Chain sequence(s) |
A: KGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYITADKQKNGIKANFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITH |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | LA221K |
Energy difference between WT (input) and mutated protein (by FoldX) | 0.0330998 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
3 | K | A | -2.4362 | |
4 | G | A | 0.0000 | |
5 | E | A | -2.4084 | |
6 | E | A | -2.4828 | |
7 | L | A | -0.8760 | |
8 | F | A | 0.0000 | |
9 | T | A | -0.2441 | |
10 | G | A | 0.5238 | |
11 | V | A | 1.3536 | |
12 | V | A | 0.0000 | |
13 | P | A | -0.9301 | |
14 | I | A | 0.0000 | |
15 | L | A | -1.3424 | |
16 | V | A | 0.0000 | |
17 | E | A | -2.6113 | |
18 | L | A | 0.0000 | |
19 | D | A | -3.6075 | |
20 | G | A | 0.0000 | |
21 | D | A | -2.8121 | |
22 | V | A | 0.0000 | |
23 | N | A | -2.1016 | |
24 | G | A | -1.7080 | |
25 | H | A | -2.2368 | |
26 | K | A | -3.0019 | |
27 | F | A | 0.0000 | |
28 | S | A | -1.8967 | |
29 | V | A | 0.0000 | |
30 | S | A | -1.2668 | |
31 | G | A | 0.0000 | |
32 | E | A | -2.2799 | |
33 | G | A | -1.6752 | |
34 | E | A | -1.4456 | |
35 | G | A | 0.0000 | |
36 | D | A | 0.0872 | |
37 | A | A | 0.0000 | |
38 | T | A | 0.1631 | |
39 | Y | A | 0.9702 | |
40 | G | A | 0.0000 | |
41 | K | A | -0.6075 | |
42 | L | A | 0.0000 | |
43 | T | A | -1.3113 | |
44 | L | A | 0.0000 | |
45 | K | A | -1.4472 | |
46 | F | A | 0.0000 | |
47 | I | A | -0.9500 | |
48 | C | A | 0.0000 | |
49 | T | A | -1.0364 | |
50 | T | A | -1.3330 | |
51 | G | A | -1.6506 | |
52 | K | A | -2.2747 | |
53 | L | A | 0.0000 | |
54 | P | A | -1.2304 | |
55 | V | A | 0.0000 | |
56 | P | A | -0.7442 | |
57 | W | A | 0.0000 | |
58 | P | A | 0.0000 | |
59 | T | A | 0.0000 | |
60 | L | A | 0.0000 | |
61 | V | A | 0.0000 | |
62 | T | A | 0.0001 | |
63 | T | A | 0.0000 | |
64 | L | A | 0.0000 | |
68 | V | A | 0.0079 | |
69 | Q | A | -0.1839 | |
70 | C | A | 0.0000 | |
71 | F | A | 0.0000 | |
72 | S | A | 0.0000 | |
73 | R | A | -1.2925 | |
74 | Y | A | 0.0000 | |
75 | P | A | -1.9175 | |
76 | D | A | -2.8574 | |
77 | H | A | -2.1422 | |
78 | M | A | 0.0000 | |
79 | K | A | -2.8504 | |
80 | R | A | -2.8547 | |
81 | H | A | -1.7277 | |
82 | D | A | 0.0000 | |
83 | F | A | 0.0000 | |
84 | F | A | 0.0000 | |
85 | K | A | 0.0000 | |
86 | S | A | -1.1996 | |
87 | A | A | 0.0000 | |
88 | M | A | 0.0000 | |
89 | P | A | -1.6187 | |
90 | E | A | -2.2005 | |
91 | G | A | 0.0000 | |
92 | Y | A | 0.0000 | |
93 | V | A | -0.8636 | |
94 | Q | A | 0.0000 | |
95 | E | A | -2.3532 | |
96 | R | A | 0.0000 | |
97 | T | A | -1.0670 | |
98 | I | A | 0.0000 | |
99 | S | A | -1.2960 | |
100 | F | A | 0.0000 | |
101 | K | A | -2.5427 | |
102 | D | A | -2.9337 | |
103 | D | A | -2.8715 | |
104 | G | A | 0.0000 | |
105 | N | A | -1.5683 | |
106 | Y | A | 0.0000 | |
107 | K | A | -2.5624 | |
108 | T | A | 0.0000 | |
109 | R | A | -3.4388 | |
110 | A | A | 0.0000 | |
111 | E | A | -2.3191 | |
112 | V | A | 0.0000 | |
113 | K | A | -1.6669 | |
114 | F | A | -1.8725 | |
115 | E | A | -2.6836 | |
116 | G | A | -2.2574 | |
117 | D | A | -2.3913 | |
118 | T | A | -1.5519 | |
119 | L | A | 0.0000 | |
120 | V | A | 0.0000 | |
121 | N | A | 0.0000 | |
122 | R | A | -3.4244 | |
123 | I | A | 0.0000 | |
124 | E | A | -4.2785 | |
125 | L | A | 0.0000 | |
126 | K | A | -3.1114 | |
127 | G | A | 0.0000 | |
128 | I | A | -1.2424 | |
129 | D | A | -2.2779 | |
130 | F | A | 0.0000 | |
131 | K | A | -3.9548 | |
132 | E | A | -3.9994 | |
133 | D | A | -3.6519 | |
134 | G | A | -2.8614 | |
135 | N | A | -2.3203 | |
136 | I | A | 0.0000 | |
137 | L | A | -2.0536 | |
138 | G | A | -2.3825 | |
139 | H | A | -2.2777 | |
140 | K | A | -2.6099 | |
141 | L | A | -1.9361 | |
142 | E | A | -2.3872 | |
143 | Y | A | -1.0215 | |
144 | N | A | -0.7091 | |
145 | Y | A | -0.8049 | |
146 | N | A | -1.0153 | |
147 | S | A | -1.0088 | |
148 | H | A | 0.0000 | |
149 | N | A | -1.4592 | |
150 | V | A | 0.0000 | |
151 | Y | A | -0.0400 | |
152 | I | A | 0.0000 | |
153 | T | A | -1.1445 | |
154 | A | A | -1.7207 | |
155 | D | A | -2.2292 | |
156 | K | A | -3.2073 | |
157 | Q | A | -3.1666 | |
158 | K | A | -3.2467 | |
159 | N | A | -2.8730 | |
160 | G | A | 0.0000 | |
161 | I | A | 0.0000 | |
162 | K | A | -1.0801 | |
163 | A | A | 0.0000 | |
164 | N | A | -1.2651 | |
165 | F | A | 0.0000 | |
166 | K | A | -1.8271 | |
167 | I | A | 0.0000 | |
168 | R | A | -1.1564 | |
169 | H | A | 0.0000 | |
170 | N | A | -1.4604 | |
171 | I | A | 0.0000 | |
172 | E | A | -3.4499 | |
173 | D | A | -3.0634 | |
174 | G | A | -1.8715 | |
175 | S | A | -0.8002 | |
176 | V | A | 0.1146 | |
177 | Q | A | 0.0000 | |
178 | L | A | -0.9215 | |
179 | A | A | 0.0000 | |
180 | D | A | -1.4493 | |
181 | H | A | 0.0000 | |
182 | Y | A | -0.3596 | |
183 | Q | A | 0.0000 | |
184 | Q | A | -1.1024 | |
185 | N | A | 0.0000 | |
186 | T | A | -0.7876 | |
187 | P | A | -0.9128 | |
188 | I | A | -0.3961 | |
189 | G | A | -1.3276 | |
190 | D | A | -2.1315 | |
191 | G | A | -1.4910 | |
192 | P | A | -0.7957 | |
193 | V | A | -0.1069 | |
194 | L | A | -0.2333 | |
195 | L | A | -0.6429 | |
196 | P | A | 0.0000 | |
197 | D | A | -2.4703 | |
198 | N | A | -1.8734 | |
199 | H | A | 0.0000 | |
200 | Y | A | -0.3017 | |
201 | L | A | 0.0000 | |
202 | S | A | -0.6348 | |
203 | T | A | -0.8017 | |
204 | Q | A | -1.4002 | |
205 | S | A | -0.9035 | |
206 | A | A | -0.5160 | |
207 | L | A | -0.5107 | |
208 | S | A | -1.0160 | |
209 | K | A | -2.0421 | |
210 | D | A | -2.1693 | |
211 | P | A | -1.8353 | |
212 | N | A | -2.4864 | |
213 | E | A | -2.7210 | |
214 | K | A | -3.3438 | |
215 | R | A | -3.3707 | |
216 | D | A | -2.2830 | |
217 | H | A | 0.0000 | |
218 | M | A | 0.0000 | |
219 | V | A | -0.8522 | |
220 | L | A | 0.0000 | |
221 | K | A | -1.2445 | mutated: LA221K |
222 | E | A | -0.7868 | |
223 | F | A | 0.1819 | |
224 | V | A | 0.0000 | |
225 | T | A | -0.4149 | |
226 | A | A | 0.0000 | |
227 | A | A | -0.4267 | |
228 | G | A | -0.6622 | |
229 | I | A | -0.7212 | |
230 | T | A | -0.5728 | |
231 | H | A | -1.3146 |