Project name: 4e8f87c6bccb576
Status: done
submitted: 2018-06-12 17:30:55, status changed: 2018-06-12 17:42:00
Settings
Chain sequence(s)
|
A: MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLNDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEY
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.1109
-
Maximal score value
-
1.0615
-
Average score
-
-0.7055
-
Total score value
-
-261.0205
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
0.9166 |
|
2 |
A |
A |
0.3013 |
|
3 |
S |
A |
-0.0409 |
|
4 |
L |
A |
0.2212 |
|
5 |
P |
A |
-0.1444 |
|
6 |
V |
A |
0.0114 |
|
7 |
L |
A |
-0.0623 |
|
8 |
Q |
A |
0.0000 |
|
9 |
K |
A |
-2.0231 |
|
10 |
E |
A |
-1.9841 |
|
11 |
S |
A |
-1.3958 |
|
12 |
V |
A |
0.0000 |
|
13 |
F |
A |
0.0000 |
|
14 |
Q |
A |
-2.0198 |
|
15 |
S |
A |
-1.6521 |
|
16 |
G |
A |
-1.1355 |
|
17 |
A |
A |
-0.4849 |
|
18 |
H |
A |
-1.0241 |
|
19 |
A |
A |
0.0000 |
|
20 |
Y |
A |
0.0000 |
|
21 |
R |
A |
0.0000 |
|
22 |
I |
A |
0.0000 |
|
23 |
P |
A |
0.0000 |
|
24 |
A |
A |
0.0000 |
|
25 |
L |
A |
0.0000 |
|
26 |
L |
A |
0.0000 |
|
27 |
Y |
A |
-0.5046 |
|
28 |
L |
A |
0.0000 |
|
29 |
P |
A |
-1.0840 |
|
30 |
G |
A |
-1.1587 |
|
31 |
Q |
A |
-1.5111 |
|
32 |
Q |
A |
-1.9201 |
|
33 |
S |
A |
0.0000 |
|
34 |
L |
A |
0.0000 |
|
35 |
L |
A |
0.0000 |
|
36 |
A |
A |
0.0000 |
|
37 |
F |
A |
0.0000 |
|
38 |
A |
A |
0.0000 |
|
39 |
E |
A |
0.0000 |
|
40 |
Q |
A |
-0.3253 |
|
41 |
R |
A |
0.0000 |
|
42 |
A |
A |
-0.9509 |
|
43 |
S |
A |
-1.4445 |
|
44 |
K |
A |
-2.3504 |
|
45 |
K |
A |
-2.8512 |
|
46 |
D |
A |
-2.9079 |
|
47 |
E |
A |
-2.4409 |
|
48 |
H |
A |
-2.0266 |
|
49 |
A |
A |
0.0000 |
|
50 |
E |
A |
-1.2808 |
|
51 |
L |
A |
-0.4094 |
|
52 |
I |
A |
0.0000 |
|
53 |
V |
A |
0.0000 |
|
54 |
L |
A |
-0.8528 |
|
55 |
R |
A |
-1.4428 |
|
56 |
R |
A |
-1.7145 |
|
57 |
G |
A |
0.0000 |
|
58 |
D |
A |
-2.0632 |
|
59 |
Y |
A |
-1.5540 |
|
60 |
D |
A |
-1.6044 |
|
61 |
A |
A |
-0.8906 |
|
62 |
P |
A |
-0.6318 |
|
63 |
T |
A |
-0.6648 |
|
64 |
H |
A |
-0.9402 |
|
65 |
Q |
A |
-1.3309 |
|
66 |
V |
A |
0.0000 |
|
67 |
Q |
A |
-2.0894 |
|
68 |
W |
A |
-1.5892 |
|
69 |
Q |
A |
-2.0394 |
|
70 |
A |
A |
-1.3882 |
|
71 |
Q |
A |
-1.5926 |
|
72 |
E |
A |
-1.9778 |
|
73 |
V |
A |
-0.4968 |
|
74 |
V |
A |
0.0000 |
|
75 |
A |
A |
-0.5919 |
|
76 |
Q |
A |
-0.9788 |
|
77 |
A |
A |
0.0000 |
|
78 |
R |
A |
-2.2877 |
|
79 |
L |
A |
-2.0581 |
|
80 |
D |
A |
-2.3841 |
|
81 |
G |
A |
-1.8439 |
|
82 |
H |
A |
-1.7400 |
|
83 |
R |
A |
0.0000 |
|
84 |
S |
A |
0.0000 |
|
85 |
M |
A |
-0.4446 |
|
86 |
N |
A |
0.0000 |
|
87 |
P |
A |
0.0000 |
|
88 |
C |
A |
0.0000 |
|
89 |
P |
A |
0.0000 |
|
90 |
L |
A |
0.0000 |
|
91 |
Y |
A |
0.0293 |
|
92 |
D |
A |
0.0000 |
|
93 |
A |
A |
-0.7110 |
|
94 |
Q |
A |
-1.3408 |
|
95 |
T |
A |
-0.7263 |
|
96 |
G |
A |
-0.6266 |
|
97 |
T |
A |
-0.3873 |
|
98 |
L |
A |
0.0000 |
|
99 |
F |
A |
0.0000 |
|
100 |
L |
A |
0.0000 |
|
101 |
F |
A |
0.0000 |
|
102 |
F |
A |
0.0000 |
|
103 |
I |
A |
0.0000 |
|
104 |
A |
A |
0.0000 |
|
105 |
I |
A |
0.0000 |
|
106 |
P |
A |
-0.8327 |
|
107 |
G |
A |
-1.3590 |
|
108 |
Q |
A |
-1.7438 |
|
109 |
V |
A |
-0.9501 |
|
110 |
T |
A |
-1.8883 |
|
111 |
E |
A |
-2.4299 |
|
112 |
Q |
A |
-2.5048 |
|
113 |
Q |
A |
-2.1470 |
|
114 |
Q |
A |
0.0000 |
|
115 |
L |
A |
-1.9691 |
|
116 |
Q |
A |
-2.2858 |
|
117 |
T |
A |
-1.4315 |
|
118 |
R |
A |
-1.8052 |
|
119 |
A |
A |
-0.9351 |
|
120 |
N |
A |
-0.8304 |
|
121 |
V |
A |
-0.1079 |
|
122 |
T |
A |
0.0000 |
|
123 |
R |
A |
-1.2093 |
|
124 |
L |
A |
0.0000 |
|
125 |
C |
A |
0.0000 |
|
126 |
Q |
A |
0.0000 |
|
127 |
V |
A |
0.0000 |
|
128 |
T |
A |
-0.2948 |
|
129 |
S |
A |
0.0000 |
|
130 |
T |
A |
-0.6037 |
|
131 |
D |
A |
-1.0537 |
|
132 |
H |
A |
-1.0875 |
|
133 |
G |
A |
-1.2484 |
|
134 |
R |
A |
-2.0942 |
|
135 |
T |
A |
-1.1273 |
|
136 |
W |
A |
-0.6195 |
|
137 |
S |
A |
-0.4169 |
|
138 |
S |
A |
-0.8592 |
|
139 |
P |
A |
-1.4016 |
|
140 |
R |
A |
-1.5046 |
|
141 |
D |
A |
-1.7264 |
|
142 |
L |
A |
0.0000 |
|
143 |
T |
A |
0.0000 |
|
144 |
D |
A |
-2.0249 |
|
145 |
A |
A |
-1.0126 |
|
146 |
A |
A |
0.0000 |
|
147 |
I |
A |
0.0000 |
|
148 |
G |
A |
-1.2761 |
|
149 |
P |
A |
-1.0504 |
|
150 |
A |
A |
0.0000 |
|
151 |
Y |
A |
-1.4850 |
|
152 |
R |
A |
-2.3934 |
|
153 |
E |
A |
-1.9388 |
|
154 |
W |
A |
0.0000 |
|
155 |
S |
A |
0.0000 |
|
156 |
T |
A |
0.0000 |
|
157 |
F |
A |
0.0000 |
|
158 |
A |
A |
0.0000 |
|
159 |
V |
A |
0.0000 |
|
160 |
G |
A |
0.0000 |
|
161 |
P |
A |
0.0000 |
|
162 |
G |
A |
0.0000 |
|
163 |
H |
A |
0.0000 |
|
164 |
C |
A |
0.0000 |
|
165 |
L |
A |
0.0301 |
|
166 |
Q |
A |
0.0000 |
|
167 |
L |
A |
0.0000 |
|
168 |
N |
A |
-2.1106 |
|
169 |
D |
A |
-2.3618 |
|
170 |
R |
A |
-2.4785 |
|
171 |
A |
A |
-1.8884 |
|
172 |
R |
A |
-1.9464 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
V |
A |
0.0000 |
|
176 |
V |
A |
0.0000 |
|
177 |
P |
A |
0.0000 |
|
178 |
A |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
A |
A |
0.0000 |
|
181 |
Y |
A |
0.0000 |
|
182 |
R |
A |
-1.2427 |
|
183 |
K |
A |
-1.0579 |
|
184 |
L |
A |
0.2579 |
|
185 |
H |
A |
-0.1896 |
|
186 |
P |
A |
0.1975 |
|
187 |
I |
A |
1.0615 |
|
188 |
Q |
A |
-0.6123 |
|
189 |
R |
A |
-1.5378 |
|
190 |
P |
A |
0.0000 |
|
191 |
I |
A |
-0.6359 |
|
192 |
P |
A |
0.0000 |
|
193 |
S |
A |
0.0000 |
|
194 |
A |
A |
0.0000 |
|
195 |
F |
A |
0.0000 |
|
196 |
C |
A |
0.0000 |
|
197 |
F |
A |
0.0000 |
|
198 |
L |
A |
0.0000 |
|
199 |
S |
A |
0.0000 |
|
200 |
H |
A |
-1.6643 |
|
201 |
D |
A |
-1.5360 |
|
202 |
H |
A |
-1.4941 |
|
203 |
G |
A |
0.0000 |
|
204 |
R |
A |
-2.1884 |
|
205 |
T |
A |
-1.2073 |
|
206 |
W |
A |
0.0000 |
|
207 |
A |
A |
-0.4433 |
|
208 |
R |
A |
-0.7442 |
|
209 |
G |
A |
0.0000 |
|
210 |
H |
A |
-1.0319 |
|
211 |
F |
A |
-0.4026 |
|
212 |
V |
A |
-0.7668 |
|
213 |
A |
A |
-0.9332 |
|
214 |
Q |
A |
-1.2446 |
|
215 |
D |
A |
-1.0252 |
|
216 |
T |
A |
0.0000 |
|
217 |
L |
A |
0.0000 |
|
218 |
E |
A |
0.0000 |
|
219 |
C |
A |
0.0000 |
|
220 |
Q |
A |
0.0000 |
|
221 |
V |
A |
0.0000 |
|
222 |
A |
A |
0.0000 |
|
223 |
E |
A |
-1.1712 |
|
224 |
V |
A |
0.0000 |
|
225 |
E |
A |
-2.5813 |
|
229 |
Q |
A |
-2.4083 |
|
230 |
R |
A |
-3.1109 |
|
231 |
V |
A |
0.0000 |
|
232 |
V |
A |
0.0000 |
|
233 |
T |
A |
0.0000 |
|
234 |
L |
A |
0.0000 |
|
235 |
N |
A |
0.0000 |
|
236 |
A |
A |
0.0000 |
|
237 |
R |
A |
-0.7535 |
|
238 |
S |
A |
0.0000 |
|
239 |
H |
A |
-1.9139 |
|
240 |
L |
A |
-1.4090 |
|
241 |
R |
A |
-2.1714 |
|
242 |
A |
A |
0.0000 |
|
243 |
R |
A |
0.0000 |
|
244 |
V |
A |
0.0000 |
|
245 |
Q |
A |
0.0000 |
|
246 |
A |
A |
0.0000 |
|
247 |
Q |
A |
-1.6007 |
|
248 |
S |
A |
0.0000 |
|
249 |
T |
A |
-1.7739 |
|
250 |
N |
A |
-1.5998 |
|
251 |
D |
A |
-1.6923 |
|
252 |
G |
A |
0.0000 |
|
253 |
L |
A |
-0.9310 |
|
254 |
D |
A |
-1.6510 |
|
255 |
F |
A |
-1.6472 |
|
256 |
Q |
A |
-2.3263 |
|
257 |
E |
A |
-2.8288 |
|
258 |
S |
A |
-1.6929 |
|
259 |
Q |
A |
-1.5734 |
|
260 |
L |
A |
-0.7492 |
|
261 |
V |
A |
0.0000 |
|
262 |
K |
A |
-2.7206 |
|
263 |
K |
A |
-2.6092 |
|
264 |
L |
A |
0.0000 |
|
265 |
V |
A |
-0.9372 |
|
266 |
E |
A |
0.0000 |
|
267 |
P |
A |
0.0000 |
|
268 |
P |
A |
-1.0707 |
|
269 |
P |
A |
-1.1996 |
|
270 |
Q |
A |
-1.8097 |
|
271 |
G |
A |
0.0000 |
|
272 |
C |
A |
0.0000 |
|
273 |
Q |
A |
0.0000 |
|
274 |
G |
A |
0.0000 |
|
275 |
S |
A |
0.0000 |
|
276 |
V |
A |
0.0000 |
|
277 |
I |
A |
0.0000 |
|
278 |
S |
A |
-0.2586 |
|
279 |
F |
A |
0.0000 |
|
280 |
P |
A |
-0.7489 |
|
281 |
S |
A |
-1.1513 |
|
282 |
P |
A |
-1.1336 |
|
283 |
R |
A |
-1.9425 |
|
288 |
S |
A |
-1.0954 |
|
289 |
P |
A |
-1.3354 |
|
290 |
A |
A |
-1.1627 |
|
291 |
Q |
A |
-1.3576 |
|
292 |
W |
A |
0.0000 |
|
293 |
L |
A |
0.0000 |
|
294 |
L |
A |
0.0000 |
|
295 |
Y |
A |
0.0000 |
|
296 |
T |
A |
0.0000 |
|
297 |
H |
A |
0.0000 |
|
298 |
P |
A |
0.0000 |
|
299 |
T |
A |
-0.6239 |
|
300 |
H |
A |
-0.7683 |
|
301 |
S |
A |
-0.5564 |
|
302 |
W |
A |
0.0485 |
|
303 |
Q |
A |
-1.1429 |
|
304 |
R |
A |
-1.3889 |
|
305 |
A |
A |
-1.5292 |
|
306 |
D |
A |
-1.2610 |
|
307 |
L |
A |
0.0000 |
|
308 |
G |
A |
0.0000 |
|
309 |
A |
A |
0.0000 |
|
310 |
Y |
A |
0.0000 |
|
311 |
L |
A |
0.0000 |
|
312 |
N |
A |
0.0000 |
|
313 |
P |
A |
-1.3361 |
|
314 |
R |
A |
-2.1877 |
|
315 |
P |
A |
0.0000 |
|
316 |
P |
A |
-1.0592 |
|
317 |
A |
A |
-1.2123 |
|
318 |
P |
A |
-1.7165 |
|
319 |
E |
A |
-2.5336 |
|
320 |
A |
A |
-1.7637 |
|
321 |
W |
A |
0.0000 |
|
322 |
S |
A |
-1.4226 |
|
323 |
E |
A |
-2.0726 |
|
324 |
P |
A |
-0.9107 |
|
325 |
V |
A |
0.0544 |
|
326 |
L |
A |
0.2600 |
|
327 |
L |
A |
0.0000 |
|
328 |
A |
A |
0.0000 |
|
329 |
K |
A |
-1.7860 |
|
330 |
G |
A |
-1.8608 |
|
331 |
S |
A |
-2.0652 |
|
332 |
C |
A |
0.0000 |
|
333 |
A |
A |
0.0000 |
|
334 |
Y |
A |
0.0000 |
|
335 |
S |
A |
0.0000 |
|
336 |
D |
A |
0.0000 |
|
337 |
L |
A |
0.0000 |
|
338 |
Q |
A |
-0.1792 |
|
339 |
S |
A |
-0.3196 |
|
340 |
M |
A |
0.0000 |
|
341 |
G |
A |
-0.8013 |
|
342 |
T |
A |
-0.7272 |
|
343 |
G |
A |
0.0000 |
|
344 |
P |
A |
-0.9772 |
|
345 |
D |
A |
-1.7975 |
|
346 |
G |
A |
-1.3486 |
|
347 |
S |
A |
0.0000 |
|
348 |
P |
A |
-0.7528 |
|
349 |
L |
A |
0.0000 |
|
350 |
F |
A |
0.0000 |
|
351 |
G |
A |
0.0000 |
|
352 |
C |
A |
0.0000 |
|
353 |
L |
A |
0.0000 |
|
354 |
Y |
A |
0.0000 |
|
355 |
E |
A |
0.0000 |
|
356 |
A |
A |
0.0000 |
|
357 |
N |
A |
-2.9329 |
|
358 |
D |
A |
-3.0037 |
|
359 |
Y |
A |
-2.2286 |
|
360 |
E |
A |
-3.0919 |
|
361 |
E |
A |
-2.3192 |
|
362 |
I |
A |
0.0000 |
|
363 |
V |
A |
0.0000 |
|
364 |
F |
A |
0.0000 |
|
365 |
L |
A |
0.0000 |
|
366 |
M |
A |
0.0000 |
|
367 |
F |
A |
0.0000 |
|
368 |
T |
A |
0.0000 |
|
369 |
L |
A |
0.0000 |
|
370 |
K |
A |
-1.1276 |
|
371 |
Q |
A |
-0.7323 |
|
372 |
A |
A |
0.0000 |
|
373 |
F |
A |
-0.1658 |
|
374 |
P |
A |
-0.2651 |
|
375 |
A |
A |
-0.0221 |
|
376 |
E |
A |
-0.3742 |
|
377 |
Y |
A |
0.5838 |
|