Project name: test8
Status: done
submitted: 2019-02-12 14:32:44, status changed: 2019-02-12 14:44:38
Settings
Chain sequence(s)
|
A: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY
|
Distance of aggregation |
5 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-2.4514
-
Maximal score value
-
1.948
-
Average score
-
-0.4153
-
Total score value
-
-151.187
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
2 |
S |
A |
-0.3712 |
|
3 |
H |
A |
-0.9000 |
|
4 |
P |
A |
-0.2837 |
|
5 |
S |
A |
0.0000 |
|
6 |
P |
A |
-0.2500 |
|
7 |
Q |
A |
-1.1929 |
|
8 |
A |
A |
-0.4718 |
|
9 |
K |
A |
-1.7073 |
|
10 |
P |
A |
-0.5639 |
|
11 |
S |
A |
-0.1392 |
|
12 |
N |
A |
-0.3980 |
|
13 |
P |
A |
-0.3562 |
|
14 |
S |
A |
-0.2592 |
|
15 |
N |
A |
0.0000 |
|
16 |
P |
A |
-0.0840 |
|
17 |
R |
A |
-0.2226 |
|
18 |
V |
A |
0.0000 |
|
19 |
F |
A |
0.2055 |
|
20 |
F |
A |
0.0000 |
|
21 |
D |
A |
0.0000 |
|
22 |
V |
A |
0.0000 |
|
23 |
D |
A |
-0.3449 |
|
24 |
I |
A |
0.0795 |
|
25 |
G |
A |
-0.5136 |
|
26 |
G |
A |
-0.8868 |
|
27 |
E |
A |
-2.0795 |
|
28 |
R |
A |
-1.2454 |
|
29 |
V |
A |
0.1583 |
|
30 |
G |
A |
-0.0658 |
|
31 |
R |
A |
-0.2260 |
|
32 |
I |
A |
0.0000 |
|
33 |
V |
A |
0.0000 |
|
34 |
L |
A |
0.0000 |
|
35 |
E |
A |
0.0000 |
|
36 |
L |
A |
0.0000 |
|
37 |
F |
A |
0.0000 |
|
38 |
A |
A |
-0.2909 |
|
39 |
D |
A |
-1.3251 |
|
40 |
I |
A |
0.2627 |
|
41 |
V |
A |
0.0000 |
|
42 |
P |
A |
-0.4066 |
|
43 |
K |
A |
-0.9405 |
|
44 |
T |
A |
0.0000 |
|
45 |
A |
A |
0.0000 |
|
46 |
E |
A |
-0.8444 |
|
47 |
N |
A |
0.0000 |
|
48 |
F |
A |
0.0000 |
|
49 |
R |
A |
-0.3155 |
|
50 |
A |
A |
0.0000 |
|
51 |
L |
A |
0.0000 |
|
52 |
C |
A |
0.0000 |
|
53 |
T |
A |
-0.0452 |
|
54 |
G |
A |
-0.4434 |
|
55 |
E |
A |
-2.1389 |
|
56 |
K |
A |
-2.0642 |
|
57 |
G |
A |
-0.1540 |
|
58 |
I |
A |
1.9480 |
|
59 |
G |
A |
0.0000 |
|
60 |
P |
A |
-0.2683 |
|
61 |
T |
A |
-0.1230 |
|
62 |
T |
A |
-0.1219 |
|
63 |
G |
A |
-0.6178 |
|
64 |
K |
A |
-0.9285 |
|
65 |
P |
A |
-0.0291 |
|
66 |
L |
A |
0.0000 |
|
67 |
H |
A |
-0.1950 |
|
68 |
F |
A |
0.0000 |
|
69 |
K |
A |
-1.4895 |
|
70 |
G |
A |
-0.5792 |
|
71 |
C |
A |
0.0000 |
|
72 |
P |
A |
0.0000 |
|
73 |
F |
A |
0.0000 |
|
74 |
H |
A |
0.0000 |
|
75 |
R |
A |
-0.6371 |
|
76 |
I |
A |
0.0000 |
|
77 |
I |
A |
0.2870 |
|
78 |
K |
A |
-1.8986 |
|
79 |
K |
A |
-1.9431 |
|
80 |
F |
A |
0.0645 |
|
81 |
M |
A |
0.0000 |
|
82 |
I |
A |
0.0000 |
|
83 |
Q |
A |
0.0000 |
|
84 |
G |
A |
0.0000 |
|
85 |
G |
A |
0.0000 |
|
86 |
D |
A |
0.0000 |
|
87 |
F |
A |
0.0000 |
|
88 |
S |
A |
-0.2732 |
|
89 |
N |
A |
-1.4058 |
|
90 |
Q |
A |
-1.1479 |
|
91 |
N |
A |
-1.3709 |
|
92 |
G |
A |
-0.4457 |
|
93 |
T |
A |
-0.1258 |
|
94 |
G |
A |
-0.1146 |
|
95 |
G |
A |
-0.0756 |
|
96 |
E |
A |
0.0000 |
|
97 |
S |
A |
0.0000 |
|
98 |
I |
A |
0.0000 |
|
99 |
Y |
A |
0.6894 |
|
100 |
G |
A |
-0.3390 |
|
101 |
E |
A |
-2.0683 |
|
102 |
K |
A |
-1.5561 |
|
103 |
F |
A |
0.0000 |
|
104 |
E |
A |
-2.0299 |
|
105 |
D |
A |
-0.8235 |
|
106 |
E |
A |
-0.6855 |
|
107 |
N |
A |
-0.4418 |
|
108 |
F |
A |
0.5136 |
|
109 |
H |
A |
-0.1711 |
|
110 |
Y |
A |
-0.1238 |
|
111 |
K |
A |
-0.5305 |
|
112 |
H |
A |
0.0000 |
|
113 |
D |
A |
-0.6840 |
|
114 |
K |
A |
-0.6202 |
|
115 |
E |
A |
-1.1839 |
|
116 |
G |
A |
0.0000 |
|
117 |
L |
A |
0.0000 |
|
118 |
L |
A |
0.0000 |
|
119 |
S |
A |
0.0000 |
|
120 |
M |
A |
0.0000 |
|
121 |
A |
A |
-0.0386 |
|
122 |
N |
A |
-0.2321 |
|
123 |
A |
A |
-0.0146 |
|
124 |
G |
A |
-0.1774 |
|
125 |
S |
A |
-0.4304 |
|
126 |
N |
A |
-1.3824 |
|
127 |
T |
A |
-0.2117 |
|
128 |
N |
A |
0.0000 |
|
129 |
G |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
Q |
A |
-0.1262 |
|
132 |
F |
A |
0.0000 |
|
133 |
F |
A |
0.0000 |
|
134 |
I |
A |
0.0000 |
|
135 |
T |
A |
0.0000 |
|
136 |
T |
A |
0.0000 |
|
137 |
V |
A |
0.1164 |
|
138 |
P |
A |
-0.2236 |
|
139 |
T |
A |
0.0000 |
|
140 |
P |
A |
-0.4362 |
|
141 |
H |
A |
-1.0368 |
|
142 |
L |
A |
0.0000 |
|
143 |
D |
A |
-0.7865 |
|
144 |
G |
A |
-0.8499 |
|
145 |
K |
A |
-1.4594 |
|
146 |
H |
A |
0.0000 |
|
147 |
V |
A |
0.0000 |
|
148 |
V |
A |
0.0000 |
|
149 |
F |
A |
0.0000 |
|
150 |
G |
A |
0.0000 |
|
151 |
Q |
A |
0.0000 |
|
152 |
V |
A |
0.0000 |
|
153 |
I |
A |
0.0000 |
|
154 |
K |
A |
-0.2552 |
|
155 |
G |
A |
0.0000 |
|
156 |
M |
A |
0.1801 |
|
157 |
G |
A |
-0.1163 |
|
158 |
V |
A |
0.0000 |
|
159 |
A |
A |
0.0000 |
|
160 |
K |
A |
-0.5183 |
|
161 |
I |
A |
0.7370 |
|
162 |
L |
A |
0.0000 |
|
163 |
E |
A |
0.0000 |
|
164 |
N |
A |
-1.2399 |
|
165 |
V |
A |
-0.3018 |
|
166 |
E |
A |
-1.1221 |
|
167 |
V |
A |
0.3475 |
|
168 |
K |
A |
-1.6201 |
|
169 |
G |
A |
-0.9578 |
|
170 |
E |
A |
-1.2536 |
|
171 |
K |
A |
-1.3919 |
|
172 |
P |
A |
-0.0958 |
|
173 |
A |
A |
-0.1406 |
|
174 |
K |
A |
-0.7627 |
|
175 |
L |
A |
1.3482 |
|
176 |
C |
A |
0.0000 |
|
177 |
V |
A |
0.2040 |
|
178 |
I |
A |
0.0000 |
|
179 |
A |
A |
-0.1146 |
|
180 |
E |
A |
-0.6709 |
|
181 |
C |
A |
0.0000 |
|
182 |
G |
A |
-0.1013 |
|
183 |
E |
A |
-0.2947 |
|
184 |
L |
A |
0.0000 |
|
185 |
K |
A |
-2.0374 |
|
186 |
E |
A |
-2.2211 |
|
187 |
G |
A |
-1.0873 |
|
188 |
D |
A |
-1.9570 |
|
189 |
D |
A |
-1.9985 |
|
190 |
W |
A |
0.0827 |
|
191 |
G |
A |
0.0768 |
|
192 |
I |
A |
0.4613 |
|
193 |
F |
A |
1.0701 |
|
194 |
P |
A |
-0.0421 |
|
195 |
K |
A |
-1.2175 |
|
196 |
D |
A |
-0.9921 |
|
197 |
G |
A |
-0.6026 |
|
198 |
S |
A |
-0.2147 |
|
199 |
G |
A |
-0.4742 |
|
200 |
D |
A |
0.0000 |
|
201 |
S |
A |
-0.2356 |
|
202 |
H |
A |
-0.1688 |
|
203 |
P |
A |
0.0051 |
|
204 |
D |
A |
-0.3432 |
|
205 |
F |
A |
0.2019 |
|
206 |
P |
A |
0.0000 |
|
207 |
E |
A |
-1.8594 |
|
208 |
D |
A |
-0.5479 |
|
209 |
A |
A |
-0.3653 |
|
210 |
D |
A |
-1.7552 |
|
211 |
V |
A |
-0.4802 |
|
212 |
D |
A |
-1.7200 |
|
213 |
L |
A |
-0.4438 |
|
214 |
K |
A |
-1.9069 |
|
215 |
D |
A |
-1.6470 |
|
216 |
V |
A |
0.0000 |
|
217 |
D |
A |
-1.9763 |
|
218 |
K |
A |
-1.3516 |
|
219 |
I |
A |
0.0000 |
|
220 |
L |
A |
0.4891 |
|
221 |
L |
A |
1.5856 |
|
222 |
I |
A |
0.0000 |
|
223 |
S |
A |
0.0000 |
|
224 |
E |
A |
-1.3966 |
|
225 |
D |
A |
-1.2534 |
|
226 |
L |
A |
0.0000 |
|
227 |
K |
A |
-0.5906 |
|
228 |
N |
A |
-1.2995 |
|
229 |
I |
A |
-0.0155 |
|
230 |
G |
A |
0.0000 |
|
231 |
N |
A |
-0.2770 |
|
232 |
T |
A |
-0.0778 |
|
233 |
F |
A |
0.3223 |
|
234 |
F |
A |
0.0622 |
|
235 |
K |
A |
-1.6689 |
|
236 |
S |
A |
-0.7393 |
|
237 |
Q |
A |
-1.3329 |
|
238 |
N |
A |
-0.7127 |
|
239 |
W |
A |
-0.2774 |
|
240 |
E |
A |
-1.7652 |
|
241 |
M |
A |
-0.3767 |
|
242 |
A |
A |
0.0000 |
|
243 |
I |
A |
-0.0102 |
|
244 |
K |
A |
-1.6277 |
|
245 |
K |
A |
0.0000 |
|
246 |
Y |
A |
0.0000 |
|
247 |
T |
A |
-0.0268 |
|
248 |
K |
A |
0.0000 |
|
249 |
V |
A |
0.0000 |
|
250 |
L |
A |
0.1032 |
|
251 |
R |
A |
-0.5302 |
|
252 |
Y |
A |
0.0000 |
|
253 |
V |
A |
0.0000 |
|
254 |
E |
A |
-1.8326 |
|
255 |
G |
A |
-0.4024 |
|
256 |
S |
A |
0.0000 |
|
257 |
R |
A |
-1.8332 |
|
258 |
A |
A |
-0.2810 |
|
259 |
A |
A |
0.0311 |
|
260 |
A |
A |
-0.5304 |
|
261 |
E |
A |
-2.1467 |
|
262 |
D |
A |
-2.1124 |
|
263 |
A |
A |
-0.5544 |
|
264 |
D |
A |
-1.4880 |
|
265 |
G |
A |
0.0000 |
|
266 |
A |
A |
-0.2037 |
|
267 |
K |
A |
-1.2649 |
|
268 |
L |
A |
0.0000 |
|
269 |
Q |
A |
-0.6939 |
|
270 |
P |
A |
-0.3716 |
|
271 |
V |
A |
0.0000 |
|
272 |
A |
A |
0.0000 |
|
273 |
L |
A |
0.2144 |
|
274 |
S |
A |
0.0014 |
|
275 |
C |
A |
0.0000 |
|
276 |
V |
A |
0.0000 |
|
277 |
L |
A |
0.0000 |
|
278 |
N |
A |
-0.2470 |
|
279 |
I |
A |
0.0000 |
|
280 |
G |
A |
0.0000 |
|
281 |
A |
A |
-0.0156 |
|
282 |
C |
A |
0.0000 |
|
283 |
K |
A |
-0.1835 |
|
284 |
L |
A |
-0.1698 |
|
285 |
K |
A |
-1.5973 |
|
286 |
M |
A |
-0.0130 |
|
287 |
S |
A |
-0.2839 |
|
288 |
D |
A |
-0.8326 |
|
289 |
W |
A |
0.0245 |
|
290 |
Q |
A |
-0.8690 |
|
291 |
G |
A |
-0.2259 |
|
292 |
A |
A |
0.0000 |
|
293 |
V |
A |
0.0000 |
|
294 |
D |
A |
-1.2687 |
|
295 |
S |
A |
0.0000 |
|
296 |
C |
A |
0.0000 |
|
297 |
L |
A |
0.4712 |
|
298 |
E |
A |
-1.2725 |
|
299 |
A |
A |
0.0000 |
|
300 |
L |
A |
0.0000 |
|
301 |
E |
A |
-1.6803 |
|
302 |
I |
A |
0.3420 |
|
303 |
D |
A |
-0.3312 |
|
304 |
P |
A |
-0.3706 |
|
305 |
S |
A |
-0.2784 |
|
306 |
N |
A |
-0.1934 |
|
307 |
T |
A |
-0.2590 |
|
308 |
K |
A |
-1.1890 |
|
309 |
A |
A |
0.0000 |
|
310 |
L |
A |
0.0000 |
|
311 |
Y |
A |
0.1068 |
|
312 |
R |
A |
-0.4954 |
|
313 |
R |
A |
-0.3267 |
|
314 |
A |
A |
0.0000 |
|
315 |
Q |
A |
-0.4460 |
|
316 |
G |
A |
0.0000 |
|
317 |
W |
A |
0.1492 |
|
318 |
Q |
A |
0.0000 |
|
319 |
G |
A |
0.0347 |
|
320 |
L |
A |
0.3124 |
|
321 |
K |
A |
-1.7394 |
|
322 |
E |
A |
-1.1546 |
|
323 |
Y |
A |
-0.3532 |
|
324 |
D |
A |
-1.8771 |
|
325 |
Q |
A |
-0.9446 |
|
326 |
A |
A |
0.0000 |
|
327 |
L |
A |
0.2924 |
|
328 |
A |
A |
0.0947 |
|
329 |
D |
A |
0.0000 |
|
330 |
L |
A |
0.0000 |
|
331 |
K |
A |
-1.5100 |
|
332 |
K |
A |
-1.1371 |
|
333 |
A |
A |
0.0000 |
|
334 |
Q |
A |
-0.5846 |
|
335 |
E |
A |
-1.6597 |
|
336 |
I |
A |
0.7684 |
|
337 |
A |
A |
0.1419 |
|
338 |
P |
A |
-0.6120 |
|
339 |
E |
A |
-1.9721 |
|
340 |
D |
A |
-1.2216 |
|
341 |
K |
A |
-1.8540 |
|
342 |
A |
A |
-0.2837 |
|
343 |
I |
A |
0.0000 |
|
344 |
Q |
A |
-0.7063 |
|
345 |
A |
A |
-0.0835 |
|
346 |
E |
A |
0.0000 |
|
347 |
L |
A |
0.0000 |
|
348 |
L |
A |
1.2550 |
|
349 |
K |
A |
-1.2552 |
|
350 |
V |
A |
0.0000 |
|
351 |
K |
A |
-1.7644 |
|
352 |
Q |
A |
-1.6228 |
|
353 |
K |
A |
-0.8943 |
|
354 |
I |
A |
0.1278 |
|
355 |
K |
A |
-1.5898 |
|
356 |
A |
A |
-0.3781 |
|
357 |
Q |
A |
-0.7623 |
|
358 |
K |
A |
-1.8964 |
|
359 |
D |
A |
-1.2394 |
|
360 |
K |
A |
-2.1527 |
|
361 |
E |
A |
-2.4514 |
|
362 |
K |
A |
-2.0257 |
|
363 |
A |
A |
-0.2365 |
|
364 |
A |
A |
0.3100 |
|
365 |
Y |
A |
1.3260 |
|