Project name: 2IV1 [mutate: KA64Y, DA66Y, DA68Y, EA69Y, DA70Y, KB64Y, DB66Y, DB68Y, EB69Y, DB70Y, KC64Y, DC66Y, DC68Y, EC69Y, DC70Y, KD64Y, DD66Y, DD68Y, ED69Y, DD70Y, KE64Y, DE66Y, DE68Y, EE69Y, DE70Y, KF64Y, DF66Y, DF68Y, EF69Y, DF70Y, KG64Y, DG66Y, DG68Y, EG69Y

Status: done

submitted: 2017-09-13 10:41:51, status changed: 2017-09-13 12:06:29
Settings
Chain sequence(s) A: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
C: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
B: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
E: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
D: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
G: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
F: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
I: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
H: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
J: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues KA64Y, DA66Y, DA68Y, EA69Y, DA70Y, KB64Y, DB66Y, DB68Y, EB69Y, DB70Y, KC64Y, DC66Y, DC68Y, EC69Y, DC70Y, KD64Y, DD66Y, DD68Y, ED69Y, DD70Y, KE64Y, DE66Y, DE68Y, EE69Y, DE70Y, KF64Y, DF66Y, DF68Y, EF69Y, DF70Y, KG64Y, DG66Y, DG68Y, EG69Y, DG70Y, KH64Y, DH66Y, DH68Y, EH69Y, DH70Y, KI64Y, DI66Y, DI68Y, EI69Y, DI70Y, KJ64Y, DJ66Y, DJ68Y, EJ69Y, DJ70Y
Energy difference between WT (input) and mutated protein (by FoldX) 85.6604 kcal/mol
Show buried residues

Minimal score value
-3.4265
Maximal score value
2.8254
Average score
-0.4319
Total score value
-673.7416

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 0.3853
2 I A 0.4325
3 Q A 0.0000
4 S A 0.0000
5 Q A 0.0000
6 I A -0.1918
7 N A -0.9697
8 R A -1.1144
9 N A -1.6750
10 I A -0.7623
11 R A 0.0000
12 L A -1.1162
13 D A -2.0169
14 L A 0.0000
15 A A 0.0000
16 D A -0.7688
17 A A -0.3712
18 I A 0.0000
19 L A 0.0000
20 L A -0.4819
21 S A -0.8044
22 K A 0.0000
23 A A 0.0000
24 K A -2.4952
25 K A -2.6313
26 D A -2.5064
27 L A -1.3602
28 S A 0.0000
29 F A 0.0000
30 A A -1.6481
31 E A -2.2871
32 I A 0.0000
33 A A 0.0000
34 D A -2.8003
35 G A -1.6305
36 T A -1.6706
37 G A -0.9680
38 L A -0.5815
39 A A -1.1078
40 E A -1.9278
41 A A 0.0000
42 F A 0.0000
43 V A 0.0000
44 T A 0.0000
45 A A 0.0000
46 A A 0.0000
47 L A 0.0000
48 L A 0.0000
49 G A 0.0000
50 Q A 0.0000
51 Q A 0.0000
52 A A -0.3549
53 L A 0.0000
54 P A -0.9220
55 A A -1.2999
56 D A -2.3171
57 A A 0.0000
58 A A 0.0000
59 R A -1.6876
60 L A -0.8808
61 V A 0.0000
62 G A 0.0000
63 A A 0.7486
64 Y A 0.6224 mutated: KA64Y
65 L A 0.0000
66 Y A 1.8071 mutated: DA66Y
67 L A 1.8837
68 Y A 2.6848 mutated: DA68Y
69 Y A 2.3317 mutated: EA69Y
70 Y A 1.8787 mutated: DA70Y
71 S A 0.0000
72 I A 0.9391
73 L A 0.6638
74 L A 0.0000
75 L A 0.0000
76 Q A -0.4759
77 M A 0.0000
78 I A 0.0000
79 P A 0.0000
80 L A 0.0000
81 R A 0.0000
82 G A 0.0000
83 C A 0.0000
84 I A 0.0000
85 D A -2.8675
86 D A -3.4265
87 R A -2.0898
88 I A 0.0000
89 P A 0.0000
90 T A -0.8459
91 D A 0.0000
92 P A 0.0000
93 T A 0.0000
94 M A 0.0000
95 Y A 0.0000
96 Q A 0.0000
97 F A 0.0000
98 Y A 0.0000
99 E A 0.0000
100 M A 0.0000
101 L A 0.0000
102 Q A 0.0000
103 V A 0.0000
104 Y A 0.0000
105 G A 0.0000
106 T A 0.0000
107 T A 0.0000
108 L A 0.0000
109 K A 0.0000
110 A A 0.0000
111 L A 0.0000
112 V A 0.0000
113 H A 0.0000
114 E A -0.1723
115 K A -1.0899
116 F A -0.6817
117 G A -0.2772
118 D A -0.5413
119 G A 0.0000
120 I A 0.0000
121 I A 0.0000
122 S A 0.0000
123 A A 0.0000
124 I A -0.6913
125 N A -1.3585
126 F A 0.0000
127 K A -1.9411
128 L A 0.0000
129 D A -2.5679
130 V A 0.0000
131 K A -2.7187
132 K A -2.3069
133 V A -0.9326
134 A A -0.8917
135 D A 0.0000
136 P A -1.3693
137 E A -2.2886
138 G A -1.6939
139 G A -1.3640
140 E A -1.5079
141 R A 0.0000
142 A A 0.0000
143 V A -1.1246
144 I A 0.0000
145 T A -1.1644
146 L A 0.0000
147 D A -1.2530
148 G A 0.0000
149 K A -1.0518
150 Y A -0.6226
151 L A -0.5506
152 P A -0.8941
153 T A -1.0336
154 K A -1.9235
155 P A -0.8358
156 F A -0.3299
1 M B 0.4223
2 I B 0.4331
3 Q B 0.0000
4 S B 0.0000
5 Q B 0.0000
6 I B -0.2998
7 N B -1.1407
8 R B -1.2721
9 N B -1.7703
10 I B -0.9659
11 R B 0.0000
12 L B -1.1363
13 D B -2.0302
14 L B 0.0000
15 A B 0.0000
16 D B 0.0000
17 A B -0.2657
18 I B 0.0000
19 L B 0.0000
20 L B -0.2149
21 S B -0.6000
22 K B 0.0000
23 A B 0.0000
24 K B -1.9268
25 K B -2.2639
26 D B -2.3284
27 L B 0.0000
28 S B 0.0000
29 F B 0.0000
30 A B -1.2601
31 E B -1.6546
32 I B 0.0000
33 A B 0.0000
34 D B -2.5017
35 G B -1.4855
36 T B -1.5673
37 G B -0.9141
38 L B -0.4922
39 A B -1.0151
40 E B -1.7047
41 A B 0.0000
42 F B 0.0000
43 V B 0.0000
44 T B 0.0000
45 A B 0.0000
46 A B 0.0000
47 L B 0.0000
48 L B 0.0000
49 G B 0.0000
50 Q B 0.0000
51 Q B 0.0000
52 A B -0.3849
53 L B 0.0000
54 P B -1.1159
55 A B -1.3189
56 D B -2.3128
57 A B 0.0000
58 A B 0.0000
59 R B -1.7493
60 L B -0.8019
61 V B 0.0000
62 G B 0.0000
63 A B 0.6861
64 Y B 0.5487 mutated: KB64Y
65 L B 0.0000
66 Y B 1.7776 mutated: DB66Y
67 L B 1.8586
68 Y B 2.7691 mutated: DB68Y
69 Y B 2.3818 mutated: EB69Y
70 Y B 2.0719 mutated: DB70Y
71 S B 0.0000
72 I B 0.9636
73 L B 0.5642
74 L B 0.0000
75 L B 0.0000
76 Q B -0.5523
77 M B 0.0000
78 I B 0.0000
79 P B 0.0000
80 L B -0.0760
81 R B 0.0000
82 G B 0.0000
83 C B 0.0000
84 I B 0.0000
85 D B -2.2990
86 D B -3.1235
87 R B -2.0029
88 I B 0.0000
89 P B 0.0000
90 T B 0.0000
91 D B 0.0000
92 P B 0.0000
93 T B 0.0000
94 M B 0.0000
95 Y B 0.0000
96 Q B 0.0000
97 F B 0.0000
98 Y B 0.0000
99 E B 0.0000
100 M B 0.0000
101 L B 0.0000
102 Q B 0.0000
103 V B 0.0000
104 Y B 0.0000
105 G B 0.0000
106 T B 0.0000
107 T B 0.0000
108 L B 0.0000
109 K B 0.0000
110 A B 0.0000
111 L B 0.0000
112 V B 0.0000
113 H B 0.0000
114 E B -0.2739
115 K B -1.2802
116 F B -0.8392
117 G B -0.3383
118 D B -0.5774
119 G B 0.0000
120 I B 0.0000
121 I B 0.0000
122 S B 0.0000
123 A B 0.0000
124 I B -0.6700
125 N B -1.2993
126 F B 0.0000
127 K B -1.9018
128 L B 0.0000
129 D B -2.5787
130 V B 0.0000
131 K B -2.6144
132 K B -2.1065
133 V B -0.8534
134 A B -0.9192
135 D B 0.0000
136 P B -1.3907
137 E B -2.3157
138 G B -1.7857
139 G B -1.4402
140 E B -1.5691
141 R B -1.3315
142 A B 0.0000
143 V B -1.1271
144 I B 0.0000
145 T B -0.9388
146 L B 0.0000
147 D B 0.0000
148 G B 0.0000
149 K B -1.0183
150 Y B 0.0000
151 L B -0.5983
152 P B -0.9202
153 T B -1.0474
154 K B -1.9119
155 P B -0.8023
156 F B -0.2454
1 M C 0.6241
2 I C 0.6238
3 Q C 0.0000
4 S C 0.0000
5 Q C 0.0000
6 I C 0.0000
7 N C -1.2207
8 R C -1.2872
9 N C -1.7580
10 I C -0.9053
11 R C 0.0000
12 L C -1.1092
13 D C -1.9998
14 L C 0.0000
15 A C 0.0000
16 D C 0.0000
17 A C -0.2711
18 I C 0.0000
19 L C 0.0000
20 L C -0.4485
21 S C -0.7877
22 K C 0.0000
23 A C 0.0000
24 K C -2.4525
25 K C -2.5404
26 D C -2.5306
27 L C 0.0000
28 S C 0.0000
29 F C 0.0000
30 A C -1.2809
31 E C -1.6601
32 I C 0.0000
33 A C 0.0000
34 D C -2.4955
35 G C -1.4635
36 T C -1.5727
37 G C -0.9440
38 L C -0.4912
39 A C -1.0154
40 E C -1.7893
41 A C 0.0000
42 F C 0.0000
43 V C 0.0000
44 T C 0.0000
45 A C 0.0000
46 A C 0.0000
47 L C 0.0000
48 L C 0.0000
49 G C 0.0000
50 Q C 0.0000
51 Q C 0.0000
52 A C -0.3481
53 L C 0.0000
54 P C -1.0789
55 A C -1.2939
56 D C -2.2574
57 A C 0.0000
58 A C 0.0000
59 R C -1.6094
60 L C -0.7023
61 V C 0.0000
62 G C 0.0000
63 A C 0.6621
64 Y C 0.4905 mutated: KC64Y
65 L C 0.0000
66 Y C 1.7227 mutated: DC66Y
67 L C 1.6590
68 Y C 2.2440 mutated: DC68Y
69 Y C 1.8784 mutated: EC69Y
70 Y C 1.5133 mutated: DC70Y
71 S C 1.1482
72 I C 0.0000
73 L C 0.4370
74 L C 0.4658
75 L C 0.0000
76 Q C -0.4860
77 M C 0.0000
78 I C 0.0000
79 P C 0.0000
80 L C -0.1351
81 R C 0.0000
82 G C 0.0000
83 C C 0.0000
84 I C 0.0000
85 D C -1.6123
86 D C -2.2287
87 R C -1.3025
88 I C 0.0000
89 P C 0.0000
90 T C -0.5818
91 D C 0.0000
92 P C 0.0000
93 T C 0.0000
94 M C 0.0000
95 Y C 0.0000
96 Q C 0.0000
97 F C 0.0000
98 Y C 0.0000
99 E C 0.0000
100 M C 0.0000
101 L C 0.0000
102 Q C 0.0000
103 V C 0.0000
104 Y C 0.0000
105 G C 0.0000
106 T C 0.0000
107 T C 0.0000
108 L C 0.0000
109 K C 0.0000
110 A C 0.0000
111 L C 0.0000
112 V C 0.0000
113 H C 0.0000
114 E C -0.0865
115 K C -0.8979
116 F C -0.6472
117 G C -0.2554
118 D C -0.5647
119 G C 0.0000
120 I C 0.0000
121 I C 0.0000
122 S C 0.0000
123 A C 0.0000
124 I C -0.6623
125 N C -1.2198
126 F C 0.0000
127 K C -1.7573
128 L C 0.0000
129 D C -2.5932
130 V C 0.0000
131 K C -2.5855
132 K C -1.9942
133 V C -0.8131
134 A C -0.8510
135 D C 0.0000
136 P C -1.3852
137 E C -2.2849
138 G C -1.7100
139 G C -1.3684
140 E C -1.4542
141 R C -1.1700
142 A C 0.0000
143 V C -1.0878
144 I C 0.0000
145 T C -1.0747
146 L C 0.0000
147 D C 0.0000
148 G C 0.0000
149 K C -1.0089
150 Y C 0.0000
151 L C -0.5703
152 P C -0.9045
153 T C -1.0323
154 K C -1.7891
155 P C -0.8900
156 F C -0.3775
1 M D 0.5881
2 I D 0.5334
3 Q D 0.0000
4 S D 0.0000
5 Q D 0.0000
6 I D 0.0000
7 N D -1.2360
8 R D -1.3114
9 N D -1.8317
10 I D -1.1943
11 R D 0.0000
12 L D -1.2035
13 D D -2.0914
14 L D 0.0000
15 A D 0.0000
16 D D -0.6597
17 A D -0.3545
18 I D 0.0000
19 L D 0.0000
20 L D -0.4257
21 S D -0.7772
22 K D 0.0000
23 A D 0.0000
24 K D -2.4400
25 K D -2.5718
26 D D -2.4734
27 L D -1.3207
28 S D 0.0000
29 F D 0.0000
30 A D -1.5563
31 E D -2.1564
32 I D 0.0000
33 A D 0.0000
34 D D -2.7365
35 G D -1.6123
36 T D -1.6643
37 G D -1.1058
38 L D -0.4927
39 A D -1.0587
40 E D -1.8193
41 A D 0.0000
42 F D 0.0000
43 V D 0.0000
44 T D 0.0000
45 A D 0.0000
46 A D 0.0000
47 L D 0.0000
48 L D 0.0000
49 G D 0.0000
50 Q D 0.0000
51 Q D 0.0000
52 A D -0.3950
53 L D 0.0000
54 P D -1.1218
55 A D -1.3384
56 D D -2.4044
57 A D 0.0000
58 A D 0.0000
59 R D -1.6777
60 L D -0.9439
61 V D 0.0000
62 G D 0.0000
63 A D 0.6923
64 Y D 0.6066 mutated: KD64Y
65 L D 0.0000
66 Y D 1.7912 mutated: DD66Y
67 L D 1.8749
68 Y D 2.4970 mutated: DD68Y
69 Y D 2.2405 mutated: ED69Y
70 Y D 1.7887 mutated: DD70Y
71 S D 0.0000
72 I D 0.8366
73 L D 0.4934
74 L D 0.0000
75 L D 0.0000
76 Q D -0.5930
77 M D 0.0000
78 I D 0.0000
79 P D 0.0000
80 L D 0.0000
81 R D 0.0000
82 G D 0.0000
83 C D 0.0000
84 I D 0.0000
85 D D -1.8657
86 D D -2.8046
87 R D -1.5835
88 I D 0.0000
89 P D 0.0000
90 T D 0.0000
91 D D 0.0000
92 P D 0.0000
93 T D 0.0000
94 M D 0.0000
95 Y D 0.0000
96 Q D 0.0000
97 F D 0.0000
98 Y D 0.0000
99 E D 0.0000
100 M D 0.0000
101 L D 0.0000
102 Q D 0.0000
103 V D 0.0000
104 Y D 0.0000
105 G D 0.0000
106 T D 0.0000
107 T D 0.0000
108 L D 0.0000
109 K D 0.0000
110 A D 0.0000
111 L D 0.0000
112 V D 0.0000
113 H D 0.0000
114 E D -0.2785
115 K D -1.2620
116 F D -0.7885
117 G D -0.4372
118 D D -0.5830
119 G D 0.0000
120 I D 0.0000
121 I D 0.0000
122 S D 0.0000
123 A D 0.0000
124 I D -0.6250
125 N D -1.1874
126 F D 0.0000
127 K D -1.7049
128 L D 0.0000
129 D D -2.5670
130 V D 0.0000
131 K D -2.6709
132 K D -2.2907
133 V D -0.9962
134 A D -0.9903
135 D D 0.0000
136 P D -1.3982
137 E D -2.3035
138 G D -1.7340
139 G D -1.4195
140 E D -1.6670
141 R D -1.3636
142 A D 0.0000
143 V D -1.2801
144 I D 0.0000
145 T D -1.1209
146 L D 0.0000
147 D D 0.0000
148 G D 0.0000
149 K D -0.8912
150 Y D 0.0000
151 L D -0.5765
152 P D -0.8799
153 T D -1.0558
154 K D -1.9334
155 P D -0.8286
156 F D -0.2712
1 M E 0.4847
2 I E 0.6511
3 Q E 0.0000
4 S E 0.0000
5 Q E 0.0000
6 I E -0.2696
7 N E -1.0937
8 R E -1.2186
9 N E -1.6895
10 I E -0.7462
11 R E 0.0000
12 L E -1.0775
13 D E -1.9443
14 L E 0.0000
15 A E 0.0000
16 D E 0.0000
17 A E -0.2732
18 I E 0.0000
19 L E 0.0000
20 L E -0.2777
21 S E -0.6203
22 K E 0.0000
23 A E 0.0000
24 K E -2.0942
25 K E -2.2150
26 D E -2.2701
27 L E 0.0000
28 S E 0.0000
29 F E 0.0000
30 A E -1.2985
31 E E -1.5049
32 I E 0.0000
33 A E 0.0000
34 D E -2.4762
35 G E -1.4635
36 T E -1.5722
37 G E -0.9662
38 L E -0.5495
39 A E -1.1118
40 E E -1.7783
41 A E 0.0000
42 F E 0.0000
43 V E 0.0000
44 T E 0.0000
45 A E 0.0000
46 A E 0.0000
47 L E 0.0000
48 L E 0.0000
49 G E 0.0000
50 Q E 0.0000
51 Q E 0.0000
52 A E -0.3407
53 L E 0.0000
54 P E -1.1040
55 A E -1.2888
56 D E -2.2866
57 A E 0.0000
58 A E 0.0000
59 R E -1.5293
60 L E -0.6688
61 V E 0.0000
62 G E 0.0000
63 A E 0.8293
64 Y E 0.8314 mutated: KE64Y
65 L E 0.0000
66 Y E 1.8659 mutated: DE66Y
67 L E 1.9849
68 Y E 2.6485 mutated: DE68Y
69 Y E 2.5599 mutated: EE69Y
70 Y E 2.3985 mutated: DE70Y
71 S E 0.0000
72 I E 1.1464
73 L E 0.8649
74 L E 0.7613
75 L E 0.0000
76 Q E -0.3787
77 M E 0.0000
78 I E 0.0000
79 P E 0.0000
80 L E 0.0000
81 R E 0.0000
82 G E 0.0000
83 C E 0.0000
84 I E 0.0000
85 D E -2.6942
86 D E -3.0318
87 R E -1.6415
88 I E -0.8469
89 P E 0.0000
90 T E -0.6440
91 D E 0.0000
92 P E 0.0000
93 T E 0.0000
94 M E 0.0000
95 Y E 0.0000
96 Q E 0.0000
97 F E 0.0000
98 Y E 0.0000
99 E E 0.0000
100 M E 0.0000
101 L E 0.0000
102 Q E 0.0000
103 V E 0.0000
104 Y E 0.0000
105 G E 0.0000
106 T E 0.0000
107 T E 0.0000
108 L E 0.0000
109 K E 0.0000
110 A E 0.0000
111 L E 0.0000
112 V E 0.0000
113 H E 0.0000
114 E E -0.2873
115 K E -1.2785
116 F E -0.8243
117 G E -0.4643
118 D E -0.6098
119 G E 0.0000
120 I E 0.0000
121 I E 0.0000
122 S E 0.0000
123 A E -0.4079
124 I E -0.6722
125 N E -1.3078
126 F E 0.0000
127 K E -2.1925
128 L E 0.0000
129 D E -2.6660
130 V E 0.0000
131 K E -2.4734
132 K E -1.8127
133 V E -0.6708
134 A E -0.8157
135 D E 0.0000
136 P E -1.3815
137 E E -2.3005
138 G E -1.7403
139 G E -1.3765
140 E E -1.4028
141 R E -1.0890
142 A E 0.0000
143 V E -1.0622
144 I E 0.0000
145 T E -1.0814
146 L E 0.0000
147 D E -1.4987
148 G E 0.0000
149 K E -1.1108
150 Y E 0.0000
151 L E -0.5906
152 P E -0.9198
153 T E -1.0136
154 K E -1.8699
155 P E -0.7918
156 F E -0.1620
1 M F 0.4812
2 I F 0.5555
3 Q F 0.0000
4 S F 0.0000
5 Q F 0.0000
6 I F -0.2349
7 N F -1.0405
8 R F -1.2166
9 N F -1.6713
10 I F -0.7520
11 R F 0.0000
12 L F -1.1717
13 D F -2.0303
14 L F 0.0000
15 A F 0.0000
16 D F -0.8545
17 A F -0.3697
18 I F 0.0000
19 L F 0.0000
20 L F -0.3661
21 S F -0.6568
22 K F 0.0000
23 A F 0.0000
24 K F -2.3836
25 K F -2.4845
26 D F -2.4565
27 L F 0.0000
28 S F 0.0000
29 F F 0.0000
30 A F -1.4577
31 E F -1.8194
32 I F 0.0000
33 A F 0.0000
34 D F -2.5940
35 G F -1.5016
36 T F -1.5558
37 G F -0.9326
38 L F -0.5239
39 A F -1.1002
40 E F -1.8922
41 A F 0.0000
42 F F 0.0000
43 V F 0.0000
44 T F 0.0000
45 A F 0.0000
46 A F 0.0000
47 L F 0.0000
48 L F 0.0000
49 G F 0.0000
50 Q F 0.0000
51 Q F 0.0000
52 A F -0.3701
53 L F 0.0000
54 P F -1.1246
55 A F -1.3691
56 D F -2.3070
57 A F 0.0000
58 A F 0.0000
59 R F -1.6453
60 L F -0.7221
61 V F 0.0000
62 G F 0.0000
63 A F 0.6725
64 Y F 0.5343 mutated: KF64Y
65 L F 0.0000
66 Y F 1.7337 mutated: DF66Y
67 L F 1.8563
68 Y F 2.5594 mutated: DF68Y
69 Y F 2.4069 mutated: EF69Y
70 Y F 2.2375 mutated: DF70Y
71 S F 0.0000
72 I F 0.0000
73 L F 0.0000
74 L F 0.5417
75 L F 0.0000
76 Q F -0.6008
77 M F 0.0000
78 I F 0.0000
79 P F 0.0000
80 L F -0.0499
81 R F 0.0000
82 G F 0.0000
83 C F 0.0000
84 I F 0.0000
85 D F -2.1719
86 D F -3.0198
87 R F -2.0135
88 I F 0.0000
89 P F 0.0000
90 T F 0.0000
91 D F 0.0000
92 P F 0.0000
93 T F 0.0000
94 M F 0.0000
95 Y F 0.0000
96 Q F 0.0000
97 F F 0.0000
98 Y F 0.0000
99 E F 0.0000
100 M F 0.0000
101 L F 0.0000
102 Q F 0.0000
103 V F 0.0000
104 Y F 0.0000
105 G F 0.0000
106 T F 0.0000
107 T F 0.0000
108 L F 0.0000
109 K F 0.0000
110 A F 0.0000
111 L F 0.0000
112 V F 0.0000
113 H F 0.0000
114 E F -0.2589
115 K F -1.2440
116 F F -0.7839
117 G F -0.4519
118 D F -0.6062
119 G F 0.0000
120 I F 0.0000
121 I F 0.0000
122 S F 0.0000
123 A F 0.0000
124 I F -0.5943
125 N F -1.1666
126 F F 0.0000
127 K F -1.8702
128 L F 0.0000
129 D F -2.6262
130 V F 0.0000
131 K F -2.7431
132 K F -2.3437
133 V F -1.0006
134 A F -0.9359
135 D F 0.0000
136 P F -1.3817
137 E F -2.2744
138 G F -1.6799
139 G F -1.3602
140 E F -1.5953
141 R F -1.3288
142 A F 0.0000
143 V F -1.1865
144 I F 0.0000
145 T F -0.9594
146 L F 0.0000
147 D F -1.1993
148 G F 0.0000
149 K F -1.1964
150 Y F 0.0000
151 L F 0.0000
152 P F -1.0247
153 T F -1.0954
154 K F -1.9942
155 P F -0.9149
156 F F -0.4788
1 M G 0.3891
2 I G 0.4020
3 Q G -0.2082
4 S G 0.0000
5 Q G 0.0000
6 I G -0.2271
7 N G -1.0297
8 R G -1.1847
9 N G -1.7068
10 I G -0.8178
11 R G 0.0000
12 L G -1.0814
13 D G -1.9556
14 L G 0.0000
15 A G 0.0000
16 D G 0.0000
17 A G -0.2648
18 I G 0.0000
19 L G 0.0000
20 L G -0.2683
21 S G -0.6351
22 K G 0.0000
23 A G 0.0000
24 K G -2.0760
25 K G -2.3073
26 D G -2.3746
27 L G 0.0000
28 S G -0.7669
29 F G 0.0000
30 A G -1.3275
31 E G -1.6131
32 I G 0.0000
33 A G 0.0000
34 D G -2.4932
35 G G -1.4563
36 T G -1.5148
37 G G -0.9599
38 L G -0.5386
39 A G -1.0780
40 E G -1.8186
41 A G 0.0000
42 F G 0.0000
43 V G 0.0000
44 T G 0.0000
45 A G 0.0000
46 A G 0.0000
47 L G 0.0000
48 L G 0.0000
49 G G 0.0000
50 Q G 0.0000
51 Q G 0.0000
52 A G -0.3889
53 L G 0.0000
54 P G -0.9028
55 A G -1.1905
56 D G -2.1472
57 A G 0.0000
58 A G 0.0000
59 R G -1.3492
60 L G -0.4603
61 V G 0.0000
62 G G 0.0000
63 A G 0.8313
64 Y G 0.6212 mutated: KG64Y
65 L G 0.0000
66 Y G 1.8321 mutated: DG66Y
67 L G 1.9175
68 Y G 2.7648 mutated: DG68Y
69 Y G 2.3970 mutated: EG69Y
70 Y G 1.9961 mutated: DG70Y
71 S G 0.0000
72 I G 1.1121
73 L G 0.6074
74 L G 0.0000
75 L G 0.0000
76 Q G -0.4930
77 M G 0.0000
78 I G 0.0000
79 P G 0.0000
80 L G 0.0000
81 R G 0.0000
82 G G 0.0000
83 C G 0.0000
84 I G 0.0000
85 D G -2.8007
86 D G -3.2636
87 R G -1.7842
88 I G 0.0000
89 P G 0.0000
90 T G -0.8278
91 D G 0.0000
92 P G 0.0000
93 T G 0.0000
94 M G 0.0000
95 Y G 0.0000
96 Q G 0.0000
97 F G 0.0000
98 Y G 0.0000
99 E G 0.0000
100 M G 0.0000
101 L G 0.0000
102 Q G 0.0000
103 V G 0.0000
104 Y G 0.0000
105 G G 0.0000
106 T G 0.0000
107 T G 0.0000
108 L G 0.0000
109 K G 0.0000
110 A G 0.0000
111 L G 0.0000
112 V G 0.0000
113 H G 0.0000
114 E G -0.2158
115 K G -1.1997
116 F G -0.5095
117 G G -0.3627
118 D G -0.5068
119 G G 0.0000
120 I G 0.0000
121 I G 0.0000
122 S G 0.0000
123 A G 0.0000
124 I G -0.5628
125 N G -1.1222
126 F G 0.0000
127 K G -1.8834
128 L G 0.0000
129 D G -2.6369
130 V G 0.0000
131 K G -2.7396
132 K G -2.2443
133 V G -1.0149
134 A G -0.9883
135 D G -1.5452
136 P G -1.4701
137 E G -2.3529
138 G G -1.7902
139 G G -1.4858
140 E G -1.6147
141 R G -1.3977
142 A G 0.0000
143 V G -1.3584
144 I G 0.0000
145 T G -1.1939
146 L G 0.0000
147 D G 0.0000
148 G G 0.0000
149 K G -0.8521
150 Y G -0.4045
151 L G -0.4270
152 P G -0.6205
153 T G -0.9800
154 K G -1.9043
155 P G -0.8382
156 F G -0.1709
1 M H 0.7145
2 I H 0.7404
3 Q H 0.0000
4 S H 0.0000
5 Q H 0.0000
6 I H -0.2301
7 N H -1.0358
8 R H -1.1891
9 N H -1.6656
10 I H -0.7946
11 R H 0.0000
12 L H -1.0831
13 D H -1.9757
14 L H 0.0000
15 A H 0.0000
16 D H 0.0000
17 A H -0.2820
18 I H 0.0000
19 L H 0.0000
20 L H -0.3090
21 S H -0.5807
22 K H 0.0000
23 A H 0.0000
24 K H -1.9001
25 K H -2.2684
26 D H -2.3013
27 L H 0.0000
28 S H -1.0256
29 F H 0.0000
30 A H -1.5323
31 E H -2.3719
32 I H 0.0000
33 A H 0.0000
34 D H -2.6887
35 G H -1.5931
36 T H -1.5891
37 G H -0.8868
38 L H -0.3747
39 A H -0.7449
40 E H -1.3342
41 A H 0.0000
42 F H 0.0000
43 V H 0.0000
44 T H 0.0000
45 A H 0.0000
46 A H 0.0000
47 L H 0.0000
48 L H 0.0000
49 G H 0.0000
50 Q H 0.0000
51 Q H 0.0000
52 A H -0.3977
53 L H 0.0000
54 P H -1.1238
55 A H -1.3429
56 D H -2.2995
57 A H 0.0000
58 A H 0.0000
59 R H -1.8040
60 L H -0.7905
61 V H 0.0000
62 G H 0.0000
63 A H 0.6282
64 Y H 0.3260 mutated: KH64Y
65 L H 0.0000
66 Y H 1.7142 mutated: DH66Y
67 L H 1.8028
68 Y H 2.7550 mutated: DH68Y
69 Y H 2.4028 mutated: EH69Y
70 Y H 2.2064 mutated: DH70Y
71 S H 0.0000
72 I H 0.0000
73 L H 0.0000
74 L H 0.0000
75 L H 0.0000
76 Q H -0.6234
77 M H 0.0000
78 I H 0.0000
79 P H 0.0000
80 L H -0.0474
81 R H 0.0000
82 G H 0.0000
83 C H 0.0000
84 I H 0.0000
85 D H -2.4193
86 D H -2.4661
87 R H -1.5866
88 I H 0.0000
89 P H 0.0000
90 T H -0.6468
91 D H 0.0000
92 P H 0.0000
93 T H 0.0000
94 M H 0.0000
95 Y H 0.0000
96 Q H 0.0000
97 F H 0.0000
98 Y H 0.0000
99 E H 0.0000
100 M H 0.0000
101 L H 0.0000
102 Q H 0.0000
103 V H 0.0000
104 Y H 0.0000
105 G H 0.0000
106 T H 0.0000
107 T H 0.0000
108 L H 0.0000
109 K H 0.0000
110 A H 0.0000
111 L H 0.0000
112 V H 0.0000
113 H H 0.0000
114 E H -0.3328
115 K H -1.2386
116 F H -0.7124
117 G H -0.3944
118 D H -0.5212
119 G H 0.0000
120 I H 0.0000
121 I H 0.0000
122 S H 0.0000
123 A H -0.3208
124 I H -0.6248
125 N H -1.1977
126 F H 0.0000
127 K H -1.7095
128 L H 0.0000
129 D H -2.2538
130 V H 0.0000
131 K H -2.6307
132 K H -2.2804
133 V H -1.0063
134 A H -0.9846
135 D H -1.5084
136 P H -1.4468
137 E H -2.3134
138 G H -1.7115
139 G H -1.4090
140 E H -1.6358
141 R H -1.3501
142 A H 0.0000
143 V H -1.1481
144 I H 0.0000
145 T H -1.0154
146 L H 0.0000
147 D H 0.0000
148 G H 0.0000
149 K H -0.8683
150 Y H -0.4476
151 L H -0.4009
152 P H -0.7054
153 T H -0.9397
154 K H -1.8844
155 P H -0.8730
156 F H -0.2623
1 M I 0.5063
2 I I 0.6484
3 Q I 0.0000
4 S I 0.0000
5 Q I 0.0000
6 I I -0.2575
7 N I -1.0808
8 R I -1.2016
9 N I -1.6614
10 I I -0.7661
11 R I 0.0000
12 L I -1.0723
13 D I -1.9638
14 L I 0.0000
15 A I 0.0000
16 D I 0.0000
17 A I -0.2779
18 I I 0.0000
19 L I 0.0000
20 L I -0.2589
21 S I -0.5941
22 K I 0.0000
23 A I 0.0000
24 K I -1.9170
25 K I -2.4613
26 D I -2.4307
27 L I 0.0000
28 S I 0.0000
29 F I 0.0000
30 A I -1.3577
31 E I -1.6545
32 I I 0.0000
33 A I 0.0000
34 D I -2.6020
35 G I -1.4984
36 T I -1.5472
37 G I -0.9879
38 L I -0.5908
39 A I -1.0777
40 E I -1.7840
41 A I 0.0000
42 F I 0.0000
43 V I 0.0000
44 T I 0.0000
45 A I 0.0000
46 A I 0.0000
47 L I 0.0000
48 L I 0.0000
49 G I 0.0000
50 Q I 0.0000
51 Q I 0.0000
52 A I -0.3773
53 L I 0.0000
54 P I -1.0784
55 A I -1.3140
56 D I -2.2934
57 A I 0.0000
58 A I 0.0000
59 R I -1.6521
60 L I -0.5352
61 V I 0.0000
62 G I 0.0000
63 A I 0.6889
64 Y I 0.5249 mutated: KI64Y
65 L I 0.0000
66 Y I 1.6949 mutated: DI66Y
67 L I 1.6717
68 Y I 2.2332 mutated: DI68Y
69 Y I 1.8266 mutated: EI69Y
70 Y I 1.4885 mutated: DI70Y
71 S I 1.1162
72 I I 0.0000
73 L I 0.3456
74 L I 0.0000
75 L I 0.0000
76 Q I -0.5545
77 M I 0.0000
78 I I 0.0000
79 P I 0.0000
80 L I -0.0616
81 R I 0.0000
82 G I 0.0000
83 C I 0.0000
84 I I 0.0000
85 D I -1.6058
86 D I -2.3947
87 R I -1.3737
88 I I 0.0000
89 P I 0.0000
90 T I -0.6407
91 D I 0.0000
92 P I 0.0000
93 T I 0.0000
94 M I 0.0000
95 Y I 0.0000
96 Q I 0.0000
97 F I 0.0000
98 Y I 0.0000
99 E I 0.0000
100 M I 0.0000
101 L I 0.0000
102 Q I 0.0000
103 V I 0.0000
104 Y I 0.0000
105 G I 0.0000
106 T I 0.0000
107 T I 0.0000
108 L I 0.0000
109 K I 0.0000
110 A I 0.0000
111 L I 0.0000
112 V I 0.0000
113 H I 0.0000
114 E I -0.3056
115 K I -1.3377
116 F I -0.8120
117 G I -0.4944
118 D I -0.6501
119 G I 0.0000
120 I I 0.0000
121 I I 0.0000
122 S I 0.0000
123 A I -0.3784
124 I I -0.5809
125 N I -1.2044
126 F I 0.0000
127 K I -1.7870
128 L I 0.0000
129 D I -1.8907
130 V I 0.0000
131 K I -1.9893
132 K I -2.1554
133 V I -0.7305
134 A I -0.8777
135 D I 0.0000
136 P I -1.3611
137 E I -2.2876
138 G I -1.7060
139 G I -1.3405
140 E I -1.5641
141 R I -1.2053
142 A I 0.0000
143 V I -0.8961
144 I I 0.0000
145 T I -0.9441
146 L I 0.0000
147 D I -1.3881
148 G I 0.0000
149 K I -1.2275
150 Y I -0.7547
151 L I 0.0000
152 P I -1.0123
153 T I -1.0818
154 K I -1.9210
155 P I -0.7937
156 F I -0.1888
1 M J 0.4832
2 I J 0.5282
3 Q J 0.0000
4 S J 0.0000
5 Q J 0.0000
6 I J -0.2940
7 N J -1.1275
8 R J -1.2660
9 N J -1.8038
10 I J -1.0172
11 R J 0.0000
12 L J -1.2470
13 D J -2.0957
14 L J 0.0000
15 A J 0.0000
16 D J -0.7945
17 A J -0.3374
18 I J 0.0000
19 L J 0.0000
20 L J -0.2118
21 S J -0.5050
22 K J 0.0000
23 A J 0.0000
24 K J -1.8766
25 K J -2.2701
26 D J -2.2251
27 L J -1.2430
28 S J 0.0000
29 F J 0.0000
30 A J -1.7189
31 E J -2.4503
32 I J 0.0000
33 A J 0.0000
34 D J -2.8313
35 G J -1.6494
36 T J -1.6622
37 G J -0.9350
38 L J -0.4992
39 A J -1.0315
40 E J -1.8102
41 A J 0.0000
42 F J 0.0000
43 V J 0.0000
44 T J 0.0000
45 A J 0.0000
46 A J 0.0000
47 L J 0.0000
48 L J 0.0000
49 G J 0.0000
50 Q J 0.0000
51 Q J 0.0000
52 A J -0.3626
53 L J 0.0000
54 P J -1.0300
55 A J -1.1992
56 D J -2.1694
57 A J 0.0000
58 A J 0.0000
59 R J -1.3293
60 L J -0.7090
61 V J 0.0000
62 G J 0.0000
63 A J 0.8139
64 Y J 0.5964 mutated: KJ64Y
65 L J 0.0000
66 Y J 1.8331 mutated: DJ66Y
67 L J 1.9873
68 Y J 2.8254 mutated: DJ68Y
69 Y J 2.5524 mutated: EJ69Y
70 Y J 2.2579 mutated: DJ70Y
71 S J 0.0000
72 I J 1.1170
73 L J 0.0000
74 L J 0.0000
75 L J 0.0000
76 Q J -0.4774
77 M J 0.0000
78 I J 0.0000
79 P J 0.0000
80 L J 0.0000
81 R J 0.0000
82 G J 0.0000
83 C J 0.0000
84 I J 0.0000
85 D J -2.8117
86 D J -3.2081
87 R J -1.8440
88 I J 0.0000
89 P J 0.0000
90 T J -0.6995
91 D J 0.0000
92 P J 0.0000
93 T J 0.0000
94 M J 0.0000
95 Y J 0.0000
96 Q J 0.0000
97 F J 0.0000
98 Y J 0.0000
99 E J 0.0000
100 M J 0.0000
101 L J 0.0000
102 Q J 0.0000
103 V J 0.0000
104 Y J 0.0000
105 G J 0.0000
106 T J 0.0000
107 T J 0.0000
108 L J 0.0000
109 K J 0.0000
110 A J 0.0000
111 L J 0.0000
112 V J 0.0000
113 H J 0.0000
114 E J -0.2964
115 K J -1.2255
116 F J -0.8119
117 G J -0.4490
118 D J -0.5993
119 G J 0.0000
120 I J 0.0000
121 I J 0.0000
122 S J 0.0000
123 A J -0.3222
124 I J -0.5906
125 N J -1.2129
126 F J 0.0000
127 K J -1.8510
128 L J 0.0000
129 D J -2.6094
130 V J 0.0000
131 K J -2.6496
132 K J -2.1245
133 V J -0.8903
134 A J -0.9459
135 D J 0.0000
136 P J -1.4166
137 E J -2.3350
138 G J -1.8270
139 G J -1.4594
140 E J -1.6428
141 R J -1.4073
142 A J 0.0000
143 V J -1.3069
144 I J 0.0000
145 T J -1.1451
146 L J 0.0000
147 D J -1.1421
148 G J 0.0000
149 K J -1.0006
150 Y J 0.0000
151 L J -0.6072
152 P J -0.9506
153 T J -1.0923
154 K J -1.9576
155 P J -0.8968
156 F J -0.3795

 

Laboratory of Theory of Biopolymers 2015