Project name: fenilananina hidroxilasa [mutate: IA65S]

Status: done

submitted: 2017-03-10 09:02:11, status changed: 2017-03-10 09:19:54
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Chain sequence(s) A: GQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDINLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNT
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues IA65S
Energy difference between WD and mutated (by FoldX) 4.83897 kcal/mol
Show buried residues

Minimal score value
-4.1987
Maximal score value
1.8288
Average score
-0.9475
Total score value
-381.8256

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
19 G A -1.8043
20 Q A -2.4502
21 E A -2.2233
22 T A -1.3146
23 S A -0.4828
24 Y A -0.9439
25 I A -0.7231
26 E A -2.6993
27 D A -2.1152
28 N A -2.2656
29 S A -2.1308
30 N A -2.8301
31 Q A -2.4261
32 N A -1.9961
33 G A 0.0000
34 A A 0.0000
35 I A 0.0000
36 S A 0.0000
37 L A 0.0000
38 I A 0.0000
39 F A 0.0000
40 S A -1.0812
41 L A 0.0000
42 K A -3.0982
43 E A -3.4321
44 E A -2.4032
45 V A 0.0560
46 G A -0.7719
47 A A -1.3047
48 L A -0.7968
49 A A -0.9812
50 K A -2.0255
51 V A 0.0000
52 L A -1.7427
53 R A -3.3038
54 L A -2.4055
55 F A 0.0000
56 E A -4.1987
57 E A -4.0914
58 N A -2.8470
59 D A -3.1398
60 I A 0.0000
61 N A -2.2091
62 L A -1.2631
63 T A -0.5201
64 H A -0.7143
65 S A 0.0000 mutated: IA65S
66 E A -0.5574
67 S A -0.7977
68 R A -1.7496
69 P A -1.9846
70 S A -1.5821
71 R A -0.9400
72 L A 0.0297
73 N A -2.0539
74 K A -3.2335
75 D A -3.9869
76 E A -3.2015
77 Y A -1.8034
78 E A 0.0000
79 F A 0.0000
80 F A 0.0000
81 T A 0.0000
82 Y A -0.2892
83 L A 0.0000
84 D A -1.5594
85 K A -2.3437
86 R A -2.6887
87 T A -2.1053
88 K A -2.2734
89 P A -1.2568
90 V A -0.7827
91 L A 0.0000
92 G A -1.2347
93 S A -1.2268
94 I A 0.0000
95 I A 0.0000
96 K A -3.2343
97 S A -2.6171
98 L A 0.0000
99 R A -3.5731
100 N A -3.5643
101 D A -3.2237
102 I A -2.0353
103 G A -2.2476
104 A A -1.6315
105 T A -0.7780
106 V A 0.0000
107 H A -0.4980
108 E A -0.7794
109 L A 0.0000
110 S A 0.0000
111 R A 0.0000
112 D A -2.1779
113 K A -2.2232
114 E A -2.4720
115 K A -2.8892
116 N A -2.4269
117 T A -1.7860
118 V A -1.0230
119 P A 0.0000
120 W A 0.0000
121 F A 0.0000
122 P A 0.0000
123 R A 0.0000
124 T A 0.0000
125 I A 0.0000
126 Q A -2.0433
127 E A 0.0000
128 L A 0.0000
129 D A -2.1931
130 R A -2.6335
131 F A 0.0000
132 A A 0.0000
133 N A -0.8540
134 Q A -0.4609
135 I A 1.3073
136 L A 1.8288
143 D A -2.5156
144 A A -1.8883
145 D A -2.5472
146 H A -1.9331
147 P A -1.5114
148 G A -1.6399
149 F A -1.7467
150 K A -2.2440
151 D A -1.1642
152 P A -0.6157
153 V A 0.5497
154 Y A -0.8824
155 R A -2.3050
156 A A -1.3344
157 R A -1.3697
158 R A -1.9356
159 K A -2.6094
160 Q A -1.9481
161 F A 0.0000
162 A A -1.1542
163 D A -1.4101
164 I A -1.1035
165 A A 0.0000
166 Y A -0.6996
167 N A -1.5526
168 Y A 0.0000
169 R A -2.5590
170 H A -1.9178
171 G A -1.7320
172 Q A -1.8531
173 P A -1.7733
174 I A 0.0000
175 P A -1.2731
176 R A -2.6684
177 V A 0.0000
178 E A -2.5525
179 Y A 0.0000
180 T A -2.3308
181 E A -3.7750
182 E A -3.4620
183 E A -2.8164
184 K A -3.5733
185 Q A -3.4195
186 T A 0.0000
187 W A 0.0000
188 G A -2.8796
189 T A -1.4716
190 V A 0.0000
191 F A 0.0000
192 R A -2.8709
193 T A -1.2031
194 L A 0.0000
195 K A -1.9609
196 A A -1.0941
197 L A -1.0197
198 Y A 0.0000
199 K A -1.8374
200 T A -1.0138
201 H A -0.6347
202 A A 0.0000
203 C A 0.0000
204 Y A 0.3082
205 E A -0.3001
206 H A 0.0000
207 N A -0.7191
208 H A -0.7431
209 I A 0.0000
210 F A 0.0000
211 P A -0.4436
212 L A 0.0563
213 L A 0.0000
214 E A -1.0938
215 K A -1.2016
216 Y A 0.3260
217 C A 0.0000
218 G A -1.3876
219 F A 0.0000
220 R A -3.5418
221 E A -4.0573
222 D A -4.0473
223 N A -2.7983
224 I A 0.0000
225 P A 0.0000
226 Q A -1.7144
227 L A 0.0000
228 E A -2.1379
229 D A -2.3583
230 V A 0.0000
231 S A 0.0000
232 Q A -2.1981
233 F A -0.9429
234 L A 0.0000
235 Q A -1.4876
236 T A -0.7780
237 C A -0.8198
238 T A 0.0000
239 G A -1.2621
240 F A 0.0000
241 R A -1.4093
242 L A 0.0000
243 R A 0.0000
244 P A 0.0000
245 V A 0.0000
246 A A 0.0287
247 G A 0.6734
248 L A 1.1788
249 L A 0.0000
250 S A 0.0000
251 S A 0.0000
252 R A 0.0000
253 D A -0.4396
254 F A 0.3585
255 L A 0.0000
256 G A 0.0000
257 G A 0.0000
258 L A 0.0000
259 A A 0.0000
260 F A 0.0000
261 R A -0.8404
262 V A 0.0000
263 F A 0.0000
264 H A 0.0000
265 C A 0.0000
266 T A 0.0000
267 Q A 0.0000
268 Y A 0.0000
269 I A 0.0000
270 R A 0.0000
271 H A -1.1364
272 G A -1.6550
273 S A -1.0908
274 K A -1.4569
275 P A -0.7848
276 M A 0.1472
277 Y A 0.1612
278 T A -0.1848
279 P A -0.8071
280 E A -0.3319
281 P A -0.1494
282 D A 0.0000
283 I A 0.0000
284 C A 0.0000
285 H A -0.1826
286 E A 0.0000
287 L A 0.0000
288 L A 0.0000
289 G A 0.0000
290 H A 0.0000
291 V A 0.0000
292 P A 0.0000
293 L A 0.0000
294 F A 0.0000
295 S A 0.0000
296 D A -1.4093
297 R A -2.1686
298 S A -1.4428
299 F A 0.0000
300 A A 0.0000
301 Q A -1.2939
302 F A 0.0000
303 S A 0.0000
304 Q A 0.0000
305 E A 0.0000
306 I A 0.0000
307 G A 0.0000
308 L A -0.5092
309 A A 0.0000
310 S A 0.0000
311 L A 0.0000
312 G A 0.0000
313 A A 0.0000
314 P A -1.4442
315 D A -2.7829
316 E A -2.9123
317 Y A -1.4862
318 I A 0.0000
319 E A -2.0765
320 K A -1.3831
321 L A 0.0000
322 A A 0.0000
323 T A 0.0000
324 I A 0.0000
325 Y A 0.0000
326 W A 0.0000
327 F A 0.0000
328 T A 0.0000
329 V A 0.0000
330 E A -0.2108
331 F A 0.0000
332 G A 0.0000
333 L A 0.0000
334 C A 0.0000
335 K A -2.9275
336 E A -2.7898
337 G A -2.5381
338 D A -2.6110
339 S A -1.7581
340 I A -1.3636
341 K A -0.7241
342 A A 0.0000
343 Y A 0.0000
344 G A 0.0000
345 A A 0.0000
346 G A 0.0000
347 L A 0.0000
348 L A 0.0000
349 S A 0.0000
350 S A -0.1027
351 F A -0.1418
352 G A -0.3597
353 E A 0.0000
354 L A 0.0000
355 Q A -0.7047
356 Y A -0.6908
357 C A 0.0000
358 L A -0.5554
359 S A -1.6634
360 D A -2.7400
361 K A -2.7396
362 P A -1.7489
363 K A -1.9818
364 L A -0.3595
365 L A -0.1427
366 P A -0.8507
367 L A 0.0000
368 E A -2.4480
369 L A 0.0000
370 E A -2.6910
371 K A -2.3220
372 T A 0.0000
373 A A 0.0000
374 C A -0.7074
375 Q A -1.2230
376 E A -2.0631
377 Y A 0.0000
378 S A -1.1524
379 V A 0.0031
380 T A -0.6332
381 E A -1.1235
382 F A 0.0257
383 Q A 0.0000
384 P A -0.7792
385 L A -0.6469
386 Y A 0.0000
387 Y A 0.0000
388 V A 0.0000
389 A A 0.0000
390 E A -2.8833
391 S A -2.1438
392 F A 0.0000
393 S A -1.9644
394 D A -2.8087
395 A A 0.0000
396 K A -2.3866
397 E A -3.3622
398 K A -2.8396
399 V A 0.0000
400 R A -2.8678
401 T A -1.6206
402 F A 0.0000
403 A A 0.0000
404 A A -0.7076
405 T A -0.3333
406 I A 0.0000
407 P A -0.5541
408 R A -0.8114
409 P A -0.9540
410 F A 0.0000
411 S A -1.2889
412 V A -1.0393
413 R A -1.7124
414 Y A 0.0000
415 D A 0.0000
416 P A -0.1398
417 Y A 0.9688
418 T A 0.1013
419 Q A -0.6101
420 R A -0.7909
421 V A 0.0000
422 E A -0.7485
423 V A -0.5834
424 L A -0.8889
425 D A -2.2529
426 N A -2.1091
427 T A -1.0726

 

Laboratory of Theory of Biopolymers 2015