Project name: yolo_sap

Chain sequence(s)	H: QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS; K: QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS; M: EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC; L: EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1586
• Maximal score value: 2.243
• Average score: -0.7203
• Total score value: -947.1633

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.3765
2	V	H	-0.6843
3	Q	H	-0.7265
4	L	H	0.0000
5	V	H	0.7572
6	Q	H	0.0000
7	S	H	-0.3071
8	G	H	-0.4586
9	V	H	-0.4130
10	E	H	-0.7778
11	V	H	-0.4364
12	K	H	-1.2152
13	K	H	-1.9341
14	P	H	-1.3556
15	G	H	-1.3012
16	A	H	-1.4408
17	S	H	-1.8108
18	V	H	0.0000
19	K	H	-2.2571
20	V	H	0.0000
21	S	H	-0.4307
22	C	H	0.0000
23	K	H	-0.3498
24	A	H	0.0000
25	S	H	-0.5609
26	G	H	-0.8948
27	Y	H	-0.4633
28	T	H	-0.3934
29	F	H	0.0000
30	T	H	-0.6907
31	N	H	-1.2578
32	Y	H	-0.3239
33	Y	H	-0.0415
34	M	H	0.0000
35	Y	H	0.0591
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6342
40	A	H	-1.0243
41	P	H	-1.0962
42	G	H	-1.2233
43	Q	H	-1.7487
44	G	H	-1.1040
45	L	H	0.0000
46	E	H	-0.5585
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	G	H	0.0000
51	I	H	0.0000
52	N	H	0.0000
53	P	H	-0.8609
54	S	H	-1.0839
55	N	H	-1.6615
56	G	H	-1.1852
57	G	H	-1.1327
58	T	H	-0.9551
59	N	H	-1.5116
60	F	H	-1.6358
61	N	H	-2.0777
62	E	H	-3.4252
63	K	H	-3.1838
64	F	H	0.0000
65	K	H	-3.3074
66	N	H	-2.7471
67	R	H	-2.3083
68	V	H	0.0000
69	T	H	-1.1348
70	L	H	0.0000
71	T	H	-0.3879
72	T	H	-0.6607
73	D	H	-0.9443
74	S	H	-0.7186
75	S	H	-0.5556
76	T	H	-0.5727
77	T	H	-0.5856
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.6245
81	M	H	0.0000
82	E	H	-1.8459
83	L	H	0.0000
84	K	H	-2.3565
85	S	H	-1.6059
86	L	H	0.0000
87	Q	H	-1.0050
88	F	H	0.3319
89	D	H	-1.1289
90	D	H	0.0000
91	T	H	-0.2691
92	A	H	0.0000
93	V	H	0.1151
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	R	H	-0.1972
100	D	H	-0.4682
101	Y	H	-0.0490
102	R	H	-1.2800
103	F	H	-0.0445
104	D	H	0.0000
105	M	H	0.3370
106	G	H	0.0000
107	F	H	0.0000
108	D	H	-0.3073
109	Y	H	0.0645
110	W	H	-0.1331
111	G	H	0.0000
112	Q	H	-1.1798
113	G	H	-0.6018
114	T	H	0.0000
115	T	H	-0.1405
116	V	H	0.0000
117	T	H	0.0000
118	V	H	0.0000
119	S	H	-0.6246
120	S	H	-0.6963
121	A	H	-0.4934
122	S	H	-0.5269
123	T	H	-0.4611
124	K	H	-0.9973
125	G	H	-1.4116
126	P	H	-0.6513
127	S	H	-0.3545
128	V	H	0.0000
129	F	H	0.0000
130	P	H	-0.8070
131	L	H	0.0000
132	A	H	-0.0392
133	P	H	-0.0374
134	C	H	-0.4295
135	S	H	-0.4848
136	R	H	-0.6828
137	S	H	-0.8876
138	T	H	-1.1558
139	S	H	-1.5367
140	E	H	-2.3139
141	S	H	-1.2976
142	T	H	-0.8795
143	A	H	0.0000
144	A	H	0.0000
145	L	H	0.0000
146	G	H	0.0000
147	C	H	0.0000
148	L	H	0.0000
149	V	H	0.0000
150	K	H	-0.2434
151	D	H	-0.3156
152	Y	H	0.0000
153	F	H	-0.1252
154	P	H	0.0000
155	E	H	-0.5845
156	P	H	-0.7686
157	V	H	0.0000
158	T	H	-0.8765
159	V	H	-0.5308
160	S	H	-0.5675
161	W	H	0.0000
162	N	H	-1.2037
163	S	H	-0.8160
164	G	H	-0.6037
165	A	H	-0.2706
166	L	H	-0.0593
167	T	H	-0.1672
168	S	H	-0.1623
169	G	H	-0.1948
170	V	H	0.1980
171	H	H	-0.2951
172	T	H	0.0121
173	F	H	0.0000
174	P	H	-0.4295
175	A	H	0.1009
176	V	H	0.3657
177	L	H	1.0634
178	Q	H	0.2220
179	S	H	-0.0994
180	S	H	-0.2219
181	G	H	0.0628
182	L	H	0.2104
183	Y	H	0.4418
184	S	H	0.0000
185	L	H	0.0000
186	S	H	0.0000
187	S	H	0.0000
188	V	H	0.0000
189	V	H	0.0000
190	T	H	-0.1102
191	V	H	0.0000
192	P	H	-0.6773
193	S	H	-0.8620
194	S	H	-0.6255
195	S	H	-0.8309
196	L	H	0.0000
197	G	H	0.0000
198	T	H	-1.0628
199	K	H	-1.9212
200	T	H	-1.3923
201	Y	H	0.0000
202	T	H	-1.5978
203	C	H	0.0000
204	N	H	-1.7847
205	V	H	0.0000
206	D	H	-2.6133
207	H	H	0.0000
208	K	H	-2.9629
209	P	H	-1.5844
210	S	H	-1.8326
211	N	H	-2.6642
212	T	H	-2.2664
213	K	H	-2.9501
214	V	H	-1.8711
215	D	H	-2.6600
216	K	H	-2.0955
217	R	H	-2.3614
218	V	H	0.0000
219	E	H	0.0000
220	S	H	0.0000
221	K	H	-1.1957
222	Y	H	-0.1548
223	G	H	-0.4640
224	P	H	-0.8131
225	P	H	-0.7182
226	C	H	0.0000
227	P	H	0.0000
228	P	H	0.3766
229	C	H	0.7482
233	E	H	-0.4201
234	F	H	0.2009
235	L	H	-0.0096
236	G	H	-0.2667
237	G	H	-0.2332
238	P	H	-0.4036
239	S	H	-0.1302
240	V	H	0.0000
241	F	H	1.2169
242	L	H	0.0000
243	F	H	1.1110
244	P	H	-0.1639
245	P	H	-1.3564
246	K	H	-2.7684
247	P	H	-2.5630
248	K	H	-2.9630
249	D	H	-2.5971
250	T	H	-0.7168
251	L	H	1.5440
252	M	H	2.2430
253	I	H	2.0281
254	S	H	0.3141
255	R	H	-0.9350
256	T	H	-0.7066
257	P	H	-1.0988
258	E	H	-0.9567
259	V	H	0.0000
260	T	H	0.1042
261	C	H	0.0000
262	V	H	0.0000
263	V	H	0.0000
264	V	H	-0.3657
265	D	H	-0.9725
266	V	H	0.0000
267	S	H	0.0000
268	Q	H	-2.6058
269	E	H	-2.8564
270	D	H	-2.2280
271	P	H	-2.8056
272	E	H	-2.6710
273	V	H	-1.4219
274	Q	H	-1.0006
275	F	H	-0.5388
276	N	H	-0.8026
277	W	H	0.0000
278	Y	H	-0.5763
279	V	H	0.0000
280	D	H	-1.1530
281	G	H	-0.5545
282	V	H	0.5622
283	E	H	-0.6366
284	V	H	-0.6967
285	H	H	-1.8678
286	N	H	-2.1089
287	A	H	-1.7943
288	K	H	-2.3575
289	T	H	-1.7415
290	K	H	-2.3905
291	P	H	-2.2752
292	R	H	-3.8877
293	E	H	-4.1586
294	E	H	-3.6613
295	Q	H	-2.1694
296	F	H	-0.2755
297	N	H	-0.7384
298	S	H	-0.9620
299	T	H	0.0000
300	Y	H	0.0000
301	R	H	-3.0915
302	V	H	0.0000
303	V	H	-1.1334
304	S	H	0.0000
305	V	H	-0.7517
306	L	H	0.0000
307	T	H	-0.5562
308	V	H	-0.1641
309	L	H	-0.3720
310	H	H	-1.3572
311	Q	H	-1.4683
312	D	H	0.0000
313	W	H	-0.4196
314	L	H	-0.3454
315	N	H	0.0000
316	G	H	-1.2959
317	K	H	0.0000
318	E	H	-1.6446
319	Y	H	0.0000
320	K	H	-1.3562
321	C	H	0.0000
322	K	H	-1.0412
323	V	H	0.0000
324	S	H	0.0000
325	N	H	0.0000
326	K	H	-1.8218
327	G	H	-1.3681
328	L	H	-0.4901
329	P	H	-0.7122
330	S	H	-0.5654
331	S	H	-0.5665
332	I	H	-0.7709
333	E	H	-1.6044
334	K	H	-0.9994
335	T	H	-0.7433
336	I	H	-0.2752
337	S	H	-0.9131
338	K	H	-1.2938
339	A	H	-1.1153
340	K	H	-2.0935
341	G	H	-1.4914
342	Q	H	-1.6697
343	P	H	-1.6817
344	R	H	-1.8293
345	E	H	-2.6200
346	P	H	0.0000
347	Q	H	-0.7812
348	V	H	-0.5342
349	Y	H	0.0000
350	T	H	0.0000
351	L	H	0.0000
352	P	H	-0.3207
353	P	H	-0.6995
354	S	H	0.0000
355	Q	H	-1.9583
356	E	H	-2.2906
357	E	H	0.0000
358	M	H	-1.6153
359	T	H	-1.4622
360	K	H	-2.1393
361	N	H	-2.4728
362	Q	H	-2.2902
363	V	H	0.0000
364	S	H	0.0000
365	L	H	0.0000
366	T	H	0.0000
367	C	H	0.0000
368	L	H	0.0000
369	V	H	0.0000
370	K	H	-0.4534
371	G	H	-0.8440
372	F	H	0.0000
373	Y	H	0.0000
374	P	H	-1.3192
375	S	H	-0.9429
376	D	H	-1.9044
377	I	H	-0.8671
378	A	H	-0.2324
379	V	H	0.0000
380	E	H	-1.3839
381	W	H	0.0000
382	E	H	-1.7363
383	S	H	0.0000
384	N	H	-1.7601
385	G	H	-1.7189
386	Q	H	-2.1457
387	P	H	-1.8982
388	E	H	-1.9413
389	N	H	-2.0583
390	N	H	-1.4071
391	Y	H	-0.9482
392	K	H	-0.8060
393	T	H	-0.3254
394	T	H	0.0000
395	P	H	-0.2928
396	P	H	-0.1846
397	V	H	0.1871
398	L	H	0.1685
399	D	H	-0.6530
400	S	H	-1.1352
401	D	H	-1.7090
402	G	H	0.0000
403	S	H	0.0000
404	F	H	-0.1522
405	F	H	0.0000
406	L	H	0.0000
407	Y	H	0.0000
408	S	H	0.0000
409	R	H	0.0000
410	L	H	0.0000
411	T	H	-0.8366
412	V	H	0.0000
413	D	H	-2.5189
414	K	H	-2.5325
415	S	H	-2.2111
416	R	H	-2.0342
417	W	H	0.0000
418	Q	H	-2.3391
419	Q	H	-2.1189
420	G	H	-1.3091
421	N	H	-0.8967
422	V	H	-0.1159
423	F	H	0.0000
424	S	H	0.0000
425	C	H	0.0000
426	S	H	0.0000
427	V	H	0.0000
428	M	H	-0.8200
429	H	H	0.0000
430	E	H	-2.8283
431	A	H	-2.1554
432	L	H	-1.9358
433	H	H	-2.1634
434	N	H	-2.2184
435	H	H	-2.2186
436	Y	H	-0.9579
437	T	H	-0.8075
438	Q	H	-1.1212
439	K	H	-0.8529
440	S	H	-0.4995
441	L	H	0.0000
442	S	H	-0.1841
443	L	H	-0.2164
444	S	H	-0.1937
1	Q	K	-1.3750
2	V	K	-0.6816
3	Q	K	-0.8135
4	L	K	0.0000
5	V	K	0.4192
6	Q	K	0.0000
7	S	K	-0.1948
8	G	K	0.2751
9	V	K	1.4694
10	E	K	0.4426
11	V	K	0.2816
12	K	K	-1.0786
13	K	K	-1.9478
14	P	K	-1.5237
15	G	K	-1.4179
16	A	K	-1.3988
17	S	K	-1.8247
18	V	K	0.0000
19	K	K	-2.2157
20	V	K	0.0000
21	S	K	-0.5328
22	C	K	0.0000
23	K	K	-0.7416
24	A	K	0.0000
25	S	K	-0.6999
26	G	K	-0.9215
27	Y	K	-0.5013
28	T	K	-0.4221
29	F	K	0.0000
30	T	K	-0.7256
31	N	K	-1.3164
32	Y	K	-0.3099
33	Y	K	-0.2108
34	M	K	0.0000
35	Y	K	0.0000
36	W	K	0.0000
37	V	K	0.0000
38	R	K	0.0000
39	Q	K	-0.6429
40	A	K	-1.0332
41	P	K	-1.0587
42	G	K	-1.2540
43	Q	K	-1.7578
44	G	K	-1.1125
45	L	K	0.0000
46	E	K	-0.5640
47	W	K	0.0000
48	M	K	0.0000
49	G	K	0.0000
50	G	K	0.0000
51	I	K	0.0000
52	N	K	0.0000
53	P	K	-0.9249
54	S	K	-1.1692
55	N	K	-1.6438
56	G	K	-1.2510
57	G	K	-0.9867
58	T	K	-0.6208
59	N	K	-0.8653
60	F	K	-1.3336
61	N	K	-2.0990
62	E	K	-3.3845
63	K	K	-3.2841
64	F	K	0.0000
65	K	K	-3.4916
66	N	K	-2.9240
67	R	K	-2.3424
68	V	K	0.0000
69	T	K	-1.2109
70	L	K	0.0000
71	T	K	-0.3510
72	T	K	-0.7990
73	D	K	-1.1582
74	S	K	-0.7868
75	S	K	-0.5863
76	T	K	-0.6597
77	T	K	-0.7702
78	T	K	0.0000
79	A	K	0.0000
80	Y	K	-0.5923
81	M	K	0.0000
82	E	K	-1.8139
83	L	K	0.0000
84	K	K	-2.4373
85	S	K	-1.7704
86	L	K	0.0000
87	Q	K	-1.5168
88	F	K	0.0952
89	D	K	-1.2650
90	D	K	0.0000
91	T	K	-0.2901
92	A	K	0.0000
93	V	K	0.1595
94	Y	K	0.0000
95	Y	K	0.0000
96	C	K	0.0000
97	A	K	0.0000
98	R	K	0.0000
99	R	K	-0.1390
100	D	K	-0.2561
101	Y	K	0.2080
102	R	K	-0.7131
103	F	K	1.1985
104	D	K	0.4842
105	M	K	0.6025
106	G	K	0.0000
107	F	K	0.0000
108	D	K	-0.3103
109	Y	K	0.0498
110	W	K	-0.1820
111	G	K	0.0000
112	Q	K	-1.2501
113	G	K	-0.4835
114	T	K	0.0000
115	T	K	0.3701
116	V	K	0.0000
117	T	K	0.0000
118	V	K	0.0000
119	S	K	0.0000
120	S	K	-0.6125
121	A	K	-0.7490
122	S	K	-0.8482
123	T	K	-0.9148
124	K	K	-1.8073
125	G	K	-1.6692
126	P	K	-0.7881
127	S	K	-0.6059
128	V	K	0.0000
129	F	K	0.0000
130	P	K	0.0000
131	L	K	0.0000
132	A	K	0.0000
133	P	K	0.0128
134	C	K	0.0565
135	S	K	0.0420
136	R	K	-0.4414
137	S	K	-0.4462
138	T	K	-1.0574
139	S	K	-1.8207
140	E	K	-2.3268
141	S	K	-1.5847
142	T	K	-0.8027
143	A	K	0.0000
144	A	K	0.0000
145	L	K	0.0000
146	G	K	0.0000
147	C	K	0.0000
148	L	K	0.0000
149	V	K	0.0000
150	K	K	0.0000
151	D	K	-0.6154
152	Y	K	0.0000
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160	S	M	-0.4266
161	G	M	-1.0064
162	N	M	-0.9607
163	S	M	-1.4685
164	Q	M	-2.0637
165	E	M	-2.3174
166	S	M	-1.0440
167	V	M	-0.9138
168	T	M	-1.1667
169	E	M	-2.2727
170	Q	M	-1.8168
171	D	M	-1.8635
172	S	M	-1.6921
173	K	M	-2.1985
174	D	M	-1.6152
175	S	M	-1.6085
176	T	M	0.0000
177	Y	M	0.0000
178	S	M	0.0000
179	L	M	0.0000
180	S	M	0.0000
181	S	M	0.0000
182	T	M	-0.8906
183	L	M	0.0000
184	T	M	-0.5577
185	L	M	-0.7988
186	S	M	-1.4095
187	K	M	-2.2489
188	A	M	-2.1576
189	D	M	-3.0078
190	Y	M	0.0000
191	E	M	-3.6707
192	K	M	-3.4893
193	H	M	-2.5901
194	K	M	-2.1708
195	V	M	-0.8839
196	Y	M	0.0000
197	A	M	0.0000
198	C	M	0.0000
199	E	M	-1.0664
200	V	M	0.0000
201	T	M	-1.2767
202	H	M	0.0000
203	Q	M	-1.3807
204	G	M	-0.5114
205	L	M	-0.2658
206	S	M	-0.4701
207	S	M	-0.4364
208	P	M	-0.5844
209	V	M	-0.1809
210	T	M	-0.5688
211	K	M	-0.7561
212	S	M	-0.5741
213	F	M	0.0000
214	N	M	-1.0149
215	R	M	-1.3334
216	G	M	-0.9322
217	E	M	0.0000
218	C	M	0.0665