Project name: Transthyretin [mutate: TA119R]

Status: done

submitted: 2017-03-11 21:14:15, status changed: 2017-03-11 21:24:17
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Chain sequence(s) A: PLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN
B: PLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTTAVVTN
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues TA119R
Energy difference between WD and mutated (by FoldX) -0.152849 kcal/mol
Show buried residues

Minimal score value
-3.46
Maximal score value
1.2264
Average score
-0.7873
Total score value
-179.5074

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
11 P A -2.0184
12 L A 0.0000
13 M A -0.6152
14 V A 0.0000
15 K A -0.5268
16 V A 0.0000
17 L A 0.4494
18 D A 0.0000
19 A A 0.4679
20 V A 0.9115
21 R A -0.8172
22 G A -0.6282
23 S A -0.4724
24 P A -0.6233
25 A A 0.0000
26 I A -0.8051
27 N A -1.9933
28 V A 0.0000
29 A A -1.4726
30 V A 0.0000
31 H A -1.1022
32 V A 0.0000
33 F A -0.7560
34 R A -1.3242
35 K A -1.8243
36 A A -1.9136
37 A A -1.7045
38 D A -2.8666
39 D A -3.0259
40 T A -2.0081
41 W A -1.4641
42 E A -2.3290
43 P A -1.1120
44 F A -0.6777
45 A A -0.6020
46 S A -0.8646
47 G A -1.5613
48 K A -2.6113
49 T A 0.0000
50 S A -1.8748
51 E A -2.1582
52 S A -1.1796
53 G A 0.0000
54 E A -1.4774
55 L A 0.0000
56 H A -1.5372
57 G A -0.9107
58 L A -0.6702
59 T A -1.3470
60 T A -2.1006
61 E A -3.4600
62 E A -3.4071
63 E A -3.1701
64 F A 0.0000
65 V A -1.4842
66 E A -2.2970
67 G A -1.1639
68 I A -0.4077
69 Y A 0.0000
70 K A 0.0000
71 V A 0.0000
72 E A -0.6858
73 I A 0.0000
74 D A -1.4389
75 T A 0.0000
76 K A -1.4870
77 S A -1.3503
78 Y A 0.0000
79 W A 0.0000
80 K A -1.7971
81 A A -0.6927
82 L A -0.0522
83 G A -0.6170
84 I A -0.1574
85 S A -0.4833
86 P A -0.5975
87 F A 0.0000
88 H A 0.0000
89 E A -0.6383
90 H A -0.7444
91 A A 0.0000
92 E A 0.0000
93 V A 0.0000
94 V A 0.0000
95 F A 0.0000
96 T A -0.7962
97 A A 0.0000
98 N A 0.0000
99 D A -2.4702
100 S A -1.5380
101 G A -1.4250
102 P A -2.1045
103 R A -2.7249
104 R A -2.4264
105 Y A 0.0000
106 T A -0.3514
107 I A 0.0000
108 A A -0.4224
109 A A 0.0000
110 L A 0.6388
111 L A 0.0000
112 S A 0.5387
113 P A 0.3146
114 Y A 0.5850
115 S A 0.3483
116 Y A 0.0000
117 S A -0.1580
118 T A 0.0000
119 R A -1.2756 mutated: TA119R
120 A A 0.0000
121 V A 0.8846
122 V A -0.0233
123 T A -0.9624
124 N A -1.9485
11 P B -1.5414
12 L B 0.0000
13 M B -0.4839
14 V B 0.0000
15 K B -0.4599
16 V B 0.0000
17 L B 0.3649
18 D B 0.0000
19 A B 0.4542
20 V B 0.9228
21 R B -0.8749
22 G B -0.5892
23 S B -0.5798
24 P B -0.7428
25 A B 0.0000
26 I B -1.1399
27 N B -2.1422
28 V B 0.0000
29 A B -1.4163
30 V B 0.0000
31 H B -1.0828
32 V B 0.0000
33 F B -0.8619
34 R B -1.3598
35 K B -1.9372
36 A B -1.9489
37 A B -1.7126
38 D B -2.8755
39 D B -3.0482
40 T B -2.0512
41 W B -1.5825
42 E B -2.3907
43 P B -1.1992
44 F B -0.6728
45 A B -0.5421
46 S B -0.8685
47 G B -1.5320
48 K B -2.6169
49 T B 0.0000
50 S B -1.9693
51 E B -2.2779
52 S B -1.2483
53 G B 0.0000
54 E B -1.4554
55 L B 0.0000
56 H B -1.5055
57 G B -0.9075
58 L B -0.6403
59 T B -1.0929
60 T B -1.6997
61 E B -2.8334
62 E B -2.8432
63 E B -2.1203
64 F B -1.1689
65 V B -0.8422
66 E B -2.0968
67 G B -1.1624
68 I B -0.4338
69 Y B 0.0000
70 K B 0.0000
71 V B 0.0000
72 E B -0.7100
73 I B 0.0000
74 D B -1.4171
75 T B 0.0000
76 K B -1.4350
77 S B -1.3804
78 Y B 0.0000
79 W B 0.0000
80 K B -1.7861
81 A B -0.6913
82 L B -0.0614
83 G B -0.6005
84 I B -0.0549
85 S B -0.4413
86 P B -0.5228
87 F B 0.0000
88 H B 0.0000
89 E B -0.6481
90 H B -0.7281
91 A B 0.0000
92 E B 0.0000
93 V B 0.0000
94 V B 0.0000
95 F B 0.0000
96 T B -1.0223
97 A B 0.0000
98 N B -2.6714
99 D B -3.1251
100 S B -1.9215
101 G B -1.7943
102 P B -1.7690
103 R B -2.1681
104 R B -1.9053
105 Y B 0.0000
106 T B 0.0129
107 I B 0.0000
108 A B 0.2323
109 A B 0.0000
110 L B 0.8764
111 L B 0.0000
112 S B 0.3968
113 P B 0.0694
114 Y B 0.3056
115 S B -0.3346
116 Y B 0.0000
117 S B -0.0053
118 T B 0.0000
119 T B 0.4765
120 A B 0.0000
121 V B 1.2264
122 V B 0.1966
123 T B -0.8288
124 N B -1.8731

 

Laboratory of Theory of Biopolymers 2015