.2566 | |
156 | S | B | 0.0000 | |
157 | K | B | -3.1985 | |
158 | K | B | -3.5914 | |
159 | E | B | -3.5606 | |
160 | M | B | 0.0000 | |
161 | Q | B | -2.3753 | |
162 | P | B | -1.4806 | |
163 | T | B | 0.0000 | |
164 | H | B | -0.8120 | |
165 | P | B | -0.5419 | |
166 | I | B | -0.1985 | |
167 | R | B | 0.0000 | |
168 | L | B | 0.0000 | |
169 | G | B | 0.0405 | |
170 | L | B | 0.0000 | |
171 | A | B | 0.0000 | |
172 | L | B | 0.0008 | |
173 | N | B | -0.0162 | |
174 | F | B | 0.0000 | |
175 | S | B | 0.0000 | |
176 | V | B | -0.3035 | |
177 | F | B | 0.0000 | |
178 | Y | B | -0.5990 | |
179 | Y | B | -1.1037 | |
180 | E | B | -1.9430 | |
181 | I | B | 0.0000 | |
182 | L | B | -0.4632 | |
183 | N | B | -1.8064 | |
184 | N | B | -1.4891 | |
185 | P | B | -1.3293 | |
186 | E | B | -1.7617 | |
187 | L | B | -0.4703 | |
188 | A | B | 0.0000 | |
189 | C | B | -0.6048 | |
190 | T | B | -0.6109 | |
191 | L | B | 0.0000 | |
192 | A | B | 0.0000 | |
193 | K | B | -1.5260 | |
194 | T | B | -0.9305 | |
195 | A | B | 0.0000 | |
196 | F | B | 0.0000 | |
197 | D | B | -1.2093 | |
198 | E | B | -0.9704 | |
199 | A | B | 0.0000 | |
200 | I | B | 0.4239 | |
201 | A | B | -0.3436 | |
202 | E | B | -1.2271 | |
203 | L | B | -0.3805 | |
204 | D | B | -1.7268 | |
205 | T | B | -1.5156 | |
206 | L | B | -1.6461 | |
207 | N | B | -2.7106 | |
208 | E | B | -3.4486 | |
209 | D | B | -3.4028 | |
210 | S | B | -2.4078 | |
211 | Y | B | -1.9639 | |
212 | K | B | -2.5039 | |
213 | D | B | -2.3400 | |
214 | S | B | 0.0000 | |
215 | T | B | -0.5557 | |
216 | L | B | -0.2398 | |
217 | I | B | -0.4860 | |
218 | M | B | 0.0000 | |
219 | Q | B | -1.4939 | |
220 | L | B | -0.6149 | |
221 | L | B | 0.0000 | |
222 | R | B | -2.0216 | |
223 | D | B | -1.6494 | |
224 | N | B | -0.6603 | |
225 | L | B | -0.6687 | |
226 | T | B | -0.1370 | |
227 | L | B | 0.8763 | |
228 | W | B | 0.0000 | |
229 | T | B | 0.0576 | |
230 | S | B | 0.2403 |