Project name: AD_33

Chain sequence(s)	A: MERRRITSAARREYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAAEYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.56
• Maximal score value: 1.7505
• Average score: -0.2869
• Total score value: -123.9263

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.5616
2	E	A	-0.9650
3	R	A	-0.6092
4	R	A	-2.2108
5	R	A	-2.1749
6	I	A	0.0245
7	T	A	-0.7655
8	S	A	-0.8233
9	A	A	-0.2381
10	A	A	-0.3153
11	R	A	-2.1925
12	R	A	-2.2685
13	E	A	-0.6326
14	Y	A	1.4171
15	V	A	1.3228
16	S	A	-0.0280
17	S	A	-0.2168
18	G	A	-0.4838
19	E	A	-1.2767
20	M	A	0.4207
21	M	A	0.1291
22	V	A	0.0000
23	G	A	0.0000
24	G	A	0.0060
25	L	A	0.2249
26	A	A	0.0000
27	P	A	0.0000
28	G	A	0.0000
29	R	A	0.0000
30	R	A	0.0000
31	L	A	0.0000
32	G	A	0.0000
33	P	A	0.0000
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	0.0000
42	M	A	0.0000
43	P	A	0.0000
44	P	A	0.0000
45	P	A	0.0923
46	L	A	0.7131
47	P	A	0.0000
48	T	A	-0.3872
49	R	A	-1.7808
50	V	A	-0.2810
51	D	A	-1.0744
52	F	A	0.0997
53	S	A	0.1131
54	L	A	1.2752
55	A	A	0.1782
56	G	A	-0.4545
57	A	A	-0.0260
58	L	A	0.0000
59	N	A	-0.2069
60	A	A	0.0084
61	G	A	0.0000
62	F	A	0.0000
63	K	A	-2.0336
64	E	A	-2.1315
65	T	A	0.0000
66	R	A	-1.2528
67	A	A	-0.3025
68	S	A	0.0000
69	E	A	0.0000
70	R	A	-1.0336
71	A	A	-0.1813
72	E	A	0.0000
73	M	A	0.5360
74	M	A	0.6974
75	E	A	-0.5399
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.0627
79	R	A	-0.9644
80	F	A	0.0000
81	A	A	-0.1159
82	S	A	-0.0880
83	Y	A	0.0000
84	I	A	0.0000
85	E	A	-0.5264
86	K	A	-1.3004
87	V	A	0.0000
88	R	A	-0.0731
89	F	A	0.9102
90	L	A	0.0000
91	E	A	0.0000
92	Q	A	-1.3750
93	Q	A	-1.1883
94	N	A	0.0000
95	K	A	-0.3765
96	A	A	-0.0814
97	L	A	0.1957
98	A	A	0.0513
99	A	A	-0.2619
100	E	A	-1.7718
101	L	A	0.0000
102	N	A	-0.3664
103	Q	A	-1.0314
104	L	A	-0.0624
105	R	A	-0.2147
106	A	A	-0.1144
107	K	A	-0.4761
108	E	A	0.0000
109	P	A	-0.0892
110	T	A	-0.3507
111	K	A	-0.7911
112	L	A	1.3507
113	A	A	0.0602
114	D	A	-1.6542
115	V	A	0.4404
116	Y	A	0.2342
117	Q	A	-0.4425
118	A	A	-0.0607
119	E	A	-0.5035
120	L	A	-0.2518
121	R	A	-2.0281
122	E	A	-1.5439
123	L	A	0.0000
124	R	A	-0.1841
125	L	A	1.1000
126	R	A	-1.0934
127	L	A	0.0000
128	D	A	-1.1783
129	Q	A	-1.3976
130	L	A	0.0000
131	T	A	0.0000
132	A	A	-0.1311
133	N	A	-0.3674
134	S	A	0.0000
135	A	A	-0.3382
136	R	A	-1.8589
137	L	A	0.0000
138	E	A	0.0722
139	V	A	1.5093
140	E	A	-0.8782
141	R	A	0.0000
142	D	A	-1.3567
143	N	A	-1.4774
144	L	A	0.0000
145	A	A	0.0000
146	Q	A	-1.3088
147	D	A	-0.8366
148	L	A	0.0000
149	A	A	-0.0425
150	T	A	-0.0271
151	V	A	0.1501
152	R	A	-0.4246
153	Q	A	-0.7575
154	K	A	-0.7750
155	L	A	0.0000
156	Q	A	-0.5323
157	D	A	-1.5556
158	E	A	-0.4836
159	T	A	0.0000
160	N	A	-0.7288
161	L	A	1.3668
162	R	A	0.0000
163	L	A	0.0221
164	E	A	-1.7538
165	A	A	-0.3248
166	E	A	0.0000
167	N	A	-0.7666
168	N	A	-0.9439
169	L	A	0.0179
170	A	A	0.0000
171	A	A	0.2636
172	Y	A	1.3201
173	R	A	0.0000
174	Q	A	-0.6470
175	E	A	-1.8752
176	A	A	-0.8102
177	D	A	-2.0311
178	E	A	-1.6725
179	A	A	0.0000
180	T	A	0.0857
181	L	A	1.5472
182	A	A	0.2897
183	R	A	0.0000
184	L	A	0.5249
185	D	A	-0.7642
186	L	A	0.0000
187	E	A	-0.4498
188	R	A	-1.9906
189	K	A	-0.5172
190	I	A	-0.1616
191	E	A	-1.7888
192	S	A	-0.3912
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-0.5372
196	E	A	-0.2667
197	I	A	0.0000
198	R	A	-0.3124
199	F	A	0.2647
200	L	A	0.0000
201	R	A	0.0000
202	K	A	-0.2102
203	I	A	0.0761
204	H	A	-0.7145
205	E	A	0.0000
206	E	A	-2.0400
207	E	A	-1.4605
208	V	A	0.0000
209	R	A	-0.3659
210	E	A	0.0000
211	L	A	0.0000
212	Q	A	0.0000
213	E	A	0.0000
214	Q	A	0.0000
215	L	A	0.6590
216	A	A	0.1433
217	R	A	-0.3909
218	Q	A	-1.2300
219	Q	A	0.0000
220	V	A	1.5901
221	H	A	0.1436
222	V	A	0.0000
223	E	A	-1.7682
224	L	A	-0.2645
225	D	A	-1.0207
226	V	A	0.0000
227	A	A	-0.1383
228	K	A	0.0000
229	P	A	0.0000
230	D	A	0.0000
231	L	A	0.1767
232	T	A	0.0202
233	A	A	0.0058
234	A	A	0.0000
235	L	A	0.1156
236	K	A	-0.6350
237	E	A	-0.4951
238	I	A	0.0000
239	R	A	-0.4861
240	T	A	-0.1774
241	Q	A	0.0479
242	Y	A	1.1525
243	E	A	-0.4788
244	A	A	0.0341
245	M	A	0.6394
246	A	A	0.0000
247	S	A	-0.0989
248	S	A	-0.1431
249	N	A	-0.1831
250	M	A	0.0000
251	H	A	-0.6937
252	E	A	-0.7273
253	A	A	0.0000
254	E	A	-1.0259
255	E	A	-1.6158
256	W	A	0.2804
257	Y	A	-0.0277
258	R	A	-1.8212
259	S	A	-0.3515
260	K	A	0.0000
261	F	A	1.7505
262	A	A	0.3244
263	D	A	-0.2623
264	L	A	0.0000
265	T	A	-0.2117
266	D	A	-0.9890
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-0.1141
270	R	A	-0.6755
271	N	A	0.0000
272	A	A	-0.2225
273	E	A	-1.5297
274	L	A	1.4484
275	L	A	1.2386
276	R	A	-1.8357
277	Q	A	-1.5501
278	A	A	-0.2013
279	K	A	0.0000
280	H	A	-0.4600
281	E	A	-0.4472
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-0.2081
285	Y	A	0.0000
286	R	A	0.0000
287	R	A	0.0000
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0000
293	T	A	0.0000
294	C	A	0.0000
295	D	A	-0.1924
296	L	A	0.0000
297	E	A	-0.6560
298	S	A	-0.1583
299	L	A	0.0000
300	R	A	-0.3423
301	G	A	-0.1617
302	T	A	0.0000
303	N	A	0.0000
304	E	A	-0.3368
305	S	A	-0.0821
306	L	A	0.0000
307	E	A	0.0000
308	R	A	-1.8441
309	Q	A	0.0000
310	M	A	0.0000
311	R	A	-1.4439
312	E	A	-0.6367
313	Q	A	0.0000
314	E	A	-0.7004
315	E	A	-1.9414
316	R	A	-0.7684
317	H	A	0.0000
318	V	A	0.7719
319	R	A	-1.5976
320	E	A	0.0000
321	A	A	0.0000
322	A	A	-0.1643
323	E	A	-1.3027
324	Y	A	0.0000
325	Q	A	-0.7621
326	E	A	-1.3824
327	A	A	0.0000
328	L	A	0.2180
329	A	A	-0.2524
330	R	A	-1.1458
331	L	A	0.0000
332	E	A	-2.2113
333	E	A	-2.5600
334	E	A	-2.1992
335	G	A	-0.6545
336	Q	A	-0.5390
337	E	A	-1.5687
338	L	A	1.2197
339	K	A	0.0000
340	D	A	-1.9917
341	E	A	-1.4495
342	M	A	0.0000
343	A	A	-0.4452
344	R	A	-1.3350
345	H	A	-0.5038
346	L	A	0.0000
347	Q	A	-0.7293
348	E	A	-1.0444
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-0.6328
352	L	A	0.0000
353	L	A	0.0000
354	N	A	-0.7902
355	V	A	0.1678
356	K	A	0.0000
357	L	A	0.3133
358	A	A	0.1188
359	L	A	0.0000
360	D	A	0.0000
361	I	A	0.5693
362	E	A	-0.0945
363	I	A	0.0000
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	0.0000
367	R	A	0.0000
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	0.0000
372	G	A	0.0000
373	E	A	0.0000
374	E	A	0.0000
375	N	A	0.0000
376	R	A	-0.1201
377	I	A	0.0000
378	T	A	0.0000
379	I	A	0.0941
380	P	A	-0.1385
381	V	A	0.4963
382	Q	A	-0.1403
383	T	A	0.2926
384	F	A	1.7499
385	S	A	0.3180
386	N	A	0.0000
387	L	A	0.9350
388	Q	A	-0.4979
389	I	A	0.0000
390	R	A	-2.0341
391	E	A	-1.0526
392	T	A	-0.1664
393	S	A	-0.3039
394	L	A	-0.0433
395	D	A	0.0000
396	T	A	-0.1750
397	K	A	-1.0162
398	S	A	-0.1368
399	V	A	0.0856
400	S	A	0.0000
401	E	A	-0.9084
402	G	A	0.0000
403	H	A	-0.4251
404	L	A	1.1086
405	K	A	-1.5776
406	R	A	-0.7857
407	N	A	-1.1977
408	I	A	0.1025
409	V	A	0.1435
410	V	A	0.0000
411	K	A	0.0000
412	T	A	-0.1414
413	V	A	0.0743
414	E	A	-0.2748
415	M	A	0.0000
416	R	A	0.0000
417	D	A	0.0000
418	G	A	0.0000
419	E	A	0.0000
420	V	A	-0.0207
421	I	A	0.0000
422	K	A	-0.6789
423	E	A	-2.0883
424	S	A	-0.5891
425	K	A	-1.5294
426	Q	A	-1.2857
427	E	A	0.0000
428	H	A	0.0000
429	K	A	-1.2046
430	D	A	-0.4612
431	V	A	0.0000
432	M	A	0.5293